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Items: 1 to 50 of 90

1.

Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus.

Tsetsarkin KA, Maximova OA, Liu G, Kenney H, Teterina NL, Pletnev AG.

MBio. 2019 Apr 23;10(2). pii: e02904-18. doi: 10.1128/mBio.02904-18.

2.

The Roles of prM-E Proteins in Historical and Epidemic Zika Virus-mediated Infection and Neurocytotoxicity.

Li G, Bos S, Tsetsarkin KA, Pletnev AG, Desprès P, Gadea G, Zhao RY.

Viruses. 2019 Feb 14;11(2). pii: E157. doi: 10.3390/v11020157.

3.

Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice.

Tsetsarkin KA, Maximova OA, Liu G, Kenney H, Teterina N, Bloom ME, Grabowski JM, Mlera L, Nagata BM, Moore I, Martens C, Amaro-Carambot E, Lamirande EW, Whitehead SS, Pletnev AG.

Nat Commun. 2018 Dec 17;9(1):5350. doi: 10.1038/s41467-018-07782-x.

4.

Flaviviruses and the Central Nervous System: Revisiting Neuropathological Concepts.

Maximova OA, Pletnev AG.

Annu Rev Virol. 2018 Sep 29;5(1):255-272. doi: 10.1146/annurev-virology-092917-043439. Review.

PMID:
30265628
5.

Decreased accumulation of subgenomic RNA in human cells infected with vaccine candidate DEN4Δ30 increases viral susceptibility to type I interferon.

Bustos-Arriaga J, Gromowski GD, Tsetsarkin KA, Firestone CY, Castro-Jiménez T, Pletnev AG, Cedillo-Barrón L, Whitehead SS.

Vaccine. 2018 Jun 7;36(24):3460-3467. doi: 10.1016/j.vaccine.2018.04.087. Epub 2018 May 8.

PMID:
29752023
6.

Flavivirus Infection of Ixodes scapularis (Black-Legged Tick) Ex Vivo Organotypic Cultures and Applications for Disease Control.

Grabowski JM, Tsetsarkin KA, Long D, Scott DP, Rosenke R, Schwan TG, Mlera L, Offerdahl DK, Pletnev AG, Bloom ME.

MBio. 2017 Aug 22;8(4). pii: e01255-17. doi: 10.1128/mBio.01255-17.

7.

Synergistic Internal Ribosome Entry Site/MicroRNA-Based Approach for Flavivirus Attenuation and Live Vaccine Development.

Tsetsarkin KA, Liu G, Volkova E, Pletnev AG.

MBio. 2017 Apr 18;8(2). pii: e02326-16. doi: 10.1128/mBio.02326-16.

8.

Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.

Bardina SV, Brown JA, Michlmayr D, Hoffman KW, Sum J, Pletnev AG, Lira SA, Lim JK.

J Virol. 2017 Apr 28;91(10). pii: e02409-16. doi: 10.1128/JVI.02409-16. Print 2017 May 15.

9.

A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers.

Pierce KK, Whitehead SS, Kirkpatrick BD, Grier PL, Jarvis A, Kenney H, Carmolli MP, Reynolds C, Tibery CM, Lovchik J, Janiak A, Luke CJ, Durbin AP, Pletnev AG.

J Infect Dis. 2017 Jan 1;215(1):52-55. doi: 10.1093/infdis/jiw501. Epub 2016 Oct 25.

10.

Concurrent micro-RNA mediated silencing of tick-borne flavivirus replication in tick vector and in the brain of vertebrate host.

Tsetsarkin KA, Liu G, Kenney H, Hermance M, Thangamani S, Pletnev AG.

Sci Rep. 2016 Sep 13;6:33088. doi: 10.1038/srep33088.

11.

West Nile Virus Spreads Transsynaptically within the Pathways of Motor Control: Anatomical and Ultrastructural Mapping of Neuronal Virus Infection in the Primate Central Nervous System.

Maximova OA, Bernbaum JG, Pletnev AG.

PLoS Negl Trop Dis. 2016 Sep 12;10(9):e0004980. doi: 10.1371/journal.pntd.0004980. eCollection 2016 Sep.

12.

A Full-Length Infectious cDNA Clone of Zika Virus from the 2015 Epidemic in Brazil as a Genetic Platform for Studies of Virus-Host Interactions and Vaccine Development.

Tsetsarkin KA, Kenney H, Chen R, Liu G, Manukyan H, Whitehead SS, Laassri M, Chumakov K, Pletnev AG.

MBio. 2016 Aug 23;7(4). pii: e01114-16. doi: 10.1128/mBio.01114-16.

13.

Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.

Michlmayr D, Bardina SV, Rodriguez CA, Pletnev AG, Lim JK.

