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Items: 1 to 50 of 60

1.

Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs.

Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T Jr, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M.

Sci Transl Med. 2018 May 9;10(440). pii: eaam6651. doi: 10.1126/scitranslmed.aam6651.

PMID:
29743351
2.

Time-dependent, bidirectional, anti- and pro-spinal hyper-reflexia and muscle spasticity effect after chronic spinal glycine transporter 2 (GlyT2) oligonucleotide-induced downregulation.

Kamizato K, Marsala S, Navarro M, Kakinohana M, Platoshyn O, Yoshizumi T, Lukacova N, Wancewicz E, Powers B, Mazur C, Marsala M.

Exp Neurol. 2018 Jul;305:66-75. doi: 10.1016/j.expneurol.2018.03.013. Epub 2018 Mar 30.

PMID:
29608917
3.

Subpial Adeno-associated Virus 9 (AAV9) Vector Delivery in Adult Mice.

Tadokoro T, Miyanohara A, Navarro M, Kamizato K, Juhas S, Juhasova J, Marsala S, Platoshyn O, Curtis E, Gabel B, Ciacci J, Lukacova N, Bimbova K, Marsala M.

J Vis Exp. 2017 Jul 13;(125). doi: 10.3791/55770.

PMID:
28745630
4.

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.

Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C.

Neuron. 2016 May 4;90(3):535-50. doi: 10.1016/j.neuron.2016.04.006. Epub 2016 Apr 21.

5.

Thoracic 9 Spinal Transection-Induced Model of Muscle Spasticity in the Rat: A Systematic Electrophysiological and Histopathological Characterization.

Corleto JA, Bravo-Hernández M, Kamizato K, Kakinohana O, Santucci C, Navarro MR, Platoshyn O, Cizkova D, Lukacova N, Taylor J, Marsala M.

PLoS One. 2015 Dec 29;10(12):e0144642. doi: 10.1371/journal.pone.0144642. eCollection 2015.

6.

Translation of the rat thoracic contusion model; part 2 - forward versus backward locomotion testing.

van Gorp S, Leerink M, Nguyen S, Platoshyn O, Marsala M, Joosten EA.

Spinal Cord. 2014 Jul;52(7):529-35. doi: 10.1038/sc.2014.73. Epub 2014 May 13.

PMID:
24819507
7.

Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes.

Zemljic-Harpf AE, Godoy JC, Platoshyn O, Asfaw EK, Busija AR, Domenighetti AA, Ross RS.

J Cell Sci. 2014 Mar 1;127(Pt 5):1104-16. doi: 10.1242/jcs.143743. Epub 2014 Jan 10.

8.

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation.

van Gorp S, Leerink M, Kakinohana O, Platoshyn O, Santucci C, Galik J, Joosten EA, Hruska-Plochan M, Goldberg D, Marsala S, Johe K, Ciacci JD, Marsala M.

Stem Cell Res Ther. 2013 May 28;4(3):57. doi: 10.1186/scrt209.

9.

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

Arnold ES, Ling SC, Huelga SC, Lagier-Tourenne C, Polymenidou M, Ditsworth D, Kordasiewicz HB, McAlonis-Downes M, Platoshyn O, Parone PA, Da Cruz S, Clutario KM, Swing D, Tessarollo L, Marsala M, Shaw CE, Yeo GW, Cleveland DW.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E736-45. doi: 10.1073/pnas.1222809110. Epub 2013 Feb 4.

10.

Survival and differentiation of human embryonic stem cell-derived neural precursors grafted spinally in spinal ischemia-injured rats or in naive immunosuppressed minipigs: a qualitative and quantitative study.

Kakinohana O, Juhasova J, Juhas S, Motlik J, Platoshyn O, Galik J, Hefferan M, Yuan SH, Vidal JG, Carson CT, van Gorp S, Goldberg D, Leerink M, Lazar P, Marsala S, Miyanohara A, Keshavarzi S, Ciacci JD, Marsala M.

Cell Transplant. 2012;21(12):2603-19. doi: 10.3727/096368912X653200. Epub 2012 Aug 10.

PMID:
22889456
11.

Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity.

