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Items: 1 to 50 of 56

1.

Toxin-resolved antivenomics-guided assessment of the immunorecognition landscape of antivenoms.

Calvete JJ, Rodríguez Y, Quesada-Bernat S, Pla D.

Toxicon. 2018 Jun 15;148:107-122. doi: 10.1016/j.toxicon.2018.04.015. Epub 2018 Apr 25.

PMID:
29704534
2.

Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam.

Pla D, Petras D, Saviola AJ, Modahl CM, Sanz L, Pérez A, Juárez E, Frietze S, Dorrestein PC, Mackessy SP, Calvete JJ.

J Proteomics. 2018 Mar 1;174:71-84. doi: 10.1016/j.jprot.2017.12.020. Epub 2017 Dec 29.

PMID:
29292096
3.

A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins.

Julve Parreño JM, Huet E, Fernández-Del-Carmen A, Segura A, Venturi M, Gandía A, Pan WS, Albaladejo I, Forment J, Pla D, Wigdorovitz A, Calvete JJ, Gutiérrez C, Gutiérrez JM, Granell A, Orzáez D.

Plant Biotechnol J. 2018 Mar;16(3):727-736. doi: 10.1111/pbi.12823. Epub 2017 Sep 22.

4.

Drought Tolerance in Pinus halepensis Seed Sources As Identified by Distinctive Physiological and Molecular Markers.

Taïbi K, Del Campo AD, Vilagrosa A, Bellés JM, López-Gresa MP, Pla D, Calvete JJ, López-Nicolás JM, Mulet JM.

Front Plant Sci. 2017 Jul 24;8:1202. doi: 10.3389/fpls.2017.01202. eCollection 2017.

5.

Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms.

Madrigal M, Pla D, Sanz L, Barboza E, Arroyo-Portilla C, Corrêa-Netto C, Gutiérrez JM, Alape-Girón A, Flores-Díaz M, Calvete JJ.

PLoS Negl Trop Dis. 2017 Aug 7;11(8):e0005793. doi: 10.1371/journal.pntd.0005793. eCollection 2017 Aug.

6.

Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead.

Gutiérrez JM, Solano G, Pla D, Herrera M, Segura Á, Vargas M, Villalta M, Sánchez A, Sanz L, Lomonte B, León G, Calvete JJ.

Toxins (Basel). 2017 May 13;9(5). pii: E163. doi: 10.3390/toxins9050163. Review.

7.

Third Generation Antivenomics: Pushing the Limits of the In Vitro Preclinical Assessment of Antivenoms.

Pla D, Rodríguez Y, Calvete JJ.

Toxins (Basel). 2017 May 10;9(5). pii: E158. doi: 10.3390/toxins9050158.

8.

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus.

Pla D, Sanz L, Whiteley G, Wagstaff SC, Harrison RA, Casewell NR, Calvete JJ.

Biochim Biophys Acta. 2017 Apr;1861(4):814-823. doi: 10.1016/j.bbagen.2017.01.020. Epub 2017 Jan 24.

9.

[18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane.

Perrio C, Schmitt S, Pla D, Gabbaï FP, Chansaenpak K, Mestre-Voegtle B, Gras E.

Chem Commun (Camb). 2016 Dec 22;53(2):340-343. doi: 10.1039/c6cc05168e.

PMID:
27929169
10.

Selection for higher fertility reflects in the seminal fluid proteome of modern domestic chicken.

Atikuzzaman M, Sanz L, Pla D, Alvarez-Rodriguez M, Rubér M, Wright D, Calvete JJ, Rodriguez-Martinez H.

Comp Biochem Physiol Part D Genomics Proteomics. 2017 Mar;21:27-40. doi: 10.1016/j.cbd.2016.10.006. Epub 2016 Nov 3.

11.

Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis).

Pla D, Sanz L, Sasa M, Acevedo ME, Dwyer Q, Durban J, Pérez A, Rodriguez Y, Lomonte B, Calvete JJ.

J Proteomics. 2017 Jan 30;152:1-12. doi: 10.1016/j.jprot.2016.10.006. Epub 2016 Oct 21.

PMID:
27777178
12.

Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses.

Lomonte B, Rey-Suárez P, Fernández J, Sasa M, Pla D, Vargas N, Bénard-Valle M, Sanz L, Corrêa-Netto C, Núñez V, Alape-Girón A, Alagón A, Gutiérrez JM, Calvete JJ.

Toxicon. 2016 Nov;122:7-25. doi: 10.1016/j.toxicon.2016.09.008. Epub 2016 Sep 15. Review.

PMID:
27641749
13.

