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Items: 48

1.

Characterization of CyrI, the hydroxylase involved in the last step of cylindrospermopsin biosynthesis: Binding studies, site-directed mutagenesis and stereoselectivity.

Mazmouz R, Essadik I, Hamdane D, Méjean A, Ploux O.

Arch Biochem Biophys. 2018 Jun 1;647:1-9. doi: 10.1016/j.abb.2018.04.007. Epub 2018 Apr 11.

PMID:
29653078
2.

Fluorescence in situ hybridization of Microcystis strains producing microcystin using specific mRNA probes.

Zeller P, Méjean A, Biegala I, Contremoulins V, Ploux O.

Lett Appl Microbiol. 2016 Nov;63(5):376-383. doi: 10.1111/lam.12634. Epub 2016 Sep 14.

PMID:
27538762
3.

Dihydroanatoxin-a Is Biosynthesized from Proline in Cylindrospermum stagnale PCC 7417: Isotopic Incorporation Experiments and Mass Spectrometry Analysis.

Méjean A, Dalle K, Paci G, Bouchonnet S, Mann S, Pichon V, Ploux O.

J Nat Prod. 2016 Jul 22;79(7):1775-82. doi: 10.1021/acs.jnatprod.6b00189. Epub 2016 Jun 24.

PMID:
27340731
4.

A simple protocol for attenuating the auto-fluorescence of cyanobacteria for optimized fluorescence in situ hybridization (FISH) imaging.

Zeller P, Ploux O, Méjean A.

J Microbiol Methods. 2016 Mar;122:16-9. doi: 10.1016/j.mimet.2016.01.006. Epub 2016 Jan 15.

PMID:
26780689
5.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

6.

Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme.

Delzor A, Couratier P, Boumédiène F, Nicol M, Druet-Cabanac M, Paraf F, Méjean A, Ploux O, Leleu JP, Brient L, Lengronne M, Pichon V, Combès A, El Abdellaoui S, Bonneterre V, Lagrange E, Besson G, Bicout DJ, Boutonnat J, Camu W, Pageot N, Juntas-Morales R, Rigau V, Masseret E, Abadie E, Preux PM, Marin B.

BMJ Open. 2014 Sep 1;4(8):e005528. doi: 10.1136/bmjopen-2014-005528.

7.

Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria.

Méjean A, Paci G, Gautier V, Ploux O.

Toxicon. 2014 Dec;91:15-22. doi: 10.1016/j.toxicon.2014.07.016. Epub 2014 Aug 6.

PMID:
25108149
8.

Structure of the prolyl-acyl carrier protein oxidase involved in the biosynthesis of the cyanotoxin anatoxin-a.

Moncoq K, Regad L, Mann S, Méjean A, Ploux O.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2340-52. doi: 10.1107/S0907444913021859. Epub 2013 Nov 19.

PMID:
24311576
9.

An active site mutant of Escherichia coli cyclopropane fatty acid synthase forms new non-natural fatty acids providing insights on the mechanism of the enzymatic reaction.

E G, Drujon T, Correia I, Ploux O, Guianvarc'h D.

Biochimie. 2013 Dec;95(12):2336-44. doi: 10.1016/j.biochi.2013.08.007. Epub 2013 Aug 15.

PMID:
23954860
10.

Validation of the analytical procedure for the determination of the neurotoxin β-N-methylamino-L-alanine in complex environmental samples.

Combes A, El Abdellaoui S, Sarazin C, Vial J, Mejean A, Ploux O, Pichon V; BMAALS group.

Anal Chim Acta. 2013 Apr 10;771:42-9. doi: 10.1016/j.aca.2013.02.016. Epub 2013 Feb 19.

PMID:
23522111
11.
12.

A microplate fluorescence assay for DAPA aminotransferase by detection of the vicinal diamine 7,8-diaminopelargonic acid.

Mann S, Eveleigh L, Lequin O, Ploux O.

Anal Biochem. 2013 Jan 15;432(2):90-6. doi: 10.1016/j.ab.2012.09.038. Epub 2012 Oct 12.

PMID:
23068037
13.

