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Items: 1 to 50 of 60

1.

Australian Veterinarians' Perceptions Regarding the Zoonotic Potential of Mycobacterium avium Subspecies Paratuberculosis.

Acharya KR, Plain KM, Whittington RJ, Dhand NK.

Vet Sci. 2020 Mar 19;7(1). pii: E33. doi: 10.3390/vetsci7010033.

2.

Autoantigen specific IL-2 activated CD4+CD25+T regulatory cells inhibit induction of experimental autoimmune neuritis.

Tran GT, Hodgkinson SJ, Carter N, Verma ND, Robinson CM, Plain KM, Nomura M, Hall BM.

J Neuroimmunol. 2020 Apr 15;341:577186. doi: 10.1016/j.jneuroim.2020.577186. Epub 2020 Feb 3.

PMID:
32058174
3.

Comparison of methods for miRNA isolation and quantification from ovine plasma.

Wright K, de Silva K, Purdie AC, Plain KM.

Sci Rep. 2020 Jan 21;10(1):825. doi: 10.1038/s41598-020-57659-7.

4.

Determining an optimal pool size for testing beef herds for Johne's disease in Australia.

Ly A, Dhand NK, Sergeant ESG, Marsh I, Plain KM.

PLoS One. 2019 Nov 20;14(11):e0225524. doi: 10.1371/journal.pone.0225524. eCollection 2019.

5.

Alloactivation of Naïve CD4+CD8-CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction.

Verma ND, Robinson CM, Carter N, Wilcox P, Tran GT, Wang C, Sharland A, Nomura M, Plain KM, Bishop GA, Hodgkinson SJ, Hall BM.

Front Immunol. 2019 Oct 14;10:2397. doi: 10.3389/fimmu.2019.02397. eCollection 2019.

6.

The humoral immune response is essential for successful vaccine protection against paratuberculosis in sheep.

Pooley HB, Begg DJ, Plain KM, Whittington RJ, Purdie AC, de Silva K.

BMC Vet Res. 2019 Jul 2;15(1):223. doi: 10.1186/s12917-019-1972-z.

7.

The immunogenicity and tissue reactivity of Mycobacterium avium subsp paratuberculosis inactivated whole cell vaccine is dependent on the adjuvant used.

Begg DJ, Dhungyel O, Naddi A, Dhand NK, Plain KM, de Silva K, Purdie AC, Whittington RJ.

Heliyon. 2019 Jun 18;5(6):e01911. doi: 10.1016/j.heliyon.2019.e01911. eCollection 2019 Jun.

8.

Gene expression profiles during subclinical Mycobacterium avium subspecies paratuberculosis infection in sheep can predict disease outcome.

Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ.

Sci Rep. 2019 Jun 3;9(1):8245. doi: 10.1038/s41598-019-44670-w.

9.

Mycobacterium avium subspecies paratuberculosis is able to manipulate host lipid metabolism and accumulate cholesterol within macrophages.

Johansen MD, de Silva K, Plain KM, Whittington RJ, Purdie AC.

Microb Pathog. 2019 May;130:44-53. doi: 10.1016/j.micpath.2019.02.031. Epub 2019 Mar 1.

PMID:
30831227
10.

Sheep and cattle exposed to Mycobacterium avium subspecies paratuberculosis exhibit altered total serum cholesterol profiles during the early stages of infection.

Johansen MD, de Silva K, Plain KM, Begg DJ, Whittington RJ, Purdie AC.

Vet Immunol Immunopathol. 2018 Aug;202:164-171. doi: 10.1016/j.vetimm.2018.07.009. Epub 2018 Jul 17.

PMID:
30078591
11.

Immunopathological changes and apparent recovery from infection revealed in cattle in an experimental model of Johne's disease using a lyophilised culture of Mycobacterium avium subspecies paratuberculosis.

Begg DJ, Plain KM, de Silva K, Gurung R, Gunn A, Purdie AC, Whittington RJ.

