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Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a nationwide German registry.

Birndt S, Schenk T, Heinevetter B, Brunkhorst FM, Maschmeyer G, Rothmann F, Weber T, Müller M, Panse J, Penack O, Schroers R, Braess J, Frickhofen N, Ehl S, Janka G, Lehmberg K, Pletz MW, Hochhaus A, Ernst T, La Rosée P.

J Cancer Res Clin Oncol. 2020 Feb 20. doi: 10.1007/s00432-020-03139-4. [Epub ahead of print]


Antimicrobial stewardship in patients with acute bacterial skin and skin structures infections: an international Delphi consensus.

Soriano A, Stefani S, Pletz MW, Menichetti F; Italian Group for Antimicrobial Stewardship (GISA).

J Glob Antimicrob Resist. 2020 Feb 14. pii: S2213-7165(20)30031-X. doi: 10.1016/j.jgar.2020.02.002. [Epub ahead of print] Review.


Hospital-wide ELectronic medical record evaluated computerised decision support system to improve outcomes of Patients with staphylococcal bloodstream infection (HELP): study protocol for a multicentre stepped-wedge cluster randomised trial.

Hagel S, Gantner J, Spreckelsen C, Fischer C, Ammon D, Saleh K, Phan-Vogtmann LA, Heidel A, Müller S, Helhorn A, Kruse H, Thomas E, Rißner F, Haferkamp S, Vorwerk J, Deffge S, Juzek-Küpper MF, Lippmann N, Lübbert C, Trawinski H, Wendt S, Wendt T, Dürschmid A, Konik M, Moritz S, Tiller D, Röhrig R, Schulte-Coerne J, Fortmann J, Jonas S, Witzke O, Rath PM, Pletz MW, Scherag A.

BMJ Open. 2020 Feb 10;10(2):e033391. doi: 10.1136/bmjopen-2019-033391.


Changes in inflammatory and vasoactive mediator profiles during valvular surgery with or without infective endocarditis: A case control pilot study.

Diab M, Tasar R, Sponholz C, Lehmann T, Pletz MW, Bauer M, Brunkhorst FM, Doenst T.

PLoS One. 2020 Feb 3;15(2):e0228286. doi: 10.1371/journal.pone.0228286. eCollection 2020.


Clinically Approved Drugs Inhibit the Staphylococcus aureus Multidrug NorA Efflux Pump and Reduce Biofilm Formation.

Zimmermann S, Klinger-Strobel M, Bohnert JA, Wendler S, Rödel J, Pletz MW, Löffler B, Tuchscherr L.

Front Microbiol. 2019 Dec 3;10:2762. doi: 10.3389/fmicb.2019.02762. eCollection 2019.


Highly Sensitive Detection of the Antibiotic Ciprofloxacin by Means of Fiber Enhanced Raman Spectroscopy.

Wolf S, Frosch T, Popp J, Pletz MW, Frosch T.

Molecules. 2019 Dec 10;24(24). pii: E4512. doi: 10.3390/molecules24244512.


Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia.

Forstner C, Kolditz M, Kesselmeier M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ study group.

Vaccine. 2020 Jan 29;38(5):1129-1136. doi: 10.1016/j.vaccine.2019.11.026. Epub 2019 Nov 21.


Rate and Predictors of Bacteremia in Afebrile Community-Acquired Pneumonia.

Forstner C, Patchev V, Rohde G, Rupp J, Witzenrath M, Welte T, Burgmann H, Pletz MW; CAPNETZ Study Group.

Chest. 2019 Oct 26. pii: S0012-3692(19)34102-9. doi: 10.1016/j.chest.2019.10.006. [Epub ahead of print]


Reply to Theilacker et al.

Kolditz M, Schmitt J, Pletz MW, Tesch F.

Clin Infect Dis. 2019 Sep 7. pii: ciz883. doi: 10.1093/cid/ciz883. [Epub ahead of print] No abstract available.


MBEC Versus MBIC: the Lack of Differentiation between Biofilm Reducing and Inhibitory Effects as a Current Problem in Biofilm Methodology.

