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Items: 47

1.

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.

Stuhlmann T, Planells-Cases R, Jentsch TJ.

Nat Commun. 2018 May 17;9(1):1974. doi: 10.1038/s41467-018-04353-y.

2.

VRAC: molecular identification as LRRC8 heteromers with differential functions.

Jentsch TJ, Lutter D, Planells-Cases R, Ullrich F, Voss FK.

Pflugers Arch. 2016 Mar;468(3):385-93. doi: 10.1007/s00424-015-1766-5. Epub 2015 Dec 3. Review.

PMID:
26635246
3.

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

Planells-Cases R, Lutter D, Guyader C, Gerhards NM, Ullrich F, Elger DA, Kucukosmanoglu A, Xu G, Voss FK, Reincke SM, Stauber T, Blomen VA, Vis DJ, Wessels LF, Brummelkamp TR, Borst P, Rottenberg S, Jentsch TJ.

EMBO J. 2015 Dec 14;34(24):2993-3008. doi: 10.15252/embj.201592409. Epub 2015 Nov 3.

4.

Whirlin increases TRPV1 channel expression and cellular stability.

Ciardo MG, Andrés-Bordería A, Cuesta N, Valente P, Camprubí-Robles M, Yang J, Planells-Cases R, Ferrer-Montiel A.

Biochim Biophys Acta. 2016 Jan;1863(1):115-27. doi: 10.1016/j.bbamcr.2015.10.016. Epub 2015 Oct 26.

5.

Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease.

Belghiti M, Estévez-Herrera J, Giménez-Garzó C, González-Usano A, Montoliu C, Ferrer-Montiel A, Felipo V, Planells-Cases R.

J Biol Chem. 2013 Apr 5;288(14):9675-85. doi: 10.1074/jbc.M113.455162. Epub 2013 Feb 13.

6.

Advances in modulating thermosensory TRP channels.

Ferrer-Montiel A, Fernández-Carvajal A, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Messeguer A, González-Muñiz R.

Expert Opin Ther Pat. 2012 Sep;22(9):999-1017. doi: 10.1517/13543776.2012.711320. Epub 2012 Jul 27. Review.

PMID:
22835143
7.

Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation.

Sanz-Salvador L, Andrés-Borderia A, Ferrer-Montiel A, Planells-Cases R.

J Biol Chem. 2012 Jun 1;287(23):19462-71. doi: 10.1074/jbc.M111.289751. Epub 2012 Apr 6.

8.

An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain.

Ponsati B, Carreño C, Curto-Reyes V, Valenzuela B, Duart MJ, Van den Nest W, Cauli O, Beltran B, Fernandez J, Borsini F, Caprioli A, Di Serio S, Veretchy M, Baamonde A, Menendez L, Barros F, de la Pena P, Borges R, Felipo V, Planells-Cases R, Ferrer-Montiel A.

J Pharmacol Exp Ther. 2012 Jun;341(3):634-45. doi: 10.1124/jpet.111.190678. Epub 2012 Mar 5.

9.

Role of the transient receptor potential vanilloid 1 in inflammation and sepsis.

Devesa I, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Ferrer-Montiel A, Fernández-Carvajal A.

J Inflamm Res. 2011;4:67-81. doi: 10.2147/JIR.S12978. Epub 2011 May 24.

10.

Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis.

Vidal-Mosquera M, Fernández-Carvajal A, Moure A, Valente P, Planells-Cases R, González-Ros JM, Bujons J, Ferrer-Montiel A, Messeguer A.

J Med Chem. 2011 Nov 10;54(21):7441-52. doi: 10.1021/jm200981s. Epub 2011 Oct 10.

PMID:
21950613
11.

Membrane-tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity.

Valente P, Fernández-Carvajal A, Camprubí-Robles M, Gomis A, Quirce S, Viana F, Fernández-Ballester G, González-Ros JM, Belmonte C, Planells-Cases R, Ferrer-Montiel A.

FASEB J. 2011 May;25(5):1628-40. doi: 10.1096/fj.10-174433. Epub 2011 Feb 9.

PMID:
21307333
12.

Complex regulation of TRPV1 and related thermo-TRPs: implications for therapeutic intervention.

Planells-Cases R, Valente P, Ferrer-Montiel A, Qin F, Szallasi A.

Adv Exp Med Biol. 2011;704:491-515. doi: 10.1007/978-94-007-0265-3_27. Review.

PMID:
21290313
13.

TRP Channel Trafficking.

Planells-Cases R, Ferrer-Montiel A.

In: Liedtke WB, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 23.

14.

GABAA receptor associated protein (GABARAP) modulates TRPV1 expression and channel function and desensitization.

Laínez S, Valente P, Ontoria-Oviedo I, Estévez-Herrera J, Camprubí-Robles M, Ferrer-Montiel A, Planells-Cases R.

