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Items: 37

1.

Translating biased signaling in the ghrelin receptor system into differential in vivo functions.

Mende F, Hundahl C, Plouffe B, Skov LJ, Sivertsen B, Madsen AN, Lückmann M, Diep TA, Offermanns S, Frimurer TM, Bouvier M, Holst B.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10255-E10264. doi: 10.1073/pnas.1804003115. Epub 2018 Oct 9.

2.

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.

Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7650. doi: 10.1126/scisignal.aat7650.

PMID:
30254056
3.

Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling.

Karamitri A, Plouffe B, Bonnefond A, Chen M, Gallion J, Guillaume JL, Hegron A, Boissel M, Canouil M, Langenberg C, Wareham NJ, Le Gouill C, Lukasheva V, Lichtarge O, Froguel P, Bouvier M, Jockers R.

Sci Signal. 2018 Aug 28;11(545). pii: eaan6622. doi: 10.1126/scisignal.aan6622.

PMID:
30154102
4.

Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication.

Mensah SA, Cheng MJ, Homayoni H, Plouffe BD, Coury AJ, Ebong EE.

PLoS One. 2017 Oct 12;12(10):e0186116. doi: 10.1371/journal.pone.0186116. eCollection 2017.

5.

Circulating Endothelial Cell Quantification by Microfluidics Chip in Pulmonary Arterial Hypertension.

Sallmon H, Hatch A, Murthy SK, Plouffe BD, Hansmann G.

Am J Respir Cell Mol Biol. 2017 May;56(5):680-682. doi: 10.1165/rcmb.2017-0026LE. No abstract available.

6.

Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells.

Stallaert W, van der Westhuizen ET, Schönegge AM, Plouffe B, Hogue M, Lukashova V, Inoue A, Ishida S, Aoki J, Le Gouill C, Bouvier M.

Mol Pharmacol. 2017 May;91(5):533-544. doi: 10.1124/mol.116.106419. Epub 2017 Mar 9.

PMID:
28280061
7.

Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.

Möller D, Banerjee A, Uzuneser TC, Skultety M, Huth T, Plouffe B, Hübner H, Alzheimer C, Friedland K, Müller CP, Bouvier M, Gmeiner P.

J Med Chem. 2017 Apr 13;60(7):2908-2929. doi: 10.1021/acs.jmedchem.6b01857. Epub 2017 Mar 22.

PMID:
28248104
8.

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567. doi: 10.1073/pnas.1701529114. Epub 2017 Feb 21.

9.

Fluorescence-based lateral flow assays for rapid oral fluid roadside detection of cannabis use.

Plouffe BD, Murthy SK.

Electrophoresis. 2017 Feb;38(3-4):501-506. doi: 10.1002/elps.201600075. Epub 2016 Nov 28.

PMID:
27862053
10.

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ.

Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4.

11.

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.

Bradley SJ, Wiegman CH, Iglesias MM, Kong KC, Butcher AJ, Plouffe B, Goupil E, Bourgognon JM, Macedo-Hatch T, LeGouill C, Russell K, Laporte SA, König GM, Kostenis E, Bouvier M, Chung KF, Amrani Y, Tobin AB.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4524-9. doi: 10.1073/pnas.1521706113. Epub 2016 Apr 8.

12.

Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension.

Calvier L, Legchenko E, Grimm L, Sallmon H, Hatch A, Plouffe BD, Schroeder C, Bauersachs J, Murthy SK, Hansmann G.

Heart. 2016 Mar;102(5):390-6. doi: 10.1136/heartjnl-2015-308365.

PMID:
26869635
13.

An Integrated Platform for Isolation, Processing, and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood.

Li S, Plouffe BD, Belov AM, Ray S, Wang X, Murthy SK, Karger BL, Ivanov AR.

Mol Cell Proteomics. 2015 Jun;14(6):1672-83. doi: 10.1074/mcp.M114.045724. Epub 2015 Mar 9.

14.

Fundamentals and application of magnetic particles in cell isolation and enrichment: a review.

Plouffe BD, Murthy SK, Lewis LH.

Rep Prog Phys. 2015 Jan;78(1):016601. doi: 10.1088/0034-4885/78/1/016601. Epub 2014 Dec 4. Review.

15.

Perspective on microfluidic cell separation: a solved problem?

Plouffe BD, Murthy SK.

Anal Chem. 2014 Dec 2;86(23):11481-8. doi: 10.1021/ac5013283. Epub 2014 Nov 10. Review.

16.

Constitutive activities and inverse agonism in dopamine receptors.

Zhang B, Albaker A, Plouffe B, Lefebvre C, Tiberi M.

Adv Pharmacol. 2014;70:175-214. doi: 10.1016/B978-0-12-417197-8.00007-9. Review.

PMID:
24931197
17.

Multisite evaluation of a monoclonal IMMULITE erythropoietin immunoassay.

Owen WE, Lambert-Messerlian G, Delaney C, Christenson R, Plouffe B, Ludewig R, Woods A, Lei JD, Thompson S, Roberts WL, Straseski JA.

Clin Biochem. 2014 Feb;47(3):216-9. doi: 10.1016/j.clinbiochem.2013.11.012. Epub 2013 Nov 26.

PMID:
24291051
19.

Clinically relevant microfluidic magnetophoretic isolation of rare-cell populations for diagnostic and therapeutic monitoring applications.

Plouffe BD, Mahalanabis M, Lewis LH, Klapperich CM, Murthy SK.

Anal Chem. 2012 Feb 7;84(3):1336-44. doi: 10.1021/ac2022844. Epub 2012 Jan 27.