Vet Microbiol. 2018 Jun;219:53-62. doi: 10.1016/j.vetmic.2018.03.029. Epub 2018 Mar 29.

PMID:
29778205
12.

Integrated vaccine screening system: using cellular functional capacity in vitro to assess genuine vaccine protectiveness in ruminants.

Pooley HB, Plain KM, Purdie AC, Begg DJ, Whittington RJ, de Silva K.

Pathog Dis. 2018 Apr 1;76(3). doi: 10.1093/femspd/fty029.

PMID:
29718267
13.

Culture-Independent Identification of Mycobacterium avium Subspecies paratuberculosis in Ovine Tissues: Comparison with Bacterial Culture and Histopathological Lesions.

Acharya KR, Dhand NK, Whittington RJ, Plain KM.

Front Vet Sci. 2017 Dec 22;4:232. doi: 10.3389/fvets.2017.00232. eCollection 2017.

14.

Case definition terminology for paratuberculosis (Johne's disease).

Whittington RJ, Begg DJ, de Silva K, Purdie AC, Dhand NK, Plain KM.

BMC Vet Res. 2017 Nov 9;13(1):328. doi: 10.1186/s12917-017-1254-6.

15.

Changes in Reactivity In Vitro of CD4+CD25+ and CD4+CD25- T Cell Subsets in Transplant Tolerance.

Hall BM, Robinson CM, Plain KM, Verma ND, Tran GT, Nomura M, Carter N, Boyd R, Hodgkinson SJ.

Front Immunol. 2017 Aug 22;8:994. doi: 10.3389/fimmu.2017.00994. eCollection 2017.

16.

Cytokines affecting CD4+T regulatory cells in transplant tolerance. III. Interleukin-5 (IL-5) promotes survival of alloantigen-specific CD4+ T regulatory cells.

Hall BM, Plain KM, Tran GT, Verma ND, Robinson CM, Nomura M, Boyd R, Hodgkinson SJ.

Transpl Immunol. 2017 Aug;43-44:33-41. doi: 10.1016/j.trim.2017.06.003. Epub 2017 Jun 23.

PMID:
28652007
17.

Detection of Mycobacterium avium subspecies paratuberculosis in powdered infant formula using IS900 quantitative PCR and liquid culture media.

Acharya KR, Dhand NK, Whittington RJ, Plain KM.

Int J Food Microbiol. 2017 Sep 18;257:1-9. doi: 10.1016/j.ijfoodmicro.2017.06.005. Epub 2017 Jun 8.

PMID:
28646666
18.

Variation in susceptibility of different breeds of sheep to Mycobacterium avium subspecies paratuberculosis following experimental inoculation.

Begg DJ, Purdie AC, de Silva K, Dhand NK, Plain KM, Whittington RJ.

Vet Res. 2017 Jun 17;48(1):36. doi: 10.1186/s13567-017-0440-7.

19.

IFN-γ fails to overcome inhibition of selected macrophage activation events in response to pathogenic mycobacteria.

Thirunavukkarasu S, Plain KM, Purdie AC, Whittington RJ, de Silva K.

PLoS One. 2017 May 15;12(5):e0176400. doi: 10.1371/journal.pone.0176400. eCollection 2017.

20.

Cytokines affecting CD4+T regulatory cells in transplant tolerance. II. Interferon gamma (IFN-γ) promotes survival of alloantigen-specific CD4+T regulatory cells.

Nomura M, Hodgkinson SJ, Tran GT, Verma ND, Robinson C, Plain KM, Boyd R, Hall BM.

Transpl Immunol. 2017 Jun;42:24-33. doi: 10.1016/j.trim.2017.05.002. Epub 2017 May 6.

21.

PCR Inhibition of a Quantitative PCR for Detection of Mycobacterium avium Subspecies Paratuberculosis DNA in Feces: Diagnostic Implications and Potential Solutions.

