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Application of a new methodology and R package reveals a high burden of healthcare-associated infections (HAI) in Germany compared to the average in the European Union/European Economic Area, 2011 to 2012.

Zacher B, Haller S, Willrich N, Walter J, Abu Sin M, Cassini A, Plachouras D, Suetens C, Behnke M, Gastmeier P, Wieler LH, Eckmanns T.

Euro Surveill. 2019 Nov;24(46). doi: 10.2807/1560-7917.ES.2019.24.46.1900135.


International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass.

Hasse B, Hannan M, Keller PM, Maurer FP, Sommerstein R, Mertz D, Wagner D, Fernández-Hidalgo N, Nomura J, Manfrin V, Bettex D, Conte AH, Durante-Mangoni E, Hing-Cheung Tang T, Stuart RL, Lundgren J, Gordon S, Jarashow MC, Schreiber PW, Niemann S, Kohl TA, Daley C, Stewardson AJ, Whitener CJ, Perkins K, Plachouras D, Lamagni T, Chand M, Freiberger T, Zweifel S, Sander P, Schulthess B, Scriven J, Sax H, van Ingen J, Mestres CA, Diekema D, Brown-Elliott BA, Wallace RJ Jr, Baddour LM, Miro JM, Hoen B; M. chimaera ISCVID investigators; Infectious Diseases specialists; Hospital epidemiologists; Microbiologists and molecular typing specialists; Cardiac surgeons/ perfusionists/ cardiologists; Ophthalmology; Anaesthesiologists; Public Health.

J Hosp Infect. 2019 Nov 9. pii: S0195-6701(19)30444-X. doi: 10.1016/j.jhin.2019.10.009. [Epub ahead of print]


A governance framework for development and assessment of national action plans on antimicrobial resistance.

Anderson M, Schulze K, Cassini A, Plachouras D, Mossialos E.

Lancet Infect Dis. 2019 Nov;19(11):e371-e384. doi: 10.1016/S1473-3099(19)30415-3. Epub 2019 Oct 3. Review.


Targets for the reduction of antibiotic use in humans in the Transatlantic Taskforce on Antimicrobial Resistance (TATFAR) partner countries.

D'Atri F, Arthur J, Blix HS, Hicks LA, Plachouras D, Monnet DL; The European Survey On Transatlantic Task Force On Antimicrobial Resistance Tatfar Action Group.

Euro Surveill. 2019 Jul;24(28). doi: 10.2807/1560-7917.ES.2019.24.28.1800339.


Attributable deaths caused by infections with antibiotic-resistant bacteria in France - Authors' reply.

Cassini A, Plachouras D, Monnet DL.

Lancet Infect Dis. 2019 Feb;19(2):129-130. doi: 10.1016/S1473-3099(19)30004-0. Epub 2019 Jan 30. No abstract available.


Development of case vignettes for assessment of the inter-rater variability of national validation teams for the point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals.

van Hauwermeiren E, Iosifidis E, Kärki T, Suetens C, Kinross P, Plachouras D.

J Hosp Infect. 2019 Apr;101(4):455-460. doi: 10.1016/j.jhin.2019.01.018. Epub 2019 Jan 23.


Burden of healthcare-associated infections in European acute care hospitals.

Kärki T, Plachouras D, Cassini A, Suetens C.

Wien Med Wochenschr. 2019 Feb;169(Suppl 1):3-5. doi: 10.1007/s10354-018-0679-2. Epub 2019 Jan 24.


Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017.

Plachouras D, Kärki T, Hansen S, Hopkins S, Lyytikäinen O, Moro ML, Reilly J, Zarb P, Zingg W, Kinross P, Weist K, Monnet DL, Suetens C; The Point Prevalence Survey Study Group.

Euro Surveill. 2018 Nov;23(46). doi: 10.2807/1560-7917.ES.23.46.1800393. Erratum in: Euro Surveill. 2018 Nov;23(47):.


Antimicrobial use in European long-term care facilities: results from the third point prevalence survey of healthcare-associated infections and antimicrobial use, 2016 to 2017.

Ricchizzi E, Latour K, Kärki T, Buttazzi R, Jans B, Moro ML, Nakitanda OA, Plachouras D, Monnet DL, Suetens C, Kinross P; The Halt Study Group.

Euro Surveill. 2018 Nov;23(46). doi: 10.2807/1560-7917.ES.2018.23.46.1800394.


