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Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix.

Jailkhani N, Ingram JR, Rashidian M, Rickelt S, Tian C, Mak H, Jiang Z, Ploegh HL, Hynes RO.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14181-14190. doi: 10.1073/pnas.1817442116. Epub 2019 May 8.


Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein.

Fang T, Li R, Li Z, Cho J, Guzman JS, Kamm RD, Ploegh HL.

Mol Pharm. 2019 Jun 3;16(6):2838-2844. doi: 10.1021/acs.molpharmaceut.9b00078. Epub 2019 Apr 29.


Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice.

Xie YJ, Dougan M, Jailkhani N, Ingram J, Fang T, Kummer L, Momin N, Pishesha N, Rickelt S, Hynes RO, Ploegh H.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7624-7631. doi: 10.1073/pnas.1817147116. Epub 2019 Apr 1.


Protection of tissue physicochemical properties using polyfunctional crosslinkers.

Park YG, Sohn CH, Chen R, McCue M, Yun DH, Drummond GT, Ku T, Evans NB, Oak HC, Trieu W, Choi H, Jin X, Lilascharoen V, Wang J, Truttmann MC, Qi HW, Ploegh HL, Golub TR, Chen SC, Frosch MP, Kulik HJ, Lim BK, Chung K.

Nat Biotechnol. 2018 Dec 17. doi: 10.1038/nbt.4281. [Epub ahead of print]


Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles.

Yang YS, Moynihan KD, Bekdemir A, Dichwalkar TM, Noh MM, Watson N, Melo M, Ingram J, Suh H, Ploegh H, Stellacci FR, Irvine DJ.

Biomater Sci. 2018 Dec 18;7(1):113-124. doi: 10.1039/c8bm01208c.


Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure.

Fang T, Lu X, Berger D, Gmeiner C, Cho J, Schalek R, Ploegh H, Lichtman J.

Nat Methods. 2018 Dec;15(12):1029-1032. doi: 10.1038/s41592-018-0177-x. Epub 2018 Nov 5.


Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity.

Kaur M, Kumar D, Butty V, Singh S, Esteban A, Fink GR, Ploegh HL, Sehrawat S.

iScience. 2018 Nov 30;9:101-119. doi: 10.1016/j.isci.2018.10.013. Epub 2018 Oct 17.


Targeted Delivery of Cyclotides via Conjugation to a Nanobody.

Kwon S, Duarte JN, Li Z, Ling JJ, Cheneval O, Durek T, Schroeder CI, Craik DJ, Ploegh HL.

ACS Chem Biol. 2018 Oct 19;13(10):2973-2980. doi: 10.1021/acschembio.8b00653. Epub 2018 Oct 5.


One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1.

Harmand TJ, Bousbaine D, Chan A, Zhang X, Liu DR, Tam JP, Ploegh HL.

Bioconjug Chem. 2018 Oct 17;29(10):3245-3249. doi: 10.1021/acs.bioconjchem.8b00563. Epub 2018 Sep 21.


Sortase A: A Model for Transpeptidation and Its Biological Applications.

Pishesha N, Ingram JR, Ploegh HL.

Annu Rev Cell Dev Biol. 2018 Oct 6;34:163-188. doi: 10.1146/annurev-cellbio-100617-062527. Epub 2018 Aug 15. Review.


Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation.

Bartels L, Ploegh HL, Spits H, Wagner K.

Methods. 2019 Feb 1;154:93-101. doi: 10.1016/j.ymeth.2018.07.013. Epub 2018 Aug 3.


Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.

Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC.

Elife. 2018 Jun 8;7. pii: e35850. doi: 10.7554/eLife.35850.


Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses.

Woodham AW, Cheloha RW, Ling J, Rashidian M, Kolifrath SC, Mesyngier M, Duarte JN, Bader JM, Skeate JG, Da Silva DM, Kast WM, Ploegh HL.

Cancer Immunol Res. 2018 Jul;6(7):870-880. doi: 10.1158/2326-6066.CIR-17-0661. Epub 2018 May 23.


Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.

Truttmann MC, Pincus D, Ploegh HL.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5008-E5017. doi: 10.1073/pnas.1801989115. Epub 2018 May 14.


The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan3464. doi: 10.1126/scitranslmed.aan3464.


Anti-CTLA-4 therapy requires an Fc domain for efficacy.

Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3912-3917. doi: 10.1073/pnas.1801524115. Epub 2018 Mar 26.


Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC.

J Cell Biol. 2018 May 7;217(5):1739-1755. doi: 10.1083/jcb.201709137. Epub 2018 Mar 6.


Exploiting Nanobodies' Singular Traits.

Ingram JR, Schmidt FI, Ploegh HL.

Annu Rev Immunol. 2018 Apr 26;36:695-715. doi: 10.1146/annurev-immunol-042617-053327. Epub 2018 Feb 28.


Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1-Specific VHHs.

Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK.

Cancer Immunol Res. 2018 Apr;6(4):389-401. doi: 10.1158/2326-6066.CIR-17-0495. Epub 2018 Feb 19.


Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen.

Pichugin A, Zarling S, Perazzo L, Duffy PE, Ploegh HL, Krzych U.

Front Immunol. 2018 Jan 29;9:91. doi: 10.3389/fimmu.2018.00091. eCollection 2018.


The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent.

Bachran C, Schröder M, Conrad L, Cragnolini JJ, Tafesse FG, Helming L, Ploegh HL, Swee LK.

Sci Rep. 2017 Dec 20;7(1):17916. doi: 10.1038/s41598-017-17948-0.


In vitro AMPylation Assays Using Purified, Recombinant Proteins.

Truttmann MC, Ploegh HL.

Bio Protoc. 2017 Jul 20;7(14). pii: e2416. doi: 10.21769/BioProtoc.2416.


Machinery that guides immunity.

Ploegh H.

Nature. 2017 Nov 23;551(7681):442-443. doi: 10.1038/d41586-017-07268-8. No abstract available.


Podocytes exhibit a specialized protein quality control employing derlin-2 in kidney disease.

Ren G, Tardi NJ, Matsuda F, Koh KH, Ruiz P, Wei C, Altintas MM, Ploegh H, Reiser J.

Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F471-F482. doi: 10.1152/ajprenal.00691.2016. Epub 2017 Nov 22.


Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity.

Fang T, Van Elssen CHMJ, Duarte JN, Guzman JS, Chahal JS, Ling J, Ploegh HL.

Chem Sci. 2017 Aug 1;8(8):5591-5597. doi: 10.1039/c7sc00446j. Epub 2017 May 26.


PD-L1 is an activation-independent marker of brown adipocytes.

Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL.

Nat Commun. 2017 Sep 21;8(1):647. doi: 10.1038/s41467-017-00799-8.


Localized CD47 blockade enhances immunotherapy for murine melanoma.

Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10184-10189. doi: 10.1073/pnas.1710776114. Epub 2017 Sep 5.


Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor.

Bilate AM, Bousbaine D, Mesin L, Agudelo M, Leube J, Kratzert A, Dougan SK, Victora GD, Ploegh HL.

Sci Immunol. 2016 Aug 26;1(2):eaaf7471. doi: 10.1126/sciimmunol.aaf7471. Epub 2016 Aug 26.


Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation.

Antos JM, Ingram J, Fang T, Pishesha N, Truttmann MC, Ploegh HL.

Curr Protoc Protein Sci. 2017 Aug 1;89:15.3.1-15.3.19. doi: 10.1002/cpps.38.


Editorial: Crystal death: it's not always the inflammasome...

Schmidt FI, Ploegh HL.

J Leukoc Biol. 2017 Jul;102(1):1-4. doi: 10.1189/jlb.3CE0117-022R. No abstract available.


Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL.

J Exp Med. 2017 Aug 7;214(8):2243-2255. doi: 10.1084/jem.20161950. Epub 2017 Jun 30.


Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets.

Clancy-Thompson E, Chen GZ, Tyler PM, Servos MM, Barisa M, Brennan PJ, Ploegh HL, Dougan SK.

J Immunol. 2017 Jul 1;199(1):159-171. doi: 10.4049/jimmunol.1700214. Epub 2017 Jun 2.


rAMPing Up Stress Signaling: Protein AMPylation in Metazoans.

Truttmann MC, Ploegh HL.

Trends Cell Biol. 2017 Aug;27(8):608-620. doi: 10.1016/j.tcb.2017.03.004. Epub 2017 Apr 19. Review.


Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas.

Dongre A, Rashidian M, Reinhardt F, Bagnato A, Keckesova Z, Ploegh HL, Weinberg RA.

Cancer Res. 2017 Aug 1;77(15):3982-3989. doi: 10.1158/0008-5472.CAN-16-3292. Epub 2017 Apr 20.


Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.

Hanke L, Schmidt FI, Knockenhauer KE, Morin B, Whelan SP, Schwartz TU, Ploegh HL.

EMBO Rep. 2017 Jun;18(6):1027-1037. doi: 10.15252/embr.201643764. Epub 2017 Apr 10.


An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model.

Chahal JS, Fang T, Woodham AW, Khan OF, Ling J, Anderson DG, Ploegh HL.

Sci Rep. 2017 Mar 21;7(1):252. doi: 10.1038/s41598-017-00193-w.


Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3157-3162. doi: 10.1073/pnas.1701746114. Epub 2017 Mar 7. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 25;114(17 ):E3583. Dhesycka, Rhogerry [corrected to Deshycka, Rhogerry].


Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease.

Van Elssen CHMJ, Rashidian M, Vrbanac V, Wucherpfennig KW, Habre ZE, Sticht J, Freund C, Jacobsen JT, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh HL.

J Nucl Med. 2017 Jun;58(6):1003-1008. doi: 10.2967/jnumed.116.186007. Epub 2017 Feb 16.


Hepta-Mutant Staphylococcus aureus Sortase A (SrtA7m) as a Tool for in Vivo Protein Labeling in Caenorhabditis elegans.

Wu Q, Ploegh HL, Truttmann MC.

ACS Chem Biol. 2017 Mar 17;12(3):664-673. doi: 10.1021/acschembio.6b00998. Epub 2017 Jan 18.


Enhanced Cell Capture on Functionalized Graphene Oxide Nanosheets through Oxygen Clustering.

Bardhan NM, Kumar PV, Li Z, Ploegh HL, Grossman JC, Belcher AM, Chen GY.

ACS Nano. 2017 Feb 28;11(2):1548-1558. doi: 10.1021/acsnano.6b06979. Epub 2017 Jan 24.


Cocapture of cognate and bystander antigens can activate autoreactive B cells.

Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss T.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):734-739. doi: 10.1073/pnas.1614472114. Epub 2017 Jan 5.


Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.

Truttmann MC, Zheng X, Hanke L, Damon JR, Grootveld M, Krakowiak J, Pincus D, Ploegh HL.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E152-E160. doi: 10.1073/pnas.1619234114. Epub 2016 Dec 28.


The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment.

Hanke L, Knockenhauer KE, Brewer RC, van Diest E, Schmidt FI, Schwartz TU, Ploegh HL.

MBio. 2016 Dec 13;7(6). pii: e01569-16. doi: 10.1128/mBio.01569-16.


Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.

Swee LK, Tan ZW, Sanecka A, Yoshida N, Patel H, Grotenbreg G, Frickel EM, Ploegh HL.

Open Biol. 2016 Nov;6(11). pii: 160293.


Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter.

Bozzi AT, Bane LB, Weihofen WA, Singharoy A, Guillen ER, Ploegh HL, Schulten K, Gaudet R.

Structure. 2016 Dec 6;24(12):2102-2114. doi: 10.1016/j.str.2016.09.017. Epub 2016 Nov 10.


Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs.

Duarte JN, Cragnolini JJ, Swee LK, Bilate AM, Bader J, Ingram JR, Rashidfarrokhi A, Fang T, Schiepers A, Hanke L, Ploegh HL.

J Immunol. 2016 Dec 15;197(12):4838-4847. Epub 2016 Nov 7.


Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell.

Chen GY, Li Z, Duarte JN, Esteban A, Cheloha RW, Theile CS, Fink GR, Ploegh HL.

Biosens Bioelectron. 2017 Mar 15;89(Pt 2):789-794. doi: 10.1016/j.bios.2016.10.015. Epub 2016 Oct 5.


Phenotypic lentivirus screens to identify functional single domain antibodies.

Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SP, Ploegh HL.

Nat Microbiol. 2016 Jun 20;1(8):16080. doi: 10.1038/nmicrobiol.2016.80.


Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e.

Hagiwara M, Ling J, Koenig PA, Ploegh HL.

Mol Cell. 2016 Sep 1;63(5):753-67. doi: 10.1016/j.molcel.2016.07.014. Epub 2016 Aug 25.


Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.

von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L.

J Exp Med. 2016 Aug 22;213(9):1685-94. doi: 10.1084/jem.20160316. Epub 2016 Aug 8.

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