FASEB J. 2010 Jun;24(6):1958-70. doi: 10.1096/fj.09-151472. Epub 2010 Feb 23.

PMID:
20179142
15.

Chloride channelopathies.

Planells-Cases R, Jentsch TJ.

Biochim Biophys Acta. 2009 Mar;1792(3):173-89. doi: 10.1016/j.bbadis.2009.02.002. Review.

16.

Differential contribution of SNARE-dependent exocytosis to inflammatory potentiation of TRPV1 in nociceptors.

Camprubí-Robles M, Planells-Cases R, Ferrer-Montiel A.

FASEB J. 2009 Nov;23(11):3722-33. doi: 10.1096/fj.09-134346. Epub 2009 Jul 7.

PMID:
19584302
17.

Activated spinal cord ependymal stem cells rescue neurological function.

Moreno-Manzano V, Rodríguez-Jiménez FJ, García-Roselló M, Laínez S, Erceg S, Calvo MT, Ronaghi M, Lloret M, Planells-Cases R, Sánchez-Puelles JM, Stojkovic M.

Stem Cells. 2009 Mar;27(3):733-43. doi: 10.1002/stem.24.

18.

Physiology and pharmacology of the vanilloid receptor.

Messeguer A, Planells-Cases R, Ferrer-Montiel A.

Curr Neuropharmacol. 2006 Jan;4(1):1-15.

19.

Differentiation of postnatal neural stem cells into glia and functional neurons on laminin-coated polymeric substrates.

Martínez-Ramos C, Lainez S, Sancho F, García Esparza MA, Planells-Cases R, García Verdugo JM, Gómez Ribelles JL, Salmerón Sánchez M, Monleón Pradas M, Barcia JA, Soria JM.

Tissue Eng Part A. 2008 Aug;14(8):1365-75. doi: 10.1089/ten.tea.2007.0295.

PMID:
18491954
20.

Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions.

Erceg S, Laínez S, Ronaghi M, Stojkovic P, Pérez-Aragó MA, Moreno-Manzano V, Moreno-Palanques R, Planells-Cases R, Stojkovic M.

PLoS One. 2008 May 7;3(5):e2122. doi: 10.1371/journal.pone.0002122.

21.

Pharmacological intervention at ionotropic glutamate receptor complexes.

Planells-Cases R, Lerma J, Ferrer-Montiel A.

Curr Pharm Des. 2006;12(28):3583-96. Review.

PMID:
17073661
22.

Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6.

Poët M, Kornak U, Schweizer M, Zdebik AA, Scheel O, Hoelter S, Wurst W, Schmitt A, Fuhrmann JC, Planells-Cases R, Mole SE, Hübner CA, Jentsch TJ.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13854-9. Epub 2006 Sep 1.

23.

Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia.

Planells-Cases R, Garcìa-Sanz N, Morenilla-Palao C, Ferrer-Montiel A.

Pflugers Arch. 2005 Oct;451(1):151-9. Epub 2005 May 21. Review.

PMID:
15909179
24.

Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration.

Kasper D, Planells-Cases R, Fuhrmann JC, Scheel O, Zeitz O, Ruether K, Schmitt A, Poët M, Steinfeld R, Schweizer M, Kornak U, Jentsch TJ.

EMBO J. 2005 Mar 9;24(5):1079-91. Epub 2005 Feb 10.

25.

Modulation of botulinum neurotoxin A catalytic domain stability by tyrosine phosphorylation.

Ibañez C, Blanes-Mira C, Fernández-Ballester G, Planells-Cases R, Ferrer-Montiel A.

FEBS Lett. 2004 Dec 3;578(1-2):121-7.

26.

Identification of a tetramerization domain in the C terminus of the vanilloid receptor.

García-Sanz N, Fernández-Carvajal A, Morenilla-Palao C, Planells-Cases R, Fajardo-Sánchez E, Fernández-Ballester G, Ferrer-Montiel A.

J Neurosci. 2004 Jun 9;24(23):5307-14.

27.

Molecular architecture of the vanilloid receptor. Insights for drug design.

Ferrer-Montiel A, García-Martínez C, Morenilla-Palao C, García-Sanz N, Fernández-Carvajal A, Fernández-Ballester G, Planells-Cases R.

Eur J Biochem. 2004 May;271(10):1820-6. Review.

28.

Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity.

Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A.

J Biol Chem. 2004 Jun 11;279(24):25665-72. Epub 2004 Apr 5.

29.

Small molecules targeting the NMDA receptor complex as drugs for neuropathic pain.

Planells-Cases R, Pérez-Payá E, Messeguer A, Carreño C, Ferrer-Montiel A.

Mini Rev Med Chem. 2003 Nov;3(7):749-56. Review.

PMID:
14529515
30.

GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity.

Caprini M, Gomis A, Cabedo H, Planells-Cases R, Belmonte C, Viana F, Ferrer-Montiel A.

