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Crocin, a natural molecule with potentially beneficial effects against skin aging.

Fagot D, Pham DM, Laboureau J, Planel E, Guerin L, Nègre C, Donovan M, Bernard BA.

Int J Cosmet Sci. 2018 Jun 12. doi: 10.1111/ics.12472. [Epub ahead of print]


Impaired Resolution of Inflammation in Alzheimer's Disease: A Review.

Whittington RA, Planel E, Terrando N.

Front Immunol. 2017 Nov 6;8:1464. doi: 10.3389/fimmu.2017.01464. eCollection 2017. Review.


Co-occurrence of mixed proteinopathies in late-stage Huntington's disease.

St-Amour I, Turgeon A, Goupil C, Planel E, Hébert SS.

Acta Neuropathol. 2018 Feb;135(2):249-265. doi: 10.1007/s00401-017-1786-7. Epub 2017 Nov 13.


Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.

Cisbani G, Maxan A, Kordower JH, Planel E, Freeman TB, Cicchetti F.

Brain. 2017 Nov 1;140(11):2982-2992. doi: 10.1093/brain/awx255.


Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet.

Gratuze M, Julien J, Morin F, Marette A, Planel E.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):452-461. doi: 10.1016/j.pnpbp.2017.08.001. Epub 2017 Aug 3.


Regulation of brain insulin signaling: A new function for tau.

Gratuze M, Planel E.

J Exp Med. 2017 Aug 7;214(8):2171-2173. doi: 10.1084/jem.20170979. Epub 2017 Jun 26.


Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology.

Gratuze M, Julien J, Petry FR, Morin F, Planel E.

Sci Rep. 2017 Apr 12;7:46359. doi: 10.1038/srep46359.


Old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with Alzheimer's disease.

Tournissac M, Vandal M, François A, Planel E, Calon F.

Neurobiol Aging. 2017 Feb;50:25-29. doi: 10.1016/j.neurobiolaging.2016.09.024. Epub 2016 Oct 12.


Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease.

Gratuze M, El Khoury NB, Turgeon A, Julien C, Marcouiller F, Morin F, Whittington RA, Marette A, Calon F, Planel E.

Neurobiol Dis. 2017 Feb;98:1-8. doi: 10.1016/j.nbd.2016.10.004. Epub 2016 Oct 26.


High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology.

Gratuze M, Julien J, Morin F, Calon F, Hébert SS, Marette A, Planel E.

Neurobiol Aging. 2016 Nov;47:71-73. doi: 10.1016/j.neurobiolaging.2016.07.016. Epub 2016 Jul 29.


microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice.

Hernandez-Rapp J, Rainone S, Goupil C, Dorval V, Smith PY, Saint-Pierre M, Vallée M, Planel E, Droit A, Calon F, Cicchetti F, Hébert SS.

Sci Rep. 2016 Aug 3;6:30953. doi: 10.1038/srep30953.


Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease.

Vandal M, White PJ, Tournissac M, Tremblay C, St-Amour I, Drouin-Ouellet J, Bousquet M, Traversy MT, Planel E, Marette A, Calon F.

Neurobiol Aging. 2016 Jul;43:47-57. doi: 10.1016/j.neurobiolaging.2016.03.024. Epub 2016 Mar 30.


Is Huntington's disease a tauopathy?

Gratuze M, Cisbani G, Cicchetti F, Planel E.

Brain. 2016 Apr;139(Pt 4):1014-25. doi: 10.1093/brain/aww021. Epub 2016 Mar 11. Review.


Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma.

Winston CN, Noël A, Neustadtl A, Parsadanian M, Barton DJ, Chellappa D, Wilkins TE, Alikhani AD, Zapple DN, Villapol S, Planel E, Burns MP.

Am J Pathol. 2016 Mar;186(3):552-67. doi: 10.1016/j.ajpath.2015.11.006. Epub 2016 Feb 5.


Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.

El Khoury NB, Gratuze M, Petry F, Papon MA, Julien C, Marcouiller F, Morin F, Nicholls SB, Calon F, Hébert SS, Marette A, Planel E.

Neurobiol Dis. 2016 Apr;88:55-65. doi: 10.1016/j.nbd.2016.01.005. Epub 2016 Jan 9.


miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.

Smith PY, Hernandez-Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, Dorval V, Parsi S, Morin F, Planel E, Bennett DA, Fernandez-Gomez FJ, Sergeant N, Buée L, Tremblay MÈ, Calon F, Hébert SS.