Kakinohana O, Hefferan MP, Miyanohara A, Nejime T, Marsala S, Juhas S, Juhasova J, Motlik J, Kucharova K, Strnadel J, Platoshyn O, Lazar P, Galik J, Vinay L, Marsala M.

PLoS One. 2012;7(1):e30561. doi: 10.1371/journal.pone.0030561. Epub 2012 Jan 23.

12.

Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels.

Firth AL, Remillard CV, Platoshyn O, Fantozzi I, Ko EA, Yuan JX.

Pulm Circ. 2011 Jan 1;1(1):48-71.

13.

Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.

Fuchigami T, Kakinohana O, Hefferan MP, Lukacova N, Marsala S, Platoshyn O, Sugahara K, Yaksh TL, Marsala M.

Neuroscience. 2011 Oct 27;194:160-9. doi: 10.1016/j.neuroscience.2011.08.022. Epub 2011 Aug 16.

14.

Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns.

Burg ED, Platoshyn O, Tsigelny IF, Lozano-Ruiz B, Rana BK, Yuan JX.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C496-509. doi: 10.1152/ajpcell.00464.2009. Epub 2009 Dec 16.

15.

Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells.

Firth AL, Platoshyn O, Brevnova EE, Burg ED, Powell F, Haddad GH, Yuan JX.

Ann N Y Acad Sci. 2009 Oct;1177:101-11. doi: 10.1111/j.1749-6632.2009.05040.x.

PMID:
19845612
16.

Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.

Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E.

PLoS One. 2008 Sep 4;3(9):e3135. doi: 10.1371/journal.pone.0003135.

17.

p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction.

Xu M, Remillard CV, Sachs BD, Makino A, Platoshyn O, Yao W, Dillmann WH, Akassoglou K, Yuan JX.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1529-38. doi: 10.1152/ajpheart.00115.2008. Epub 2008 Aug 8.

18.

Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice.

Makino A, Platoshyn O, Suarez J, Yuan JX, Dillmann WH.

Am J Physiol Cell Physiol. 2008 Jul;295(1):C221-30. doi: 10.1152/ajpcell.00433.2007. Epub 2008 May 7.

19.

Characterization of agonist-induced vasoconstriction in mouse pulmonary artery.

Xu M, Platoshyn O, Makino A, Dillmann WH, Akassoglou K, Remillard CV, Yuan JX.

Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H220-8. Epub 2007 Nov 2.

20.

Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells.

Wu W, Platoshyn O, Firth AL, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L952-9. Epub 2007 Aug 10.

21.

Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells.

Ko EA, Burg ED, Platoshyn O, Msefya J, Firth AL, Yuan JX.

Am J Physiol Cell Physiol. 2007 Sep;293(3):C928-37. Epub 2007 Jun 20.

22.

Heterogeneity of hypoxia-mediated decrease in I(K(V)) and increase in [Ca2+](cyt) in pulmonary artery smooth muscle cells.

Platoshyn O, Yu Y, Ko EA, Remillard CV, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L402-16. Epub 2007 May 25.

23.

Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).

Yu Y, Platoshyn O, Safrina O, Tsigelny I, Yuan JX, Keller SH.

Biol Cell. 2007 Aug;99(8):433-44.

PMID:
17388782
24.

Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein.

Tsigelny IF, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JX, Masliah E.

FEBS J. 2007 Apr;274(7):1862-77.

25.

Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension.

Remillard CV, Tigno DD, Platoshyn O, Burg ED, Brevnova EE, Conger D, Nicholson A, Rana BK, Channick RN, Rubin LJ, O'connor DT, Yuan JX.

Am J Physiol Cell Physiol. 2007 May;292(5):C1837-53. Epub 2007 Jan 31.

26.

Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels.

Schach C, Xu M, Platoshyn O, Keller SH, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L685-98. Epub 2006 Nov 10.

27.

Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.

Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L993-1004. Epub 2006 Jun 30.

28.

Divergent effects of BMP-2 on gene expression in pulmonary artery smooth muscle cells from normal subjects and patients with idiopathic pulmonary arterial hypertension.

Fantozzi I, Huang W, Zhang J, Zhang S, Platoshyn O, Remillard CV, Thistlethwaite PA, Yuan JX.

Exp Lung Res. 2005 Oct;31(8):783-806. doi: 10.1080/01902140500461026.

