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Items: 1 to 50 of 370

1.

Site-specific phosphorylation regulates the functions of kindlin-3 in a variety of cells.

Bialkowska K, Sossey-Alaoui K, Pluskota E, Izem L, Qin J, Plow EF.

Life Sci Alliance. 2020 Feb 5;3(3). pii: e201900594. doi: 10.26508/lsa.201900594. Print 2019 Mar.

2.

Effects of thrombospondin-4 on pro-inflammatory phenotype differentiation and apoptosis in macrophages.

Rahman MT, Muppala S, Wu J, Krukovets I, Solovjev D, Verbovetskiy D, Obiako C, Plow EF, Stenina-Adognravi O.

Cell Death Dis. 2020 Jan 23;11(1):53. doi: 10.1038/s41419-020-2237-2.

3.

The Kindlin2-p53-SerpinB2 signaling axis is required for cellular senescence in breast cancer.

Sossey-Alaoui K, Pluskota E, Szpak D, Plow EF.

Cell Death Dis. 2019 Jul 15;10(8):539. doi: 10.1038/s41419-019-1774-z.

4.

VEGFR2 survival and mitotic signaling depends on joint activation of associated C3ar1/C5ar1 and IL-6R-gp130.

Hwang MS, Strainic MG, Pohlmann E, Kim H, Pluskota E, Ramirez-Bergeron DL, Plow EF, Medof ME.

J Cell Sci. 2019 Mar 28;132(6). pii: jcs219352. doi: 10.1242/jcs.219352.

5.

The Kindlin Family of Adapter Proteins.

Plow EF, Qin J.

Circ Res. 2019 Jan 18;124(2):202-204. doi: 10.1161/CIRCRESAHA.118.314362. Review. No abstract available.

6.

Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion.

Vaynberg J, Fukuda K, Lu F, Bialkowska K, Chen Y, Plow EF, Qin J.

Nat Commun. 2018 Oct 26;9(1):4465. doi: 10.1038/s41467-018-06906-7.

7.

The Kindlin-2 regulation of epithelial-to-mesenchymal transition in breast cancer metastasis is mediated through miR-200b.

Sossey-Alaoui K, Pluskota E, Szpak D, Schiemann WP, Plow EF.

Sci Rep. 2018 May 9;8(1):7360. doi: 10.1038/s41598-018-25373-0.

8.

The search for new antithrombotic mechanisms and therapies that may spare hemostasis.

Plow EF, Wang Y, Simon DI.

Blood. 2018 Apr 26;131(17):1899-1902. doi: 10.1182/blood-2017-10-784074. Epub 2018 Feb 21. Review.

9.

A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.

Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc DM, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von Zur Muhlen C, Reinöhl J, Gerhardt T, Plow EF, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A.

Nat Commun. 2018 Feb 6;9(1):525. doi: 10.1038/s41467-018-02896-8.

10.

The WAVE3-YB1 interaction regulates cancer stem cells activity in breast cancer.

Bledzka K, Schiemann B, Schiemann WP, Fox P, Plow EF, Sossey-Alaoui K.

Oncotarget. 2017 Oct 24;8(61):104072-104089. doi: 10.18632/oncotarget.22009. eCollection 2017 Nov 28.

11.

Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation.

Zhu L, Yang J, Bromberger T, Holly A, Lu F, Liu H, Sun K, Klapproth S, Hirbawi J, Byzova TV, Plow EF, Moser M, Qin J.

Nat Commun. 2017 Nov 23;8(1):1744. doi: 10.1038/s41467-017-01822-8.

12.

Thrombospondin-4 in tissue remodeling.

Stenina-Adognravi O, Plow EF.

Matrix Biol. 2019 Jan;75-76:300-313. doi: 10.1016/j.matbio.2017.11.006. Epub 2017 Nov 11. Review.

13.

Kindlin-2 interacts with endothelial adherens junctions to support vascular barrier integrity.

Pluskota E, Bledzka KM, Bialkowska K, Szpak D, Soloviev DA, Jones SV, Verbovetskiy D, Plow EF.

