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Items: 1 to 50 of 125

1.

Transgenic expression of the positive selected human GLUD2 gene improves in vivo glucose homeostasis by regulating basic insulin secretion.

Petraki Z, Droubogiannis S, Mylonaki K, Chlouverakis G, Plaitakis A, Spanaki C.

Metabolism. 2019 Aug 7;100:153958. doi: 10.1016/j.metabol.2019.153958. [Epub ahead of print]

PMID:
31400387
2.

The Cretan Aging Cohort: Cohort Description and Burden of Dementia and Mild Cognitive Impairment.

Zaganas IV, Simos P, Basta M, Kapetanaki S, Panagiotakis S, Koutentaki I, Fountoulakis N, Bertsias A, Duijker G, Tziraki C, Scarmeas N, Plaitakis A, Boumpas D, Lionis C, Vgontzas AN.

Am J Alzheimers Dis Other Demen. 2019 Feb;34(1):23-33. doi: 10.1177/1533317518802414. Epub 2018 Sep 27.

PMID:
30259758
3.

Transgenic Mice Carrying GLUD2 as a Tool for Studying the Expressional and the Functional Adaptation of this Positive Selected Gene in Human Brain Evolution.

Plaitakis A, Kotzamani D, Petraki Z, Delidaki M, Rinotas V, Zaganas I, Douni E, Sidiropoulou K, Spanaki C.

Neurochem Res. 2019 Jan;44(1):154-169. doi: 10.1007/s11064-018-2546-3. Epub 2018 May 18.

PMID:
29777493
4.

The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease.

Plaitakis A, Kalef-Ezra E, Kotzamani D, Zaganas I, Spanaki C.

Biology (Basel). 2017 Feb 8;6(1). pii: E11. doi: 10.3390/biology6010011. Review.

5.

Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence.

Kalef-Ezra E, Kotzamani D, Zaganas I, Katrakili N, Plaitakis A, Tokatlidis K.

Biochem J. 2016 Sep 15;473(18):2813-29. doi: 10.1042/BCJ20160535. Epub 2016 Jul 15.

6.

Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.

Spanaki C, Kotzamani D, Plaitakis A.

Neurochem Res. 2017 Jan;42(1):92-107. doi: 10.1007/s11064-016-1986-x. Epub 2016 Jul 16.

PMID:
27422263
7.

Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons.

Spanaki C, Kotzamani D, Kleopa K, Plaitakis A.

Mol Neurobiol. 2016 Oct;53(8):5140-8. doi: 10.1007/s12035-015-9429-2. Epub 2015 Sep 23.

PMID:
26399640
8.

Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.

Spanaki C, Kotzamani D, Petraki Z, Drakos E, Plaitakis A.

Mol Cell Endocrinol. 2015 Nov 5;415:1-11. doi: 10.1016/j.mce.2015.07.020. Epub 2015 Aug 1.

PMID:
26241911
9.

Differential interaction of hGDH1 and hGDH2 with manganese: Implications for metabolism and toxicity.

Dimovasili C, Aschner M, Plaitakis A, Zaganas I.

Neurochem Int. 2015 Sep;88:60-5. doi: 10.1016/j.neuint.2015.03.004. Epub 2015 Mar 30.

PMID:
25837286
10.

Side-chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation.

Mastorodemos V, Kanavouras K, Sundaram S, Providaki M, Petraki Z, Kokkinidis M, Zaganas I, Logothetis DE, Plaitakis A.

J Neurochem. 2015 Apr;133(1):73-82. doi: 10.1111/jnc.13019. Epub 2015 Jan 26.

11.

Regional MRI perfusion measures predict motor/executive function in patients with clinically isolated syndrome.

Papadaki EZ, Simos PG, Mastorodemos VC, Panou T, Maris TG, Karantanas AH, Plaitakis A.

Behav Neurol. 2014;2014:252419. doi: 10.1155/2014/252419. Epub 2014 Jan 23.

12.

Heterogeneous cellular distribution of glutamate dehydrogenase in brain and in non-neural tissues.

Spanaki C, Kotzamani D, Petraki Z, Drakos E, Plaitakis A.

Neurochem Res. 2014;39(3):500-15. doi: 10.1007/s11064-013-1235-5. Epub 2014 Jan 17. Review.

PMID:
24436052
13.

Hemodynamic evidence linking cognitive deficits in clinically isolated syndrome to regional brain inflammation.

Papadaki EZ, Simos PG, Panou T, Mastorodemos VC, Maris TG, Karantanas AH, Plaitakis A.

Eur J Neurol. 2014 Mar;21(3):499-505. doi: 10.1111/ene.12338. Epub 2013 Dec 26.

PMID:
24373026
14.

