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Items: 43


Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.

Lynagh T, Flood E, Boiteux C, Sheikh ZP, Allen TW, Pless SA.

J Gen Physiol. 2020 Feb 3;152(2). pii: e201812297. doi: 10.1085/jgp.201812297.


Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels.

Kasimova MA, Lynagh T, Sheikh ZP, Granata D, Borg CB, Carnevale V, Pless SA.

Biophys J. 2019 Sep 6. pii: S0006-3495(19)30755-6. doi: 10.1016/j.bpj.2019.09.001. [Epub ahead of print]


A tale of ligands big and small: an update on how pentameric ligand-gated ion channels interact with agonists and proteins.

Pless SA, Sivilotti LG.

Curr Opin Physiol. 2019 Jun 12;2:19-26. doi: 10.1016/j.cophys.2017.12.012.


Molecular determinants for agonist recognition and discrimination in P2X2 receptors.

Gasparri F, Wengel J, Grutter T, Pless SA.

J Gen Physiol. 2019 Jul 1;151(7):898-911. doi: 10.1085/jgp.201912347. Epub 2019 May 24.


One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels.

Yau MC, Kim RY, Wang CK, Li J, Ammar T, Yang RY, Pless SA, Kurata HT.

J Gen Physiol. 2018 Oct 1;150(10):1421-1431. doi: 10.1085/jgp.201812013. Epub 2018 Aug 30.


Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener.

Wang AW, Yau MC, Wang CK, Sharmin N, Yang RY, Pless SA, Kurata HT.

J Gen Physiol. 2018 Oct 1;150(10):1432-1443. doi: 10.1085/jgp.201812014. Epub 2018 Aug 30.


Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations.

Sereikaitė V, Jensen TMT, Bartling CRO, Jemth P, Pless SA, Strømgaard K.

Chembiochem. 2018 Oct 18;19(20):2136-2145. doi: 10.1002/cbic.201800350. Epub 2018 Oct 1. Review.


Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes.

Lynagh T, Mikhaleva Y, Colding JM, Glover JC, Pless SA.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8430-8435. doi: 10.1073/pnas.1806614115. Epub 2018 Jul 30.


Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results.

Chua HC, Servatius H, Asatryan B, Schaller A, Rieubland C, Noti F, Seiler J, Roten L, Baldinger SH, Tanner H, Fuhrer J, Haeberlin A, Lam A, Pless SA, Medeiros-Domingo A.

Clin Res Cardiol. 2018 Aug;107(8):670-678. doi: 10.1007/s00392-018-1233-3. Epub 2018 Mar 26.


How an intrinsic ligand tunes the activity of a potassium channel.

Khoo KK, Pless SA.

J Gen Physiol. 2018 Apr 2;150(4):517-520. doi: 10.1085/jgp.201812011. Epub 2018 Mar 22. No abstract available.


Phenotypic Spectrum of HCN4 Mutations: A Clinical Case.

Servatius H, Porro A, Pless SA, Schaller A, Asatryan B, Tanner H, de Marchi SF, Roten L, Seiler J, Haeberlin A, Baldinger SH, Noti F, Lam A, Fuhrer J, Moroni A, Medeiros-Domingo A.

Circ Genom Precis Med. 2018 Feb;11(2):e002033. doi: 10.1161/CIRCGEN.117.002033. No abstract available.


High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics.

Wulf M, Pless SA.

Cell Rep. 2018 Feb 6;22(6):1615-1626. doi: 10.1016/j.celrep.2018.01.029.


Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel.

Callau-Vázquez D, Pless SA, Lynagh T.

Biochemistry. 2018 Feb 27;57(8):1360-1368. doi: 10.1021/acs.biochem.7b01245. Epub 2018 Feb 7.


PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels.

Kim RY, Pless SA, Kurata HT.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9702-E9711. doi: 10.1073/pnas.1705802114. Epub 2017 Oct 23.


Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen.

Lynagh T, Romero-Rojo JL, Lund C, Pless SA.

J Med Chem. 2017 Oct 12;60(19):8192-8200. doi: 10.1021/acs.jmedchem.7b01072. Epub 2017 Sep 26.


A selectivity filter at the intracellular end of the acid-sensing ion channel pore.

Lynagh T, Flood E, Boiteux C, Wulf M, Komnatnyy VV, Colding JM, Allen TW, Pless SA.

Elife. 2017 May 12;6. pii: e24630. doi: 10.7554/eLife.24630.


Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel.

Lynagh T, Komnatnyy VV, Pless SA.

J Biol Chem. 2017 Mar 3;292(9):3940-3946. doi: 10.1074/jbc.M116.772939. Epub 2017 Jan 17.


Role of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop Receptors.

Braun N, Lynagh T, Yu R, Biggin PC, Pless SA.

ACS Chem Neurosci. 2016 Mar 16;7(3):339-48. doi: 10.1021/acschemneuro.5b00298. Epub 2016 Jan 29.


Introduction: Applying Chemical Biology to Ion Channels.

Pless SA, Ahern CA.

Adv Exp Med Biol. 2015;869:1-4. doi: 10.1007/978-1-4939-2845-3_1.


Atomic basis for therapeutic activation of neuronal potassium channels.

Kim RY, Yau MC, Galpin JD, Seebohm G, Ahern CA, Pless SA, Kurata HT.