Proteomics and antivenomics of Papuan black snake (Pseudechis papuanus) venom with analysis of its toxicological profile and the preclinical efficacy of Australian antivenoms.

Pla D, Bande BW, Welton RE, Paiva OK, Sanz L, Segura Á, Wright CE, Calvete JJ, Gutiérrez JM, Williams DJ.

J Proteomics. 2017 Jan 6;150:201-215. doi: 10.1016/j.jprot.2016.09.007. Epub 2016 Sep 17.

PMID:
27650695
14.

Standalone ethanol micro-reformer integrated on silicon technology for onboard production of hydrogen-rich gas.

Pla D, Salleras M, Morata A, Garbayo I, Gerbolés M, Sabaté N, Divins NJ, Casanovas A, Llorca J, Tarancón A.

Lab Chip. 2016 Aug 7;16(15):2900-10. doi: 10.1039/c6lc00583g. Epub 2016 Jul 5.

PMID:
27378399
15.

Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics.

Calvete JJ, Arias AS, Rodríguez Y, Quesada-Bernat S, Sánchez LV, Chippaux JP, Pla D, Gutiérrez JM.

Toxicon. 2016 Sep 1;119:280-8. doi: 10.1016/j.toxicon.2016.06.022. Epub 2016 Jul 1.

PMID:
27377229
16.

Identification of the major proteins present in the seminal plasma of European eel, and how hormonal treatment affects their evolution. Correlation with sperm quality.

Vílchez MC, Pla D, Gallego V, Sanz L, Pérez L, Asturiano JF, Calvete JJ, Peñaranda DS.

Comp Biochem Physiol A Mol Integr Physiol. 2016 Nov;201:37-45. doi: 10.1016/j.cbpa.2016.06.025. Epub 2016 Jun 22. No abstract available.

17.

Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA₂ Dichotomy across Micrurus Venoms.

Sanz L, Pla D, Pérez A, Rodríguez Y, Zavaleta A, Salas M, Lomonte B, Calvete JJ.

Toxins (Basel). 2016 Jun 7;8(6). pii: E178. doi: 10.3390/toxins8060178.

18.

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina.

Gay C, Sanz L, Calvete JJ, Pla D.

Toxins (Basel). 2015 Dec 25;8(1). pii: E9. doi: 10.3390/toxins8010009.

19.

A steric tethering approach enables palladium-catalysed C-H activation of primary amino alcohols.

Calleja J, Pla D, Gorman TW, Domingo V, Haffemayer B, Gaunt MJ.

Nat Chem. 2015 Dec;7(12):1009-16. doi: 10.1038/nchem.2367. Epub 2015 Nov 2.

PMID:
26587717
20.

Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria.

Sánchez LV, Pla D, Herrera M, Chippaux JP, Calvete JJ, Gutiérrez JM.

Toxicon. 2015 Nov;106:97-107. doi: 10.1016/j.toxicon.2015.09.027. Epub 2015 Sep 28.

PMID:
26415904
21.

Constructing comprehensive venom proteome reference maps for integrative venomics.

Eichberg S, Sanz L, Calvete JJ, Pla D.

Expert Rev Proteomics. 2015;12(5):557-73. doi: 10.1586/14789450.2015.1073590.

PMID:
26400467
22.

Naphthylaminoborane: from structural switches to frustrated Lewis pair reactivity.

Pla D, Sadek O, Cadet S, Mestre-Voegtlé B, Gras E.

Dalton Trans. 2015 Nov 14;44(42):18340-6. doi: 10.1039/c5dt02659h. Epub 2015 Sep 9.

PMID:
26352756
23.

Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids.

Fernández J, Vargas-Vargas N, Pla D, Sasa M, Rey-Suárez P, Sanz L, Gutiérrez JM, Calvete JJ, Lomonte B.

Toxicon. 2015 Dec 1;107(Pt B):217-33. doi: 10.1016/j.toxicon.2015.08.016. Epub 2015 Aug 29.

PMID:
26325292
24.

Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest.

Gonçalves-Machado L, Pla D, Sanz L, Jorge RJB, Leitão-De-Araújo M, Alves MLM, Alvares DJ, De Miranda J, Nowatzki J, de Morais-Zani K, Fernandes W, Tanaka-Azevedo AM, Fernández J, Zingali RB, Gutiérrez JM, Corrêa-Netto C, Calvete JJ.

J Proteomics. 2016 Mar 1;135:73-89. doi: 10.1016/j.jprot.2015.04.029. Epub 2015 May 9.

PMID:
25968638
25.
26.

Omics meets biology: application to the design and preclinical assessment of antivenoms.

Calvete JJ, Sanz L, Pla D, Lomonte B, Gutiérrez JM.