29.

TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding.

Rao JN, Platoshyn O, Golovina VA, Liu L, Zou T, Marasa BS, Turner DJ, Yuan JX, Wang JY.

Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G782-92. Epub 2005 Nov 10.

30.

Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways.

Keller SH, Platoshyn O, Yuan JX.

Cell Biochem Biophys. 2005;43(3):365-77.

PMID:
16244363
31.

Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells.

Platoshyn O, Brevnova EE, Burg ED, Yu Y, Remillard CV, Yuan JX.

Am J Physiol Cell Physiol. 2006 Mar;290(3):C907-16. Epub 2005 Oct 19.

32.

Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.

Platoshyn O, Remillard CV, Fantozzi I, Sison T, Yuan JX.

Pflugers Arch. 2005 Nov;451(2):380-387. doi: 10.1007/s00424-005-1478-3. Epub 2005 Jul 29.

33.

Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages.

Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR.

Nature. 2005 Feb 10;433(7026):647-53. Erratum in: Nature. 2007 Apr 19;446(7138):934.

34.

Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.

Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX.

Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13861-6. Epub 2004 Sep 9.

35.

Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry.

Kunichika N, Yu Y, Remillard CV, Platoshyn O, Zhang S, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2004 Nov;287(5):L962-9. Epub 2004 Jun 25.

36.

Overexpression of human KCNA5 increases IK V and enhances apoptosis.

Brevnova EE, Platoshyn O, Zhang S, Yuan JX.

Am J Physiol Cell Physiol. 2004 Sep;287(3):C715-22. Epub 2004 May 12.

37.

Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells.

Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L226-38. Epub 2004 Mar 26.

38.

Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells.

Fantozzi I, Zhang S, Platoshyn O, Remillard CV, Cowling RT, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1233-45. Epub 2003 Aug 8.

39.

Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.

Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L740-54. Epub 2003 May 9.

40.

Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents.

Ekhterae D, Platoshyn O, Zhang S, Remillard CV, Yuan JX.

Am J Physiol Cell Physiol. 2003 Jun;284(6):C1405-10. Epub 2003 Jan 29.

41.

PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression.

Yu Y, Sweeney M, Zhang S, Platoshyn O, Landsberg J, Rothman A, Yuan JX.

Am J Physiol Cell Physiol. 2003 Feb;284(2):C316-30.

42.

Cytochrome c activates K+ channels before inducing apoptosis.

Platoshyn O, Zhang S, McDaniel SS, Yuan JX.

Am J Physiol Cell Physiol. 2002 Oct;283(4):C1298-305.

43.

Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation.

Sweeney M, Yu Y, Platoshyn O, Zhang S, McDaniel SS, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L144-55.

44.

Role of capacitative Ca2+ entry in bronchial contraction and remodeling.

Sweeney M, McDaniel SS, Platoshyn O, Zhang S, Yu Y, Lapp BR, Zhao Y, Thistlethwaite PA, Yuan JX.

J Appl Physiol (1985). 2002 Apr;92(4):1594-602.

45.

Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding.

Rao JN, Platoshyn O, Li L, Guo X, Golovina VA, Yuan JX, Wang JY.

Am J Physiol Cell Physiol. 2002 Apr;282(4):C885-98.

46.

Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cells.

Krick S, Platoshyn O, Sweeney M, McDaniel SS, Zhang S, Rubin LJ, Yuan JX.

Am J Physiol Heart Circ Physiol. 2002 Jan;282(1):H184-93.

47.

Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells.

McDaniel SS, Platoshyn O, Yu Y, Sweeney M, Miriel VA, Golovina VA, Krick S, Lapp BR, Wang JY, Yuan JX.

J Appl Physiol (1985). 2001 Nov;91(5):2322-33.

48.

c-Jun decreases voltage-gated K(+) channel activity in pulmonary artery smooth muscle cells.

Yu Y, Platoshyn O, Zhang J, Krick S, Zhao Y, Rubin LJ, Rothman A, Yuan JX.

Circulation. 2001 Sep 25;104(13):1557-63.

PMID:
11571252
49.

Augmented K(+) currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis.

Krick S, Platoshyn O, McDaniel SS, Rubin LJ, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2001 Oct;281(4):L887-94.

50.

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