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Items: 1 to 50 of 141


Repurposing EGFR Inhibitor Utility in Colorectal Cancer in Mutant APC and TP53 Subpopulations.

Yang M, Schell MJ, Loboda A, Nebozhyn M, Li J, Teer JK, Pledger WJ, Yeatman TJ.

Cancer Epidemiol Biomarkers Prev. 2019 Jul;28(7):1141-1152. doi: 10.1158/1055-9965.EPI-18-1383. Epub 2019 Apr 23.


PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation.

Davis TB, Yang M, Schell MJ, Wang H, Ma L, Pledger WJ, Yeatman TJ.

Sci Rep. 2018 Jun 18;8(1):9296. doi: 10.1038/s41598-018-27584-x.


Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.

Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ.

J Biol Chem. 2016 Oct 21;291(43):22848. No abstract available.


Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle progression.

He L, Yang H, Ma Y, Pledger WJ, Cress WD, Cheng JQ.

J Biol Chem. 2016 Oct 21;291(43):22842. No abstract available.


The non-canonical functions of p27(Kip1) in normal and tumor biology.

Sharma SS, Pledger WJ.

Cell Cycle. 2016 May 2;15(9):1189-201. doi: 10.1080/15384101.2016.1157238. Epub 2016 Apr 15. Review.


p27Kip1 inhibits the cell cycle through non-canonical G1/S phase-specific gatekeeper mechanism.

Sharma SS, Ma L, Pledger WJ.

Cell Cycle. 2015;14(24):3954-64. doi: 10.1080/15384101.2015.1100775.


Assessing needs and assets for building a regional network infrastructure to reduce cancer related health disparities.

Wells KJ, Lima DS, Meade CD, Muñoz-Antonia T, Scarinci I, McGuire A, Gwede CK, Pledger WJ, Partridge E, Lipscomb J, Matthews R, Matta J, Flores I, Weiner R, Turner T, Miele L, Wiese TE, Fouad M, Moreno CS, Lacey M, Christie DW, Price-Haywood EG, Quinn GP, Coppola D, Sodeke SO, Green BL, Lichtveld MY; Region 3 GMaP/BMaP investigators.

Eval Program Plann. 2014 Jun;44:14-25. doi: 10.1016/j.evalprogplan.2013.12.003. Epub 2013 Dec 26.


Proliferative status regulates HDAC11 mRNA abundance in nontransformed fibroblasts.

Bagui TK, Sharma SS, Ma L, Pledger WJ.

Cell Cycle. 2013 Nov 1;12(21):3433-41. doi: 10.4161/cc.26433. Epub 2013 Sep 18.


Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor.

Fu W, Sharma SS, Ma L, Chu B, Bui MM, Reed D, Pledger WJ.

Cell Death Dis. 2013 Mar 28;4:e566. doi: 10.1038/cddis.2013.101.


Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism.

Hodul PJ, Dong Y, Husain K, Pimiento JM, Chen J, Zhang A, Francois R, Pledger WJ, Coppola D, Sebti SM, Chen DT, Malafa MP.

PLoS One. 2013;8(2):e52526. doi: 10.1371/journal.pone.0052526. Epub 2013 Feb 5.


p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression.

Zheng H, Chen L, Pledger WJ, Fang J, Chen J.

Oncogene. 2014 Feb 6;33(6):734-44. doi: 10.1038/onc.2013.6. Epub 2013 Feb 4.


A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation.

Sharma SS, Ma L, Bagui TK, Forinash KD, Pledger WJ.

Oncogene. 2012 Aug 30;31(35):3989-98. doi: 10.1038/onc.2011.550. Epub 2011 Dec 12.


The Establishment of the First Cancer Tissue Biobank at a Hispanic-Serving Institution: A National Cancer Institute-Funded Initiative between Moffitt Cancer Center in Florida and the Ponce School of Medicine and Health Sciences in Puerto Rico.