Insights into the reaction mechanism of the prolyl-acyl carrier protein oxidase involved in anatoxin-a and homoanatoxin-a biosynthesis.

Mann S, Lombard B, Loew D, Méjean A, Ploux O.

Biochemistry. 2011 Aug 23;50(33):7184-97. doi: 10.1021/bi200892a. Epub 2011 Jul 27.

PMID:
21786780
14.

The last step of the biosynthesis of the cyanotoxins cylindrospermopsin and 7-epi-cylindrospermopsin is catalysed by CyrI, a 2-Oxoglutarate-dependent iron oxygenase.

Mazmouz R, Chapuis-Hugon F, Pichon V, Méjean A, Ploux O.

Chembiochem. 2011 Apr 11;12(6):858-62. doi: 10.1002/cbic.201000726. Epub 2011 Mar 14. No abstract available.

PMID:
21404419
15.

Pyridoxal-5'-phosphate-dependent enzymes involved in biotin biosynthesis: structure, reaction mechanism and inhibition.

Mann S, Ploux O.

Biochim Biophys Acta. 2011 Nov;1814(11):1459-66. doi: 10.1016/j.bbapap.2010.12.004. Epub 2010 Dec 21. Review.

PMID:
21182990
16.

The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506 reveals several gene clusters responsible for the biosynthesis of toxins and secondary metabolites.

Méjean A, Mazmouz R, Mann S, Calteau A, Médigue C, Ploux O.

J Bacteriol. 2010 Oct;192(19):5264-5. doi: 10.1128/JB.00704-10. Epub 2010 Jul 30.

17.

Insight into the reaction mechanism of the Escherichia coli cyclopropane fatty acid synthase: isotope exchange and kinetic isotope effects.

Guangqi E, Lesage D, Ploux O.

Biochimie. 2010 Oct;92(10):1454-7. doi: 10.1016/j.biochi.2010.05.019. Epub 2010 Jun 9.

PMID:
20538038
18.

Biosynthesis of cylindrospermopsin and 7-epicylindrospermopsin in Oscillatoria sp. strain PCC 6506: identification of the cyr gene cluster and toxin analysis.

Mazmouz R, Chapuis-Hugon F, Mann S, Pichon V, Méjean A, Ploux O.

Appl Environ Microbiol. 2010 Aug;76(15):4943-9. doi: 10.1128/AEM.00717-10. Epub 2010 Jun 4.

19.

In vitro reconstitution of the first steps of anatoxin-a biosynthesis in Oscillatoria PCC 6506: from free L-proline to acyl carrier protein bound dehydroproline.

Méjean A, Mann S, Vassiliadis G, Lombard B, Loew D, Ploux O.

Biochemistry. 2010 Jan 12;49(1):103-13. doi: 10.1021/bi9018785.

PMID:
19954230
20.

Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline.

Méjean A, Mann S, Maldiney T, Vassiliadis G, Lequin O, Ploux O.

J Am Chem Soc. 2009 Jun 10;131(22):7512-3. doi: 10.1021/ja9024353.

PMID:
19489636
21.

Identification of a polyketide synthase coding sequence specific for anatoxin-a-producing Oscillatoria cyanobacteria.

Cadel-Six S, Iteman I, Peyraud-Thomas C, Mann S, Ploux O, Méjean A.

Appl Environ Microbiol. 2009 Jul;75(14):4909-12. doi: 10.1128/AEM.02478-08. Epub 2009 May 15.

22.

S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases.

Vaubourgeix J, Bardou F, Boissier F, Julien S, Constant P, Ploux O, Daffé M, Quémard A, Mourey L.

J Biol Chem. 2009 Jul 17;284(29):19321-30. doi: 10.1074/jbc.M809599200. Epub 2009 May 13.

23.

Inhibition of 7,8-diaminopelargonic acid aminotransferase from Mycobacterium tuberculosis by chiral and achiral anologs of its substrate: biological implications.

Mann S, Colliandre L, Labesse G, Ploux O.

Biochimie. 2009 Jul;91(7):826-34. doi: 10.1016/j.biochi.2009.03.019. Epub 2009 Apr 2.

PMID:
19345718
24.

