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In vivo assembly and large-scale purification of a GPCR - Gα fusion with Gβγ, and characterization of the active complex.

Kumar A, Plückthun A.

PLoS One. 2019 Jan 8;14(1):e0210131. doi: 10.1371/journal.pone.0210131. eCollection 2019.


Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.

Schöppe J, Ehrenmann J, Klenk C, Rucktooa P, Schütz M, Doré AS, Plückthun A.

Nat Commun. 2019 Jan 3;10(1):17. doi: 10.1038/s41467-018-07939-8.


Correction: DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations (doi:10.1242/bio.036749).

Vigano MA, Bieli D, Schaefer JV, Jakob RP, Matsuda S, Maier T, Plückthun A, Affolter M.

Biol Open. 2018 Dec 13;7(12). pii: bio040832. doi: 10.1242/bio.040832. No abstract available.


Peptide binding affinity redistributes preassembled repeat protein fragments.

Michel E, Zerbe O, Plückthun A.

Biol Chem. 2018 Dec 1. pii: /j/bchm.just-accepted/hsz-2018-0355/hsz-2018-0355.xml. doi: 10.1515/hsz-2018-0355. [Epub ahead of print]


High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist.

Ehrenmann J, Schöppe J, Klenk C, Rappas M, Kummer L, Doré AS, Plückthun A.

Nat Struct Mol Biol. 2018 Dec;25(12):1086-1092. doi: 10.1038/s41594-018-0151-4. Epub 2018 Nov 19.


DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations.

Vigano MA, Bieli D, Schaefer JV, Jakob RP, Matsuda S, Maier T, Plückthun A, Affolter M.

Biol Open. 2018 Oct 29;7(11). pii: bio036749. doi: 10.1242/bio.036749. Erratum in: Biol Open. 2018 Dec 13;7(12):.


Rapid Selection of High-Affinity Antibody scFv Fragments Using Ribosome Display.

Dreier B, Plückthun A.

Methods Mol Biol. 2018;1827:235-268. doi: 10.1007/978-1-4939-8648-4_13.


An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture.

ElGamacy M, Coles M, Ernst P, Zhu H, Hartmann MD, Plückthun A, Lupas AN.

ACS Synth Biol. 2018 Sep 21;7(9):2226-2235. doi: 10.1021/acssynbio.8b00224. Epub 2018 Sep 4.


A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors.

Hartmann J, Münch RC, Freiling RT, Schneider IC, Dreier B, Samukange W, Koch J, Seeger MA, Plückthun A, Buchholz CJ.

Mol Ther Methods Clin Dev. 2018 Jul 6;10:128-143. doi: 10.1016/j.omtm.2018.07.001. eCollection 2018 Sep 21.


PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling.

Yen HY, Hoi KK, Liko I, Hedger G, Horrell MR, Song W, Wu D, Heine P, Warne T, Lee Y, Carpenter B, Plückthun A, Tate CG, Sansom MSP, Robinson CV.

Nature. 2018 Jul;559(7714):423-427. doi: 10.1038/s41586-018-0325-6. Epub 2018 Jul 11.


Assessment of ab initio models of protein complexes by molecular dynamics.

Radom F, Plückthun A, Paci E.

PLoS Comput Biol. 2018 Jun 4;14(6):e1006182. doi: 10.1371/journal.pcbi.1006182. eCollection 2018 Jun. Erratum in: PLoS Comput Biol. 2018 Nov 9;14(11):e1006598.


Modification of the kinetic stability of immunoglobulin G by solvent additives.

Schaefer JV, Sedlák E, Kast F, Nemergut M, Plückthun A.

MAbs. 2018 May/Jun;10(4):607-623. doi: 10.1080/19420862.2018.1450126. Epub 2018 Apr 25.


Determinants of Ligand Subtype-Selectivity at α1A-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR.

Yong KJ, Vaid TM, Shilling PJ, Wu FJ, Williams LM, Deluigi M, Plückthun A, Bathgate RAD, Gooley PR, Scott DJ.

ACS Chem Biol. 2018 Apr 20;13(4):1090-1102. doi: 10.1021/acschembio.8b00191. Epub 2018 Mar 22.


Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation.

Mikula KM, Krumwiede L, Plückthun A, Iwaï H.

J Biomol NMR. 2018 Aug;71(4):225-235. doi: 10.1007/s10858-018-0175-4. Epub 2018 Mar 13.


Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.

Stichling N, Suomalainen M, Flatt JW, Schmid M, Pacesa M, Hemmi S, Jungraithmayr W, Maler MD, Freudenberg MA, Plückthun A, May T, Köster M, Fejer G, Greber UF.

PLoS Pathog. 2018 Mar 9;14(3):e1006914. doi: 10.1371/journal.ppat.1006914. eCollection 2018 Mar.


Peptide-Guided Assembly of Repeat Protein Fragments.

Michel E, Plückthun A, Zerbe O.

Angew Chem Int Ed Engl. 2018 Apr 16;57(17):4576-4579. doi: 10.1002/anie.201713377. Epub 2018 Mar 13.


Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.