J Immunol. 2016 Jun 1;196(11):4622-31. doi: 10.4049/jimmunol.1502452. Epub 2016 Apr 29.

15.

MicroRNA-based control of tick-borne flavivirus neuropathogenesis: Challenges and perspectives.

Teterina NL, Maximova OA, Kenney H, Liu G, Pletnev AG.

Antiviral Res. 2016 Mar;127:57-67. doi: 10.1016/j.antiviral.2016.01.003. Epub 2016 Jan 19.

16.

Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection.

Bardina SV, Michlmayr D, Hoffman KW, Obara CJ, Sum J, Charo IF, Lu W, Pletnev AG, Lim JK.

J Immunol. 2015 Nov 1;195(9):4306-18. doi: 10.4049/jimmunol.1500352. Epub 2015 Sep 23.

17.

Dual miRNA targeting restricts host range and attenuates neurovirulence of flaviviruses.

Tsetsarkin KA, Liu G, Kenney H, Bustos-Arriaga J, Hanson CT, Whitehead SS, Pletnev AG.

PLoS Pathog. 2015 Apr 23;11(4):e1004852. doi: 10.1371/journal.ppat.1004852. eCollection 2015 Apr.

18.

Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions.

Teterina NL, Liu G, Maximova OA, Pletnev AG.

Virology. 2014 May;456-457:247-58. doi: 10.1016/j.virol.2014.04.001. Epub 2014 Apr 19.

19.

Assurance of neuroattenuation of a live vaccine against West Nile virus: a comprehensive study of neuropathogenesis after infection with chimeric WN/DEN4Δ30 vaccine in comparison to two parental viruses and a surrogate flavivirus reference vaccine.

Maximova OA, Speicher JM, Skinner JR, Murphy BR, St Claire MC, Ragland DR, Herbert RL, Pare DR, Moore RM, Pletnev AG.

Vaccine. 2014 May 30;32(26):3187-97. doi: 10.1016/j.vaccine.2014.04.002. Epub 2014 Apr 13.

20.

The live attenuated chimeric vaccine rWN/DEN4Δ30 is well-tolerated and immunogenic in healthy flavivirus-naïve adult volunteers.

Durbin AP, Wright PF, Cox A, Kagucia W, Elwood D, Henderson S, Wanionek K, Speicher J, Whitehead SS, Pletnev AG.

Vaccine. 2013 Nov 19;31(48):5772-7. doi: 10.1016/j.vaccine.2013.07.064. Epub 2013 Aug 19.

21.

MicroRNA targeting of neurotropic flavivirus: effective control of virus escape and reversion to neurovirulent phenotype.

Heiss BL, Maximova OA, Thach DC, Speicher JM, Pletnev AG.

J Virol. 2012 May;86(10):5647-59. doi: 10.1128/JVI.07125-11. Epub 2012 Mar 14.

22.

Microarray hybridization for assessment of the genetic stability of chimeric West Nile/dengue 4 virus.

Laassri M, Bidzhieva B, Speicher J, Pletnev AG, Chumakov K.

J Med Virol. 2011 May;83(5):910-20. doi: 10.1002/jmv.22033. Epub 2011 Feb 25.

23.

Chimeric tick-borne encephalitis/dengue virus is attenuated in Ixodes scapularis ticks and Aedes aegypti mosquitoes.

Engel AR, Mitzel DN, Hanson CT, Wolfinbarger JB, Bloom ME, Pletnev AG.

Vector Borne Zoonotic Dis. 2011 Jun;11(6):665-74. doi: 10.1089/vbz.2010.0179. Epub 2010 Dec 13.

24.

Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis.

Lim JK, Obara CJ, Rivollier A, Pletnev AG, Kelsall BL, Murphy PM.

J Immunol. 2011 Jan 1;186(1):471-8. doi: 10.4049/jimmunol.1003003. Epub 2010 Dec 3.

25.

Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype.

Heiss BL, Maximova OA, Pletnev AG.

J Virol. 2011 Feb;85(4):1464-72. doi: 10.1128/JVI.02091-10. Epub 2010 Dec 1.

26.

High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence.

Maximova OA, Murphy BR, Pletnev AG.

Vaccine. 2010 Dec 6;28(52):8315-26. doi: 10.1016/j.vaccine.2010.07.070. Epub 2010 Aug 3.

27.

The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome.

Engel AR, Rumyantsev AA, Maximova OA, Speicher JM, Heiss B, Murphy BR, Pletnev AG.

Virology. 2010 Sep 15;405(1):243-52. doi: 10.1016/j.virol.2010.06.014. Epub 2010 Jul 1.

28.