Acharya KR, Dhand NK, Whittington RJ, Plain KM.

Front Microbiol. 2017 Feb 2;8:115. doi: 10.3389/fmicb.2017.00115. eCollection 2017.

22.

Applying the One Health Concept to Mycobacterial Research - Overcoming Parochialism.

Thirunavukkarasu S, Plain KM, de Silva K, Marais BJ, Whittington RJ.

Zoonoses Public Health. 2017 Sep;64(6):401-422. doi: 10.1111/zph.12334. Epub 2017 Jan 13. Review.

PMID:
28084673
23.

A Rapid Method for Quantifying Viable Mycobacterium avium subsp. paratuberculosis in Cellular Infection Assays.

Pooley HB, de Silva K, Purdie AC, Begg DJ, Whittington RJ, Plain KM.

Appl Environ Microbiol. 2016 Aug 30;82(18):5553-62. doi: 10.1128/AEM.01668-16. Print 2016 Sep 15.

24.

Evaluation of the limitations and methods to improve rapid phage-based detection of viable Mycobacterium avium subsp. paratuberculosis in the blood of experimentally infected cattle.

Swift BM, Huxley JN, Plain KM, Begg DJ, de Silva K, Purdie AC, Whittington RJ, Rees CE.

BMC Vet Res. 2016 Jun 16;12(1):115. doi: 10.1186/s12917-016-0728-2.

25.

Macrophage polarization in cattle experimentally exposed to Mycobacterium avium subsp. paratuberculosis.

Thirunavukkarasu S, de Silva K, Begg DJ, Whittington RJ, Plain KM.

Pathog Dis. 2015 Dec;73(9):ftv085. doi: 10.1093/femspd/ftv085. Epub 2015 Oct 9.

26.

Histopathological Characterization of Cutaneous Delayed-type Hypersensitivity and Correlations with Intestinal Pathology and Systemic Immune Responses in Sheep with Paratuberculosis.

Gulliver EL, Plain KM, Begg DJ, Whittington RJ.

J Comp Pathol. 2015 Aug-Oct;153(2-3):67-80. doi: 10.1016/j.jcpa.2015.05.005. Epub 2015 Jul 9.

PMID:
26164087
27.

Specific faecal antibody responses in sheep infected with Mycobacterium avium subspecies paratuberculosis.

Begg DJ, de Silva K, Plain KM, Purdie AC, Dhand N, Whittington RJ.

Vet Immunol Immunopathol. 2015 Aug 15;166(3-4):125-31. doi: 10.1016/j.vetimm.2015.06.011. Epub 2015 Jun 25.

PMID:
26144891
28.

Efficient, validated method for detection of mycobacterial growth in liquid culture media by use of bead beating, magnetic-particle-based nucleic acid isolation, and quantitative PCR.

Plain KM, Waldron AM, Begg DJ, de Silva K, Purdie AC, Whittington RJ.

J Clin Microbiol. 2015 Apr;53(4):1121-8. doi: 10.1128/JCM.03521-14. Epub 2015 Jan 21.

29.

Role of host- and pathogen-associated lipids in directing the immune response in mycobacterial infections, with emphasis on Mycobacterium avium subsp. paratuberculosis.

Thirunavukkarasu S, de Silva K, Plain KM, J Whittington R.

Crit Rev Microbiol. 2016;42(2):262-75. doi: 10.3109/1040841X.2014.932327. Epub 2014 Aug 28. Review.

PMID:
25163812
30.

Expression of genes associated with cholesterol and lipid metabolism identified as a novel pathway in the early pathogenesis of Mycobacterium avium subspecies paratuberculosis-infection in cattle.

Thirunavukkarasu S, Plain KM, de Silva K, Begg D, Whittington RJ, Purdie AC.

Vet Immunol Immunopathol. 2014 Aug 15;160(3-4):147-57. doi: 10.1016/j.vetimm.2014.04.002. Epub 2014 Apr 18.