Thieme L, Hartung A, Tramm K, Klinger-Strobel M, Jandt KD, Makarewicz O, Pletz MW.

Biol Proced Online. 2019 Sep 13;21:18. doi: 10.1186/s12575-019-0106-0. eCollection 2019.


Carbapenem-resistant Klebsiella pneumoniae with low chlorhexidine susceptibility.

Stein C, Vincze S, Kipp F, Makarewicz O, Al Dahouk S, Pletz MW.

Lancet Infect Dis. 2019 Sep;19(9):932-933. doi: 10.1016/S1473-3099(19)30427-X. No abstract available.


Assessing genetic diversity and similarity of 435 KPC-carrying plasmids.

Brandt C, Viehweger A, Singh A, Pletz MW, Wibberg D, Kalinowski J, Lerch S, Müller B, Makarewicz O.

Sci Rep. 2019 Aug 2;9(1):11223. doi: 10.1038/s41598-019-47758-5.


[Vaccination of the immunocompromised patient].

Jablonka A, Rößler S, Pletz MW, Schleenvoigt BT.

MMW Fortschr Med. 2019 Jul;161(13):56-60. doi: 10.1007/s15006-019-0715-1. Review. German. No abstract available.


PCR-based routine diagnostics uncover hidden burden of Legionnaires' disease.

Pletz MW, Ewig S, Welte T.

Lancet Infect Dis. 2019 Jul;19(7):681-683. doi: 10.1016/S1473-3099(19)30171-9. Epub 2019 Jun 10. No abstract available.


Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised controlled trial.

Hagel S, Fiedler S, Hohn A, Brinkmann A, Frey OR, Hoyer H, Schlattmann P, Kiehntopf M, Roberts JA, Pletz MW; TARGET Study Group.

Trials. 2019 Jun 6;20(1):330. doi: 10.1186/s13063-019-3437-x.


One step closer to precision medicine for infectious diseases.

Pletz MW, Bauer M, Brakhage AA.

Lancet Infect Dis. 2019 Jun;19(6):564-565. doi: 10.1016/S1473-3099(19)30070-2. Epub 2019 May 2. No abstract available. Erratum in: Lancet Infect Dis. 2019 Aug;19(8):e259.


Cefazolin versus anti-staphylococcal penicillins for the treatment of patients with Staphylococcus aureus bacteraemia.

Weis S, Kesselmeier M, Davis JS, Morris AM, Lee S, Scherag A, Hagel S, Pletz MW.

Clin Microbiol Infect. 2019 Jul;25(7):818-827. doi: 10.1016/j.cmi.2019.03.010. Epub 2019 Mar 27.


[Staphylococcus aureus Bacteraemia - an Interdisciplinary Challenge].

Hagel S, Kaasch AJ, Weis S, Seifert H, Pletz MW, Rieg S.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2019 Mar;54(3):206-216. doi: 10.1055/a-0756-8263. Epub 2019 Mar 13. German.


Personalized medicine with IgGAM compared with standard of care for treatment of peritonitis after infectious source control (the PEPPER trial): study protocol for a randomized controlled trial.

Kalvelage C, Zacharowski K, Bauhofer A, Gockel U, Adamzik M, Nierhaus A, Kujath P, Eckmann C, Pletz MW, Bracht H, Simon TP, Winkler M, Kindgen-Milles D, Albertsmeier M, Weigand M, Ellger B, Ragaller M, Ullrich R, Marx G.

Trials. 2019 Mar 4;20(1):156. doi: 10.1186/s13063-019-3244-4.


Healthcare-associated pneumonia: is there any reason to continue to utilize this label in 2019?

Ewig S, Kolditz M, Pletz MW, Chalmers J.

Clin Microbiol Infect. 2019 Oct;25(10):1173-1179. doi: 10.1016/j.cmi.2019.02.022. Epub 2019 Feb 27.


EBV miRNA expression profiles in different infection stages: A prospective cohort study.

