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Items: 1 to 50 of 90

1.

Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection.

Shi Z, Zou J, Zhang Z, Zhao X, Noriega J, Zhang B, Zhao C, Ingle H, Bittinger K, Mattei LM, Pruijssers AJ, Plemper RK, Nice TJ, Baldridge MT, Dermody TS, Chassaing B, Gewirtz AT.

Cell. 2019 Oct 17;179(3):644-658.e13. doi: 10.1016/j.cell.2019.09.028. Epub 2019 Oct 10.

PMID:
31607511
2.

Bipartite interface of the measles virus phosphoprotein X domain with the large polymerase protein regulates viral polymerase dynamics.

Du Pont V, Jiang Y, Plemper RK.

PLoS Pathog. 2019 Aug 5;15(8):e1007995. doi: 10.1371/journal.ppat.1007995. eCollection 2019 Aug.

3.

Editorial overview: Antiviral strategies: Antiviral drug development for single-stranded RNA viruses.

Brinton MA, Plemper RK.

Curr Opin Virol. 2019 Apr;35:iii-v. doi: 10.1016/j.coviro.2019.05.011. Epub 2019 May 29. No abstract available.

PMID:
31151832
4.

Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses.

Du Pont V, Plemper RK, Schnell MJ.

Curr Opin Virol. 2019 Apr;35:1-13. doi: 10.1016/j.coviro.2018.12.009. Epub 2019 Feb 10. Review.

PMID:
30753961
5.

Primary resistance mechanism of the canine distemper virus fusion protein against a small-molecule membrane fusion inhibitor.

Kalbermatter D, Shrestha N, Ader-Ebert N, Herren M, Moll P, Plemper RK, Altmann KH, Langedijk JP, Gall F, Lindenmann U, Riedl R, Fotiadis D, Plattet P.

Virus Res. 2019 Jan 2;259:28-37. doi: 10.1016/j.virusres.2018.10.003. Epub 2018 Oct 5.

PMID:
30296457
6.

Engineered Small-Molecule Control of Influenza A Virus Replication.

Fay EJ, Aron SL, Stone IA, Waring BM, Plemper RK, Langlois RA.

J Virol. 2018 Dec 10;93(1). pii: e01677-18. doi: 10.1128/JVI.01677-18. Print 2019 Jan 1.

7.

Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex.

Cox RM, Toots M, Yoon JJ, Sourimant J, Ludeke B, Fearns R, Bourque E, Patti J, Lee E, Vernachio J, Plemper RK.

J Biol Chem. 2018 Oct 26;293(43):16761-16777. doi: 10.1074/jbc.RA118.004862. Epub 2018 Sep 11.

PMID:
30206124
8.

Biology must develop herd immunity against bad-actor molecules.

Plemper RK, Cox RM.

PLoS Pathog. 2018 Jun 28;14(6):e1007038. doi: 10.1371/journal.ppat.1007038. eCollection 2018 Jun. No abstract available.

9.

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.

Yoon JJ, Toots M, Lee S, Lee ME, Ludeke B, Luczo JM, Ganti K, Cox RM, Sticher ZM, Edpuganti V, Mitchell DG, Lockwood MA, Kolykhalov AA, Greninger AL, Moore ML, Painter GR, Lowen AC, Tompkins SM, Fearns R, Natchus MG, Plemper RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00766-18. doi: 10.1128/AAC.00766-18. Print 2018 Aug.

10.

Promotion of virus assembly and organization by the measles virus matrix protein.

Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER.

Nat Commun. 2018 Apr 30;9(1):1736. doi: 10.1038/s41467-018-04058-2.

11.

Structures of the prefusion form of measles virus fusion protein in complex with inhibitors.

Hashiguchi T, Fukuda Y, Matsuoka R, Kuroda D, Kubota M, Shirogane Y, Watanabe S, Tsumoto K, Kohda D, Plemper RK, Yanagi Y.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2496-2501. doi: 10.1073/pnas.1718957115. Epub 2018 Feb 20.

12.

The Unstructured Paramyxovirus Nucleocapsid Protein Tail Domain Modulates Viral Pathogenesis through Regulation of Transcriptase Activity.