PMID:
24930699
31.

Interleukin-12 (IL-12p70) Promotes Induction of Highly Potent Th1-Like CD4(+)CD25(+) T Regulatory Cells That Inhibit Allograft Rejection in Unmodified Recipients.

Verma ND, Hall BM, Plain KM, Robinson CM, Boyd R, Tran GT, Wang C, Bishop GA, Hodgkinson SJ.

Front Immunol. 2014 May 9;5:190. doi: 10.3389/fimmu.2014.00190. eCollection 2014.

32.

High-throughput direct fecal PCR assay for detection of Mycobacterium avium subsp. paratuberculosis in sheep and cattle.

Plain KM, Marsh IB, Waldron AM, Galea F, Whittington AM, Saunders VF, Begg DJ, de Silva K, Purdie AC, Whittington RJ.

J Clin Microbiol. 2014 Mar;52(3):745-57. doi: 10.1128/JCM.03233-13. Epub 2013 Dec 18.

33.

Cytokines affecting CD4(+) T regulatory cells in transplant tolerance. Interleukin-4 does not maintain alloantigen specific CD4(+)CD25(+) Treg.

Plain KM, Verma ND, Tran GT, Nomura M, Boyd R, Robinson CM, Hodgkinson SJ, Hall BM.

Transpl Immunol. 2013 Dec;29(1-4):51-9. doi: 10.1016/j.trim.2013.10.003. Epub 2013 Oct 16.

PMID:
24139939
34.

In vivo and in vitro expression pattern of Toll-like receptors in Mycobacterium avium subspecies paratuberculosis infection.

Thirunavukkarasu S, de Silva K, Whittington RJ, Plain KM.

Vet Immunol Immunopathol. 2013 Nov 15;156(1-2):20-31. doi: 10.1016/j.vetimm.2013.08.008. Epub 2013 Aug 27.

PMID:
24054090
35.

Development and validation of a liquid medium (M7H9C) for routine culture of Mycobacterium avium subsp. paratuberculosis to replace modified Bactec 12B medium.

Whittington RJ, Whittington AM, Waldron A, Begg DJ, de Silva K, Purdie AC, Plain KM.

J Clin Microbiol. 2013 Dec;51(12):3993-4000. doi: 10.1128/JCM.01373-13. Epub 2013 Sep 18.

36.

Can early host responses to mycobacterial infection predict eventual disease outcomes?

de Silva K, Begg DJ, Plain KM, Purdie AC, Kawaji S, Dhand NK, Whittington RJ.

Prev Vet Med. 2013 Nov 1;112(3-4):203-12. doi: 10.1016/j.prevetmed.2013.08.006. Epub 2013 Aug 24.

PMID:
24034815
37.

Do Natural T Regulatory Cells become Activated to Antigen Specific T Regulatory Cells in Transplantation and in Autoimmunity?

Hall BM, Tran GT, Verma ND, Plain KM, Robinson CM, Nomura M, Hodgkinson SJ.

Front Immunol. 2013 Aug 2;4:208. doi: 10.3389/fimmu.2013.00208. eCollection 2013.

38.

Cellular and humoral immunogenicity of Mycobacterium avium subsp. paratuberculosis specific lipopentapeptide antigens.

Thirunavukkarasu S, Plain KM, Eckstein TM, de Silva K, Whittington RJ.

Res Vet Sci. 2013 Aug;95(1):123-9. doi: 10.1016/j.rvsc.2013.03.002. Epub 2013 Mar 27.

PMID:
23540605
39.

Enhancement of the interferon gamma assay to detect paratuberculosis using interleukin-7 and interleukin-12 potentiation.

Plain KM, Begg DJ, de Silva K, Purdie AC, Whittington RJ.

Vet Immunol Immunopathol. 2012 Sep 15;149(1-2):28-37. doi: 10.1016/j.vetimm.2012.05.023. Epub 2012 Jun 9.