Hartung A, Makarewicz O, Egerer R, Karrasch M, Klink A, Sauerbrei A, Kentouche K, Pletz MW.

PLoS One. 2019 Feb 13;14(2):e0212027. doi: 10.1371/journal.pone.0212027. eCollection 2019.


M. pneumoniae and C. pneumoniae are no relevant pathogens in critically ill patients with hospital-acquired respiratory tract infections.

Hagel S, Schmitt S, Kesselmeier M, Baier M, Welte T, Ewig S, Pletz MW.

Infection. 2019 Jun;47(3):471-474. doi: 10.1007/s15010-019-01273-x. Epub 2019 Jan 28.


Pulmonary nocardiosis in Western Europe-Clinical evaluation of 43 patients and population-based estimates of hospitalization rates.

Ott SR, Meier N, Kolditz M, Bauer TT, Rohde G, Presterl E, Schürmann D, Lepper PM, Ringshausen FC, Flick H, Leib SL, Pletz MW; OPINION Study Group.

Int J Infect Dis. 2019 Apr;81:140-148. doi: 10.1016/j.ijid.2018.12.010. Epub 2019 Jan 15. Review.


[Infectious Disease Consultations in Patients with Staphylococcus Aureus Bacteraemia - a Retrospective Observational Study at Jena University Hospital].

Kimmig A, Weis S, Hagel S, Forstner C, Kesselmeier M, Pletz MW.

Dtsch Med Wochenschr. 2018 Oct;143(21):e2. doi: 10.1055/a-0816-9947. Epub 2019 Jan 14. German. No abstract available.


ESBL colonization and acquisition in a hospital population: The molecular epidemiology and transmission of resistance genes.

Hagel S, Makarewicz O, Hartung A, Weiß D, Stein C, Brandt C, Schumacher U, Ehricht R, Patchev V, Pletz MW.

PLoS One. 2019 Jan 14;14(1):e0208505. doi: 10.1371/journal.pone.0208505. eCollection 2019.


[Vaccinations in the elderly - who, when and which vaccine to use].

Forstner C, Kwetkat A, Schleenvoigt B, Pletz MW.

MMW Fortschr Med. 2018 Dec;160(21-22):52-61. doi: 10.1007/s15006-018-0029-8. Review. German. No abstract available.


Impact of the 13-Valent Pneumococcal Conjugate Vaccine on the Incidence of All-cause Pneumonia in Adults Aged ≥60 Years: A Population-based, Retrospective Cohort Study.

Kolditz M, Schmitt J, Pletz MW, Tesch F.

Clin Infect Dis. 2019 May 30;68(12):2117-2119. doi: 10.1093/cid/ciy993.


[Management of community acquired pneumonia].

Hagel S, Moeser A, Pletz MW.

MMW Fortschr Med. 2018 Nov;160(19):52-61. doi: 10.1007/s15006-018-0027-x. Review. German. No abstract available.


Fiber-Enhanced Raman Sensing of Cefuroxime in Human Urine.

Yan D, Frosch T, Kobelke J, Bierlich J, Popp J, Pletz MW, Frosch T.

Anal Chem. 2018 Nov 20;90(22):13243-13248. doi: 10.1021/acs.analchem.8b01355. Epub 2018 Nov 2.


Development of a clinical decision rule for diagnosing sinus infections - to reduce unnecessary antibiotic prescribing.

Mainz JG, Jaudszus A, Pletz MW.

Expert Rev Clin Pharmacol. 2018 Oct;11(10):923-925. doi: 10.1080/17512433.2018.1524753. Epub 2018 Sep 24. No abstract available.


[Infectious Disease Consultations in Patients with Staphylococcus Aureus Bacteraemia - a Retrospective Observational Study at Jena University Hospital].

Kimmig A, Weis S, Hagel S, Forstner C, Kesselmeier M, Pletz MW.

Dtsch Med Wochenschr. 2018 Oct;143(21):e179-e187. doi: 10.1055/a-0653-7826. Epub 2018 Aug 31. German. Erratum in: Dtsch Med Wochenschr. 2018 Oct;143(21):e2.


