Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 32

1.

CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors.

Yu JSL, Palano G, Lim C, Moggio A, Drowley L, Plowright AT, Bohlooly-Y M, Rosen BS, Hansson EM, Wang QD, Yusa K.

Stem Cells. 2019 Apr 1. doi: 10.1002/stem.3012. [Epub ahead of print]

PMID:
30932271
2.

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.

Mills RJ, Parker BL, Quaife-Ryan GA, Voges HK, Needham EJ, Bornot A, Ding M, Andersson H, Polla M, Elliott DA, Drowley L, Clausen M, Plowright AT, Barrett IP, Wang QD, James DE, Porrello ER, Hudson JE.

Cell Stem Cell. 2019 Jun 6;24(6):895-907.e6. doi: 10.1016/j.stem.2019.03.009. Epub 2019 Mar 28.

PMID:
30930147
3.

Unique photoaffinity probes to study TGFβ signaling and receptor fates.

Längle D, Wesseler F, Flötgen D, Leek H, Plowright AT, Schade D.

Chem Commun (Camb). 2019 Apr 9;55(30):4323-4326. doi: 10.1039/c9cc00929a.

PMID:
30887988
4.

Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.

Pettersen D, Broddefalk J, Emtenäs H, Hayes MA, Lemurell M, Swanson M, Ulander J, Whatling C, Amilon C, Ericsson H, Westin Eriksson A, Granberg K, Plowright AT, Shamovsky I, Dellsèn A, Sundqvist M, Någård M, Lindstedt EL.

J Med Chem. 2019 May 9;62(9):4312-4324. doi: 10.1021/acs.jmedchem.8b02004. Epub 2019 Mar 26.

PMID:
30869888
5.

Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors.

Längle D, Werner TR, Wesseler F, Reckzeh E, Schaumann N, Drowley L, Polla M, Plowright AT, Hirt MN, Eschenhagen T, Schade D.

ChemMedChem. 2019 Apr 17;14(8):810-822. doi: 10.1002/cmdc.201900036. Epub 2019 Feb 28.

PMID:
30768867
6.

High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets.

Woo LA, Tkachenko S, Ding M, Plowright AT, Engkvist O, Andersson H, Drowley L, Barrett I, Firth M, Akerblad P, Wolf MJ, Bekiranov S, Brautigan DL, Wang QD, Saucerman JJ.

J Mol Cell Cardiol. 2019 Feb;127:204-214. doi: 10.1016/j.yjmcc.2018.12.015. Epub 2018 Dec 28.

PMID:
30597148
7.

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, Bauer U, Kessler H, Cai M, Hruby VJ, Plowright AT, Craik DJ.

J Med Chem. 2018 Apr 26;61(8):3674-3684. doi: 10.1021/acs.jmedchem.8b00170. Epub 2018 Apr 11.

8.

Directing evolution: the next revolution in drug discovery?

Davis AM, Plowright AT, Valeur E.

Nat Rev Drug Discov. 2017 Oct;16(10):681-698. doi: 10.1038/nrd.2017.146. Epub 2017 Sep 22. Review.

PMID:
28935911
9.

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.

Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodson MP, Ferguson C, Drowley L, Plowright AT, Needham EJ, Wang QD, Gregorevic P, Xin M, Thomas WG, Parton RG, Nielsen LK, Launikonis BS, James DE, Elliott DA, Porrello ER, Hudson JE.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8372-E8381. doi: 10.1073/pnas.1707316114. Epub 2017 Sep 15.

10.

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants.

Alexandru-Crivac CN, Umeobika C, Leikoski N, Jokela J, Rickaby KA, Grilo AM, Sjö P, Plowright AT, Idress M, Siebs E, Nneoyi-Egbe A, Wahlsten M, Sivonen K, Jaspars M, Trembleau L, Fewer DP, Houssen WE.

Chem Commun (Camb). 2017 Sep 26;53(77):10656-10659. doi: 10.1039/c7cc05913b.