EMBO J. 2003 Jun 16;22(12):3004-14.

31.

Neuroprotection against excitotoxicity by N-alkylglycines in rat hippocampal neurons.

Valera E, Fernández-Salguero PM, Planells-Cases R, Messeguer A, Van Den Nest W, Carreño C, Ferrer-Montiel A, Merino JM.

Neuromolecular Med. 2002;2(3):271-80.

PMID:
12622405
32.

A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity.

Planells-Cases R, Montoliu C, Humet M, Fernández AM, García-Martínez C, Valera E, Merino JM, Pérez-Payá E, Messeguer A, Felipo V, Ferrer-Montiel A.

J Pharmacol Exp Ther. 2002 Jul;302(1):163-73.

33.

Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants.

Montoliu C, Humet M, Canales JJ, Burda J, Planells-Cases R, Sánchez-Baeza F, Carbonell T, Pérez-Payá E, Messeguer A, Ferrer-Montiel A, Felipo V.

J Pharmacol Exp Ther. 2002 Apr;301(1):29-36.

34.

Attenuation of thermal nociception and hyperalgesia by VR1 blockers.

García-Martinez C, Humet M, Planells-Cases R, Gomis A, Caprini M, Viana F, De La Pena E, Sanchez-Baeza F, Carbonell T, De Felipe C, Pérez-Paya E, Belmonte C, Messeguer A, Ferrer-Montiel A.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2374-9.

35.

Thermal stabilization of the catalytic domain of botulinum neurotoxin E by phosphorylation of a single tyrosine residue.

Blanes-Mira C, Ibañez C, Fernández-Ballester G, Planells-Cases R, Pérez-Payá E, Ferrer-Montiel A.

Biochemistry. 2001 Feb 20;40(7):2234-42.

PMID:
11329292
36.

Structural compatibility between the putative voltage sensor of voltage-gated K+ channels and the prokaryotic KcsA channel.

Caprini M, Ferroni S, Planells-Cases R, Rueda J, Rapisarda C, Ferrer-Montiel A, Montal M.

J Biol Chem. 2001 Jun 15;276(24):21070-6. Epub 2001 Mar 26.

37.

Arginine-rich peptides are blockers of VR-1 channels with analgesic activity.

Planells-Cases R, Aracil A, Merino JM, Gallar J, Pérez-Payá E, Belmonte C, González-Ros JM, Ferrer-Montiel AV.

FEBS Lett. 2000 Sep 15;481(2):131-6.

38.

Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties.

García-Martínez C, Morenilla-Palao C, Planells-Cases R, Merino JM, Ferrer-Montiel A.

J Biol Chem. 2000 Oct 20;275(42):32552-8.

39.

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

Planells-Cases R, Caprini M, Zhang J, Rockenstein EM, Rivera RR, Murre C, Masliah E, Montal M.

Biophys J. 2000 Jun;78(6):2878-91.

40.

Structural and functional modularity of voltage-gated potassium channels.

Patten CD, Caprini M, Planells-Cases R, Montal M.

FEBS Lett. 1999 Dec 17;463(3):375-81.

41.

Structural determinants of the blocker binding site in glutamate and NMDA receptor channels.

Ferrer-Montiel AV, Merino JM, Planells-Cases R, Sun W, Montal M.

Neuropharmacology. 1998;37(2):139-47.

PMID:
9680238
42.

Mutation of conserved negatively charged residues in the S2 and S3 transmembrane segments of a mammalian K+ channel selectively modulates channel gating.

Planells-Cases R, Ferrer-Montiel AV, Patten CD, Montal M.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9422-6.

43.

Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively.

Collins C, Duff C, Duncan AM, Planells-Cases R, Sun W, Norremolle A, Michaelis E, Montal M, Worton R, Hayden MR.

Genomics. 1993 Jul;17(1):237-9.

PMID:
8406459
44.

Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.

Planells-Cases R, Sun W, Ferrer-Montiel AV, Montal M.

Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5057-61.

45.

Possible coexistence of two independent mechanisms contributing to anthracycline resistance in leukaemia P388 cells.

Soto F, Planells-Cases R, Canaves JM, Ferrer-Montiel AV, Aleu J, Gamarro F, Castanys S, Gonzalez-Ros JM, Ferragut JA.

Eur J Cancer. 1993;29A(15):2144-50.

PMID:
7905276
46.

Verapamil reverses the ultrastructural alterations in the plasma membrane induced by drug resistance.

García-Segura LM, Soto F, Planells-Cases R, Gonzalez-Ros JM, Ferragut JA.

FEBS Lett. 1992 Dec 21;314(3):404-8.

47.

Expression of a genomic clone encoding a brain potassium channel in mammalian cells using lipofection.

Ferroni S, Planells-Cases R, Ahmed CM, Montal M.

Eur Biophys J. 1992;21(3):185-91.

PMID:
1425474

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