Cellular inflammatory response to flaviviruses in the central nervous system of a primate host.

Maximova OA, Faucette LJ, Ward JM, Murphy BR, Pletnev AG.

J Histochem Cytochem. 2009 Oct;57(10):973-89. doi: 10.1369/jhc.2009.954180. Epub 2009 Jul 6.

29.

Attenuated West Nile viruses bearing 3'SL and envelope gene substitution mutations.

Yu L, Robert Putnak J, Pletnev AG, Markoff L.

Vaccine. 2008 Nov 5;26(47):5981-8. doi: 10.1016/j.vaccine.2008.08.064. Epub 2008 Sep 19.

PMID:
18805457
30.

Evaluation of St. Louis encephalitis virus/dengue virus type 4 antigenic chimeric viruses in mice and rhesus monkeys.

Blaney JE Jr, Speicher J, Hanson CT, Sathe NS, Whitehead SS, Murphy BR, Pletnev AG.

Vaccine. 2008 Aug 5;26(33):4150-9. doi: 10.1016/j.vaccine.2008.05.075. Epub 2008 Jun 13.

31.

Comparative neuropathogenesis and neurovirulence of attenuated flaviviruses in nonhuman primates.

Maximova OA, Ward JM, Asher DM, St Claire M, Finneyfrock BW, Speicher JM, Murphy BR, Pletnev AG.

J Virol. 2008 Jun;82(11):5255-68. doi: 10.1128/JVI.00172-08. Epub 2008 Mar 19.

32.

Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers.

Wright PF, Ankrah S, Henderson SE, Durbin AP, Speicher J, Whitehead SS, Murphy BR, Pletnev AG.

Vaccine. 2008 Feb 13;26(7):882-90. doi: 10.1016/j.vaccine.2007.12.015. Epub 2008 Jan 4.

33.

Chimeric West Nile/dengue virus vaccine candidate: preclinical evaluation in mice, geese and monkeys for safety and immunogenicity.

Pletnev AG, Swayne DE, Speicher J, Rumyantsev AA, Murphy BR.

Vaccine. 2006 Sep 29;24(40-41):6392-404. Epub 2006 Jun 21.

PMID:
16831498
35.

Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection.

Glass WG, Lim JK, Cholera R, Pletnev AG, Gao JL, Murphy PM.

J Exp Med. 2005 Oct 17;202(8):1087-98.

36.

Comparison of live and inactivated tick-borne encephalitis virus vaccines for safety, immunogenicity and efficacy in rhesus monkeys.

Rumyantsev AA, Chanock RM, Murphy BR, Pletnev AG.

Vaccine. 2006 Jan 12;24(2):133-43. Epub 2005 Aug 9.

PMID:
16115704
37.

Infectivity of West Nile/dengue chimeric viruses for West Nile and dengue mosquito vectors.

Hanley KA, Goddard LB, Gilmore LE, Scott TW, Speicher J, Murphy BR, Pletnev AG.

Vector Borne Zoonotic Dis. 2005 Spring;5(1):1-10.

PMID:
15815144
38.

Molecularly engineered live-attenuated chimeric West Nile/dengue virus vaccines protect rhesus monkeys from West Nile virus.

Pletnev AG, Claire MS, Elkins R, Speicher J, Murphy BR, Chanock RM.

Virology. 2003 Sep 15;314(1):190-5.

39.

Langat flavivirus protease NS3 binds caspase-8 and induces apoptosis.

Prikhod'ko GG, Prikhod'ko EA, Pletnev AG, Cohen JI.

J Virol. 2002 Jun;76(11):5701-10.

40.

West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy.

Pletnev AG, Putnak R, Speicher J, Wagar EJ, Vaughn DW.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3036-41. Erratum in: Proc Natl Acad Sci U S A 2002 May 14;99(10):7184.

41.

Infection with Langat Flavivirus or expression of the envelope protein induces apoptotic cell death.

Prikhod'ko GG, Prikhod'ko EA, Cohen JI, Pletnev AG.

Virology. 2001 Aug 1;286(2):328-35.

44.

Chimeric Langat/Dengue viruses protect mice from heterologous challenge with the highly virulent strains of tick-borne encephalitis virus.

Pletnev AG, Karganova GG, Dzhivanyan TI, Lashkevich VA, Bray M.

Virology. 2000 Aug 15;274(1):26-31.

45.
46.
47.

T7 DNA-dependent RNA polymerase can transcribe RNA from tick-borne encephalitis virus (TBEV) cDNA with SP6 promoter.

Dobrikova EY, Pletnev AG, Karamyshev VN, Morozova OV.

FEBS Lett. 1996 Mar 18;382(3):327-9.

48.
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