PMID:
28905052
11.

Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum.

Plowright AT, Ottmann C, Arkin M, Auberson YP, Timmerman H, Waldmann H.

Cell Chem Biol. 2017 Sep 21;24(9):1058-1065. doi: 10.1016/j.chembiol.2017.05.019. Epub 2017 Jun 8. Review.

12.

New Modalities for Challenging Targets in Drug Discovery.

Valeur E, Guéret SM, Adihou H, Gopalakrishnan R, Lemurell M, Waldmann H, Grossmann TN, Plowright AT.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10294-10323. doi: 10.1002/anie.201611914. Epub 2017 Jul 24. Review.

PMID:
28186380
13.

Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts.

Paunovic AI, Drowley L, Nordqvist A, Ericson E, Mouchet E, Jonebring A, Grönberg G, Kvist AJ, Engkvist O, Brown MR, Gedda K, Goumans MJ, Wang QD, Plowright AT.

ACS Chem Biol. 2017 Jan 20;12(1):132-141. doi: 10.1021/acschembio.6b00683. Epub 2016 Nov 30.

PMID:
28103692
14.

Comparative transcriptomic analysis identifies genes differentially expressed in human epicardial progenitors and hiPSC-derived cardiac progenitors.

Synnergren J, Drowley L, Plowright AT, Brolén G, Goumans MJ, Gittenberger-de Groot AC, Sartipy P, Wang QD.

Physiol Genomics. 2016 Nov 1;48(11):771-784. doi: 10.1152/physiolgenomics.00064.2016. Epub 2016 Sep 2.

15.

Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac Differentiation.

Drowley L, Koonce C, Peel S, Jonebring A, Plowright AT, Kattman SJ, Andersson H, Anson B, Swanson BJ, Wang QD, Brolen G.

Stem Cells Transl Med. 2016 Feb;5(2):164-74. doi: 10.5966/sctm.2015-0114. Epub 2015 Dec 18.

16.

Medicinal Chemistry Approaches to Heart Regeneration.

Schade D, Plowright AT.

J Med Chem. 2015 Dec 24;58(24):9451-79. doi: 10.1021/acs.jmedchem.5b00446. Epub 2015 Sep 3. Review.

PMID:
26288266
17.

Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9.

Geschwindner S, Andersson GM, Beisel HG, Breuer S, Hallberg C, Kihlberg BM, Lindqvist AM, O'Mahony G, Plowright AT, Raubacher F, Knecht W.

Protein Eng Des Sel. 2015 May;28(5):117-25. doi: 10.1093/protein/gzv008. Epub 2015 Mar 4.

PMID:
25744035
18.

Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases.

Lemurell M, Ulander J, Winiwarter S, Dahlén A, Davidsson Ö, Emtenäs H, Broddefalk J, Swanson M, Hovdal D, Plowright AT, Pettersen A, Rydén-Landergren M, Barlind J, Llinas A, Herslöf M, Drmota T, Sigfridsson K, Moses S, Whatling C.

J Med Chem. 2015 Jan 22;58(2):897-911. doi: 10.1021/jm501531v. Epub 2014 Dec 22.

PMID:
25478788
19.

Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction.

Cheng L, Pettersen D, Ohlsson B, Schell P, Karle M, Evertsson E, Pahlén S, Jonforsen M, Plowright AT, Boström J, Fex T, Thelin A, Hilgendorf C, Xue Y, Wahlund G, Lindberg W, Larsson LO, Gustafsson D.

ACS Med Chem Lett. 2014 Feb 18;5(5):538-43. doi: 10.1021/ml400526d. eCollection 2014 May 8.

20.

Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.

Plowright AT, Engkvist O, Gill A, Knerr L, Wang QD.

Angew Chem Int Ed Engl. 2014 Apr 14;53(16):4056-75. doi: 10.1002/anie.201307034. Epub 2014 Jan 27. Review.