Identification of inhibitors of the E. coli cyclopropane fatty acid synthase from the screening of a chemical library: In vitro and in vivo studies.

Guianvarc'h D, Guangqi E, Drujon T, Rey C, Wang Q, Ploux O.

Biochim Biophys Acta. 2008 Nov;1784(11):1652-8. doi: 10.1016/j.bbapap.2008.04.019. Epub 2008 May 5.

PMID:
18501724
26.

Identification of new inhibitors of E. coli cyclopropane fatty acid synthase using a colorimetric assay.

Guianvarc'h D, Drujon T, Leang TE, Courtois F, Ploux O.

Biochim Biophys Acta. 2006 Aug;1764(8):1381-8. Epub 2006 Jun 18.

PMID:
16872920
27.

Escherichia coli cyclopropane fatty acid synthase: is a bound bicarbonate ion the active-site base?

Courtois F, Ploux O.

Biochemistry. 2005 Oct 18;44(41):13583-90.

PMID:
16216082
28.

Inhibition of 7,8-diaminopelargonic acid aminotransferase by amiclenomycin and analogues.

Mann S, Marquet A, Ploux O.

Biochem Soc Trans. 2005 Aug;33(Pt 4):802-5. Review.

PMID:
16042602
29.

Escherichia coli cyclopropane fatty acid synthase.

Courtois F, Guérard C, Thomas X, Ploux O.

Eur J Biochem. 2004 Dec;271(23-24):4769-78.

30.

Synthesis and evaluation of analogues of S-adenosyl-L-methionine, as inhibitors of the E. coli cyclopropane fatty acid synthase.

Guérard C, Bréard M, Courtois F, Drujon T, Ploux O.

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1661-4.

PMID:
15026045
32.

Biotin synthase mechanism: on the origin of sulphur.

Bui BT, Florentin D, Fournier F, Ploux O, Méjean A, Marquet A.

FEBS Lett. 1998 Nov 27;440(1-2):226-30.

34.

Crystallization and preliminary X-ray study of the 8-amino-7-oxopelargonate synthase from Bacillus sphaericus.

Spinelli S, Ploux O, Marquet A, Anguille C, Jelsch C, Cambillau C, Martinez C.

Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):866-8.

PMID:
15299653
36.

Highly purified biotin synthase can transform dethiobiotin into biotin in the absence of any other protein, in the presence of photoreduced deazaflavin.

Méjean A, Bui BT, Florentin D, Ploux O, Izumi Y, Marquet A.

Biochem Biophys Res Commun. 1995 Dec 26;217(3):1231-7.

PMID:
8554581
40.
41.
43.

Analysis of tachykinin-binding site interactions using NMR and energy calculation data of potent cyclic analogues of substance P.

Convert O, Ploux O, Lavielle S, Cotrait M, Chassaing G.

Biochim Biophys Acta. 1988 Jun 13;954(3):287-302.

PMID:
2453217
45.

Analysis of tachykinin binding site interactions using constrained analogues of tachykinins.

Lavielle S, Chassaing G, Ploux O, Loeuillet D, Besseyre J, Julien S, Marquet A, Convert O, Beaujouan JC, Torrens Y, et al.

Biochem Pharmacol. 1988 Jan 1;37(1):41-9. Review. No abstract available.

PMID:
2827684
46.

Interaction of tachykinins with their receptors studied with cyclic analogues of substance P and neurokinin B.

Ploux O, Lavielle S, Chassaing G, Julien S, Marquet A, d'Orléans-Juste P, Dion S, Regoli D, Beaujouan JC, Bergström L, et al.

Proc Natl Acad Sci U S A. 1987 Nov;84(22):8095-9.

47.

Cyclization of peptides on a solid support. Application to cyclic analogs of substance P.

Ploux O, Chassaing G, Marquet A.

Int J Pept Protein Res. 1987 Feb;29(2):162-9.

PMID:
2437065
48.

Tachykinin receptors in the CNS.

Glowinski J, Torrens Y, Saffroy M, Bergström L, Beaujouan JC, Lavielle S, Ploux O, Chassaing G, Marquet A.

Prog Brain Res. 1987;72:197-203. No abstract available.

PMID:
3039576

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