Schmid M, Ernst P, Honegger A, Suomalainen M, Zimmermann M, Braun L, Stauffer S, Thom C, Dreier B, Eibauer M, Kipar A, Vogel V, Greber UF, Medalia O, Plückthun A.

Nat Commun. 2018 Jan 31;9(1):450. doi: 10.1038/s41467-017-02707-6.


Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity.

Hansen S, Stüber JC, Ernst P, Koch A, Bojar D, Batyuk A, Plückthun A.

Sci Rep. 2017 Nov 24;7(1):16292. doi: 10.1038/s41598-017-15711-z.


Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions.

Wu Y, Honegger A, Batyuk A, Mittl PRE, Plückthun A.

J Mol Biol. 2018 Jul 6;430(14):2128-2138. doi: 10.1016/j.jmb.2017.10.032. Epub 2017 Nov 8.


A quantitative comparison of cytosolic delivery via different protein uptake systems.

Verdurmen WPR, Mazlami M, Plückthun A.

Sci Rep. 2017 Oct 16;7(1):13194. doi: 10.1038/s41598-017-13469-y.


Rigidly connected multispecific artificial binders with adjustable geometries.

Wu Y, Batyuk A, Honegger A, Brandl F, Mittl PRE, Plückthun A.

Sci Rep. 2017 Sep 11;7(1):11217. doi: 10.1038/s41598-017-11472-x.


Curvature of designed armadillo repeat proteins allows modular peptide binding.

Hansen S, Ernst P, König SLB, Reichen C, Ewald C, Nettels D, Mittl PRE, Schuler B, Plückthun A.

J Struct Biol. 2018 Feb;201(2):108-117. doi: 10.1016/j.jsb.2017.08.009. Epub 2017 Aug 31.


Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering.

Nemergut M, Žoldák G, Schaefer JV, Kast F, Miškovský P, Plückthun A, Sedlák E.

Protein Sci. 2017 Nov;26(11):2229-2239. doi: 10.1002/pro.3278. Epub 2017 Sep 6.


Structures of designed armadillo repeat proteins binding to peptides fused to globular domains.

Hansen S, Kiefer JD, Madhurantakam C, Mittl PRE, Plückthun A.

Protein Sci. 2017 Oct;26(10):1942-1952. doi: 10.1002/pro.3229. Epub 2017 Jul 25.


Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.

Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy LAB, Laferriere F, Maniecka Z, Plückthun A, Mittl P, Paganetti P, Allain FHT, Polymenidou M.

Nat Commun. 2017 Jun 29;8(1):45. doi: 10.1038/s41467-017-00062-0.


Rigidity of the extracellular part of HER2: Evidence from engineering subdomain interfaces and shared-helix DARPin-DARPin fusions.

Jost C, Stüber JC, Honegger A, Wu Y, Batyuk A, Plückthun A.

Protein Sci. 2017 Sep;26(9):1796-1806. doi: 10.1002/pro.3216. Epub 2017 Jul 5.


Changes to International Nonproprietary Names for antibody therapeutics 2017 and beyond: of mice, men and more.

Parren PWHI, Carter PJ, Plückthun A.

MAbs. 2017 Aug/Sep;9(6):898-906. doi: 10.1080/19420862.2017.1341029. Epub 2017 Jun 16.


SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.

Huber S, Casagrande F, Hug MN, Wang L, Heine P, Kummer L, Plückthun A, Hennig M.

PLoS One. 2017 May 16;12(5):e0175842. doi: 10.1371/journal.pone.0175842. eCollection 2017.


A Biotin Ligase-Based Assay for the Quantification of the Cytosolic Delivery of Therapeutic Proteins.

Verdurmen WPR, Mazlami M, Plückthun A.

Methods Mol Biol. 2017;1575:223-236. doi: 10.1007/978-1-4939-6857-2_14.


Personalised proteome analysis by means of protein microarrays made from individual patient samples.

Syafrizayanti, Lueong SS, Di C, Schaefer JV, Plückthun A, Hoheisel JD.

Sci Rep. 2017 Jan 3;7:39756. doi: 10.1038/srep39756.


Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries.

Ranganathan A, Heine P, Rudling A, Plückthun A, Kummer L, Carlsson J.

ACS Chem Biol. 2017 Mar 17;12(3):735-745. doi: 10.1021/acschembio.6b00646. Epub 2017 Jan 24.


SPRi-MALDI MS: characterization and identification of a kinase from cell lysate by specific interaction with different designed ankyrin repeat proteins.

Anders U, Schaefer JV, Hibti FE, Frydman C, Suckau D, Plückthun A, Zenobi R.

Anal Bioanal Chem. 2017 Mar;409(7):1827-1836. doi: 10.1007/s00216-016-0127-3. Epub 2016 Dec 16.


Covalently circularized nanodiscs for studying membrane proteins and viral entry.

Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G.

Nat Methods. 2017 Jan;14(1):49-52. doi: 10.1038/nmeth.4079. Epub 2016 Nov 21.


Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.

Reichen C, Hansen S, Forzani C, Honegger A, Fleishman SJ, Zhou T, Parmeggiani F, Ernst P, Madhurantakam C, Ewald C, Mittl PRE, Zerbe O, Baker D, Caflisch A, Plückthun A.