PMID:
22749292
40.

IL-5 promotes induction of antigen-specific CD4+CD25+ T regulatory cells that suppress autoimmunity.

Tran GT, Hodgkinson SJ, Carter NM, Verma ND, Plain KM, Boyd R, Robinson CM, Nomura M, Killingsworth M, Hall BM.

Blood. 2012 May 10;119(19):4441-50. doi: 10.1182/blood-2011-12-396101. Epub 2012 Feb 6.

PMID:
22310911
41.

Expression of genes associated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. paratuberculosis infection.

Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ.

Comp Immunol Microbiol Infect Dis. 2012 Mar;35(2):151-62. doi: 10.1016/j.cimid.2011.12.007. Epub 2012 Jan 10.

PMID:
22239946
42.

Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections.

Plain KM, de Silva K, Earl J, Begg DJ, Purdie AC, Whittington RJ.

Infect Immun. 2011 Sep;79(9):3821-32. doi: 10.1128/IAI.05204-11. Epub 2011 Jul 5.

43.

Comparative immunological and microbiological aspects of paratuberculosis as a model mycobacterial infection.

Whittington RJ, Begg DJ, de Silva K, Plain KM, Purdie AC.

Vet Immunol Immunopathol. 2012 Jul 15;148(1-2):29-47. doi: 10.1016/j.vetimm.2011.03.003. Epub 2011 Mar 29. Review.

PMID:
21450348
44.

Does a Th1 over Th2 dominancy really exist in the early stages of Mycobacterium avium subspecies paratuberculosis infections?

Begg DJ, de Silva K, Carter N, Plain KM, Purdie A, Whittington RJ.

Immunobiology. 2011 Jul;216(7):840-6. doi: 10.1016/j.imbio.2010.12.004. Epub 2010 Dec 22.

PMID:
21281979
45.

Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: a review.

Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ.

Comp Immunol Microbiol Infect Dis. 2011 May;34(3):197-208. doi: 10.1016/j.cimid.2010.12.003. Epub 2011 Jan 8. Review.

PMID:
21216466
46.

Membrane attack complex of complement is not essential for immune mediated demyelination in experimental autoimmune neuritis.

Tran GT, Hodgkinson SJ, Carter NM, Killingsworth M, Nomura M, Verma ND, Plain KM, Boyd R, Hall BM.

J Neuroimmunol. 2010 Dec 15;229(1-2):98-106. doi: 10.1016/j.jneuroim.2010.07.010. Epub 2010 Sep 17.

PMID:
20850187
47.

A longitudinal study to evaluate the diagnostic potential of a direct faecal quantitative PCR test for Johne's disease in sheep.

Kawaji S, Begg DJ, Plain KM, Whittington RJ.

Vet Microbiol. 2011 Feb 24;148(1):35-44. doi: 10.1016/j.vetmic.2010.07.022. Epub 2010 Aug 5.

PMID:
20729013
48.

Toll-like receptor (TLR)6 and TLR1 differentiation in gene expression studies of Johne's disease.

Plain KM, Purdie AC, Begg DJ, de Silva K, Whittington RJ.

Vet Immunol Immunopathol. 2010 Sep 15;137(1-2):142-8. doi: 10.1016/j.vetimm.2010.04.002. Epub 2010 Apr 14.

PMID:
20434222
49.

Role of IL-4 and Th2 responses in allograft rejection and tolerance.

Tay SS, Plain KM, Bishop GA.

Curr Opin Organ Transplant. 2009 Feb;14(1):16-22. doi: 10.1097/MOT.0b013e32831ebdf5. Review.

PMID:
19337141
50.

CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses.

Verma ND, Plain KM, Nomura M, Tran GT, Robinson C, Boyd R, Hodgkinson SJ, Hall BM.

Blood. 2009 Jan 8;113(2):479-87. doi: 10.1182/blood-2008-05-156612. Epub 2008 Sep 30.

PMID:
18827184

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