Thakkar VD, Cox RM, Sawatsky B, da Fontoura Budaszewski R, Sourimant J, Wabbel K, Makhsous N, Greninger AL, von Messling V, Plemper RK.

J Virol. 2018 Mar 28;92(8). pii: e02064-17. doi: 10.1128/JVI.02064-17. Print 2018 Apr 15.

13.

Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors Carbobenzoxy-d-Phe-l-Phe-Gly and 4-Nitro-2-Phenylacetyl Amino-Benzamide.

Ha MN, Delpeut S, Noyce RS, Sisson G, Black KM, Lin LT, Bilimoria D, Plemper RK, Privé GG, Richardson CD.

J Virol. 2017 Nov 14;91(23). pii: e01026-17. doi: 10.1128/JVI.01026-17. Print 2017 Dec 1.

14.

Structure and organization of paramyxovirus particles.

Cox RM, Plemper RK.

Curr Opin Virol. 2017 Jun;24:105-114. doi: 10.1016/j.coviro.2017.05.004. Epub 2017 Jun 8. Review.

15.

Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex.

Jiménez-Somarribas A, Mao S, Yoon JJ, Weisshaar M, Cox RM, Marengo JR, Mitchell DG, Morehouse ZP, Yan D, Solis I, Liotta DC, Natchus MG, Plemper RK.

J Med Chem. 2017 Mar 23;60(6):2305-2325. doi: 10.1021/acs.jmedchem.6b01568. Epub 2017 Mar 13.

16.

The structurally disordered paramyxovirus nucleocapsid protein tail domain is a regulator of the mRNA transcription gradient.

Cox RM, Krumm SA, Thakkar VD, Sohn M, Plemper RK.

Sci Adv. 2017 Feb 3;3(2):e1602350. doi: 10.1126/sciadv.1602350. eCollection 2017 Feb.

17.

Polymerases of paramyxoviruses and pneumoviruses.

Fearns R, Plemper RK.

Virus Res. 2017 Apr 15;234:87-102. doi: 10.1016/j.virusres.2017.01.008. Epub 2017 Jan 16. Review.

18.

Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex.

Sourimant J, Plemper RK.

Viruses. 2016 Sep 10;8(9). pii: E251. doi: 10.3390/v8090251. Review.

19.

Releasing the Genomic RNA Sequestered in the Mumps Virus Nucleocapsid.

Severin C, Terrell JR, Zengel JR, Cox R, Plemper RK, He B, Luo M.

J Virol. 2016 Oct 28;90(22):10113-10119. doi: 10.1128/JVI.01422-16. Print 2016 Nov 15.

20.

Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening.

Weisshaar M, Cox R, Morehouse Z, Kumar Kyasa S, Yan D, Oberacker P, Mao S, Golden JE, Lowen AC, Natchus MG, Plemper RK.

J Virol. 2016 Jul 27;90(16):7368-7387. doi: 10.1128/JVI.00898-16. Print 2016 Aug 15.

21.

EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression.

Currier MG, Lee S, Stobart CC, Hotard AL, Villenave R, Meng J, Pretto CD, Shields MD, Nguyen MT, Todd SO, Chi MH, Hammonds J, Krumm SA, Spearman P, Plemper RK, Sakamoto K, Peebles RS Jr, Power UF, Moore ML.

PLoS Pathog. 2016 May 6;12(5):e1005622. doi: 10.1371/journal.ppat.1005622. eCollection 2016 May.

22.

Structure-guided design of small-molecule therapeutics against RSV disease.

Cox R, Plemper RK.

Expert Opin Drug Discov. 2016;11(6):543-556. Epub 2016 Apr 21.

23.

Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens.

Yan D, Weisshaar M, Lamb K, Chung HK, Lin MZ, Plemper RK.

Biochemistry. 2015 Sep 15;54(36):5589-604. doi: 10.1021/acs.biochem.5b00623. Epub 2015 Sep 1.

24.

Tunable and reversible drug control of protein production via a self-excising degron.

Chung HK, Jacobs CL, Huo Y, Yang J, Krumm SA, Plemper RK, Tsien RY, Lin MZ.

Nat Chem Biol. 2015 Sep;11(9):713-20. doi: 10.1038/nchembio.1869. Epub 2015 Jul 27.

25.

The paramyxovirus polymerase complex as a target for next-generation anti-paramyxovirus therapeutics.

