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Items: 1 to 50 of 94

1.

Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy.

Sliz A, Locker KCS, Lampe K, Godarova A, Plas DR, Janssen EM, Jones H, Herr AB, Hoebe K.

Sci Immunol. 2019 Aug 2;4(38). pii: eaav3866. doi: 10.1126/sciimmunol.aav3866.

PMID:
31375526
2.

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.

Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J.

Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.

3.

ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism.

Berman AY, Manna S, Schwartz NS, Katz YE, Sun Y, Behrmann CA, Yu JJ, Plas DR, Alayev A, Holz MK.

Signal Transduct Target Ther. 2017;2. pii: e17035. doi: 10.1038/sigtrans.2017.35. Epub 2017 Aug 25.

4.

mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment.

Orr-Asman MA, Chu Z, Jiang M, Worley M, LaSance K, Koch SE, Carreira VS, Dahche HM, Plas DR, Komurov K, Qi X, Mercer CA, Anthony LB, Rubinstein J, Thomas HE.

Mol Cancer Ther. 2017 Nov;16(11):2432-2441. doi: 10.1158/1535-7163.MCT-17-0058. Epub 2017 Sep 1.

5.

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J.

Mol Cell. 2017 Aug 3;67(3):512-527.e4. doi: 10.1016/j.molcel.2017.06.033. Epub 2017 Jul 27.

6.

Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells.

Li C, Liu X, Liu Y, Zhang E, Medepalli K, Masuda K, Li N, Wikenheiser-Brokamp KA, Osterburg A, Borchers MT, Kopras EJ, Plas DR, Sun J, Franz DN, Capal JK, Mays M, Sun Y, Kwiatkowski DJ, Alayev A, Holz MK, Krueger DA, Siroky BJ, Yu JJ.

Mol Cancer Res. 2017 Oct;15(10):1318-1330. doi: 10.1158/1541-7786.MCR-17-0077. Epub 2017 Jul 14.

7.

Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.

Liu H, Feng X, Ennis KN, Behrmann CA, Sarma P, Jiang TT, Kofuji S, Niu L, Stratton Y, Thomas HE, Yoon SO, Sasaki AT, Plas DR.

Cell Rep. 2017 Feb 28;18(9):2088-2095. doi: 10.1016/j.celrep.2017.02.022.

8.

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance.

Ghosh J, Kobayashi M, Ramdas B, Chatterjee A, Ma P, Mali RS, Carlesso N, Liu Y, Plas DR, Chan RJ, Kapur R.

J Clin Invest. 2016 Jul 1;126(7):2621-5. doi: 10.1172/JCI84565. Epub 2016 Jun 13.

9.

Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth.

Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S.

Nat Commun. 2015 Oct 12;6:8428. doi: 10.1038/ncomms9428.

PMID:
26455434
10.

ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate.

Shin S, Buel GR, Wolgamott L, Plas DR, Asara JM, Blenis J, Yoon SO.

Mol Cell. 2015 Aug 6;59(3):382-98. doi: 10.1016/j.molcel.2015.06.020. Epub 2015 Jul 16.

11.

TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.

Hall DP, Cost NG, Hegde S, Kellner E, Mikhaylova O, Stratton Y, Ehmer B, Abplanalp WA, Pandey R, Biesiada J, Harteneck C, Plas DR, Meller J, Czyzyk-Krzeska MF.

Cancer Cell. 2014 Nov 10;26(5):738-53. doi: 10.1016/j.ccell.2014.09.015. Epub 2014 Nov 10.

12.

Development and characterization of mucoadhesive chitosan films for ophthalmic delivery of cyclosporine A.

Hermans K, Van den Plas D, Kerimova S, Carleer R, Adriaensens P, Weyenberg W, Ludwig A.

Int J Pharm. 2014 Sep 10;472(1-2):10-9. doi: 10.1016/j.ijpharm.2014.06.017. Epub 2014 Jun 11.

PMID:
24929014
13.

IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels.

Raynor J, Sholl A, Plas DR, Bouillet P, Chougnet CA, Hildeman DA.

Front Immunol. 2013 Jun 24;4:161. doi: 10.3389/fimmu.2013.00161. eCollection 2013.

14.

Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.

Unruh D, Turner K, Srinivasan R, Kocatürk B, Qi X, Chu Z, Aronow BJ, Plas DR, Gallo CA, Kalthoff H, Kirchhofer D, Ruf W, Ahmad SA, Lucas FV, Versteeg HH, Bogdanov VY.

Int J Cancer. 2014 Jan 1;134(1):9-20. doi: 10.1002/ijc.28327. Epub 2013 Jul 27.

15.

Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.

Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J.

