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Items: 19


First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors.

Li Y, Gardner JJ, Fortney KR, Leus IV, Bonifay V, Zgurskaya HI, Pletnev AA, Zhang S, Zhang ZY, Gribble GW, Spinola SM, Duerfeldt AS.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1836-1841. doi: 10.1016/j.bmcl.2019.05.003. Epub 2019 May 6.


Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain.

Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR.

Biosci Rep. 2018 Jul 6;38(4). pii: BSR20180231_COR. doi: 10.1042/BSR20180231_COR. Print 2018 Aug 31. No abstract available.


Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.

Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR.

Biosci Rep. 2018 Jul 6;38(4). pii: BSR20180231. doi: 10.1042/BSR20180231. Print 2018 Aug 31. Erratum in: Biosci Rep. 2018 Jun 5;:.


Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation.

Weyburne ES, Wilkins OM, Sha Z, Williams DA, Pletnev AA, de Bruin G, Overkleeft HS, Goldberg AL, Cole MD, Kisselev AF.

Cell Chem Biol. 2017 Feb 16;24(2):218-230. doi: 10.1016/j.chembiol.2016.12.016. Epub 2017 Jan 26.


Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth.

Pal K, Pletnev AA, Dutta SK, Wang E, Zhao R, Baral A, Yadav VK, Aggarwal S, Krishnaswamy S, Alkharfy KM, Chowdhury S, Spaller MR, Mukhopadhyay D.

Mol Cancer Ther. 2014 Oct;13(10):2264-75. doi: 10.1158/1535-7163.MCT-14-0291. Epub 2014 Aug 14.


Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells.

Kettenbach AN, Schweppe DK, Faherty BK, Pechenick D, Pletnev AA, Gerber SA.

Sci Signal. 2011 Jun 28;4(179):rs5. doi: 10.1126/scisignal.2001497.


Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.

Albershardt TC, Salerni BL, Soderquist RS, Bates DJ, Pletnev AA, Kisselev AF, Eastman A.

J Biol Chem. 2011 Jul 15;286(28):24882-95. doi: 10.1074/jbc.M111.255828. Epub 2011 May 31.


Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib.

Mirabella AC, Pletnev AA, Downey SL, Florea BI, Shabaneh TB, Britton M, Verdoes M, Filippov DV, Overkleeft HS, Kisselev AF.

Chem Biol. 2011 May 27;18(5):608-18. doi: 10.1016/j.chembiol.2011.02.015.


A small fluorophore reporter of protein conformation and redox state.

Pound GJ, Pletnev AA, Fang X, Pletneva EV.

Chem Commun (Camb). 2011 May 28;47(20):5714-6. doi: 10.1039/c1cc10896d. Epub 2011 Apr 12.


Nature of pharmacophore influences active site specificity of proteasome inhibitors.

Screen M, Britton M, Downey SL, Verdoes M, Voges MJ, Blom AE, Geurink PP, Risseeuw MD, Florea BI, van der Linden WA, Pletnev AA, Overkleeft HS, Kisselev AF.

J Biol Chem. 2010 Dec 17;285(51):40125-34. doi: 10.1074/jbc.M110.160606. Epub 2010 Oct 11.


Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.

Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF.

Chem Biol. 2009 Dec 24;16(12):1278-89. doi: 10.1016/j.chembiol.2009.11.015.


Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex.

Garner KM, Pletnev AA, Eastman A.

Nat Chem Biol. 2009 Mar;5(3):129-30; author reply 130. doi: 10.1038/nchembio0309-129. No abstract available.


Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.

Belenky P, Christensen KC, Gazzaniga F, Pletnev AA, Brenner C.

J Biol Chem. 2009 Jan 2;284(1):158-64. doi: 10.1074/jbc.M807976200. Epub 2008 Nov 11. Erratum in: J Biol Chem. 2009 Mar 20;284(12):8208.


Highly efficient ruthenium catalysts for the formation of tetrasubstituted olefins via ring-closing metathesis.

Stewart IC, Ung T, Pletnev AA, Berlin JM, Grubbs RH, Schrodi Y.

Org Lett. 2007 Apr 12;9(8):1589-92. Epub 2007 Mar 23.


General synthesis of pyrroloquinolizidines: synthesis of an unnatural homologue of the pyrroloindolizidine myrmicarin alkaloid 215B.

Angle SR, Qian XL, Pletnev AA, Chinn J.

J Org Chem. 2007 Mar 16;72(6):2015-20. Epub 2007 Feb 22.


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