Toxins (Basel). 2014 Dec 15;6(12):3388-405. doi: 10.3390/toxins6123388. Review.

27.

Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil.

Jorge RJ, Monteiro HS, Gonçalves-Machado L, Guarnieri MC, Ximenes RM, Borges-Nojosa DM, Luna KP, Zingali RB, Corrêa-Netto C, Gutiérrez JM, Sanz L, Calvete JJ, Pla D.

J Proteomics. 2015 Jan 30;114:93-114. doi: 10.1016/j.jprot.2014.11.011. Epub 2014 Nov 21.

PMID:
25462430
28.

First crotoxin-like phospholipase A(2) complex from a New World non-rattlesnake species: nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis.

Lomonte B, Mora-Obando D, Fernández J, Sanz L, Pla D, Gutiérrez JM, Calvete JJ.

Toxicon. 2015 Jan;93:144-54. doi: 10.1016/j.toxicon.2014.11.235. Epub 2014 Nov 28.

PMID:
25434534
30.

Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka.

Paiva O, Pla D, Wright CE, Beutler M, Sanz L, Gutiérrez JM, Williams DJ, Calvete JJ.

J Proteomics. 2014 Oct 14;110:209-29. doi: 10.1016/j.jprot.2014.07.019. Epub 2014 Aug 8.

PMID:
25109465
31.

Peptides with in vitro anti-tumor activity from the venom of the Eastern green mamba, Dendroaspis angusticeps (Elapidae).

Conlon JM, Prajeep M, Mechkarska M, Arafat K, Attoub S, Adem A, Pla D, Calvete JJ.

J Venom Res. 2014 Jun 19;5:16-21. eCollection 2014.

32.

Preclinical efficacy of Australian antivenoms against the venom of the small-eyed snake, Micropechis ikaheka, from Papua New Guinea: an antivenomics and neutralization study.

Pla D, Paiva OK, Sanz L, Beutler M, Wright CE, Calvete JJ, Williams DJ, Gutiérrez JM.

J Proteomics. 2014 Oct 14;110:198-208. doi: 10.1016/j.jprot.2014.06.016. Epub 2014 Jun 28.

PMID:
24980637
33.

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms.

Casewell NR, Wagstaff SC, Wüster W, Cook DA, Bolton FM, King SI, Pla D, Sanz L, Calvete JJ, Harrison RA.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9205-10. doi: 10.1073/pnas.1405484111. Epub 2014 Jun 9.

34.

Two color morphs of the pelagic yellow-bellied sea snake, Pelamis platura, from different locations of Costa Rica: snake venomics, toxicity, and neutralization by antivenom.

Lomonte B, Pla D, Sasa M, Tsai WC, Solórzano A, Ureña-Díaz JM, Fernández-Montes ML, Mora-Obando D, Sanz L, Gutiérrez JM, Calvete JJ.

J Proteomics. 2014 May 30;103:137-52. doi: 10.1016/j.jprot.2014.03.034. Epub 2014 Apr 3.

PMID:
24704853
35.

Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays.

Gutiérrez JM, Lomonte B, Sanz L, Calvete JJ, Pla D.

J Proteomics. 2014 Jun 13;105:340-50. doi: 10.1016/j.jprot.2014.02.021. Epub 2014 Feb 28. Review.

PMID:
24583507
36.

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system.

Vonk FJ, Casewell NR, Henkel CV, Heimberg AM, Jansen HJ, McCleary RJ, Kerkkamp HM, Vos RA, Guerreiro I, Calvete JJ, Wüster W, Woods AE, Logan JM, Harrison RA, Castoe TA, de Koning AP, Pollock DD, Yandell M, Calderon D, Renjifo C, Currier RB, Salgado D, Pla D, Sanz L, Hyder AS, Ribeiro JM, Arntzen JW, van den Thillart GE, Boetzer M, Pirovano W, Dirks RP, Spaink HP, Duboule D, McGlinn E, Kini RM, Richardson MK.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20651-6. doi: 10.1073/pnas.1314702110. Epub 2013 Dec 2.

37.

Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis.

Pla D, Sanz L, Molina-Sánchez P, Zorita V, Madrigal M, Flores-Díaz M, Alape-Girón A, Núñez V, Andrés V, Gutiérrez JM, Calvete JJ.

J Proteomics. 2013 Aug 26;89:112-23. doi: 10.1016/j.jprot.2013.05.028. Epub 2013 Jun 4.

PMID:
23747394
38.

Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays.

Gutiérrez JM, Tsai WC, Pla D, Solano G, Lomonte B, Sanz L, Angulo Y, Calvete JJ.