J Physiol. 2017 Oct 15;595(20):6443-6462. doi: 10.1113/JP274380. Epub 2017 Sep 21.

14.

Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1-Mediated Macrophage Infiltration.

Sossey-Alaoui K, Pluskota E, Bialkowska K, Szpak D, Parker Y, Morrison CD, Lindner DJ, Schiemann WP, Plow EF.

Cancer Res. 2017 Sep 15;77(18):5129-5141. doi: 10.1158/0008-5472.CAN-16-2337. Epub 2017 Jul 7.

15.

The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation.

Hirbawi J, Bialkowska K, Bledzka KM, Liu J, Fukuda K, Qin J, Plow EF.

J Biol Chem. 2017 Aug 25;292(34):14258-14269. doi: 10.1074/jbc.M117.776195. Epub 2017 Jun 26.

16.

Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages.

Meller J, Chen Z, Dudiki T, Cull RM, Murtazina R, Bal SK, Pluskota E, Stefl S, Plow EF, Trapp BD, Byzova TV.

JCI Insight. 2017 Jun 2;2(11). pii: 93002. doi: 10.1172/jci.insight.93002. eCollection 2017 Jun 2.

17.

A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks.

Naga Prasad SV, Gupta MK, Duan ZH, Surampudi VS, Liu CG, Kotwal A, Moravec CS, Starling RC, Perez DM, Sen S, Wu Q, Plow EF, Karnik S.

PLoS One. 2017 Mar 22;12(3):e0170456. doi: 10.1371/journal.pone.0170456. eCollection 2017.

18.

An enlightening year in vascular biology.

Plow EF.

Curr Opin Hematol. 2017 May;24(3):222-223. doi: 10.1097/MOH.0000000000000340. No abstract available.

19.

Distinct Effects of Integrins αXβ2 and αMβ2 on Leukocyte Subpopulations during Inflammation and Antimicrobial Responses.

Jawhara S, Pluskota E, Cao W, Plow EF, Soloviev DA.

Infect Immun. 2016 Dec 29;85(1). pii: e00644-16. doi: 10.1128/IAI.00644-16. Print 2017 Jan.

20.

Of Kindlins and Cancer.

Plow EF, Das M, Bialkowska K, Sossey-Alaoui K.

Discoveries (Craiova). 2016 Apr-Jun;4(2). pii: e59. Epub 2016 Jun 30.

21.

Kindlin-2 directly binds actin and regulates integrin outside-in signaling.

Bledzka K, Bialkowska K, Sossey-Alaoui K, Vaynberg J, Pluskota E, Qin J, Plow EF.

J Cell Biol. 2016 Apr 11;213(1):97-108. doi: 10.1083/jcb.201501006. Epub 2016 Apr 4.

22.

The why's and wherefore's of this vascular biology section of Current Opinion in Hematology.

Plow EF.

Curr Opin Hematol. 2016 May;23(3):233-4. doi: 10.1097/MOH.0000000000000242. No abstract available.

23.

Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.

Niki M, Nayak MK, Jin H, Bhasin N, Plow EF, Pandolfi PP, Rothman PB, Chauhan AK, Lentz SR.

Thromb Haemost. 2016 May 2;115(5):969-78. doi: 10.1160/TH15-05-0373. Epub 2016 Jan 21.

24.

miR-138-Mediated Regulation of KINDLIN-2 Expression Modulates Sensitivity to Chemotherapeutics.

Sossey-Alaoui K, Plow EF.

Mol Cancer Res. 2016 Feb;14(2):228-38. doi: 10.1158/1541-7786.MCR-15-0299. Epub 2015 Oct 16.

25.

Structural mechanism of integrin inactivation by filamin.

Liu J, Das M, Yang J, Ithychanda SS, Yakubenko VP, Plow EF, Qin J.

Nat Struct Mol Biol. 2015 May;22(5):383-9. doi: 10.1038/nsmb.2999. Epub 2015 Apr 6.

26.

Site-specific phosphorylation of kindlin-3 protein regulates its capacity to control cellular responses mediated by integrin αIIbβ3.

Bialkowska K, Byzova TV, Plow EF.

