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Water as a Good Solvent for Unfolded Proteins: Folding and Collapse are Fundamentally Different.

Clark PL, Plaxco KW, Sosnick TR.

J Mol Biol. 2020 Feb 7. pii: S0022-2836(20)30095-4. doi: 10.1016/j.jmb.2020.01.031. [Epub ahead of print] Review.


Calibration-Free Measurement of Phenylalanine Levels in the Blood Using an Electrochemical Aptamer-Based Sensor Suitable for Point-of-Care Applications.

Idili A, Parolo C, Ortega G, Plaxco KW.

ACS Sens. 2019 Dec 27;4(12):3227-3233. doi: 10.1021/acssensors.9b01703. Epub 2019 Dec 13.


Seconds-resolved pharmacokinetic measurements of the chemotherapeutic irinotecan in situ in the living body.

Idili A, Arroyo-Currás N, Ploense KL, Csordas AT, Kuwahara M, Kippin TE, Plaxco KW.

Chem Sci. 2019 Jul 22;10(35):8164-8170. doi: 10.1039/c9sc01495k. eCollection 2019 Sep 21.


Electrochemical Aptamer-Based Sensors for Improved Therapeutic Drug Monitoring and High-Precision, Feedback-Controlled Drug Delivery.

Dauphin-Ducharme P, Yang K, Arroyo-Currás N, Ploense KL, Zhang Y, Gerson J, Kurnik M, Kippin TE, Stojanovic MN, Plaxco KW.

ACS Sens. 2019 Oct 25;4(10):2832-2837. doi: 10.1021/acssensors.9b01616. Epub 2019 Oct 15.


Ultra-High-Precision, in-vivo Pharmacokinetic Measurements Highlight the Need for and a Route Toward More Highly Personalized Medicine.

Vieira PA, Shin CB, Arroyo-Currás N, Ortega G, Li W, Keller AA, Plaxco KW, Kippin TE.

Front Mol Biosci. 2019 Aug 16;6:69. doi: 10.3389/fmolb.2019.00069. eCollection 2019.


Open Source Software for the Real-Time Control, Processing, and Visualization of High-Volume Electrochemical Data.

Curtis SD, Ploense KL, Kurnik M, Ortega G, Parolo C, Kippin TE, Plaxco KW, Arroyo-Currás N.

Anal Chem. 2019 Oct 1;91(19):12321-12328. doi: 10.1021/acs.analchem.9b02553. Epub 2019 Sep 10.


An electrochemical scaffold sensor for rapid syphilis diagnosis.

Ogden NE, Kurnik M, Parolo C, Plaxco KW.

Analyst. 2019 Aug 16;144(17):5277-5283. doi: 10.1039/c9an00455f.


High frequency, real-time neurochemical and neuropharmacological measurements in situ in the living body.

Scida K, Plaxco KW, Jamieson BG.

Transl Res. 2019 Nov;213:50-66. doi: 10.1016/j.trsl.2019.07.004. Epub 2019 Jul 13. Review.


Correction to "High-Precision Electrochemical Measurements of the Guanine-, Mismatch-, and Length-Dependence of Electron Transfer from Electrode-Bound DNA Are Consistent with a Contact-Mediated Mechanism".

Dauphin-Ducharme P, Arroyo-Currás N, Plaxco KW.

J Am Chem Soc. 2019 May 15;141(19):8000. doi: 10.1021/jacs.9b03972. Epub 2019 May 2. No abstract available.


Commonly used FRET fluorophores promote collapse of an otherwise disordered protein.

Riback JA, Bowman MA, Zmyslowski AM, Plaxco KW, Clark PL, Sosnick TR.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8889-8894. doi: 10.1073/pnas.1813038116. Epub 2019 Apr 16.


An electrochemical aptamer-based sensor for the rapid and convenient measurement of L-tryptophan.

Idili A, Gerson J, Parolo C, Kippin T, Plaxco KW.

Anal Bioanal Chem. 2019 Jul;411(19):4629-4635. doi: 10.1007/s00216-019-01645-0. Epub 2019 Feb 22.


Surface Attachment Enhances the Thermodynamic Stability of Protein L.