Prevalence of healthcare-associated infections, estimated incidence and composite antimicrobial resistance index in acute care hospitals and long-term care facilities: results from two European point prevalence surveys, 2016 to 2017.

Suetens C, Latour K, Kärki T, Ricchizzi E, Kinross P, Moro ML, Jans B, Hopkins S, Hansen S, Lyytikäinen O, Reilly J, Deptula A, Zingg W, Plachouras D, Monnet DL; The Healthcare-Associated Infections Prevalence Study Group.

Euro Surveill. 2018 Nov;23(46). doi: 10.2807/1560-7917.ES.2018.23.46.1800516. Erratum in: Euro Surveill. 2018 Nov;23(47):.


Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis.

Cassini A, Högberg LD, Plachouras D, Quattrocchi A, Hoxha A, Simonsen GS, Colomb-Cotinat M, Kretzschmar ME, Devleesschauwer B, Cecchini M, Ouakrim DA, Oliveira TC, Struelens MJ, Suetens C, Monnet DL; Burden of AMR Collaborative Group.

Lancet Infect Dis. 2019 Jan;19(1):56-66. doi: 10.1016/S1473-3099(18)30605-4. Epub 2018 Nov 5.


Correction to: ECDC definitions and methods for the surveillance of healthcare-associated infections in intensive care units.

Plachouras D, Lepape A, Suetens C.

Intensive Care Med. 2018 Nov;44(11):2020. doi: 10.1007/s00134-018-5370-y.


Healthcare-associated pneumonia in acute care hospitals in European Union/European Economic Area countries: an analysis of data from a point prevalence survey, 2011 to 2012.

Walter J, Haller S, Quinten C, Kärki T, Zacher B, Eckmanns T, Abu Sin M, Plachouras D, Kinross P, Suetens C, Ecdc Pps Study Group.

Euro Surveill. 2018 Aug;23(32). doi: 10.2807/1560-7917.ES.2018.23.32.1700843.


ECDC definitions and methods for the surveillance of healthcare-associated infections in intensive care units.

Plachouras D, Lepape A, Suetens C.

Intensive Care Med. 2018 Dec;44(12):2216-2218. doi: 10.1007/s00134-018-5113-0. Epub 2018 May 24. No abstract available. Erratum in: Intensive Care Med. 2018 Sep 17;:.


Candida auris: epidemiological situation, laboratory capacity and preparedness in European Union and European Economic Area countries, 2013 to 2017.

Kohlenberg A, Struelens MJ, Monnet DL, Plachouras D; The Candida Auris Survey Collaborative Group.

Euro Surveill. 2018 Mar;23(13). doi: 10.2807/1560-7917.ES.2018.23.13.18-00136.


Antimicrobial stewardship: we know it works; time to make sure it is in place everywhere.

Plachouras D, Hopkins S.

Cochrane Database Syst Rev. 2017 Feb 9;2:ED000119. doi: 10.1002/14651858.ED000119. No abstract available.


Mycobacterium chimaera infections associated with heater-cooler units (HCU): closing another loophole in patient safety.

Struelens MJ, Plachouras D.

Euro Surveill. 2016 Nov 17;21(46). doi: 10.2807/1560-7917.ES.2016.21.46.30397. No abstract available. Erratum in: Euro Surveill. 2016 Nov 24;21(47):.


Burden of Six Healthcare-Associated Infections on European Population Health: Estimating Incidence-Based Disability-Adjusted Life Years through a Population Prevalence-Based Modelling Study.

Cassini A, Plachouras D, Eckmanns T, Abu Sin M, Blank HP, Ducomble T, Haller S, Harder T, Klingeberg A, Sixtensson M, Velasco E, Weiß B, Kramarz P, Monnet DL, Kretzschmar ME, Suetens C.

PLoS Med. 2016 Oct 18;13(10):e1002150. doi: 10.1371/journal.pmed.1002150. eCollection 2016 Oct.


Planet's population on the move, infections on the rise.

Poulakou G, Plachouras D.

Intensive Care Med. 2016 Dec;42(12):2055-2058. doi: 10.1007/s00134-016-4580-4. Epub 2016 Oct 11. No abstract available.


Impact of patients' professional and educational status on perception of an antibiotic policy campaign: a pilot study at a university hospital.

Giannitsioti E, Athanasia S, Plachouras D, Kanellaki S, Bobota F, Tzepetzi G, Giamarellou H.