J Biol Chem. 2015 Mar 6;290(10):6226-42. doi: 10.1074/jbc.M114.634436. Epub 2015 Jan 21.

27.

The role of RIAM in platelets put to a test.

Plow EF, Qin J.

Blood. 2015 Jan 8;125(2):207-8. doi: 10.1182/blood-2014-11-608992.

PMID:
25573963
28.

Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness.

Meller J, Rogozin IB, Poliakov E, Meller N, Bedanov-Pack M, Plow EF, Qin J, Podrez EA, Byzova TV.

Mol Biol Cell. 2015 Feb 15;26(4):786-96. doi: 10.1091/mbc.E14-08-1294. Epub 2014 Dec 24.

29.

Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.

Yang J, Zhu L, Zhang H, Hirbawi J, Fukuda K, Dwivedi P, Liu J, Byzova T, Plow EF, Wu J, Qin J.

Nat Commun. 2014 Dec 18;5:5880. doi: 10.1038/ncomms6880.

30.

Target-selective protein S-nitrosylation by sequence motif recognition.

Jia J, Arif A, Terenzi F, Willard B, Plow EF, Hazen SL, Fox PL.

Cell. 2014 Oct 23;159(3):623-34. doi: 10.1016/j.cell.2014.09.032. Epub 2014 Oct 16.

31.

WAVE3-NFκB interplay is essential for the survival and invasion of cancer cells.

Davuluri G, Augoff K, Schiemann WP, Plow EF, Sossey-Alaoui K.

PLoS One. 2014 Oct 16;9(10):e110627. doi: 10.1371/journal.pone.0110627. eCollection 2014.

32.

Dual role of the leukocyte integrin αMβ2 in angiogenesis.

Soloviev DA, Hazen SL, Szpak D, Bledzka KM, Ballantyne CM, Plow EF, Pluskota E.

J Immunol. 2014 Nov 1;193(9):4712-21. doi: 10.4049/jimmunol.1400202. Epub 2014 Sep 26.

33.

Rising like the phoenix?

Plow EF, Das M.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2182-3. doi: 10.1161/ATVBAHA.114.304486. No abstract available.

34.

Molecular basis of kindlin-2 binding to integrin-linked kinase pseudokinase for regulating cell adhesion.

Fukuda K, Bledzka K, Yang J, Perera HD, Plow EF, Qin J.

J Biol Chem. 2014 Oct 10;289(41):28363-75. doi: 10.1074/jbc.M114.596692. Epub 2014 Aug 25.

35.

Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions.

Bachir AI, Zareno J, Moissoglu K, Plow EF, Gratton E, Horwitz AR.

Curr Biol. 2014 Aug 18;24(16):1845-53. doi: 10.1016/j.cub.2014.07.011. Epub 2014 Jul 31.

36.

Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.

Xu Z, Chen X, Zhi H, Gao J, Bialkowska K, Byzova TV, Pluskota E, White GC 2nd, Liu J, Plow EF, Ma YQ.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1961-7. doi: 10.1161/ATVBAHA.114.303851. Epub 2014 Jun 26.

37.

Plasminogen promotes macrophage phagocytosis in mice.

Das R, Ganapathy S, Settle M, Plow EF.

Blood. 2014 Jul 31;124(5):679-88. doi: 10.1182/blood-2014-01-549659. Epub 2014 May 29.

38.

Integrin function in vascular biology: a view from 2013.

Plow EF, Meller J, Byzova TV.

Curr Opin Hematol. 2014 May;21(3):241-7. doi: 10.1097/MOH.0000000000000042. Review.

39.

Control of organization and function of muscle and tendon by thrombospondin-4.

Frolova EG, Drazba J, Krukovets I, Kostenko V, Blech L, Harry C, Vasanji A, Drumm C, Sul P, Jenniskens GJ, Plow EF, Stenina-Adognravi O.

Matrix Biol. 2014 Jul;37:35-48. doi: 10.1016/j.matbio.2014.02.003. Epub 2014 Mar 1.

40.

Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional.

DiDonato JA, Aulak K, Huang Y, Wagner M, Gerstenecker G, Topbas C, Gogonea V, DiDonato AJ, Tang WH, Mehl RA, Fox PL, Plow EF, Smith JD, Fisher EA, Hazen SL.