J Mol Biol. 2016 Nov 6;428(22):4467-4489. doi: 10.1016/j.jmb.2016.09.012. Epub 2016 Sep 21.


Advances in the design and engineering of peptide-binding repeat proteins.

Ernst P, Plückthun A.

Biol Chem. 2017 Jan 1;398(1):23-29. doi: 10.1515/hsz-2016-0233. Review.


Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.

Ahmad S, Pecqueur L, Dreier B, Hamdane D, Aumont-Nicaise M, Plückthun A, Knossow M, Gigant B.

Sci Rep. 2016 Jul 6;6:28922. doi: 10.1038/srep28922.


Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding.

Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G, Hagn F.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3629-38. doi: 10.1073/pnas.1604125113. Epub 2016 Jun 13.


Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment.

Bender RR, Muth A, Schneider IC, Friedel T, Hartmann J, Plückthun A, Maisner A, Buchholz CJ.

PLoS Pathog. 2016 Jun 9;12(6):e1005641. doi: 10.1371/journal.ppat.1005641. eCollection 2016 Jun.


Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk.

Tamaskovic R, Schwill M, Nagy-Davidescu G, Jost C, Schaefer DC, Verdurmen WP, Schaefer JV, Honegger A, Plückthun A.

Nat Commun. 2016 Jun 3;7:11672. doi: 10.1038/ncomms11672.


Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors.

Hanauer JR, Gottschlich L, Riehl D, Rusch T, Koch V, Friedrich K, Hutzler S, Prüfer S, Friedel T, Hanschmann KM, Münch RC, Jost C, Plückthun A, Cichutek K, Buchholz CJ, Mühlebach MD.

Mol Ther Oncolytics. 2016 Feb 24;3:16003. doi: 10.1038/mto.2016.3. eCollection 2016.


DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography.

Batyuk A, Wu Y, Honegger A, Heberling MM, Plückthun A.

J Mol Biol. 2016 Apr 24;428(8):1574-88. doi: 10.1016/j.jmb.2016.03.002. Epub 2016 Mar 11.


Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts.

Schütz M, Schöppe J, Sedlák E, Hillenbrand M, Nagy-Davidescu G, Ehrenmann J, Klenk C, Egloff P, Kummer L, Plückthun A.

Sci Rep. 2016 Feb 25;6:21508. doi: 10.1038/srep21508.


Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects.

Reichen C, Madhurantakam C, Hansen S, Grütter MG, Plückthun A, Mittl PR.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):168-75. doi: 10.1107/S2059798315023116. Epub 2016 Jan 1.


A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution.

Klenk C, Ehrenmann J, Schütz M, Plückthun A.

Sci Rep. 2016 Feb 18;6:21294. doi: 10.1038/srep21294.


Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity.

Hansen S, Tremmel D, Madhurantakam C, Reichen C, Mittl PR, Plückthun A.

J Am Chem Soc. 2016 Mar 16;138(10):3526-32. doi: 10.1021/jacs.6b00099. Epub 2016 Mar 2.


Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools.

Schütz M, Batyuk A, Klenk C, Kummer L, de Picciotto S, Gülbakan B, Wu Y, Newby GA, Zosel F, Schöppe J, Sedlák E, Mittl PRE, Zenobi R, Wittrup KD, Plückthun A.

J Mol Biol. 2016 Mar 27;428(6):1272-1289. doi: 10.1016/j.jmb.2016.01.017. Epub 2016 Jan 23.


The INNs and outs of antibody nonproprietary names.

Jones TD, Carter PJ, Plückthun A, Vásquez M, Holgate RG, Hötzel I, Popplewell AG, Parren PW, Enzelberger M, Rademaker HJ, Clark MR, Lowe DC, Dahiyat BI, Smith V, Lambert JM, Wu H, Reilly M, Haurum JS, Dübel S, Huston JS, Schirrmann T, Janssen RA, Steegmaier M, Gross JA, Bradbury AR, Burton DR, Dimitrov DS, Chester KA, Glennie MJ, Davies J, Walker A, Martin S, McCafferty J, Baker MP.

MAbs. 2016;8(1):1-9. doi: 10.1080/19420862.2015.1114320.


Getting to reproducible antibodies: the rationale for sequenced recombinant characterized reagents.

Bradbury AR, Plückthun A.

Protein Eng Des Sel. 2015 Oct;28(10):303-5. doi: 10.1093/protein/gzv051. No abstract available.


Editorial overview: Protein design and evolution-new protein architectures, evolutionary fine-tuning and analysis.

Fleishman SJ, Plückthun A.

Curr Opin Struct Biol. 2015 Aug;33:v-vi. doi: 10.1016/ Epub 2015 Sep 30. No abstract available.


Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells.

König I, Zarrine-Afsar A, Aznauryan M, Soranno A, Wunderlich B, Dingfelder F, Stüber JC, Plückthun A, Nettels D, Schuler B.

Nat Methods. 2015 Aug;12(8):773-9. doi: 10.1038/nmeth.3475. Epub 2015 Jul 6.


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