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Items: 30


Dimethyl fumarate mitigates optic neuritis.

Zyla K, Larabee CM, Georgescu C, Berkley C, Reyna T, Plafker SM.

Mol Vis. 2019 Aug 22;25:446-461. eCollection 2019.


Clinically-approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia.

Borcherding DC, Siefert ME, Lin S, Brewington J, Sadek H, Clancy JP, Plafker SM, Ziady AG.

J Clin Invest. 2019 May 30;129(8):3448-3463. doi: 10.1172/JCI96273.


Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence.

Plafker KS, Zyla K, Berry W, Plafker SM.

Redox Biol. 2018 Jul;17:411-422. doi: 10.1016/j.redox.2018.05.008. Epub 2018 May 21.


A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.

O'Mealey GB, Plafker KS, Berry WL, Janknecht R, Chan JY, Plafker SM.

J Cell Sci. 2017 Oct 15;130(20):3467-3480. doi: 10.1242/jcs.203216. Epub 2017 Aug 24.


The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.

Chen M, Nowak DG, Narula N, Robinson B, Watrud K, Ambrico A, Herzka TM, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhut C, Wang VM, Wills L, Nasar A, Castillo-Martin M, Cordon-Cardo C, Wilkinson JE, Powers S, Sordella R, Altorki NK, Mittal V, Stiles BM, Plafker SM, Trotman LC.

J Cell Biol. 2017 Mar 6;216(3):641-656. doi: 10.1083/jcb.201604025. Epub 2017 Feb 13.


Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis.

Larabee CM, Desai S, Agasing A, Georgescu C, Wren JD, Axtell RC, Plafker SM.

Mol Vis. 2016 Dec 30;22:1503-1513. eCollection 2016.


Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.

O'Mealey GB, Berry WL, Plafker SM.

Redox Biol. 2017 Apr;11:103-110. doi: 10.1016/j.redox.2016.11.007. Epub 2016 Nov 21.


Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice.

Larabee CM, Hu Y, Desai S, Georgescu C, Wren JD, Axtell RC, Plafker SM.

Mol Vis. 2016 Apr 11;22:332-41. eCollection 2016.


Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons.

Larabee CM, Georgescu C, Wren JD, Plafker SM.

BMC Neurosci. 2015 Nov 13;16:76. doi: 10.1186/s12868-015-0194-y.


Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration.

Lambros ML, Plafker SM.

Adv Exp Med Biol. 2016;854:67-72. doi: 10.1007/978-3-319-17121-0_10. Review.


OKN-007 decreases free radical levels in a preclinical F98 rat glioma model.

Coutinho de Souza P, Smith N, Atolagbe O, Ziegler J, Njoku C, Lerner M, Ehrenshaft M, Mason RP, Meek B, Plafker SM, Saunders D, Mamedova N, Towner RA.

Free Radic Biol Med. 2015 Oct;87:157-68. doi: 10.1016/j.freeradbiomed.2015.06.026. Epub 2015 Jun 26.


The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin.

Nguyen L, Plafker KS, Starnes A, Cook M, Klevit RE, Plafker SM.

Biochemistry. 2014 Jun 24;53(24):4004-14. doi: 10.1021/bi500072v. Epub 2014 Jun 13.


High dietary fat selectively increases catalase expression within cardiac mitochondria.

Rindler PM, Plafker SM, Szweda LI, Kinter M.

J Biol Chem. 2013 Jan 18;288(3):1979-90. doi: 10.1074/jbc.M112.412890. Epub 2012 Nov 30.


Mechanisms for countering oxidative stress and damage in retinal pigment epithelium.

Plafker SM, O'Mealey GB, Szweda LI.

Int Rev Cell Mol Biol. 2012;298:135-77. doi: 10.1016/B978-0-12-394309-5.00004-3. Review.


Expression and distribution of the class III ubiquitin-conjugating enzymes in the retina.

Mirza S, Plafker KS, Aston C, Plafker SM.

Mol Vis. 2010 Nov 18;16:2425-37.


The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2.

Plafker KS, Nguyen L, Barneche M, Mirza S, Crawford D, Plafker SM.

J Biol Chem. 2010 Jul 23;285(30):23064-74. doi: 10.1074/jbc.M110.121913. Epub 2010 May 18.


Oxidative stress and the ubiquitin proteolytic system in age-related macular degeneration.

Plafker SM.

Adv Exp Med Biol. 2010;664:447-56. doi: 10.1007/978-1-4419-1399-9_51. Review.


The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases.

Plafker KS, Singer JD, Plafker SM.

Biochemistry. 2009 Apr 21;48(15):3527-37. doi: 10.1021/bi801971m.


Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion.

Hu L, Plafker K, Vorozhko V, Zuna RE, Hanigan MH, Gorbsky GJ, Plafker SM, Angeletti PC, Ceresa BP.

Virology. 2009 Feb 5;384(1):125-34. doi: 10.1016/j.virol.2008.10.011. Epub 2008 Nov 28.


The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells.

Plafker KS, Farjo KM, Wiechmann AF, Plafker SM.

Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5611-8. doi: 10.1167/iovs.08-1698. Epub 2008 Jul 9.


Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.

Pick E, Lau OS, Tsuge T, Menon S, Tong Y, Dohmae N, Plafker SM, Deng XW, Wei N.

Mol Cell Biol. 2007 Jul;27(13):4708-19. Epub 2007 Apr 23.


Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2.

Tan C, Dlugosz PJ, Peng J, Zhang Z, Lapolla SM, Plafker SM, Andrews DW, Lin J.

J Biol Chem. 2006 May 26;281(21):14764-75. Epub 2006 Mar 29.


Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import.

Plafker SM, Plafker KS, Weissman AM, Macara IG.

J Cell Biol. 2004 Nov 22;167(4):649-59. Epub 2004 Nov 15.


A novel kinase activity associated with Nef derived from neurovirulent simian immunodeficiency virus.

Barber SA, Flaherty MT, Plafker SM, Clements JE.

Virology. 1998 Nov 10;251(1):165-75.

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