J Biol Chem. 2014 Apr 11;289(15):10276-92. doi: 10.1074/jbc.M114.556506. Epub 2014 Feb 20.

41.

Kindlin-3 enhances breast cancer progression and metastasis by activating Twist-mediated angiogenesis.

Sossey-Alaoui K, Pluskota E, Davuluri G, Bialkowska K, Das M, Szpak D, Lindner DJ, Downs-Kelly E, Thompson CL, Plow EF.

FASEB J. 2014 May;28(5):2260-71. doi: 10.1096/fj.13-244004. Epub 2014 Jan 27.

42.

An abundant dysfunctional apolipoprotein A1 in human atheroma.

Huang Y, DiDonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF, Fox PL, Gogonea V, Tang WH, Parks JS, Fisher EA, Smith JD, Hazen SL.

Nat Med. 2014 Feb;20(2):193-203. doi: 10.1038/nm.3459. Epub 2014 Jan 26.

43.

Loss of WAVE3 sensitizes triple-negative breast cancers to chemotherapeutics by inhibiting the STAT-HIF-1α-mediated angiogenesis.

Davuluri G, Schiemann WP, Plow EF, Sossey-Alaoui K.

JAKSTAT. 2015 Feb 3;3(4):e1009276. doi: 10.1080/21623996.2015.1009276. eCollection 2014.

44.

A new view of integrin αIIbβ3 bound to membrane.

Qin J, Plow EF.

Blood. 2013 Dec 19;122(26):4157-9. doi: 10.1182/blood-2013-10-534149.

45.

Upregulated WAVE3 expression is essential for TGF-β-mediated EMT and metastasis of triple-negative breast cancer cells.

Taylor MA, Davuluri G, Parvani JG, Schiemann BJ, Wendt MK, Plow EF, Schiemann WP, Sossey-Alaoui K.

Breast Cancer Res Treat. 2013 Nov;142(2):341-53. doi: 10.1007/s10549-013-2753-1. Epub 2013 Nov 7.

46.

Function and distribution of apolipoprotein A1 in the artery wall are markedly distinct from those in plasma.

DiDonato JA, Huang Y, Aulak KS, Even-Or O, Gerstenecker G, Gogonea V, Wu Y, Fox PL, Tang WH, Plow EF, Smith JD, Fisher EA, Hazen SL.

Circulation. 2013 Oct 8;128(15):1644-55. doi: 10.1161/CIRCULATIONAHA.113.002624. Epub 2013 Aug 22.

47.

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex.

Huang Y, Wu Z, Riwanto M, Gao S, Levison BS, Gu X, Fu X, Wagner MA, Besler C, Gerstenecker G, Zhang R, Li XM, DiDonato AJ, Gogonea V, Tang WH, Smith JD, Plow EF, Fox PL, Shih DM, Lusis AJ, Fisher EA, DiDonato JA, Landmesser U, Hazen SL.

J Clin Invest. 2013 Sep;123(9):3815-28. doi: 10.1172/JCI67478. Epub 2013 Aug 1.

48.

Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism.

Pluskota E, Ma Y, Bledzka KM, Bialkowska K, Soloviev DA, Szpak D, Podrez EA, Fox PL, Hazen SL, Dowling JJ, Ma YQ, Plow EF.

Blood. 2013 Oct 3;122(14):2491-9. doi: 10.1182/blood-2013-04-497669. Epub 2013 Jul 29.

49.

Mechanisms of talin-dependent integrin signaling and crosstalk.

Das M, Ithychanda S, Qin J, Plow EF.

Biochim Biophys Acta. 2014 Feb;1838(2):579-88. doi: 10.1016/j.bbamem.2013.07.017. Epub 2013 Jul 24. Review.

50.

Integrin αIIbβ3: from discovery to efficacious therapeutic target.

Bledzka K, Smyth SS, Plow EF.

Circ Res. 2013 Apr 12;112(8):1189-200. doi: 10.1161/CIRCRESAHA.112.300570. Review.

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