Flores I, Muñoz-Antonia T, Matta J, García M, Fenstermacher D, Gutierrez S, Seijo E, Torres-Ruiz J, Pledger WJ, Coppola D.

Biopreserv Biobank. 2011 Dec;9(4):363-71. doi: 10.1089/bio.2011.0028. Epub 2011 Nov 10.


The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells.

Fu W, Ma L, Chu B, Wang X, Bui MM, Gemmer J, Altiok S, Pledger WJ.

Mol Cancer Ther. 2011 Jun;10(6):1018-27. doi: 10.1158/1535-7163.MCT-11-0167. Epub 2011 Apr 13.


Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, Pledger WJ, Berndt N, Hamilton A, Sebti SM.

Mol Cell Biol. 2009 Apr;29(8):2254-63. doi: 10.1128/MCB.01029-08. Epub 2009 Feb 9.


Inhibition of p27Kip1 gene transcription by mitogens.

Bagui TK, Cui D, Roy S, Mohapatra S, Shor AC, Ma L, Pledger WJ.

Cell Cycle. 2009 Jan 1;8(1):115-24.


Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle progression.

He L, Yang H, Ma Y, Pledger WJ, Cress WD, Cheng JQ.

J Biol Chem. 2008 Nov 7;283(45):31012-20. doi: 10.1074/jbc.M803547200. Epub 2008 Sep 7. Retraction in: J Biol Chem. 2016 Oct 21;291(43):22842.


Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors.

Mohapatra S, Chu B, Zhao X, Djeu J, Cheng JQ, Pledger WJ.

Int J Biochem Cell Biol. 2009 Mar;41(3):595-602. doi: 10.1016/j.biocel.2008.07.013. Epub 2008 Jul 31.


Increased cyclin D3 expression significantly correlates with p27 nuclear positivity in gastrointestinal stromal tumors.

Draper N, Bui M, Boulware DC, Lloyd M, Chiappori AA, Pledger WJ, Coppola D.

Hum Pathol. 2008 Dec;39(12):1784-91. doi: 10.1016/j.humpath.2008.05.007. Epub 2008 Aug 12.


Histone deacetylase 5 represses the transcription of cyclin D3.

Roy S, Shor AC, Bagui TK, Seto E, Pledger WJ.

J Cell Biochem. 2008 Aug 15;104(6):2143-54. doi: 10.1002/jcb.21771.


Src kinase induces tumor formation in the c-SRC C57BL/6 mouse.

Kline CL, Jackson R, Engelman R, Pledger WJ, Yeatman TJ, Irby RB.

Int J Cancer. 2008 Jun 15;122(12):2665-73. doi: 10.1002/ijc.23445.


Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms.

Bui MM, Bagui TK, Boulware DC, Letson DG, Nasir A, Kaiser HE, Pledger WJ, Coppola D.

In Vivo. 2007 Sep-Oct;21(5):729-37.


Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.

Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C, Jung JU, Cheng JQ, Mulé JJ, Pledger WJ, Wang HG.

Nat Cell Biol. 2007 Oct;9(10):1142-51. Epub 2007 Sep 23.


Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival.

Shor AC, Keschman EA, Lee FY, Muro-Cacho C, Letson GD, Trent JC, Pledger WJ, Jove R.

Cancer Res. 2007 Mar 15;67(6):2800-8.


Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice.

Engelman RW, Jackson RJ, Coppola D, Wharton W, Cantor AB, Pledger WJ.

Exp Mol Pathol. 2007 Jun;82(3):234-44. Epub 2007 Jan 4.


Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells.

Mohapatra S, Chu B, Zhao X, Pledger WJ.

Cancer Res. 2005 Sep 1;65(17):7717-23. Erratum in: Cancer Res. 2005 Nov 15;65(22):10635.


Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism.

Wang C, Hou X, Mohapatra S, Ma Y, Cress WD, Pledger WJ, Chen J.

