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Items: 29

1.

Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease.

Maldonado EM, Fisher CP, Mazzatti DJ, Barber AL, Tindall MJ, Plant NJ, Kierzek AM, Moore JB.

NPJ Syst Biol Appl. 2018 Aug 20;4:33. doi: 10.1038/s41540-018-0070-3. eCollection 2018.

2.

Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology.

Sier JH, Thumser AE, Plant NJ.

BMC Syst Biol. 2017 Dec 15;11(1):141. doi: 10.1186/s12918-017-0520-3.

3.

Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics.

Maldonado EM, Leoncikas V, Fisher CP, Moore JB, Plant NJ, Kierzek AM.

CPT Pharmacometrics Syst Pharmacol. 2017 Nov;6(11):732-746. doi: 10.1002/psp4.12230. Epub 2017 Sep 8.

4.

MUFINS: multi-formalism interaction network simulator.

Wu H, von Kamp A, Leoncikas V, Mori W, Sahin N, Gevorgyan A, Linley C, Grabowski M, Mannan AA, Stoy N, Stewart GR, Ward LT, Lewis DJM, Sroka J, Matsuno H, Klamt S, Westerhoff HV, McFadden J, Plant NJ, Kierzek AM.

NPJ Syst Biol Appl. 2016 Nov 17;2:16032. doi: 10.1038/npjsba.2016.32. eCollection 2016.

5.

Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices.

Pushparajah DS, Plant KE, Plant NJ, Ioannides C.

Environ Toxicol. 2017 Mar;32(3):764-775. doi: 10.1002/tox.22276. Epub 2016 Apr 20.

6.

Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production.

Leoncikas V, Wu H, Ward LT, Kierzek AM, Plant NJ.

Sci Rep. 2016 Jan 27;6:19771. doi: 10.1038/srep19771.

8.

Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential.

Alasmael N, Mohan R, Meira LB, Swales KE, Plant NJ.

Cancer Lett. 2016 Jan 28;370(2):250-9. doi: 10.1016/j.canlet.2015.10.031. Epub 2015 Nov 3.

9.

Inhibition of prenyltransferase activity by statins in both liver and muscle cell lines is not causative of cytotoxicity.

Gee RH, Spinks JN, Malia JM, Johnston JD, Plant NJ, Plant KE.

Toxicology. 2015 Mar 2;329:40-8. doi: 10.1016/j.tox.2015.01.005. Epub 2015 Jan 8.

10.

Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease.

Fisher CP, Kierzek AM, Plant NJ, Moore JB.

World J Gastroenterol. 2014 Nov 7;20(41):15070-8. doi: 10.3748/wjg.v20.i41.15070. Review.

11.

Primary liver cells cultured on carbon nanotube substrates for liver tissue engineering and drug discovery applications.

Che Abdullah CA, Azad CL, Ovalle-Robles R, Fang S, Lima MD, Lepró X, Collins S, Baughman RH, Dalton AB, Plant NJ, Sear RP.

ACS Appl Mater Interfaces. 2014 Jul 9;6(13):10373-80. doi: 10.1021/am5018489. Epub 2014 Jun 16.

PMID:
24933259
12.

Fatty acid binding proteins: tissue-specific functions in health and disease.

Thumser AE, Moore JB, Plant NJ.

Curr Opin Clin Nutr Metab Care. 2014 Mar;17(2):124-9. doi: 10.1097/MCO.0000000000000031. Review.

PMID:
24500438
13.

QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells.

Fisher CP, Plant NJ, Moore JB, Kierzek AM.

Bioinformatics. 2013 Dec 15;29(24):3181-90. doi: 10.1093/bioinformatics/btt552. Epub 2013 Sep 23.

15.

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.

Elphick LM, Pawolleck N, Guschina IA, Chaieb L, Eikel D, Nau H, Harwood JL, Plant NJ, Williams RS.

Dis Model Mech. 2012 Mar;5(2):231-40. doi: 10.1242/dmm.008391. Epub 2011 Oct 14.

16.

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.

Plant KE, Everett DM, Gordon Gibson G, Lyon J, Plant NJ.

Pharmacogenet Genomics. 2006 Sep;16(9):647-58.

PMID:
16906019
17.

Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression.

Phillips A, Hood SR, Gibson GG, Plant NJ.

Drug Metab Dispos. 2005 Feb;33(2):233-42. Epub 2004 Nov 2.

PMID:
15523048
18.

EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques.

Lamb DJ, Modjtahedi H, Plant NJ, Ferns GA.

Atherosclerosis. 2004 Sep;176(1):21-6.

PMID:
15306170
19.

Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth.

Crunkhorn SE, Plant KE, Gibson GG, Kramer K, Lyon J, Lord PG, Plant NJ.

Biochem Pharmacol. 2004 Jan 1;67(1):107-18.

PMID:
14667933
20.

Evaluation of the toxicological relevance of CYP3A4 induction.

Plant NJ, Gibson GG.

Curr Opin Drug Discov Devel. 2003 Jan;6(1):50-6. Review.

PMID:
12613276
21.

Receptor-dependent regulation of the CYP3A4 gene.

Gibson GG, el-Sankary W, Plant NJ.

Toxicology. 2002 Dec 27;181-182:199-202.

PMID:
12505310
22.

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

Gibson GG, Plant NJ, Swales KE, Ayrton A, El-Sankary W.

Xenobiotica. 2002 Mar;32(3):165-206. Review.

PMID:
11958559
23.

Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors.

El-Sankary W, Plant NJ, Gibson GG, Moore DJ.

Drug Metab Dispos. 2000 May;28(5):493-6.

PMID:
10772626
24.

Control and statistical analysis of in vitro reporter gene assays.

Plant NJ, Ogg M, Crowder M, Gibson GG.

Anal Biochem. 2000 Feb 15;278(2):170-4.

PMID:
10660459
25.
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27.

Peroxisome proliferators induce high levels of DNA synthesis in primary cultures of rat hepatocytes.

Bell DR, Plant NJ, Horley NJ, Elcombe CR.

Ann N Y Acad Sci. 1996 Dec 27;804:745-6. No abstract available.

PMID:
8993612
28.

Peroxisome proliferators: species differences in response of primary hepatocyte cultures.

Elcombe CR, Bell DR, Elias E, Hasmall SC, Plant NJ.

Ann N Y Acad Sci. 1996 Dec 27;804:628-35. No abstract available.

PMID:
8993577
29.

Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.

Bell DR, Plant NJ, Rider CG, Na L, Brown S, Ateitalla I, Acharya SK, Davies MH, Elias E, Jenkins NA, et al.

Biochem J. 1993 Aug 15;294 ( Pt 1):173-80.

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