Cell. 2013 Jan 31;152(3):599-611. doi: 10.1016/j.cell.2012.12.028.

16.

Not all autophagy is equal.

Czyzyk-Krzeska MF, Meller J, Plas DR.

Autophagy. 2012 Jul 1;8(7):1155-6. doi: 10.4161/auto.20650. Epub 2012 May 31.

17.

Full factorial design, physicochemical characterisation and biological assessment of cyclosporine A loaded cationic nanoparticles.

Hermans K, Van den Plas D, Everaert A, Weyenberg W, Ludwig A.

Eur J Pharm Biopharm. 2012 Sep;82(1):27-35. doi: 10.1016/j.ejpb.2012.05.003. Epub 2012 May 23.

PMID:
22634236
18.

VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma.

Mikhaylova O, Stratton Y, Hall D, Kellner E, Ehmer B, Drew AF, Gallo CA, Plas DR, Biesiada J, Meller J, Czyzyk-Krzeska MF.

Cancer Cell. 2012 Apr 17;21(4):532-46. doi: 10.1016/j.ccr.2012.02.019.

19.

S6K1 determines the metabolic requirements for BCR-ABL survival.

Barger JF, Gallo CA, Tandon P, Liu H, Sullivan A, Grimes HL, Plas DR.

Oncogene. 2013 Jan 24;32(4):453-61. doi: 10.1038/onc.2012.70. Epub 2012 Mar 5.

20.

Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.

Aksoylar HI, Lampe K, Barnes MJ, Plas DR, Hoebe K.

J Immunol. 2012 Jan 1;188(1):146-54. doi: 10.4049/jimmunol.1101206. Epub 2011 Nov 21.

21.

IKKβ and NF-κB transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1.

Sommermann TG, O'Neill K, Plas DR, Cahir-McFarland E.

Cancer Res. 2011 Dec 1;71(23):7291-300. doi: 10.1158/0008-5472.CAN-11-1715. Epub 2011 Oct 10.

22.

Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.

Zhang Y, Johansson E, Miller ML, Jänicke RU, Ferguson DJ, Plas D, Meller J, Anderson MW.

PLoS One. 2011;6(9):e25284. doi: 10.1371/journal.pone.0025284. Epub 2011 Sep 30.

23.

Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells.

Giridhar PV, Funk HM, Gallo CA, Porollo A, Mercer CA, Plas DR, Drew AF.

Clin Exp Metastasis. 2011 Dec;28(8):887-97. doi: 10.1007/s10585-011-9420-x. Epub 2011 Sep 2.

PMID:
21887537
24.

Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.

Coloff JL, Macintyre AN, Nichols AG, Liu T, Gallo CA, Plas DR, Rathmell JC.

Cancer Res. 2011 Aug 1;71(15):5204-13. doi: 10.1158/0008-5472.CAN-10-4531. Epub 2011 Jun 13.

25.

Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency.

Tandon P, Gallo CA, Khatri S, Barger JF, Yepiskoposyan H, Plas DR.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2361-5. doi: 10.1073/pnas.1013629108. Epub 2011 Jan 24.

26.

Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis.

de Weger LA, Beerthuizen T, Gast-Strookman JM, van der Plas DT, Terreehorst I, Hiemstra PS, Sont JK.

Clin Transl Allergy. 2011 Dec 21;1(1):18. doi: 10.1186/2045-7022-1-18.

27.

A major role for Bim in regulatory T cell homeostasis.

Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA.

J Immunol. 2011 Jan 1;186(1):156-63. doi: 10.4049/jimmunol.1001505. Epub 2010 Nov 22.

28.

Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin.

Barger JF, Gallo CA, Torni KA, Merk L, Seibel WL, Nelson S, Plas DR.

Cancer Biol Ther. 2010 Dec 15;10(12):1256-61. doi: 10.4161/cbt.10.12.13442. Epub 2010 Dec 15.

PMID:
20935504
29.

Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis.

Barger JF, Plas DR.

Endocr Relat Cancer. 2010 Sep 23;17(4):R287-304. doi: 10.1677/ERC-10-0106. Print 2010 Dec. Review.

PMID:
20699334
30.

The Use of a New Wound Alginogel for the Treatment of Partial-thickness Hand Burns.

Kyriopoulos E, Van den Plas D, Papadopoulos O, Papadopoulos S, Zapandioti P, Tsoutsos D.

Wounds. 2010 Jun;22(6):161-4.

PMID:
25901464
31.

FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.

Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR.

J Biol Chem. 2010 May 21;285(21):15960-5. doi: 10.1074/jbc.M110.121871. Epub 2010 Apr 6.

32.

Treatment of recalcitrant wounds of diverse etiology with a new hydroactive gel.