Ortega G, Kurnik M, Dauphin-Ducharme P, Li H, Arroyo-Currás N, Caceres A, Plaxco KW.

Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1714-1718. doi: 10.1002/anie.201812231. Epub 2019 Jan 15.


High-Precision Control of Plasma Drug Levels Using Feedback-Controlled Dosing.

Arroyo-Currás N, Ortega G, Copp DA, Ploense KL, Plaxco ZA, Kippin TE, Hespanha JP, Plaxco KW.

ACS Pharmacol Transl Sci. 2018 Oct 5;1(2):110-118. doi: 10.1021/acsptsci.8b00033. eCollection 2018 Nov 9.


Electrochemical DNA-Based Sensors for Molecular Quality Control: Continuous, Real-Time Melamine Detection in Flowing Whole Milk.

Li H, Somerson J, Xia F, Plaxco KW.

Anal Chem. 2018 Sep 18;90(18):10641-10645. doi: 10.1021/acs.analchem.8b01993. Epub 2018 Aug 30.


Quantitative measurements of protein-surface interaction thermodynamics.

Kurnik M, Ortega G, Dauphin-Ducharme P, Li H, Caceres A, Plaxco KW.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8352-8357. doi: 10.1073/pnas.1800287115. Epub 2018 Jul 30.


Experimental Measurement of Surface Charge Effects on the Stability of a Surface-Bound Biopolymer.

Watkins HM, Ricci F, Plaxco KW.

Langmuir. 2018 Dec 11;34(49):14993-14999. doi: 10.1021/acs.langmuir.8b01004. Epub 2018 Jul 18.


Expanding the Scope of Protein-Detecting Electrochemical DNA "Scaffold" Sensors.

Kang D, Parolo C, Sun S, Ogden NE, Dahlquist FW, Plaxco KW.

ACS Sens. 2018 Jul 27;3(7):1271-1275. doi: 10.1021/acssensors.8b00311. Epub 2018 Jun 19.


Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel.

Simon AJ, Walls-Smith LT, Plaxco KW.

Analyst. 2018 May 29;143(11):2531-2538. doi: 10.1039/c8an00337h.


Electrochemical Aptamer-Based Sensors for Rapid Point-of-Use Monitoring of the Mycotoxin Ochratoxin A Directly in a Food Stream.

Somerson J, Plaxco KW.

Molecules. 2018 Apr 15;23(4). pii: E912. doi: 10.3390/molecules23040912.


Subsecond-Resolved Molecular Measurements in the Living Body Using Chronoamperometrically Interrogated Aptamer-Based Sensors.

Arroyo-Currás N, Dauphin-Ducharme P, Ortega G, Ploense KL, Kippin TE, Plaxco KW.

ACS Sens. 2018 Feb 23;3(2):360-366. doi: 10.1021/acssensors.7b00787. Epub 2017 Nov 21.


High Surface Area Electrodes Generated via Electrochemical Roughening Improve the Signaling of Electrochemical Aptamer-Based Biosensors.

Arroyo-Currás N, Scida K, Ploense KL, Kippin TE, Plaxco KW.

Anal Chem. 2017 Nov 21;89(22):12185-12191. doi: 10.1021/acs.analchem.7b02830. Epub 2017 Nov 10.


New Architecture for Reagentless, Protein-Based Electrochemical Biosensors.

Kang D, Sun S, Kurnik M, Morales D, Dahlquist FW, Plaxco KW.

J Am Chem Soc. 2017 Sep 6;139(35):12113-12116. doi: 10.1021/jacs.7b05953. Epub 2017 Aug 28.


Calibration-Free Electrochemical Biosensors Supporting Accurate Molecular Measurements Directly in Undiluted Whole Blood.

Li H, Dauphin-Ducharme P, Ortega G, Plaxco KW.

J Am Chem Soc. 2017 Aug 16;139(32):11207-11213. doi: 10.1021/jacs.7b05412. Epub 2017 Aug 2.


Simulation-Based Approach to Determining Electron Transfer Rates Using Square-Wave Voltammetry.

Dauphin-Ducharme P, Arroyo-Currás N, Kurnik M, Ortega G, Li H, Plaxco KW.