Cox R, Plemper RK.

Front Microbiol. 2015 May 12;6:459. doi: 10.3389/fmicb.2015.00459. eCollection 2015. Review.

26.

Blocking Respiratory Syncytial Virus Entry: A Story with Twists.

Weisshaar M, Cox R, Plemper RK.

DNA Cell Biol. 2015 Aug;34(8):505-10. doi: 10.1089/dna.2015.2896. Epub 2015 May 11.

27.

Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process.

Ader-Ebert N, Khosravi M, Herren M, Avila M, Alves L, Bringolf F, Örvell C, Langedijk JP, Zurbriggen A, Plemper RK, Plattet P.

PLoS Pathog. 2015 May 6;11(5):e1004880. doi: 10.1371/journal.ppat.1004880. eCollection 2015 May.

28.

Recombinant influenza virus carrying the conserved domain of respiratory syncytial virus (RSV) G protein confers protection against RSV without inflammatory disease.

Lee YN, Suk Hwang H, Kim MC, Lee YT, Cho MK, Kwon YM, Seok Lee J, Plemper RK, Kang SM.

Virology. 2015 Feb;476:217-225. doi: 10.1016/j.virol.2014.12.004. Epub 2014 Dec 30.

29.

Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity.

Matharu DS, Flaherty DP, Simpson DS, Schroeder CE, Chung D, Yan D, Noah JW, Jonsson CB, White EL, Aubé J, Plemper RK, Severson WE, Golden JE.

J Med Chem. 2014 Dec 26;57(24):10314-28. doi: 10.1021/jm500902x. Epub 2014 Dec 4.

30.

Measles virus glycoprotein complexes preassemble intracellularly and relax during transport to the cell surface in preparation for fusion.

Brindley MA, Chaudhury S, Plemper RK.

J Virol. 2015 Jan 15;89(2):1230-41. doi: 10.1128/JVI.02754-14. Epub 2014 Nov 12.

31.

Canine distemper virus envelope protein interactions modulated by hydrophobic residues in the fusion protein globular head.

Avila M, Khosravi M, Alves L, Ader-Ebert N, Bringolf F, Zurbriggen A, Plemper RK, Plattet P.

J Virol. 2015 Jan 15;89(2):1445-51. doi: 10.1128/JVI.01828-14. Epub 2014 Oct 29.

32.

Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.

Hotard AL, Lee S, Currier MG, Crowe JE Jr, Sakamoto K, Newcomb DC, Peebles RS Jr, Plemper RK, Moore ML.

J Virol. 2015 Jan;89(1):512-22. doi: 10.1128/JVI.02472-14. Epub 2014 Oct 22.

33.

Efficient replication of a paramyxovirus independent of full zippering of the fusion protein six-helix bundle domain.

Brindley MA, Plattet P, Plemper RK.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3795-804. doi: 10.1073/pnas.1403609111. Epub 2014 Aug 25.

34.

Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors.

Yan D, Lee S, Thakkar VD, Luo M, Moore ML, Plemper RK.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3441-9. doi: 10.1073/pnas.1405198111. Epub 2014 Aug 4.

35.

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

Krumm SA, Yan D, Hovingh ES, Evers TJ, Enkirch T, Reddy GP, Sun A, Saindane MT, Arrendale RF, Painter G, Liotta DC, Natchus MG, von Messling V, Plemper RK.

Sci Transl Med. 2014 Apr 16;6(232):232ra52. doi: 10.1126/scitranslmed.3008517.

36.

Molecular determinants defining the triggering range of prefusion F complexes of canine distemper virus.

Avila M, Alves L, Khosravi M, Ader-Ebert N, Origgi F, Schneider-Schaulies J, Zurbriggen A, Plemper RK, Plattet P.

J Virol. 2014 Mar;88(5):2951-66. doi: 10.1128/JVI.03123-13. Epub 2013 Dec 26.

37.

Synergizing vaccinations with therapeutics for measles eradication.

Plemper RK, Hammond AL.

Expert Opin Drug Discov. 2014 Feb;9(2):201-14. doi: 10.1517/17460441.2014.867324. Epub 2013 Dec 5. Review.

38.

Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications.