Van den Plas DL, Lambrecht A, Jacobs D, Liekens J, Van Hoey M.

Wounds. 2009 Sep;21(9):243-8.

PMID:
25903818
33.

Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis.

Khatri S, Plas DR.

Cancer Biol Ther. 2009 Sep;8(17):1659-61. Epub 2009 Sep 7. No abstract available.

34.

Pre-clinical Evaluation of a New Antimicrobial Enzyme for the Control of Wound Bioburden.

De Smet K, van den Plas D, Lens D, Sollie P.

Wounds. 2009 Mar;21(3):65-73.

PMID:
25903028
35.

Tubers and tumors: rapamycin therapy for benign and malignant tumors.

Plas DR, Thomas G.

Curr Opin Cell Biol. 2009 Apr;21(2):230-6. doi: 10.1016/j.ceb.2008.12.013. Epub 2009 Feb 23. Review.

PMID:
19237273
36.

Enhanced airway dilation by positive-pressure inflation of the lungs compared with active deep inspiration in patients with asthma.

Slats AM, Janssen K, de Jeu RC, van der Plas DT, Schot R, van den Aardweg JG, Sterk PJ.

J Appl Physiol (1985). 2008 Dec;105(6):1725-32. doi: 10.1152/japplphysiol.01237.2007. Epub 2008 Sep 18.

37.

Bone morphogenetic proteins, eye patterning, and retinocollicular map formation in the mouse.

Plas DT, Dhande OS, Lopez JE, Murali D, Thaller C, Henkemeyer M, Furuta Y, Overbeek P, Crair MC.

J Neurosci. 2008 Jul 9;28(28):7057-67. doi: 10.1523/JNEUROSCI.3598-06.2008.

38.

Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma.

Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ.

J Allergy Clin Immunol. 2008 May;121(5):1196-202. doi: 10.1016/j.jaci.2008.02.017. Epub 2008 Apr 11.

PMID:
18405955
39.

Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease.

Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ.

Am J Respir Crit Care Med. 2007 Jul 15;176(2):121-8. Epub 2007 Mar 22.

PMID:
17379851
40.

Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application.

Weyenberg W, Filev P, Van den Plas D, Vandervoort J, De Smet K, Sollie P, Ludwig A.

Int J Pharm. 2007 Jun 7;337(1-2):291-8. Epub 2007 Jan 12.

PMID:
17300887
41.

Study of the environmental effect of a commercial wound cleanser used with different mechanical forces.

De Smet K, Van den Plas D, Van Hoomissen C, Jansens H, Sollie P.

J Hosp Infect. 2006 Nov;64(3):264-70. Epub 2006 Aug 24.

PMID:
16934365
42.

Akt-dependent transformation: there is more to growth than just surviving.

Plas DR, Thompson CB.

Oncogene. 2005 Nov 14;24(50):7435-42. Review.

PMID:
16288290
43.

Pretarget sorting of retinocollicular axons in the mouse.

Plas DT, Lopez JE, Crair MC.

J Comp Neurol. 2005 Oct 31;491(4):305-19.

44.

Evidence for an instructive role of retinal activity in retinotopic map refinement in the superior colliculus of the mouse.

Chandrasekaran AR, Plas DT, Gonzalez E, Crair MC.

J Neurosci. 2005 Jul 20;25(29):6929-38.

45.

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB.

Mol Cell. 2005 Apr 29;18(3):283-93.

46.

Distinct developmental programs require different levels of Bmp signaling during mouse retinal development.

Murali D, Yoshikawa S, Corrigan RR, Plas DJ, Crair MC, Oliver G, Lyons KM, Mishina Y, Furuta Y.

Development. 2005 Mar;132(5):913-23. Epub 2005 Jan 26.

47.

Adenylate Cyclase 1 dependent refinement of retinotopic maps in the mouse.

Plas DT, Visel A, Gonzalez E, She WC, Crair MC.

Vision Res. 2004 Dec;44(28):3357-64.

48.
49.

Messenger RNA electroporation is highly efficient in mouse embryonic stem cells: successful FLPe- and Cre-mediated recombination.

Ponsaerts P, Brown JP, Van den Plas D, Van den Eeden L, Van Bockstaele DR, Jorens PG, Van Tendeloo VF, Merregaert J, Singh PB, Berneman ZN.

Gene Ther. 2004 Nov;11(21):1606-10.

PMID:
15295620
50.

Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand.

Bauer DE, Harris MH, Plas DR, Lum JJ, Hammerman PS, Rathmell JC, Riley JL, Thompson CB.

FASEB J. 2004 Aug;18(11):1303-5. Epub 2004 Jun 4.

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