PMID:
22240089
20.
21.

Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension.

Hansmann G, Plouffe BD, Hatch A, von Gise A, Sallmon H, Zamanian RT, Murthy SK.

J Mol Med (Berl). 2011 Oct;89(10):971-83. doi: 10.1007/s00109-011-0779-6. Epub 2011 Jul 7.

22.

Computational design optimization for microfluidic magnetophoresis.

Plouffe BD, Lewis LH, Murthy SK.

Biomicrofluidics. 2011 Mar 30;5:13413. doi: 10.1063/1.3553239. Erratum in: Biomicrofluidics. 2011;5(4):49901.

23.

Probing the constitutive activity among dopamine D1 and D5 receptors and their mutants.

Plouffe B, D'Aoust JP, Laquerre V, Liang B, Tiberi M.

Methods Enzymol. 2010;484:295-328. doi: 10.1016/B978-0-12-381298-8.00016-2.

PMID:
21036239
24.

Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition.

Mahalingam AK, Wan Y, Murugaiah AM, Wallinder C, Wu X, Plouffe B, Botros M, Nyberg F, Hallberg A, Gallo-Payet N, Alterman M.

Bioorg Med Chem. 2010 Jun 15;18(12):4570-90. doi: 10.1016/j.bmc.2010.03.064. Epub 2010 Apr 9.

PMID:
20493713
25.

Development of microfluidics as endothelial progenitor cell capture technology for cardiovascular tissue engineering and diagnostic medicine.

Plouffe BD, Kniazeva T, Mayer JE Jr, Murthy SK, Sales VL.

FASEB J. 2009 Oct;23(10):3309-14. doi: 10.1096/fj.09-130260. Epub 2009 Jun 1.

26.

Controlled capture and release of cardiac fibroblasts using peptide-functionalized alginate gels in microfluidic channels.

Plouffe BD, Brown MA, Iyer RK, Radisic M, Murthy SK.

Lab Chip. 2009 Jun 7;9(11):1507-10. doi: 10.1039/b823523f. Epub 2009 Mar 12.

PMID:
19458855
27.

Microfluidic depletion of endothelial cells, smooth muscle cells, and fibroblasts from heterogeneous suspensions.

Plouffe BD, Radisic M, Murthy SK.

Lab Chip. 2008 Mar;8(3):462-72. doi: 10.1039/b715707j. Epub 2008 Feb 14.

PMID:
18305866
28.

In vitro irradiation of basement membrane enhances the invasiveness of breast cancer cells.

Paquette B, Baptiste C, Therriault H, Arguin G, Plouffe B, Lemay R.

Br J Cancer. 2007 Dec 3;97(11):1505-12. Epub 2007 Nov 6.

29.

Selective angiotensin II AT(2) receptor agonists devoid of the imidazole ring system.

Murugaiah AM, Wallinder C, Mahalingam AK, Wu X, Wan Y, Plouffe B, Botros M, Karlén A, Hallberg M, Gallo-Payet N, Alterman M.

Bioorg Med Chem. 2007 Nov 15;15(22):7166-83. Epub 2007 Aug 22.

PMID:
17825570
30.

Peptide-mediated selective adhesion of smooth muscle and endothelial cells in microfluidic shear flow.

Plouffe BD, Njoka DN, Harris J, Liao J, Horick NK, Radisic M, Murthy SK.

Langmuir. 2007 Apr 24;23(9):5050-5. Epub 2007 Mar 21.

PMID:
17373836
31.

Selective angiotensin II AT2 receptor agonists: arylbenzylimidazole structure-activity relationships.

Wu X, Wan Y, Mahalingam AK, Murugaiah AM, Plouffe B, Botros M, Karlén A, Hallberg M, Gallo-Payet N, Alterman M.

J Med Chem. 2006 Nov 30;49(24):7160-8.

PMID:
17125268
32.

Role of tyrosine kinase receptors in angiotensin II AT2 receptor signaling: involvement in neurite outgrowth and in p42/p44mapk activation in NG108-15 cells.

Plouffe B, Guimond MO, Beaudry H, Gallo-Payet N.

Endocrinology. 2006 Oct;147(10):4646-54. Epub 2006 Jun 29.

PMID:
16809450
33.

Short pseudopeptides containing turn scaffolds with high AT2 receptor affinity.

Georgsson J, Rosenström U, Wallinder C, Beaudry H, Plouffe B, Lindeberg G, Botros M, Nyberg F, Karlén A, Gallo-Payet N, Hallberg A.

Bioorg Med Chem. 2006 Sep 1;14(17):5963-72. Epub 2006 Jun 5.

PMID:
16753301
34.

Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity.

Georgsson J, Sköld C, Plouffe B, Lindeberg G, Botros M, Larhed M, Nyberg F, Gallo-Payet N, Gogoll A, Karlén A, Hallberg A.

J Med Chem. 2005 Oct 20;48(21):6620-31.

PMID:
16220978
35.

New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists.

Rosenström U, Sköld C, Plouffe B, Beaudry H, Lindeberg G, Botros M, Nyberg F, Wolf G, Karlén A, Gallo-Payet N, Hallberg A.

J Med Chem. 2005 Jun 16;48(12):4009-24.

PMID:
15943474
36.

Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.

Wan Y, Wallinder C, Plouffe B, Beaudry H, Mahalingam AK, Wu X, Johansson B, Holm M, Botoros M, Karlén A, Pettersson A, Nyberg F, Fändriks L, Gallo-Payet N, Hallberg A, Alterman M.

J Med Chem. 2004 Nov 18;47(24):5995-6008.

PMID:
15537354

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