The discovery of human of GLUD2 glutamate dehydrogenase and its implications for cell function in health and disease.

Shashidharan P, Plaitakis A.

Neurochem Res. 2014;39(3):460-70. doi: 10.1007/s11064-013-1227-5. Epub 2013 Dec 19. Review.

15.

Coexistence of systemic lupus erythematosus and multiple sclerosis: prevalence, clinical characteristics, and natural history.

Fanouriakis A, Mastorodemos V, Pamfil C, Papadaki E, Sidiropoulos P, Plaitakis A, Amoiridis G, Bertsias G, Boumpas DT.

Semin Arthritis Rheum. 2014 Jun;43(6):751-8. doi: 10.1016/j.semarthrit.2013.11.007. Epub 2013 Nov 13.

PMID:
24332007
16.

Assessment of Parkinson's disease risk loci in Greece.

Kara E, Xiromerisiou G, Spanaki C, Bozi M, Koutsis G, Panas M, Dardiotis E, Ralli S, Bras J, Letson C, Edsall C, Pliner H, Arepalli S, Kalinderi K, Fidani L, Bostantjopoulou S, Keller MF, Wood NW, Hardy J, Houlden H, Stefanis L, Plaitakis A, Hernandez D, Hadjigeorgiou GM, Nalls MA, Singleton AB.

Neurobiol Aging. 2014 Feb;35(2):442.e9-442.e16. doi: 10.1016/j.neurobiolaging.2013.07.011. Epub 2013 Sep 27.

17.

Hsf-1 affects podocyte markers NPHS1, NPHS2 and WT1 in a transgenic mouse model of TTRVal30Met-related amyloidosis.

Petrakis I, Mavroeidi V, Stylianou K, Andronikidi E, Lioudaki E, Perakis K, Stratigis S, Vardaki E, Zafeiri M, Giannakakis K, Plaitakis A, Amoiridis G, Saraiva MJ, Daphnis E.

Amyloid. 2013 Sep;20(3):164-72. doi: 10.3109/13506129.2013.814046. Epub 2013 Jul 5.

PMID:
23829269
18.

Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization.

Pajęcka K, Nielsen CW, Hauge A, Zaganas I, Bak LK, Schousboe A, Plaitakis A, Waagepetersen HS.

Neurochem Res. 2014;39(3):487-99. doi: 10.1007/s11064-013-1042-z. Epub 2013 Apr 26.

PMID:
23619558
19.

Deregulation of glutamate dehydrogenase in human neurologic disorders.

Plaitakis A, Zaganas I, Spanaki C.

J Neurosci Res. 2013 Aug;91(8):1007-17. doi: 10.1002/jnr.23176. Epub 2013 Mar 6. Review.

PMID:
23463419
20.

The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases.

Zaganas I, Pajęcka K, Wendel Nielsen C, Schousboe A, Waagepetersen HS, Plaitakis A.

Metab Brain Dis. 2013 Jun;28(2):127-31. doi: 10.1007/s11011-013-9382-6. Epub 2013 Feb 20.

PMID:
23420347
21.

Medical treatment with thiamine, coenzyme Q, vitamins E and C, and carnitine improved obstructive sleep apnea in an adult case of Leigh disease.

Mermigkis C, Bouloukaki I, Mastorodemos V, Plaitakis A, Alogdianakis V, Siafakas N, Schiza S.

Sleep Breath. 2013 Dec;17(4):1129-35. doi: 10.1007/s11325-013-0816-5. Epub 2013 Feb 7.

PMID:
23389837
22.

Human TTRV30M localization within podocytes in a transgenic mouse model of transthyretin related amyloidosis: does the environment play a role?

Petrakis I, Mavroeidi V, Stylianou K, Efthymiou G, Perakis K, Vardaki E, Stratigis S, Giannakakis K, Kourouniotis K, Amoiridis G, Plaitakis A, Saraiva MJ, Yamamura KI, Daphnis E.

Transgenic Res. 2013 Feb;22(1):101-16. doi: 10.1007/s11248-012-9632-0. Epub 2012 Jul 18.

PMID:
22806634
23.

The glutamatergic synapse in Aghia pelagia: the spirit of Wierzba moves south.

Albrecht J, Schousboe A, Plaitakis A.

Neurochem Int. 2012 Sep;61(4):443. doi: 10.1016/j.neuint.2012.06.005. Epub 2012 Jun 26. No abstract available.

PMID:
22743192
24.

Early signs of memory impairment among multiple sclerosis patients with clinically isolated syndrome.

Panou T, Mastorodemos V, Papadaki E, Simos PG, Plaitakis A.

Behav Neurol. 2012;25(4):311-26.

25.

Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications.

Zaganas I, Spanaki C, Plaitakis A.

Neurochem Int. 2012 Sep;61(4):455-62. doi: 10.1016/j.neuint.2012.06.007. Epub 2012 Jun 16.

PMID:
22709674
26.

Alpha helical structures in the leader sequence of human GLUD2 glutamate dehydrogenase responsible for mitochondrial import.

Kotzamani D, Plaitakis A.

Neurochem Int. 2012 Sep;61(4):463-9. doi: 10.1016/j.neuint.2012.06.006. Epub 2012 Jun 16.

PMID:
22709669
27.

The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.

Spanaki C, Zaganas I, Kounoupa Z, Plaitakis A.

Neurochem Int. 2012 Sep;61(4):470-81. doi: 10.1016/j.neuint.2012.05.020. Epub 2012 May 30.

PMID:
22658952
28.

Rising incidence of multiple sclerosis in females associated with urbanization.

Kotzamani D, Panou T, Mastorodemos V, Tzagournissakis M, Nikolakaki H, Spanaki C, Plaitakis A.

Neurology. 2012 May 29;78(22):1728-35. doi: 10.1212/WNL.0b013e31825830a9. Epub 2012 May 16.

PMID:
22592376
29.

White matter and deep gray matter hemodynamic changes in multiple sclerosis patients with clinically isolated syndrome.

Papadaki EZ, Mastorodemos VC, Amanakis EZ, Tsekouras KC, Papadakis AE, Tsavalas ND, Simos PG, Karantanas AH, Plaitakis A, Maris TG.

Magn Reson Med. 2012 Dec;68(6):1932-42. doi: 10.1002/mrm.24194. Epub 2012 Feb 24.

30.

Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease.

Ioannou M, Alissafi T, Lazaridis I, Deraos G, Matsoukas J, Gravanis A, Mastorodemos V, Plaitakis A, Sharpe A, Boumpas D, Verginis P.

J Immunol. 2012 Feb 1;188(3):1136-46. doi: 10.4049/jimmunol.1101816. Epub 2011 Dec 30. Erratum in: J Immunol. 2014 Feb 1;192(3):1334.

31.

The role of glutamate dehydrogenase in mammalian ammonia metabolism.

Spanaki C, Plaitakis A.

Neurotox Res. 2012 Jan;21(1):117-27. doi: 10.1007/s12640-011-9285-4. Epub 2011 Oct 29. Review.

PMID:
22038055
32.

A comparison of acute hemorrhagic stroke outcomes in 2 populations: the Crete-Boston study.

Zaganas I, Halpin AP, Oleinik A, Alegakis A, Kotzamani D, Zafiris S, Chlapoutaki C, Tsimoulis D, Giannakoudakis E, Chochlidakis N, Ntailiani A, Valatsou C, Papadaki E, Vakis A, Furie KL, Greenberg SM, Plaitakis A.

Stroke. 2011 Dec;42(12):3640-2. doi: 10.1161/STROKEAHA.111.632174. Epub 2011 Oct 20.

33.

A case report of motor neuron disease in a patient showing significant level of DDTs, HCHs and organophosphate metabolites in hair as well as levels of hexane and toluene in blood.

Kanavouras K, Tzatzarakis MN, Mastorodemos V, Plaitakis A, Tsatsakis AM.

Toxicol Appl Pharmacol. 2011 Nov 1;256(3):399-404. doi: 10.1016/j.taap.2011.07.022. Epub 2011 Aug 6.

PMID:
21851830
34.

An open-label, add-on study of pregabalin in patients with partial seizures: a multicenter trial in Greece.

Tsounis S, Kimiskidis VK, Kazis D, Gkiatas K, Garganis K, Karageorgiou K, Giannakodimos S, Papathanasopoulos P, Plaitakis A, Papadimitriou A, Lyras L, Emir B.

Seizure. 2011 Nov;20(9):701-5. doi: 10.1016/j.seizure.2011.06.022. Epub 2011 Jul 19.

35.

The human GLUD2 glutamate dehydrogenase and its regulation in health and disease.

Plaitakis A, Latsoudis H, Spanaki C.

Neurochem Int. 2011 Sep;59(4):495-509. doi: 10.1016/j.neuint.2011.03.015. Epub 2011 Mar 21. Review.

PMID:
21420458
36.

Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state.

Borompokas N, Papachatzaki MM, Kanavouras K, Mastorodemos V, Zaganas I, Spanaki C, Plaitakis A.

J Biol Chem. 2010 Oct 8;285(41):31380-7. doi: 10.1074/jbc.M110.146084. Epub 2010 Jul 13.

37.

Benign multiple sclerosis in Crete.