Hum Mol Genet. 2015 Dec 1;24(23):6721-35. doi: 10.1093/hmg/ddv377. Epub 2015 Sep 11.


Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease.

Vandal M, White PJ, Chevrier G, Tremblay C, St-Amour I, Planel E, Marette A, Calon F.

FASEB J. 2015 Oct;29(10):4273-84. doi: 10.1096/fj.14-268482. Epub 2015 Jun 24.


Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.

Whittington RA, Virág L, Gratuze M, Petry FR, Noël A, Poitras I, Truchetti G, Marcouiller F, Papon MA, El Khoury N, Wong K, Bretteville A, Morin F, Planel E.

Neurobiol Aging. 2015 Aug;36(8):2414-28. doi: 10.1016/j.neurobiolaging.2015.05.002. Epub 2015 May 9.


Memory formation and retention are affected in adult miR-132/212 knockout mice.

Hernandez-Rapp J, Smith PY, Filali M, Goupil C, Planel E, Magill ST, Goodman RH, Hébert SS.

Behav Brain Res. 2015;287:15-26. doi: 10.1016/j.bbr.2015.03.032. Epub 2015 Mar 23.


ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro.

Noël A, Poitras I, Julien J, Petry FR, Morin F, Charron J, Planel E.

Neurobiol Aging. 2015 Feb;36(2):901-2. doi: 10.1016/j.neurobiolaging.2014.11.005. Epub 2014 Nov 14.


Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.

Gratuze M, Noël A, Julien C, Cisbani G, Milot-Rousseau P, Morin F, Dickler M, Goupil C, Bezeau F, Poitras I, Bissonnette S, Whittington RA, Hébert SS, Cicchetti F, Parker JA, Samadi P, Planel E.

Hum Mol Genet. 2015 Jan 1;24(1):86-99. doi: 10.1093/hmg/ddu456. Epub 2014 Sep 8.


Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons.

Mohamed NV, Plouffe V, Rémillard-Labrosse G, Planel E, Leclerc N.

Sci Rep. 2014 Jul 17;4:5715. doi: 10.1038/srep05715.


Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease.

Vandal M, White PJ, Tremblay C, St-Amour I, Chevrier G, Emond V, Lefrançois D, Virgili J, Planel E, Giguere Y, Marette A, Calon F.

Diabetes. 2014 Dec;63(12):4291-301. doi: 10.2337/db14-0375. Epub 2014 Jul 9.


Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.

Petry FR, Pelletier J, Bretteville A, Morin F, Calon F, Hébert SS, Whittington RA, Planel E.

PLoS One. 2014 May 2;9(5):e94251. doi: 10.1371/journal.pone.0094251. eCollection 2014.


Insulin dysfunction and Tau pathology.

El Khoury NB, Gratuze M, Papon MA, Bretteville A, Planel E.

Front Cell Neurosci. 2014 Feb 11;8:22. doi: 10.3389/fncel.2014.00022. eCollection 2014. Review.


Anesthesia, surgery and neurodegeneration. Preface.

Eckenhoff RG, Planel E.

Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 2;47:121. doi: 10.1016/j.pnpbp.2013.10.012. No abstract available.


Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation.

Whittington RA, Bretteville A, Virág L, Emala CW, Maurin TO, Marcouiller F, Julien C, Petry FR, El-Khoury NB, Morin F, Charron J, Planel E.

Sci Rep. 2013;3:1388. doi: 10.1038/srep01388.


Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.

Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr.

Br J Anaesth. 2013 Aug;111(2):143-51. doi: 10.1093/bja/aet177. Epub 2013 May 30.


Anesthesia and tau pathology.

Whittington RA, Bretteville A, Dickler MF, Planel E.

Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 2;47:147-55. doi: 10.1016/j.pnpbp.2013.03.004. Epub 2013 Mar 25. Review.


Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice.

Papon MA, El Khoury NB, Marcouiller F, Julien C, Morin F, Bretteville A, Petry FR, Gaudreau S, Amrani A, Mathews PM, Hébert SS, Planel E.

Diabetes. 2013 Feb;62(2):609-17. doi: 10.2337/db12-0187. Epub 2012 Sep 6.


Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons.

Dorval V, Smith PY, Delay C, Calvo E, Planel E, Zommer N, Buée L, Hébert SS.

PLoS One. 2012;7(8):e44060. doi: 10.1371/journal.pone.0044060. Epub 2012 Aug 27.


Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD).

Filali M, Lalonde R, Theriault P, Julien C, Calon F, Planel E.