Langmuir. 2017 May 9;33(18):4407-4413. doi: 10.1021/acs.langmuir.7b00359. Epub 2017 Apr 26.


A DNA Nanodevice That Loads and Releases a Cargo with Hemoglobin-Like Allosteric Control and Cooperativity.

Mariottini D, Idili A, Vallée-Bélisle A, Plaxco KW, Ricci F.

Nano Lett. 2017 May 10;17(5):3225-3230. doi: 10.1021/acs.nanolett.7b00814. Epub 2017 Apr 11.


A Biomimetic Phosphatidylcholine-Terminated Monolayer Greatly Improves the In Vivo Performance of Electrochemical Aptamer-Based Sensors.

Li H, Dauphin-Ducharme P, Arroyo-Currás N, Tran CH, Vieira PA, Li S, Shin C, Somerson J, Kippin TE, Plaxco KW.

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7492-7495. doi: 10.1002/anie.201700748. Epub 2017 Mar 28.


Superwetting and aptamer functionalized shrink-induced high surface area electrochemical sensors.

Hauke A, Kumar LSS, Kim MY, Pegan J, Khine M, Li H, Plaxco KW, Heikenfeld J.

Biosens Bioelectron. 2017 Aug 15;94:438-442. doi: 10.1016/j.bios.2017.03.024. Epub 2017 Mar 12.


Real-time measurement of small molecules directly in awake, ambulatory animals.

Arroyo-Currás N, Somerson J, Vieira PA, Ploense KL, Kippin TE, Plaxco KW.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):645-650. doi: 10.1073/pnas.1613458114. Epub 2017 Jan 9.


Simultaneous Measurement of the Dissolution Kinetics of Responsive DNA Hydrogels at Multiple Length Scales.

Simon AJ, Walls-Smith LT, Freddi MJ, Fong FY, Gubala V, Plaxco KW.

ACS Nano. 2017 Jan 24;11(1):461-468. doi: 10.1021/acsnano.6b06414. Epub 2017 Jan 3.


Dual-Reporter Drift Correction To Enhance the Performance of Electrochemical Aptamer-Based Sensors in Whole Blood.

Li H, Arroyo-Currás N, Kang D, Ricci F, Plaxco KW.

J Am Chem Soc. 2016 Dec 14;138(49):15809-15812. Epub 2016 Nov 22.


Maximizing the Signal Gain of Electrochemical-DNA Sensors.

Dauphin-Ducharme P, Plaxco KW.

Anal Chem. 2016 Dec 6;88(23):11654-11662. Epub 2016 Nov 22.


Survey of Redox-Active Moieties for Application in Multiplexed Electrochemical Biosensors.

Kang D, Ricci F, White RJ, Plaxco KW.

Anal Chem. 2016 Nov 1;88(21):10452-10458. Epub 2016 Oct 11.


Using Nature's "Tricks" To Rationally Tune the Binding Properties of Biomolecular Receptors.

Ricci F, Vallée-Bélisle A, Simon AJ, Porchetta A, Plaxco KW.

Acc Chem Res. 2016 Sep 20;49(9):1884-92. doi: 10.1021/acs.accounts.6b00276. Epub 2016 Aug 26. Review.


Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure.

Mao X, Simon AJ, Pei H, Shi J, Li J, Huang Q, Plaxco KW, Fan C.

Chem Sci. 2016 Feb 1;7(2):1200-1204. doi: 10.1039/c5sc03705k. Epub 2015 Oct 26.


A Modular, DNA-Based Beacon for Single-Step Fluorescence Detection of Antibodies and Other Proteins.

Ranallo S, Rossetti M, Plaxco KW, Vallée-Bélisle A, Ricci F.

Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13214-8. doi: 10.1002/anie.201505179. Epub 2015 Sep 4.


A general approach to the design of allosteric, transcription factor-regulated DNAzymes.

Adornetto G, Porchetta A, Palleschi G, Plaxco KW, Ricci F.

Chem Sci. 2015 Jul 15;6(7):3692-3696. doi: 10.1039/c5sc00228a. Epub 2015 Mar 10.


Random coil negative control reproduces the discrepancy between scattering and FRET measurements of denatured protein dimensions.

