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Items: 22


High-resolution imaging for the detection and characterisation of circulating tumour cells from patients with oesophageal, hepatocellular, thyroid and ovarian cancers.

Dent BM, Ogle LF, O'Donnell RL, Hayes N, Malik U, Curtin NJ, Boddy AV, Plummer ER, Edmondson RJ, Reeves HL, May FE, Jamieson D.

Int J Cancer. 2016 Jan 1;138(1):206-16. doi: 10.1002/ijc.29680. Epub 2015 Aug 19.


A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors.

Peethambaram PP, Hartmann LC, Jonker DJ, de Jonge M, Plummer ER, Martin L, Konner J, Marshall J, Goss GD, Teslenko V, Clemens PL, Cohen LJ, Ahlers CM, Alland L.

Invest New Drugs. 2015 Apr;33(2):321-31. doi: 10.1007/s10637-014-0171-9. Epub 2014 Nov 8.


Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules.

Murray J, Thomas H, Berry P, Kyle S, Patterson M, Jones C, Los G, Hostomsky Z, Plummer ER, Boddy AV, Curtin NJ.

Br J Cancer. 2014 Apr 15;110(8):1977-84. doi: 10.1038/bjc.2014.91. Epub 2014 Feb 20.


Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum, and survival.

Mukhopadhyay A, Plummer ER, Elattar A, Soohoo S, Uzir B, Quinn JE, McCluggage WG, Maxwell P, Aneke H, Curtin NJ, Edmondson RJ.

Cancer Res. 2012 Nov 15;72(22):5675-82. doi: 10.1158/0008-5472.CAN-12-0324. Epub 2012 Oct 11.


Androgen receptor expression is a biological marker for androgen sensitivity in high grade serous epithelial ovarian cancer.

Elattar A, Warburton KG, Mukhopadhyay A, Freer RM, Shaheen F, Cross P, Plummer ER, Robson CN, Edmondson RJ.

Gynecol Oncol. 2012 Jan;124(1):142-7. doi: 10.1016/j.ygyno.2011.09.004. Epub 2011 Oct 15.


Defective homologous recombination in human cancers.

Cerbinskaite A, Mukhopadhyay A, Plummer ER, Curtin NJ, Edmondson RJ.

Cancer Treat Rev. 2012 Apr;38(2):89-100. doi: 10.1016/j.ctrv.2011.04.015. Epub 2011 Jun 28. Review.


Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers.

Zaremba T, Thomas HD, Cole M, Coulthard SA, Plummer ER, Curtin NJ.

Biochem J. 2011 Jun 15;436(3):671-9. doi: 10.1042/BJ20101723.


Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2.

Drew Y, Mulligan EA, Vong WT, Thomas HD, Kahn S, Kyle S, Mukhopadhyay A, Los G, Hostomsky Z, Plummer ER, Edmondson RJ, Curtin NJ.

J Natl Cancer Inst. 2011 Feb 16;103(4):334-46. doi: 10.1093/jnci/djq509. Epub 2010 Dec 23.


Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.

Daniel RA, Rozanska AL, Mulligan EA, Drew Y, Thomas HD, Castelbuono DJ, Hostomsky Z, Plummer ER, Tweddle DA, Boddy AV, Clifford SC, Curtin NJ.

Br J Cancer. 2010 Nov 9;103(10):1588-96. doi: 10.1038/sj.bjc.6605946. Epub 2010 Oct 26.


Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials.

Zaremba T, Thomas H, Cole M, Plummer ER, Curtin NJ.

Cancer Chemother Pharmacol. 2010 Sep;66(4):807-12. doi: 10.1007/s00280-010-1359-0. Epub 2010 May 21.


The role of folate receptor alpha (FRalpha) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy.

Nutt JE, Razak AR, O'Toole K, Black F, Quinn AE, Calvert AH, Plummer ER, Lunec J.

Br J Cancer. 2010 Feb 2;102(3):553-60. doi: 10.1038/sj.bjc.6605501. Epub 2010 Jan 5.


Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines.

Zaremba T, Ketzer P, Cole M, Coulthard S, Plummer ER, Curtin NJ.

Br J Cancer. 2009 Jul 21;101(2):256-62. doi: 10.1038/sj.bjc.6605166. Epub 2009 Jun 30.


Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines.

Clarke MJ, Mulligan EA, Grogan PT, Mladek AC, Carlson BL, Schroeder MA, Curtin NJ, Lou Z, Decker PA, Wu W, Plummer ER, Sarkaria JN.

Mol Cancer Ther. 2009 Feb;8(2):407-14. doi: 10.1158/1535-7163.MCT-08-0854. Epub 2009 Jan 27.


Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

Daniel RA, Rozanska AL, Thomas HD, Mulligan EA, Drew Y, Castelbuono DJ, Hostomsky Z, Plummer ER, Boddy AV, Tweddle DA, Curtin NJ, Clifford SC.

Clin Cancer Res. 2009 Feb 15;15(4):1241-9. doi: 10.1158/1078-0432.CCR-08-1095. Epub 2009 Jan 27.


PARP inhibitors and cancer therapy - early results and potential applications.

Jones C, Plummer ER.

Br J Radiol. 2008 Oct;81 Spec No 1:S2-5. doi: 10.1259/bjr/30872348.


Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy.

Plummer ER, Calvert H.

Clin Cancer Res. 2007 Nov 1;13(21):6252-6. Review.


Inhibition of poly(ADP-ribose) polymerase in cancer.

Plummer ER.

Curr Opin Pharmacol. 2006 Aug;6(4):364-8. Epub 2006 Jun 5. Review.


A phase I and pharmacokinetic study of paclitaxel poliglumex (XYOTAX), investigating both 3-weekly and 2-weekly schedules.

Boddy AV, Plummer ER, Todd R, Sludden J, Griffin M, Robson L, Cassidy J, Bissett D, Bernareggi A, Verrill MW, Calvert AH.

Clin Cancer Res. 2005 Nov 1;11(21):7834-40.


Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

Plummer ER, Middleton MR, Jones C, Olsen A, Hickson I, McHugh P, Margison GP, McGown G, Thorncroft M, Watson AJ, Boddy AV, Calvert AH, Harris AL, Newell DR, Curtin NJ.

Clin Cancer Res. 2005 May 1;11(9):3402-9.


Phase I study of temozolomide plus paclitaxel in patients with advanced malignant melanoma and associated in vitro investigations.

Azzabi A, Hughes AN, Calvert PM, Plummer ER, Todd R, Griffin MJ, Lind MJ, Maraveyas A, Kelly C, Fishwick K, Calvert AH, Boddy AV.

Br J Cancer. 2005 Mar 28;92(6):1006-12.


Seminoma metastatic to the prostate resulting in a rectovesical fistula.

Plummer ER, Greene DR, Roberts JT.

Clin Oncol (R Coll Radiol). 2000;12(4):229-30.


Metastatic adult medulloblastoma showing prolonged response to chemotherapy.

Plummer ER, Roberts JT.

Clin Oncol (R Coll Radiol). 1999;11(6):405-6. Review. No abstract available.


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