Economic burden of surgical site infections in patients undergoing cardiac surgery†.

Findeisen A, Arefian H, Doenst T, Hagel S, Pletz MW, Hartmann M, Maschmann J.

Eur J Cardiothorac Surg. 2019 Mar 1;55(3):494-500. doi: 10.1093/ejcts/ezy274.


Polyester-based particles to overcome the obstacles of mucus and biofilms in the lung for tobramycin application under static and dynamic fluidic conditions.

Ernst J, Klinger-Strobel M, Arnold K, Thamm J, Hartung A, Pletz MW, Makarewicz O, Fischer D.

Eur J Pharm Biopharm. 2018 Oct;131:120-129. doi: 10.1016/j.ejpb.2018.07.025. Epub 2018 Jul 29.


Microorganisms @ materials surfaces in aircraft: Potential risks for public health? - A systematic review.

Zhao B, Dewald C, Hennig M, Bossert J, Bauer M, Pletz MW, Jandt KD.

Travel Med Infect Dis. 2019 Mar - Apr;28:6-14. doi: 10.1016/j.tmaid.2018.07.011. Epub 2018 Jul 27.


Effectiveness of a hospital-wide infection control programme on the incidence of healthcare-associated infections and associated severe sepsis and septic shock: a prospective interventional study.

Hagel S, Ludewig K, Pletz MW, Frosinski J, Moeser A, Wolkewitz M, Gastmeier P, Harbarth S, Brunkhorst FM, Kesselmeier M, Scherag A.

Clin Microbiol Infect. 2019 Apr;25(4):462-468. doi: 10.1016/j.cmi.2018.07.010. Epub 2018 Jul 21.


Antibiotic use on paediatric inpatients in a teaching hospital in the Gambia, a retrospective study.

Chaw PS, Schlinkmann KM, Raupach-Rosin H, Karch A, Pletz MW, Huebner J, Nyan O, Mikolajczyk R.

Antimicrob Resist Infect Control. 2018 Jul 16;7:82. doi: 10.1186/s13756-018-0380-7. eCollection 2018.


Smart Medical Information Technology for Healthcare (SMITH).

Winter A, Stäubert S, Ammon D, Aiche S, Beyan O, Bischoff V, Daumke P, Decker S, Funkat G, Gewehr JE, de Greiff A, Haferkamp S, Hahn U, Henkel A, Kirsten T, Klöss T, Lippert J, Löbe M, Lowitsch V, Maassen O, Maschmann J, Meister S, Mikolajczyk R, Nüchter M, Pletz MW, Rahm E, Riedel M, Saleh K, Schuppert A, Smers S, Stollenwerk A, Uhlig S, Wendt T, Zenker S, Fleig W, Marx G, Scherag A, Löffler M.

Methods Inf Med. 2018 Jul;57(S 01):e92-e105. doi: 10.3414/ME18-02-0004. Epub 2018 Jul 17.


Increasing influenza and pneumococcal vaccine uptake in the elderly: study protocol for the multi-methods prospective intervention study Vaccination60.

Betsch C, Rossmann C, Pletz MW, Vollmar HC, Freytag A, Wichmann O, Hanke R, Hanke W, Heinemeier D, Schmid P, Eitze S, Weber W, Reinhardt A, Küpke NK, Forstner C, Fleischmann-Struzek C, Mikolajetz A, Römhild J, Neufeind J, Rieck T, Suchecka K, Reinhart K.

BMC Public Health. 2018 Jul 16;18(1):885. doi: 10.1186/s12889-018-5787-9.


Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy.

Weber M, Rüddel J, Bruns T, Pletz MW, Stallmach A.

Z Gastroenterol. 2018 Jun;56(6):569-572. doi: 10.1055/a-0614-2871. Epub 2018 Jun 11.


Author Correction: The Staphylococcus aureus extracellular matrix protein (Emp) has a fibrous structure and binds to different extracellular matrices.

