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Items: 34


Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria.

Hughes JH, Liu K, Plagge A, Wilson PJM, Sutherland H, Norman BP, Hughes AT, Keenan CM, Milan AM, Sakai T, Ranganath LR, Gallagher JA, Bou-Gharios G.

Hum Mol Genet. 2019 Oct 10. pii: ddz234. doi: 10.1093/hmg/ddz234. [Epub ahead of print]


A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23.

He Q, Shumate LT, Matthias J, Aydin C, Wein MN, Spatz JM, Goetz R, Mohammadi M, Plagge A, Divieti Pajevic P, Bastepe M.

JCI Insight. 2019 Sep 5;4(17). pii: 125007. doi: 10.1172/jci.insight.125007.


Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc-Based BRET Reporter in Combination with Firefly Luciferase.

Taylor A, Sharkey J, Plagge A, Wilm B, Murray P.

Contrast Media Mol Imaging. 2018 Dec 3;2018:2514796. doi: 10.1155/2018/2514796. eCollection 2018.


Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes.

Comenge J, Sharkey J, Fragueiro O, Wilm B, Brust M, Murray P, Levy R, Plagge A.

Elife. 2018 Jun 27;7. pii: e33140. doi: 10.7554/eLife.33140.


Functional comparison of distinct Brachyury+ states in a renal differentiation assay.

Zhou J, Plagge A, Murray P.

Biol Open. 2018 May 17;7(5). pii: bio031799. doi: 10.1242/bio.031799.


Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors.

Bantounas I, Ranjzad P, Tengku F, Silajdžić E, Forster D, Asselin MC, Lewis P, Lennon R, Plagge A, Wang Q, Woolf AS, Kimber SJ.

Stem Cell Reports. 2018 Mar 13;10(3):766-779. doi: 10.1016/j.stemcr.2018.01.008. Epub 2018 Feb 8.


Assessing the Effectiveness of a Far-Red Fluorescent Reporter for Tracking Stem Cells In Vivo.

Zhou J, Sharkey J, Shukla R, Plagge A, Murray P.

Int J Mol Sci. 2017 Dec 22;19(1). pii: E19. doi: 10.3390/ijms19010019.


Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.

He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9559-E9568. doi: 10.1073/pnas.1712670114. Epub 2017 Oct 23.


Impulsive choices in mice lacking imprinted Nesp55.

Dent CL, Humby T, Lewis K, Plagge A, Fischer-Colbrie R, Wilkins JF, Wilkinson LS, Isles AR.

Genes Brain Behav. 2016 Nov;15(8):693-701. doi: 10.1111/gbb.12316. Epub 2016 Sep 16.


Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient mice.

Holmes AP, Wong SQ, Pulix M, Johnson K, Horton NS, Thomas P, de Magalhães JP, Plagge A.

Mol Brain. 2016 Apr 14;9:39. doi: 10.1186/s13041-016-0219-1.


The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo.

He Q, Zhu Y, Corbin BA, Plagge A, Bastepe M.

Sci Signal. 2015 Aug 25;8(391):ra84. doi: 10.1126/scisignal.aaa9953.


Gene Dosage Effects at the Imprinted Gnas Cluster.

Ball ST, Kelly ML, Robson JE, Turner MD, Harrison J, Jones L, Napper D, Beechey CV, Hough T, Plagge A, Cattanach BM, Cox RD, Peters J.

PLoS One. 2013 Jun 18;8(6):e65639. doi: 10.1371/journal.pone.0065639. Print 2013.


Elevated blood pressure, heart rate and body temperature in mice lacking the XLαs protein of the Gnas locus is due to increased sympathetic tone.

Nunn N, Feetham CH, Martin J, Barrett-Jolley R, Plagge A.

Exp Physiol. 2013 Oct;98(10):1432-45. doi: 10.1113/expphysiol.2013.073064. Epub 2013 Jun 7.


Non-Coding RNAs at the Gnas and Snrpn-Ube3a Imprinted Gene Loci and Their Involvement in Hereditary Disorders.

Plagge A.

Front Genet. 2012 Nov 26;3:264. doi: 10.3389/fgene.2012.00264. eCollection 2012.


Loss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib.

Fernández-Rebollo E, Maeda A, Reyes M, Turan S, Fröhlich LF, Plagge A, Kelsey G, Jüppner H, Bastepe M.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6638-43. doi: 10.1073/pnas.1117608109. Epub 2012 Apr 10.


Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice.

Krechowec SO, Burton KL, Newlaczyl AU, Nunn N, Vlatković N, Plagge A.