J Glob Antimicrob Resist. 2016 Sep;6:123-127. doi: 10.1016/j.jgar.2016.05.001. Epub 2016 Jun 4.


A Concise Set of Structure and Process Indicators to Assess and Compare Antimicrobial Stewardship Programs Among EU and US Hospitals: Results From a Multinational Expert Panel.

Pollack LA, Plachouras D, Sinkowitz-Cochran R, Gruhler H, Monnet DL, Weber JT; Transatlantic Taskforce on Antimicrobial Resistance (TATFAR) Expert Panel on Stewardship Structure and Process Indicators.

Infect Control Hosp Epidemiol. 2016 Oct;37(10):1201-11. doi: 10.1017/ice.2016.115. Epub 2016 Jul 15.


Contamination during production of heater-cooler units by Mycobacterium chimaera potential cause for invasive cardiovascular infections: results of an outbreak investigation in Germany, April 2015 to February 2016.

Haller S, Höller C, Jacobshagen A, Hamouda O, Abu Sin M, Monnet DL, Plachouras D, Eckmanns T.

Euro Surveill. 2016 Apr 28;21(17). doi: 10.2807/1560-7917.ES.2016.21.17.30215.


Spatiotemporal Evolution of Ebola Virus Disease at Sub-National Level during the 2014 West Africa Epidemic: Model Scrutiny and Data Meagreness.

Santermans E, Robesyn E, Ganyani T, Sudre B, Faes C, Quinten C, Van Bortel W, Haber T, Kovac T, Van Reeth F, Testa M, Hens N, Plachouras D.

PLoS One. 2016 Jan 15;11(1):e0147172. doi: 10.1371/journal.pone.0147172. eCollection 2016.


Severe Ebola virus infection complicated by gram-negative septicemia.

Plachouras D, Monnet DL, Catchpole M.

N Engl J Med. 2015 Apr 2;372(14):1376-7. doi: 10.1056/NEJMc1500455. No abstract available.


First secondary case of Ebola outside Africa: epidemiological characteristics and contact monitoring, Spain, September to November 2014.

Lopaz MA, Amela C, Ordobas M, Dominguez-Berjon MF, Alvarez C, Martinez M, Sierra MJ, Simon F, Jansa JM, Plachouras D, Astray J; Working group of Ebola outbreak investigation team of Madrid.

Euro Surveill. 2015 Jan 8;20(1). pii: 21003.


Early transmission dynamics of Ebola virus disease (EVD), West Africa, March to August 2014 - Euro surveillance 17 September 2014.

Plachouras D, Sudre B, Testa M, Robesyn E, Coulombier D.

Euro Surveill. 2014 Sep 18;19(37). pii: 20907. No abstract available.


Promoting prudent use of antibiotics: the experience from a multifaceted regional campaign in Greece.

Plachouras D, Antoniadou A, Giannitsioti E, Galani L, Katsarolis I, Kavatha D, Koukos G, Panagopoulos P, Papadopoulos A, Poulakou G, Sakka V, Souli M, Sybardi S, Tsiodras S, Kanellakopoulou K, Giamarellou H.

BMC Public Health. 2014 Aug 22;14:866. doi: 10.1186/1471-2458-14-866.


Risk factors for community-associated methicillin-resistant Staphylococcus aureus colonisation in a large metropolitan area in Greece: An epidemiological study using two case definitions.

Tsiodras S, Daikos GL, Lee A, Plachouras D, Antoniadou A, Ploiarchopoulou F, Psichogiou M, Petrikkos G, Harbarth S.

J Glob Antimicrob Resist. 2014 Mar;2(1):27-33. doi: 10.1016/j.jgar.2013.10.001. Epub 2013 Oct 26.


Primary polydipsia: a case report.

Tournikioti K, Voumvourakis K, Moussas G, Plachouras D, Michopoulos I, Douzenis A, Christodoulou C, Lamboussis E, Gournellis R.

J Nerv Ment Dis. 2013 Aug;201(8):709-11. doi: 10.1097/NMD.0b013e31829c50fc.


Outbreak with a novel avian influenza A(H7N9) virus in China--scenarios and triggers for assessing risks and planning responses in the European Union, May 2013.

Schenk C, Plachouras D, Danielsson N, Nicoll A, Robesyn E, Coulombier D.

Euro Surveill. 2013 May 16;18(20). pii: 20482.