Toxicon. 2013 Mar 15;64:60-9. doi: 10.1016/j.toxicon.2012.12.024. Epub 2013 Jan 10.

PMID:
23313380
39.

Assessing the preclinical efficacy of antivenoms: from the lethality neutralization assay to antivenomics.

Gutiérrez JM, Solano G, Pla D, Herrera M, Segura Á, Villalta M, Vargas M, Sanz L, Lomonte B, Calvete JJ, León G.

Toxicon. 2013 Jul;69:168-79. doi: 10.1016/j.toxicon.2012.11.016. Epub 2012 Nov 29.

PMID:
23201503
40.

Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: keys to understand the variable immune response in horses.

Villalta M, Pla D, Yang SL, Sanz L, Segura A, Vargas M, Chen PY, Herrera M, Estrada R, Cheng YF, Lee CD, Cerdas M, Chiang JR, Angulo Y, León G, Calvete JJ, Gutiérrez JM.

J Proteomics. 2012 Oct 22;75(18):5628-45. doi: 10.1016/j.jprot.2012.08.008. Epub 2012 Aug 18.

PMID:
22906718
41.

Second generation snake antivenomics: comparing immunoaffinity and immunodepletion protocols.

Pla D, Gutiérrez JM, Calvete JJ.

Toxicon. 2012 Sep 15;60(4):688-99. doi: 10.1016/j.toxicon.2012.04.342. Epub 2012 Apr 26.

PMID:
22561422
42.

Snake venomics of Macrovipera mauritanica from Morocco, and assessment of the para-specific immunoreactivity of an experimental monospecific and a commercial antivenoms.

Makran B, Fahmi L, Pla D, Sanz L, Oukkache N, Lkhider M, Ghalim N, Calvete JJ.

J Proteomics. 2012 Apr 18;75(8):2431-41. doi: 10.1016/j.jprot.2012.02.022. Epub 2012 Feb 24.

PMID:
22387317
43.

Venomics and antivenomics profiles of North African Cerastes cerastes and C. vipera populations reveals a potentially important therapeutic weakness.

Fahmi L, Makran B, Pla D, Sanz L, Oukkache N, Lkhider M, Harrison RA, Ghalim N, Calvete JJ.

J Proteomics. 2012 Apr 18;75(8):2442-53. doi: 10.1016/j.jprot.2012.02.021. Epub 2012 Feb 24. Erratum in: J Proteomics. 2014 May 30;103:279-80.

PMID:
22387316
44.

A-type lamins and Hutchinson-Gilford progeria syndrome: pathogenesis and therapy.

Gonzalez JM, Pla D, Perez-Sala D, Andres V.

Front Biosci (Schol Ed). 2011 Jun 1;3:1133-46. Review.

PMID:
21622261
45.

Isolation, structural assignment, and total synthesis of barmumycin.

Lorente A, Pla D, Cañedo LM, Albericio F, Alvarez M.

J Org Chem. 2010 Dec 17;75(24):8508-15. doi: 10.1021/jo101834c. Epub 2010 Nov 23.

PMID:
21090754
46.

Total synthesis and antiproliferative activity screening of (+/-)-aplicyanins A, B and E and related analogues.

Sísa M, Pla D, Altuna M, Francesch A, Cuevas C, Albericio F, Alvarez M.

J Med Chem. 2009 Oct 22;52(20):6217-23. doi: 10.1021/jm900544z.

PMID:
19827832
47.

Lamellarin D bioconjugates II: Synthesis and cellular internalization of dendrimer and nuclear location signal derivatives.

Pla D, Martí M, Farrera-Sinfreu J, Pulido D, Francesch A, Calvo P, Cuevas C, Royo M, Aligué R, Albericio F, Alvarez M.

Bioconjug Chem. 2009 Jun;20(6):1112-21. doi: 10.1021/bc800504t.

PMID:
19472996
48.

Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives.

Pla D, Francesch A, Calvo P, Cuevas C, Aligué R, Albericio F, Alvarez M.

Bioconjug Chem. 2009 Jun;20(6):1100-11. doi: 10.1021/bc800503k.

49.

Optical tweezers study of topoisomerase inhibition.

Pla D, Sischka A, Albericio F, Alvarez M, Fernàndez-Busquets X, Anselmetti D.

Small. 2009 Jun;5(11):1269-72. doi: 10.1002/smll.200801322. No abstract available.

PMID:
19291733
50.

Recent advances in lamellarin alkaloids: isolation, synthesis and activity.

Pla D, Albericio F, Alvarez M.

Anticancer Agents Med Chem. 2008 Oct;8(7):746-60. Review.

PMID:
18855577

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