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Items: 1 to 20 of 52

1.

Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.

Lynagh T, Flood E, Boiteux C, Sheikh ZP, Allen TW, Pless SA.

J Gen Physiol. 2020 Feb 3;152(2). pii: e201812297. doi: 10.1085/jgp.201812297.

PMID:
31952079
2.

Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels.

Kasimova MA, Lynagh T, Sheikh ZP, Granata D, Borg CB, Carnevale V, Pless SA.

Biophys J. 2019 Sep 6. pii: S0006-3495(19)30755-6. doi: 10.1016/j.bpj.2019.09.001. [Epub ahead of print]

PMID:
31630811
3.

A tale of ligands big and small: an update on how pentameric ligand-gated ion channels interact with agonists and proteins.

Pless SA, Sivilotti LG.

Curr Opin Physiol. 2019 Jun 12;2:19-26. doi: 10.1016/j.cophys.2017.12.012.

4.

Molecular determinants for agonist recognition and discrimination in P2X2 receptors.

Gasparri F, Wengel J, Grutter T, Pless SA.

J Gen Physiol. 2019 Jul 1;151(7):898-911. doi: 10.1085/jgp.201912347. Epub 2019 May 24.

5.
6.

One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels.

Yau MC, Kim RY, Wang CK, Li J, Ammar T, Yang RY, Pless SA, Kurata HT.

J Gen Physiol. 2018 Oct 1;150(10):1421-1431. doi: 10.1085/jgp.201812013. Epub 2018 Aug 30.

7.

Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener.

Wang AW, Yau MC, Wang CK, Sharmin N, Yang RY, Pless SA, Kurata HT.

J Gen Physiol. 2018 Oct 1;150(10):1432-1443. doi: 10.1085/jgp.201812014. Epub 2018 Aug 30.

8.

Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations.

Sereikaitė V, Jensen TMT, Bartling CRO, Jemth P, Pless SA, Strømgaard K.

Chembiochem. 2018 Oct 18;19(20):2136-2145. doi: 10.1002/cbic.201800350. Epub 2018 Oct 1. Review.

PMID:
30073762
9.

Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes.

Lynagh T, Mikhaleva Y, Colding JM, Glover JC, Pless SA.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8430-8435. doi: 10.1073/pnas.1806614115. Epub 2018 Jul 30.

10.

Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results.

Chua HC, Servatius H, Asatryan B, Schaller A, Rieubland C, Noti F, Seiler J, Roten L, Baldinger SH, Tanner H, Fuhrer J, Haeberlin A, Lam A, Pless SA, Medeiros-Domingo A.

Clin Res Cardiol. 2018 Aug;107(8):670-678. doi: 10.1007/s00392-018-1233-3. Epub 2018 Mar 26.

PMID:
29582136
11.

How an intrinsic ligand tunes the activity of a potassium channel.

Khoo KK, Pless SA.

J Gen Physiol. 2018 Apr 2;150(4):517-520. doi: 10.1085/jgp.201812011. Epub 2018 Mar 22. No abstract available.

12.

Phenotypic Spectrum of HCN4 Mutations: A Clinical Case.

Servatius H, Porro A, Pless SA, Schaller A, Asatryan B, Tanner H, de Marchi SF, Roten L, Seiler J, Haeberlin A, Baldinger SH, Noti F, Lam A, Fuhrer J, Moroni A, Medeiros-Domingo A.

Circ Genom Precis Med. 2018 Feb;11(2):e002033. doi: 10.1161/CIRCGEN.117.002033. No abstract available.

13.

High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics.

Wulf M, Pless SA.

Cell Rep. 2018 Feb 6;22(6):1615-1626. doi: 10.1016/j.celrep.2018.01.029.

14.

Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel.

Callau-Vázquez D, Pless SA, Lynagh T.

Biochemistry. 2018 Feb 27;57(8):1360-1368. doi: 10.1021/acs.biochem.7b01245. Epub 2018 Feb 7.

PMID:
29411605
15.

PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels.

Kim RY, Pless SA, Kurata HT.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9702-E9711. doi: 10.1073/pnas.1705802114. Epub 2017 Oct 23.

16.

Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen.

Lynagh T, Romero-Rojo JL, Lund C, Pless SA.

J Med Chem. 2017 Oct 12;60(19):8192-8200. doi: 10.1021/acs.jmedchem.7b01072. Epub 2017 Sep 26.

PMID:
28949138
17.

A selectivity filter at the intracellular end of the acid-sensing ion channel pore.

Lynagh T, Flood E, Boiteux C, Wulf M, Komnatnyy VV, Colding JM, Allen TW, Pless SA.

Elife. 2017 May 12;6. pii: e24630. doi: 10.7554/eLife.24630.

18.

Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel.

Lynagh T, Komnatnyy VV, Pless SA.

J Biol Chem. 2017 Mar 3;292(9):3940-3946. doi: 10.1074/jbc.M116.772939. Epub 2017 Jan 17.

19.

Role of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop Receptors.

Braun N, Lynagh T, Yu R, Biggin PC, Pless SA.

ACS Chem Neurosci. 2016 Mar 16;7(3):339-48. doi: 10.1021/acschemneuro.5b00298. Epub 2016 Jan 29.

PMID:
26764897
20.

Introduction: Applying Chemical Biology to Ion Channels.

Pless SA, Ahern CA.

Adv Exp Med Biol. 2015;869:1-4. doi: 10.1007/978-1-4939-2845-3_1.

PMID:
26381937

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