A crossed brain stem syndrome without crossed sensory symptomatology.

Vrettos A, Fiotaki K, Galati E, Plachouras D.

BMJ Case Rep. 2013 Jan 25;2013. pii: bcr2012006709. doi: 10.1136/bcr-2012-006709.


Antimicrobial activity of copper surfaces against carbapenemase-producing contemporary Gram-negative clinical isolates.

Souli M, Galani I, Plachouras D, Panagea T, Armaganidis A, Petrikkos G, Giamarellou H.

J Antimicrob Chemother. 2013 Apr;68(4):852-7. doi: 10.1093/jac/dks473. Epub 2012 Dec 9.


Colistin methanesulfonate and colistin pharmacokinetics in critically ill patients receiving continuous venovenous hemodiafiltration.

Karvanen M, Plachouras D, Friberg LE, Paramythiotou E, Papadomichelakis E, Karaiskos I, Tsangaris I, Armaganidis A, Cars O, Giamarellou H.

Antimicrob Agents Chemother. 2013 Jan;57(1):668-71. doi: 10.1128/AAC.00985-12. Epub 2012 Nov 12.


Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill.

Mohamed AF, Karaiskos I, Plachouras D, Karvanen M, Pontikis K, Jansson B, Papadomichelakis E, Antoniadou A, Giamarellou H, Armaganidis A, Cars O, Friberg LE.

Antimicrob Agents Chemother. 2012 Aug;56(8):4241-9. doi: 10.1128/AAC.06426-11. Epub 2012 May 21.


Genetic polymorphisms within tumor necrosis factor gene promoter region: a role for susceptibility to ventilator-associated pneumonia.

Kotsaki A, Raftogiannis M, Routsi C, Baziaka F, Kotanidou A, Antonopoulou A, Orfanos SE, Katsenos C, Koutoukas P, Plachouras D, Mandragos K, Giamarellos-Bourboulis EJ.

Cytokine. 2012 Aug;59(2):358-63. doi: 10.1016/j.cyto.2012.04.040. Epub 2012 May 18.


A case of autophagia: a man who was mutilating his fingers by biting them.

Michopoulos I, Gournellis R, Papadopoulou M, Plachouras D, Vlahakos DV, Tournikioti K, Tsigkaropoulou E, Lykouras L.

J Nerv Ment Dis. 2012 Feb;200(2):183-5. doi: 10.1097/NMD.0b013e318243989b.


Colonization and infection by colistin-resistant Gram-negative bacteria in a cohort of critically ill patients.

Kontopidou F, Plachouras D, Papadomichelakis E, Koukos G, Galani I, Poulakou G, Dimopoulos G, Antoniadou A, Armaganidis A, Giamarellou H.

Clin Microbiol Infect. 2011 Nov;17(11):E9-E11. doi: 10.1111/j.1469-0691.2011.03649.x. Epub 2011 Sep 21.


Adaptive resistance to cationic compounds in Pseudomonas aeruginosa.

Skiada A, Markogiannakis A, Plachouras D, Daikos GL.

Int J Antimicrob Agents. 2011 Mar;37(3):187-93. doi: 10.1016/j.ijantimicag.2010.11.019. Epub 2011 Feb 4. Review.


Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study.

Porfyridis I, Plachouras D, Karagianni V, Kotanidou A, Papiris SA, Giamarellou H, Giamarellos-Bourboulis EJ.

BMC Infect Dis. 2010 Sep 29;10:286. doi: 10.1186/1471-2334-10-286.


Serum and cerebrospinal fluid levels of colistin in pediatric patients.

Antachopoulos C, Karvanen M, Iosifidis E, Jansson B, Plachouras D, Cars O, Roilides E.

Antimicrob Agents Chemother. 2010 Sep;54(9):3985-7. doi: 10.1128/AAC.01799-09. Epub 2010 Jun 28.


Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection.