Mastorodemos V, Nikolakaki H, Tzagournissakis M, Kotzamani D, Panou T, Spanaki C, Klados G, Maris T, Kontolaimaki E, Psaroudaki K, Chlouverakis G, Georgakakis G, Plaitakis A.

Mult Scler. 2010 Jun;16(6):701-6. doi: 10.1177/1352458510364631. Epub 2010 Mar 17.

PMID:
20237192
38.

Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells.

Spanaki C, Zaganas I, Kleopa KA, Plaitakis A.

J Biol Chem. 2010 May 28;285(22):16748-56. doi: 10.1074/jbc.M109.092999. Epub 2010 Mar 1.

39.

Levodopa-aggravated lateral flexion of the neck and trunk as a delayed phenomenon of unilateral pallidotomy.

Spanaki C, Zafeiris S, Plaitakis A.

Mov Disord. 2010 Apr 15;25(5):655-6. doi: 10.1002/mds.22988. No abstract available.

PMID:
20131399
40.

Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset.

Plaitakis A, Latsoudis H, Kanavouras K, Ritz B, Bronstein JM, Skoula I, Mastorodemos V, Papapetropoulos S, Borompokas N, Zaganas I, Xiromerisiou G, Hadjigeorgiou GM, Spanaki C.

Eur J Hum Genet. 2010 Mar;18(3):336-41. doi: 10.1038/ejhg.2009.179. Epub 2009 Oct 14.

41.

Anti-CV2 associated cerebellar degeneration after complete response to chemoradiation of head and neck carcinoma.

Saloustros E, Zaganas I, Mavridis M, Vamvakas L, Plaitakis A, Georgoulias V, Mavroudis D.

J Neurooncol. 2010 Apr;97(2):291-4. doi: 10.1007/s11060-009-0022-2. Epub 2009 Oct 2.

PMID:
19798470
42.

Essential tremor in Parkinson's disease kindreds from a population of similar genetic background.

Spanaki C, Plaitakis A.

Mov Disord. 2009 Aug 15;24(11):1662-8. doi: 10.1002/mds.22655.

PMID:
19514058
43.

Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.

Mastorodemos V, Kotzamani D, Zaganas I, Arianoglou G, Latsoudis H, Plaitakis A.

Biochem Cell Biol. 2009 Jun;87(3):505-16. doi: 10.1139/o09-008.

PMID:
19448744
44.

The human GLUD2 glutamate dehydrogenase: localization and functional aspects.

Zaganas I, Kanavouras K, Mastorodemos V, Latsoudis H, Spanaki C, Plaitakis A.

Neurochem Int. 2009 Jul-Aug;55(1-3):52-63. doi: 10.1016/j.neuint.2009.03.001. Epub 2009 Mar 13.

PMID:
19428807
45.

Mutations in human GLUD2 glutamate dehydrogenase affecting basal activity and regulation.

Kanavouras K, Borompokas N, Latsoudis H, Stagourakis A, Zaganas I, Plaitakis A.

J Neurochem. 2009 May;109 Suppl 1:167-73. doi: 10.1111/j.1471-4159.2009.05914.x.

46.

A8344G tRNALys mutation associated with recurrent brain stem stroke-like episodes.

Zaganas I, Latsoudis H, Papadaki E, Vorgia P, Spilioti M, Plaitakis A.

J Neurol. 2009 Feb;256(2):271-3. doi: 10.1007/s00415-009-0921-3. Epub 2009 Feb 27. No abstract available.

PMID:
19253012
47.

Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism.

Ross OA, Spanaki C, Griffith A, Lin CH, Kachergus J, Haugarvoll K, Latsoudis H, Plaitakis A, Ferreira JJ, Sampaio C, Bonifati V, Wu RM, Zabetian CP, Farrer MJ.

Parkinsonism Relat Disord. 2009 Jul;15(6):466-7. doi: 10.1016/j.parkreldis.2008.09.001. Epub 2008 Oct 26.

48.

Mitochondrial DNA polymorphisms and haplogroups in Parkinson's disease and control individuals with a similar genetic background.

Latsoudis H, Spanaki C, Chlouverakis G, Plaitakis A.

J Hum Genet. 2008;53(4):349-56. doi: 10.1007/s10038-008-0259-1. Epub 2008 Feb 20.

PMID:
18286226
49.

Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

Kanavouras K, Mastorodemos V, Borompokas N, Spanaki C, Plaitakis A.

J Neurosci Res. 2007 Nov 15;85(15):3398-406.

PMID:
17924438
50.

Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

Kanavouras K, Mastorodemos V, Borompokas N, Spanaki C, Plaitakis A.

J Neurosci Res. 2007 Apr;85(5):1101-9.

PMID:
17253646

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