Behav Brain Res. 2012 Oct 1;234(2):334-42. doi: 10.1016/j.bbr.2012.07.004. Epub 2012 Jul 14.


Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.

Julien C, Marcouiller F, Bretteville A, El Khoury NB, Baillargeon J, Hébert SS, Planel E.

PLoS One. 2012;7(6):e40020. doi: 10.1371/journal.pone.0040020. Epub 2012 Jun 29.


Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.

Bretteville A, Marcouiller F, Julien C, El Khoury NB, Petry FR, Poitras I, Mouginot D, Lévesque G, Hébert SS, Planel E.

Sci Rep. 2012;2:480. doi: 10.1038/srep00480. Epub 2012 Jun 29.


Biochemical isolation of insoluble tau in transgenic mouse models of tauopathies.

Julien C, Bretteville A, Planel E.

Methods Mol Biol. 2012;849:473-91. doi: 10.1007/978-1-61779-551-0_32. Review.


Postoperative cognitive decline: where art tau?

Eckenhoff RG, Planel E.

Anesthesiology. 2012 Apr;116(4):751-2. doi: 10.1097/ALN.0b013e31824be8e1. No abstract available.


MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy.

Smith PY, Delay C, Girard J, Papon MA, Planel E, Sergeant N, Buée L, Hébert SS.

Hum Mol Genet. 2011 Oct 15;20(20):4016-24. doi: 10.1093/hmg/ddr330. Epub 2011 Aug 1.


Alzheimer's disease and anesthesia.

Papon MA, Whittington RA, El-Khoury NB, Planel E.

Front Neurosci. 2011 Jan 31;4:272. doi: 10.3389/fnins.2010.00272. eCollection 2011.


Propofol directly increases tau phosphorylation.

Whittington RA, Virág L, Marcouiller F, Papon MA, El Khoury NB, Julien C, Morin F, Emala CW, Planel E.

PLoS One. 2011 Jan 31;6(1):e16648. doi: 10.1371/journal.pone.0016648.


Hypothermia and Alzheimer's disease neuropathogenic pathways.

Whittington RA, Papon MA, Chouinard F, Planel E.

Curr Alzheimer Res. 2010 Dec;7(8):717-25. Review.


Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration.

Hébert SS, Papadopoulou AS, Smith P, Galas MC, Planel E, Silahtaroglu AN, Sergeant N, Buée L, De Strooper B.

Hum Mol Genet. 2010 Oct 15;19(20):3959-69. doi: 10.1093/hmg/ddq311. Epub 2010 Jul 21.


In vitro tools for photobiological testing: molecular responses to simulated solar UV of keratinocytes growing as monolayers or as part of reconstructed skin.

Marrot L, Planel E, Ginestet AC, Belaïdi JP, Jones C, Meunier JR.

Photochem Photobiol Sci. 2010 Apr;9(4):448-58. doi: 10.1039/b9pp00145j.


In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice.

Morales-Corraliza J, Mazzella MJ, Berger JD, Diaz NS, Choi JH, Levy E, Matsuoka Y, Planel E, Mathews PM.

PLoS One. 2009 Sep 22;4(9):e7134. doi: 10.1371/journal.pone.0007134.


Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.

Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE.

Am J Pathol. 2009 Aug;175(2):736-47. doi: 10.2353/ajpath.2009.080928. Epub 2009 Jul 23.


Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease.

Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotás A, Perouansky M, Planel E, Silverstein JH, Wei H, Whittington RA, Xie Z, Zuo Z; First International Workshop on Anesthetics and Alzheimer's Disease.

Anesth Analg. 2009 May;108(5):1627-30. doi: 10.1213/ane.0b013e318199dc72.


Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.

Planel E, Bretteville A, Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE.

FASEB J. 2009 Aug;23(8):2595-604. doi: 10.1096/fj.08-122424. Epub 2009 Mar 11.


Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.

Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE.

J Neurosci. 2008 Nov 26;28(48):12798-807. doi: 10.1523/JNEUROSCI.4101-08.2008.


Tau aggregates: toxic, inert, or protective species?

Bretteville A, Planel E.

J Alzheimers Dis. 2008 Aug;14(4):431-6. Review.


A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.

Liu L, Orozco IJ, Planel E, Wen Y, Bretteville A, Krishnamurthy P, Wang L, Herman M, Figueroa H, Yu WH, Arancio O, Duff K.

Neurobiol Dis. 2008 Jul;31(1):46-57. doi: 10.1016/j.nbd.2008.03.005. Epub 2008 Apr 7.


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