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Items: 7


Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Steffen JD, Tholey RM, Langelier MF, Planck JL, Schiewer MJ, Lal S, Bildzukewicz NA, Yeo CJ, Knudsen KE, Brody JR, Pascal JM.

Cancer Res. 2014 Jan 1;74(1):31-7. doi: 10.1158/0008-5472.CAN-13-1701. Epub 2013 Nov 4.


Assay development for histone methyltransferases.

Horiuchi KY, Eason MM, Ferry JJ, Planck JL, Walsh CP, Smith RF, Howitz KT, Ma H.

Assay Drug Dev Technol. 2013 May;11(4):227-36. doi: 10.1089/adt.2012.480. Epub 2013 Apr 4.


Dual roles of PARP-1 promote cancer growth and progression.

Schiewer MJ, Goodwin JF, Han S, Brenner JC, Augello MA, Dean JL, Liu F, Planck JL, Ravindranathan P, Chinnaiyan AM, McCue P, Gomella LG, Raj GV, Dicker AP, Brody JR, Pascal JM, Centenera MM, Butler LM, Tilley WD, Feng FY, Knudsen KE.

Cancer Discov. 2012 Dec;2(12):1134-49. doi: 10.1158/2159-8290.CD-12-0120. Epub 2012 Sep 19.


Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.

Langelier MF, Planck JL, Roy S, Pascal JM.

Science. 2012 May 11;336(6082):728-32. doi: 10.1126/science.1216338.


Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis.

Langelier MF, Planck JL, Servent KM, Pascal JM.

Methods Mol Biol. 2011;780:209-26. doi: 10.1007/978-1-61779-270-0_13.


Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity.

Langelier MF, Planck JL, Roy S, Pascal JM.

J Biol Chem. 2011 Mar 25;286(12):10690-701. doi: 10.1074/jbc.M110.202507. Epub 2011 Jan 13.


The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.

Langelier MF, Ruhl DD, Planck JL, Kraus WL, Pascal JM.

J Biol Chem. 2010 Jun 11;285(24):18877-87. doi: 10.1074/jbc.M110.105668. Epub 2010 Apr 13.

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