J Biol Chem. 2005 Apr 1;280(13):12339-43. Epub 2005 Feb 14.


Efficient down-regulation of cyclin A-associated activity and expression in suspended primary keratinocytes requires p21(Cip1).

Hauser P, Ma L, Agrawal D, Haura E, Cress WD, Pledger WJ.

Mol Cancer Res. 2004 Feb;2(2):96-104.


Cell cycle control: a complex issue.

Olashaw N, Bagui TK, Pledger WJ.

Cell Cycle. 2004 Mar;3(3):263-4. Epub 2004 Mar 1.


Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2.

Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R, Pledger WJ.

Cancer Res. 2003 Dec 1;63(23):8523-30.


P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes.

Bagui TK, Mohapatra S, Haura E, Pledger WJ.

Mol Cell Biol. 2003 Oct;23(20):7285-90.


Role of Gadd45alpha in the density-dependent G1 arrest induced by p27(Kip1).

Zhang X, Ma L, Enkemann SA, Pledger WJ.

Oncogene. 2003 Jul 3;22(27):4166-74.


p21Cip1 nullizygosity increases tumor metastasis in irradiated mice.

Jackson RJ, Engelman RW, Coppola D, Cantor AB, Wharton W, Pledger WJ.

Cancer Res. 2003 Jun 15;63(12):3021-5.


Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models.

Jackson RJ, Adnane J, Coppola D, Cantor A, Sebti SM, Pledger WJ.

Oncogene. 2002 Dec 5;21(55):8486-97.


Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.

Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ.

J Biol Chem. 2002 Sep 20;277(38):35364-70. Epub 2002 Jul 11. Retraction in: J Biol Chem. 2016 Oct 21;291(43):22848.


Paradigms of growth control: relation to Cdk activation.

Olashaw N, Pledger WJ.

Sci STKE. 2002 May 28;2002(134):re7. Review.


Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.

Bowman T, Broome MA, Sinibaldi D, Wharton W, Pledger WJ, Sedivy JM, Irby R, Yeatman T, Courtneidge SA, Jove R.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7319-24. Epub 2001 Jun 12.


p27Kip1 regulates T cell proliferation.

Mohapatra S, Agrawal D, Pledger WJ.

J Biol Chem. 2001 Jun 15;276(24):21976-83. Epub 2001 Apr 10.


Interdependence of cdk2 activation and interleukin-2Ralpha accumulation in T cells.

Mohapatra S, Pledger WJ.

J Biol Chem. 2001 Jun 15;276(24):21984-9. Epub 2001 Mar 27.


Permanent growth arrest in irradiated human fibroblasts.

Savell J, Rao S, Pledger WJ, Wharton W.

Radiat Res. 2001 Apr;155(4):554-63.


Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling.

Sinibaldi D, Wharton W, Turkson J, Bowman T, Pledger WJ, Jove R.

Oncogene. 2000 Nov 16;19(48):5419-27.


Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model.

Adnane J, Jackson RJ, Nicosia SV, Cantor AB, Pledger WJ, Sebti SM.

Oncogene. 2000 Nov 9;19(47):5338-47.


PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition.

Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG.

Oncogene. 2000 Nov 2;19(46):5291-7.


Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1).

Bagui TK, Jackson RJ, Agrawal D, Pledger WJ.

Mol Cell Biol. 2000 Dec;20(23):8748-57.


Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).

Hazlehurst LA, Damiano JS, Buyuksal I, Pledger WJ, Dalton WS.

Oncogene. 2000 Sep 7;19(38):4319-27.


Density-dependent growth inhibition of fibroblasts ectopically expressing p27(kip1).

Zhang X, Wharton W, Donovan M, Coppola D, Croxton R, Cress WD, Pledger WJ.

Mol Biol Cell. 2000 Jun;11(6):2117-30.


Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity.

Wang YZ, Wharton W, Garcia R, Kraker A, Jove R, Pledger WJ.

Oncogene. 2000 Apr 20;19(17):2075-85.

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