PLoS One. 2012;7(1):e29753. doi: 10.1371/journal.pone.0029753. Epub 2012 Jan 11.


Comparison of fluorescence in situ hybridization, p57 immunostaining, flow cytometry, and digital image analysis for diagnosing molar and nonmolar products of conception.

Kipp BR, Ketterling RP, Oberg TN, Cousin MA, Plagge AM, Wiktor AE, Ihrke JM, Meyers CH, Morice WG, Halling KC, Clayton AC.

Am J Clin Pathol. 2010 Feb;133(2):196-204. doi: 10.1309/AJCPV7BRDUCX0WAQ.


GNAS haploinsufficiency leads to subcutaneous tumor formation with collagen and elastin deposition and calcification.

Sakamoto A, Weinstein LS, Plagge A, Eckhaus M, Kelsey G.

Endocr Res. 2009;34(1-2):1-9. doi: 10.1080/07435800902841280.


Characterization of a novel obesity phenotype caused by interspecific hybridization.

Singh U, Rizvi F, Yu Y, Shi W, Orth A, Karimi M, Ekström TJ, Plagge A, Kelsey G, Fundele R.

Arch Physiol Biochem. 2008 Dec;114(5):301-30. doi: 10.1080/13813450802542495 .


Physiological dysfunctions associated with mutations of the imprinted Gnas locus.

Krechowec S, Plagge A.

Physiology (Bethesda). 2008 Aug;23:221-9. doi: 10.1152/physiol.00010.2008. Review.


A study of the reproducibility of a fluorescence in situ hybridization bladder cancer detection assay.

Brankley SM, Adams EJ, Christensen MR, Everts CR, Lund JD, Oberg TN, Plagge AM, Zieman AH, Kipp BR, Halling KC.

Anal Quant Cytol Histol. 2008 Jun;30(3):145-51.


Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis.

Frontera M, Dickins B, Plagge A, Kelsey G.

Adv Exp Med Biol. 2008;626:41-61. Review.


Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse.

Plagge A, Kelsey G, Germain-Lee EL.

J Endocrinol. 2008 Feb;196(2):193-214. doi: 10.1677/JOE-07-0544. Review.


The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice.

Xie T, Plagge A, Gavrilova O, Pack S, Jou W, Lai EW, Frontera M, Kelsey G, Weinstein LS.

J Biol Chem. 2006 Jul 14;281(28):18989-99. Epub 2006 May 2.


Imprinting the Gnas locus.

Plagge A, Kelsey G.

Cytogenet Genome Res. 2006;113(1-4):178-87.


Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster.

Williamson CM, Turner MD, Ball ST, Nottingham WT, Glenister P, Fray M, Tymowska-Lalanne Z, Plagge A, Powles-Glover N, Kelsey G, Maconochie M, Peters J.

Nat Genet. 2006 Mar;38(3):350-5. Epub 2006 Feb 5.


Imprinted Nesp55 influences behavioral reactivity to novel environments.

Plagge A, Isles AR, Gordon E, Humby T, Dean W, Gritsch S, Fischer-Colbrie R, Wilkinson LS, Kelsey G.

Mol Cell Biol. 2005 Apr;25(8):3019-26.


A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas.

Williamson CM, Ball ST, Nottingham WT, Skinner JA, Plagge A, Turner MD, Powles N, Hough T, Papworth D, Fraser WD, Maconochie M, Peters J.

Nat Genet. 2004 Aug;36(8):894-9. Epub 2004 Jul 25.


The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding.

Plagge A, Gordon E, Dean W, Boiani R, Cinti S, Peters J, Kelsey G.

Nat Genet. 2004 Aug;36(8):818-26. Epub 2004 Jul 25.


A new module arrangement for plasmapheresis.

Hilke R, Albrecht W, Weidemann S, Groth T, Weigel T, Plagge A, Paul D.

Transfus Apher Sci. 2001 Aug;25(1):5-15.


The contactin-related protein FAR-2 defines purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum.

Plagge A, Sendtner-Voelderndorff L, Sirim P, Freigang J, Rader C, Sonderegger P, Brümmendorf T.

Mol Cell Neurosci. 2001 Jul;18(1):91-107.


Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP.

Marg A, Sirim P, Spaltmann F, Plagge A, Kauselmann G, Buck F, Rathjen FG, Brümmendorf T.

J Cell Biol. 1999 May 17;145(4):865-76.


Epitope mapping on extracellular domains of cell-surface proteins using exonuclease III.

Brümmendorf T, Plagge A, Treubert U.

Methods Mol Biol. 1996;66:319-42. No abstract available.


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