Geraci J, Neubauer S, Pöllath C, Hansen U, Rizzo F, Krafft C, Westermann M, Hussain M, Peters G, Pletz MW, Löffler B, Makarewicz O, Tuchscherr L.

Sci Rep. 2018 May 25;8(1):8396. doi: 10.1038/s41598-018-26315-6.


Perceptions and attitudes regarding antibiotic resistance in Germany: a cross-sectoral survey amongst physicians, veterinarians, farmers and the general public.

Schneider S, Salm F, Vincze S, Moeser A, Petruschke I, Schmücker K, Ludwig N, Hanke R, Schröder C, Gropmann A, Behnke M, Lübke-Becker A, Wieler LH, Hagel S, Pletz MW, Gensichen J, Gastmeier P; RAI Study Group.

J Antimicrob Chemother. 2018 Jul 1;73(7):1984-1988. doi: 10.1093/jac/dky100.


S. aureus endocarditis: Clinical aspects and experimental approaches.

Hoerr V, Franz M, Pletz MW, Diab M, Niemann S, Faber C, Doenst T, Schulze PC, Deinhardt-Emmer S, Löffler B.

Int J Med Microbiol. 2018 Aug;308(6):640-652. doi: 10.1016/j.ijmm.2018.02.004. Epub 2018 Feb 21. Review.


In vitro synergism and anti-biofilm activity of ampicillin, gentamicin, ceftaroline and ceftriaxone against Enterococcus faecalis.

Thieme L, Klinger-Strobel M, Hartung A, Stein C, Makarewicz O, Pletz MW.

J Antimicrob Chemother. 2018 Jun 1;73(6):1553-1561. doi: 10.1093/jac/dky051.



Pletz MW, Weis S, Forstner C, Wagenlehner F.

Med Klin Intensivmed Notfmed. 2018 Mar;113(2):143-156. doi: 10.1007/s00063-018-0406-1. German.


Next-generation sequencing diagnostics of bacteremia in sepsis (Next GeneSiS-Trial): Study protocol of a prospective, observational, noninterventional, multicenter, clinical trial.

Brenner T, Decker SO, Grumaz S, Stevens P, Bruckner T, Schmoch T, Pletz MW, Bracht H, Hofer S, Marx G, Weigand MA, Sohn K; TIFOnet Critical Care Trials Group.

Medicine (Baltimore). 2018 Feb;97(6):e9868. doi: 10.1097/MD.0000000000009868.


Bacterial sepsis : Diagnostics and calculated antibiotic therapy.

Richter DC, Heininger A, Brenner T, Hochreiter M, Bernhard M, Briegel J, Dubler S, Grabein B, Hecker A, Kruger WA, Mayer K, Pletz MW, Storzinger D, Pinder N, Hoppe-Tichy T, Weiterer S, Zimmermann S, Brinkmann A, Weigand MA, Lichtenstern C.

Anaesthesist. 2019 Feb;68(Suppl 1):40-62. doi: 10.1007/s00101-017-0396-z. Review.


A Nosocomial Foodborne Outbreak of a VIM Carbapenemase-Expressing Citrobacter freundii.

Pletz MW, Wollny A, Dobermann UH, Rödel J, Neubauer S, Stein C, Brandt C, Hartung A, Mellmann A, Trommer S, Edel B, Patchev V, Makarewicz O, Maschmann J.

Clin Infect Dis. 2018 Jun 18;67(1):58-64. doi: 10.1093/cid/ciy034.



Pletz MW, Weis S, Forstner C, Wagenlehner F.

Urologe A. 2018 Jan;57(1):79-92. doi: 10.1007/s00120-017-0559-1. German.


Naso- and oropharyngeal bacterial carriage in nursing home residents: Impact of multimorbidity and functional impairment.

Kwetkat A, Pfister W, Pansow D, Pletz MW, Sieber CC, Hoyer H.

PLoS One. 2018 Jan 5;13(1):e0190716. doi: 10.1371/journal.pone.0190716. eCollection 2018.

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