PMID:
24470316
21.

Discovery of agonists of cannabinoid receptor 1 with restricted central nervous system penetration aimed for treatment of gastroesophageal reflux disease.

Plowright AT, Nilsson K, Antonsson M, Amin K, Broddefalk J, Jensen J, Lehmann A, Jin S, St-Onge S, Tomaszewski MJ, Tremblay M, Walpole C, Wei Z, Yang H, Ulander J.

J Med Chem. 2013 Jan 10;56(1):220-40. doi: 10.1021/jm301511h. Epub 2012 Dec 24.

PMID:
23227781
22.

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.

McCoull W, Addie MS, Birch AM, Birtles S, Buckett LK, Butlin RJ, Bowker SS, Boyd S, Chapman S, Davies RD, Donald CS, Green CP, Jenner C, Kemmitt PD, Leach AG, Moody GC, Gutierrez PM, Newcombe NJ, Nowak T, Packer MJ, Plowright AT, Revill J, Schofield P, Sheldon C, Stokes S, Turnbull AV, Wang SJ, Whalley DP, Wood JM.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8. doi: 10.1016/j.bmcl.2012.04.117. Epub 2012 May 2.

PMID:
22608962
23.

What is the most important approach in current drug discovery: doing the right things or doing things right?

Elebring T, Gill A, Plowright AT.

Drug Discov Today. 2012 Nov;17(21-22):1166-9. doi: 10.1016/j.drudis.2012.04.009. Epub 2012 Apr 27.

PMID:
22569181
24.

Oxadiazoles in medicinal chemistry.

Boström J, Hogner A, Llinàs A, Wellner E, Plowright AT.

J Med Chem. 2012 Mar 8;55(5):1817-30. doi: 10.1021/jm2013248. Epub 2012 Jan 13.

PMID:
22185670
25.

Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle.

Plowright AT, Johnstone C, Kihlberg J, Pettersson J, Robb G, Thompson RA.

Drug Discov Today. 2012 Jan;17(1-2):56-62. doi: 10.1016/j.drudis.2011.09.012. Epub 2011 Sep 22. Review.

PMID:
21963616
26.

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.

Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallén S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Löfgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Ståhlberg P, Sörme P, Wan H, Wellner E, Oster L.

Bioorg Med Chem. 2011 May 15;19(10):3039-53. doi: 10.1016/j.bmc.2011.04.014. Epub 2011 Apr 13.

PMID:
21515056
27.

Discovery of a series of indan carboxylic acid glycogen phosphorylase inhibitors.

Bennett SN, Campbell AD, Hancock A, Johnstone C, Kenny PW, Pickup A, Plowright AT, Selmi N, Simpson I, Stocker A, Whalley DP, Whittamore PR.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3511-4. doi: 10.1016/j.bmcl.2010.04.147. Epub 2010 May 5.

PMID:
20493691
28.

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

Wyatt EE, Galloway WR, Thomas GL, Welch M, Loiseleur O, Plowright AT, Spring DR.

Chem Commun (Camb). 2008 Oct 28;(40):4962-4. doi: 10.1039/b812901k. Epub 2008 Sep 10.

PMID:
18931753
29.

Skeletal diversity construction via a branching synthetic strategy.

Wyatt EE, Fergus S, Galloway WR, Bender A, Fox DJ, Plowright AT, Jessiman AS, Welch M, Spring DR.

Chem Commun (Camb). 2006 Aug 21;(31):3296-8. Epub 2006 Jul 10.

PMID:
16883415
30.

Total synthesis of (+)-phorboxazole A, a potent cytostatic agent from the sponge Phorbas sp.

Pattenden G, González MA, Little PB, Millan DS, Plowright AT, Tornos JA, Ye T.

Org Biomol Chem. 2003 Dec 7;1(23):4173-208. Epub 2003 Oct 16.

PMID:
14685321
32.

Supplemental Content

Loading ...
Support Center