Nat Commun. 2015 Sep 3;6:8116. doi: 10.1038/ncomms9116.


A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels.

Zhang RS, Wright JD, Pless SA, Nunez JJ, Kim RY, Li JB, Yang R, Ahern CA, Kurata HT.

J Biol Chem. 2015 Jun 19;290(25):15450-61. doi: 10.1074/jbc.M114.631960. Epub 2015 May 1.


Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology.

Pless SA, Kim RY, Ahern CA, Kurata HT.

J Physiol. 2015 Jun 15;593(12):2627-34. doi: 10.1113/jphysiol.2014.287714. Epub 2015 Mar 13. Review.


Caught in the act: multiple binding sites for memantine.

Pless SA.

Structure. 2014 Oct 7;22(10):1373-4. doi: 10.1016/j.str.2014.09.003.


Principles of agonist recognition in Cys-loop receptors.

Lynagh T, Pless SA.

Front Physiol. 2014 Apr 24;5:160. doi: 10.3389/fphys.2014.00160. eCollection 2014. Review.


Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains.

Pless SA, Elstone FD, Niciforovic AP, Galpin JD, Yang R, Kurata HT, Ahern CA.

J Gen Physiol. 2014 May;143(5):645-56. doi: 10.1085/jgp.201311036.


Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels.

Pless SA, Galpin JD, Niciforovic AP, Kurata HT, Ahern CA.

Elife. 2013 Dec 10;2:e01289. doi: 10.7554/eLife.01289.


A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.

Pless SA, Niciforovic AP, Galpin JD, Nunez JJ, Kurata HT, Ahern CA.

Nat Commun. 2013;4:1784. doi: 10.1038/ncomms2761.


Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes.

Rivera-Acevedo RE, Pless SA, Schwarz SK, Ahern CA.

Channels (Austin). 2013 Jan 1;7(1):47-50. doi: 10.4161/chan.23105.


Unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences.

Pless SA, Ahern CA.

Annu Rev Pharmacol Toxicol. 2013;53:211-29. doi: 10.1146/annurev-pharmtox-011112-140343. Review.


Intermediate state trapping of a voltage sensor.

Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B, Bezanilla F.

J Gen Physiol. 2012 Dec;140(6):635-52. doi: 10.1085/jgp.201210827.


Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes.

Rivera-Acevedo RE, Pless SA, Schwarz SK, Ahern CA.

Mol Pharmacol. 2012 Dec;82(6):1129-35. doi: 10.1124/mol.112.079277. Epub 2012 Sep 6.


Contributions of conserved residues at the gating interface of glycine receptors.

Pless SA, Leung AW, Galpin JD, Ahern CA.

J Biol Chem. 2011 Oct 7;286(40):35129-36. doi: 10.1074/jbc.M111.269027. Epub 2011 Aug 11.


Contributions of counter-charge in a potassium channel voltage-sensor domain.

Pless SA, Galpin JD, Niciforovic AP, Ahern CA.

Nat Chem Biol. 2011 Jul 24;7(9):617-23. doi: 10.1038/nchembio.622.


Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels.

Pless SA, Galpin JD, Frankel A, Ahern CA.

Nat Commun. 2011 Jun 14;2:351. doi: 10.1038/ncomms1351.


The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro.

Rivera-Acevedo RE, Pless SA, Ahern CA, Schwarz SK.

Anesthesiology. 2011 Jun;114(6):1425-34. doi: 10.1097/ALN.0b013e318216ea0c. Erratum in: Anesthesiology. 2015 Aug;123(2):492.


A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.

Pless SA, Hanek AP, Price KL, Lynch JW, Lester HA, Dougherty DA, Lummis SC.

Mol Pharmacol. 2011 Apr;79(4):742-8. doi: 10.1124/mol.110.069583. Epub 2011 Jan 25.


Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors.

Wang Q, Pless SA, Lynch JW.

J Biol Chem. 2010 Dec 17;285(51):40373-86. doi: 10.1074/jbc.M110.161513. Epub 2010 Oct 11.


Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy.

Pless SA, Lynch JW.

J Biol Chem. 2009 Oct 2;284(40):27370-6. doi: 10.1074/jbc.M109.048405. Epub 2009 Jul 30.


Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain.

Pless SA, Lynch JW.

J Biol Chem. 2009 Jun 5;284(23):15847-56. doi: 10.1074/jbc.M809343200. Epub 2009 Mar 13.


Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits.

Pless SA, Lynch JW.

J Neurochem. 2009 Mar;108(6):1585-94. doi: 10.1111/j.1471-4159.2009.05930.x. Epub 2009 Jan 24.


A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue.

Pless SA, Millen KS, Hanek AP, Lynch JW, Lester HA, Lummis SC, Dougherty DA.

J Neurosci. 2008 Oct 22;28(43):10937-42. doi: 10.1523/JNEUROSCI.2540-08.2008.


Illuminating the structure and function of Cys-loop receptors.

Pless SA, Lynch JW.

Clin Exp Pharmacol Physiol. 2008 Oct;35(10):1137-42. doi: 10.1111/j.1440-1681.2008.04954.x. Epub 2008 May 25. Review.


Conformational variability of the glycine receptor M2 domain in response to activation by different agonists.

Pless SA, Dibas MI, Lester HA, Lynch JW.

J Biol Chem. 2007 Dec 7;282(49):36057-67. Epub 2007 Oct 2.

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