Gogos C, Kotsaki A, Pelekanou A, Giannikopoulos G, Vaki I, Maravitsa P, Adamis S, Alexiou Z, Andrianopoulos G, Antonopoulou A, Athanassia S, Baziaka F, Charalambous A, Christodoulou S, Dimopoulou I, Floros I, Giannitsioti E, Gkanas P, Ioakeimidou A, Kanellakopoulou K, Karabela N, Karagianni V, Katsarolis I, Kontopithari G, Kopterides P, Koutelidakis I, Koutoukas P, Kranidioti H, Lignos M, Louis K, Lymberopoulou K, Mainas E, Marioli A, Massouras C, Mavrou I, Mpalla M, Michalia M, Mylona H, Mytas V, Papanikolaou I, Papanikolaou K, Patrani M, Perdios I, Plachouras D, Pistiki A, Protopapas K, Rigaki K, Sakka V, Sartzi M, Skouras V, Souli M, Spyridaki A, Strouvalis I, Tsaganos T, Zografos G, Mandragos K, Klouva-Molyvdas P, Maggina N, Giamarellou H, Armaganidis A, Giamarellos-Bourboulis EJ.

Crit Care. 2010;14(3):R96. doi: 10.1186/cc9031. Epub 2010 May 26.


Dispensing of antibiotics without prescription in Greece, 2008: another link in the antibiotic resistance chain.

Plachouras D, Kavatha D, Antoniadou A, Giannitsioti E, Poulakou G, Kanellakopoulou K, Giamarellou H.

Euro Surveill. 2010 Feb 18;15(7). pii: 19488.


Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay.

Tsangaris I, Plachouras D, Kavatha D, Gourgoulis GM, Tsantes A, Kopterides P, Tsaknis G, Dimopoulou I, Orfanos S, Giamarellos-Bourboulis E, Giamarellou H, Armaganidis A.

BMC Infect Dis. 2009 Dec 22;9:213. doi: 10.1186/1471-2334-9-213.


Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by gram-negative bacteria.

Plachouras D, Karvanen M, Friberg LE, Papadomichelakis E, Antoniadou A, Tsangaris I, Karaiskos I, Poulakou G, Kontopidou F, Armaganidis A, Cars O, Giamarellou H.

Antimicrob Agents Chemother. 2009 Aug;53(8):3430-6. doi: 10.1128/AAC.01361-08. Epub 2009 May 11.


Efficacy and tolerability of linezolid in chronic osteomyelitis and prosthetic joint infections: a case-control study.

Papadopoulos A, Plachouras D, Giannitsioti E, Poulakou G, Giamarellou H, Kanellakopoulou K.

J Chemother. 2009 Apr;21(2):165-9.


Quantitative analysis of colistin A and colistin B in plasma and culture medium using a simple precipitation step followed by LC/MS/MS.

Jansson B, Karvanen M, Cars O, Plachouras D, Friberg LE.

J Pharm Biomed Anal. 2009 Apr 5;49(3):760-7. doi: 10.1016/j.jpba.2008.12.016. Epub 2008 Dec 24.


Does a bed rail system of alcohol-based handrub antiseptic improve compliance of health care workers with hand hygiene? Results from a pilot study.

Giannitsioti E, Athanasia S, Antoniadou A, Fytrou H, Athanassiou K, Bourvani P, Kanellakopoulou K, Kouvelas K, Papadopoulos A, Plachouras D, Giamarellou H.

Am J Infect Control. 2009 Mar;37(2):160-3. doi: 10.1016/j.ajic.2008.04.252. Epub 2008 Oct 22.


In vitro elution of moxifloxacin and fusidic acid by a synthetic crystallic semihydrate form of calcium sulphate (Stimulan).

Panagopoulos P, Tsaganos T, Plachouras D, Carrer DP, Papadopoulos A, Giamarellou H, Kanellakopoulou K.

Int J Antimicrob Agents. 2008 Dec;32(6):485-7. doi: 10.1016/j.ijantimicag.2008.06.029. Epub 2008 Sep 13.


Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) detection in cancer patients: a prognostic marker for lung metastases from solid malignancies.

Karapanagiotou EM, Pelekanou E, Charpidou A, Tsaganos T, Anagnostou V, Plachouras D, Giamarellos-Bourboulis EJ, Syrigos KN.

Anticancer Res. 2008 Mar-Apr;28(2B):1411-5.


Effect of clarithromycin in patients with sepsis and ventilator-associated pneumonia.

Giamarellos-Bourboulis EJ, Pechère JC, Routsi C, Plachouras D, Kollias S, Raftogiannis M, Zervakis D, Baziaka F, Koronaios A, Antonopoulou A, Markaki V, Koutoukas P, Papadomichelakis E, Tsaganos T, Armaganidis A, Koussoulas V, Kotanidou A, Roussos C, Giamarellou H.

Clin Infect Dis. 2008 Apr 15;46(8):1157-64. doi: 10.1086/529439.


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