Kiss G, Chen X, Brindley MA, Campbell P, Afonso CL, Ke Z, Holl JM, Guerrero-Ferreira RC, Byrd-Leotis LA, Steel J, Steinhauer DA, Plemper RK, Kelly DF, Spearman PW, Wright ER.

Microsc Microanal. 2014 Feb;20(1):164-74. doi: 10.1017/S1431927613013937. Epub 2013 Nov 26.

39.

The measles virus nucleocapsid protein tail domain is dispensable for viral polymerase recruitment and activity.

Krumm SA, Takeda M, Plemper RK.

J Biol Chem. 2013 Oct 11;288(41):29943-53. doi: 10.1074/jbc.M113.503862. Epub 2013 Sep 3.

40.

A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion.

Brindley MA, Suter R, Schestak I, Kiss G, Wright ER, Plemper RK.

J Virol. 2013 Nov;87(21):11693-703. doi: 10.1128/JVI.01945-13. Epub 2013 Aug 21.

41.

Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy.

Moore TW, Sana K, Yan D, Krumm SA, Thepchatri P, Snyder JP, Marengo J, Arrendale RF, Prussia AJ, Natchus MG, Liotta DC, Plemper RK, Sun A.

ACS Med Chem Lett. 2013 Aug 8;4(8):762-767.

42.

Dual myxovirus screen identifies a small-molecule agonist of the host antiviral response.

Yan D, Krumm SA, Sun A, Steinhauer DA, Luo M, Moore ML, Plemper RK.

J Virol. 2013 Oct;87(20):11076-87. doi: 10.1128/JVI.01425-13. Epub 2013 Aug 7.

43.

The respiratory syncytial virus fusion protein and neutrophils mediate the airway mucin response to pathogenic respiratory syncytial virus infection.

Stokes KL, Currier MG, Sakamoto K, Lee S, Collins PL, Plemper RK, Moore ML.

J Virol. 2013 Sep;87(18):10070-82. doi: 10.1128/JVI.01347-13. Epub 2013 Jul 10.

44.

Envelope protein dynamics in paramyxovirus entry.

Plattet P, Plemper RK.

MBio. 2013 Jul 2;4(4). pii: e00413-13. doi: 10.1128/mBio.00413-13. Review.

45.

Asymmetric synthesis of host-directed inhibitors of myxoviruses.

Moore TW, Sana K, Yan D, Thepchatri P, Ndungu JM, Saindane MT, Lockwood MA, Natchus MG, Liotta DC, Plemper RK, Snyder JP, Sun A.

Beilstein J Org Chem. 2013;9:197-203. doi: 10.3762/bjoc.9.23. Epub 2013 Jan 30.

46.

The receptor-binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope.

Tahara M, Ohno S, Sakai K, Ito Y, Fukuhara H, Komase K, Brindley MA, Rota PA, Plemper RK, Maenaka K, Takeda M.

J Virol. 2013 Mar;87(6):3583-6. doi: 10.1128/JVI.03029-12. Epub 2013 Jan 2.

47.

Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein.

Tahara M, Ito Y, Brindley MA, Ma X, He J, Xu S, Fukuhara H, Sakai K, Komase K, Rota PA, Plemper RK, Maenaka K, Takeda M.

J Virol. 2013 Jan;87(1):666-75. doi: 10.1128/JVI.02033-12. Epub 2012 Oct 31.

48.

Mechanism for active membrane fusion triggering by morbillivirus attachment protein.

Ader N, Brindley M, Avila M, Örvell C, Horvat B, Hiltensperger G, Schneider-Schaulies J, Vandevelde M, Zurbriggen A, Plemper RK, Plattet P.

J Virol. 2013 Jan;87(1):314-26. doi: 10.1128/JVI.01826-12. Epub 2012 Oct 17.

49.

A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis.

Hotard AL, Shaikh FY, Lee S, Yan D, Teng MN, Plemper RK, Crowe JE Jr, Moore ML.

Virology. 2012 Dec 5;434(1):129-36. doi: 10.1016/j.virol.2012.09.022. Epub 2012 Oct 11.

50.

Triggering the measles virus membrane fusion machinery.

Brindley MA, Takeda M, Plattet P, Plemper RK.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3018-27. doi: 10.1073/pnas.1210925109. Epub 2012 Oct 1.

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