Watkins HM, Simon AJ, Sosnick TR, Lipman EA, Hjelm RP, Plaxco KW.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6631-6. doi: 10.1073/pnas.1418673112. Epub 2015 May 11.


High-precision gigahertz-to-terahertz spectroscopy of aqueous salt solutions as a probe of the femtosecond-to-picosecond dynamics of liquid water.

Vinh NQ, Sherwin MS, Allen SJ, George DK, Rahmani AJ, Plaxco KW.

J Chem Phys. 2015 Apr 28;142(16):164502. doi: 10.1063/1.4918708.


Integrated electrochemical microsystems for genetic detection of pathogens at the point of care.

Hsieh K, Ferguson BS, Eisenstein M, Plaxco KW, Soh HT.

Acc Chem Res. 2015 Apr 21;48(4):911-20. doi: 10.1021/ar500456w. Epub 2015 Mar 18.


Intrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors.

Simon AJ, Vallée-Bélisle A, Ricci F, Plaxco KW.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15048-53. doi: 10.1073/pnas.1410796111. Epub 2014 Oct 6.


Using the population-shift mechanism to rationally introduce "Hill-type" cooperativity into a normally non-cooperative receptor.

Simon AJ, Vallée-Bélisle A, Ricci F, Watkins HM, Plaxco KW.

Angew Chem Int Ed Engl. 2014 Sep 1;53(36):9471-5. doi: 10.1002/anie.201403777. Epub 2014 Jul 11.


Effects of crowding on the stability of a surface-tethered biopolymer: an experimental study of folding in a highly crowded regime.

Watkins HM, Simon AJ, Ricci F, Plaxco KW.

J Am Chem Soc. 2014 Jun 25;136(25):8923-7. doi: 10.1021/ja411486g. Epub 2014 Jun 11.


Accurate zygote-specific discrimination of single-nucleotide polymorphisms using microfluidic electrochemical DNA melting curves.

Yang AH, Hsieh K, Patterson AS, Ferguson BS, Eisenstein M, Plaxco KW, Soh HT.

Angew Chem Int Ed Engl. 2014 Mar 17;53(12):3163-7. doi: 10.1002/anie.201310059. Epub 2014 Feb 12.


Real-time, aptamer-based tracking of circulating therapeutic agents in living animals.

Ferguson BS, Hoggarth DA, Maliniak D, Ploense K, White RJ, Woodward N, Hsieh K, Bonham AJ, Eisenstein M, Kippin TE, Plaxco KW, Soh HT.

Sci Transl Med. 2013 Nov 27;5(213):213ra165. doi: 10.1126/scitranslmed.3007095.


A comparison of the folding kinetics of a small, artificially selected DNA aptamer with those of equivalently simple naturally occurring proteins.

Lawrence C, Vallée-Bélisle A, Pfeil SH, de Mornay D, Lipman EA, Plaxco KW.

Protein Sci. 2014 Jan;23(1):56-66. doi: 10.1002/pro.2390. Epub 2013 Nov 28.


Thermodynamic basis for engineering high-affinity, high-specificity binding-induced DNA clamp nanoswitches.

Idili A, Plaxco KW, Vallée-Bélisle A, Ricci F.

ACS Nano. 2013 Dec 23;7(12):10863-9. doi: 10.1021/nn404305e. Epub 2013 Nov 20.


Electrochemical real-time nucleic acid amplification: towards point-of-care quantification of pathogens.

Patterson AS, Hsieh K, Soh HT, Plaxco KW.

Trends Biotechnol. 2013 Dec;31(12):704-12. doi: 10.1016/j.tibtech.2013.09.005. Epub 2013 Oct 24. Review.


Allosterically tunable, DNA-based switches triggered by heavy metals.

Porchetta A, Vallée-Bélisle A, Plaxco KW, Ricci F.

J Am Chem Soc. 2013 Sep 11;135(36):13238-41. doi: 10.1021/ja404653q. Epub 2013 Aug 28.


Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor.

Bonham AJ, Paden NG, Ricci F, Plaxco KW.

Analyst. 2013 Oct 7;138(19):5580-3. doi: 10.1039/c3an01079a.

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