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Molecular Determinants of Surface Colonisation in Diarrhoeagenic Escherichia coli (DEC): from Bacterial Adhesion to Biofilm Formation.

Ageorges V, Monteiro R, Leroy S, Burgess CM, Pizza M, Chaucheyras-Durand F, Desvaux M.

FEMS Microbiol Rev. 2020 Apr 2. pii: fuaa008. doi: 10.1093/femsre/fuaa008. [Epub ahead of print]


Vaccines to Overcome Antibiotic Resistance: The Challenge of Burkholderia cenocepacia.

Scoffone VC, Barbieri G, Buroni S, Scarselli M, Pizza M, Rappuoli R, Riccardi G.

Trends Microbiol. 2020 Apr;28(4):315-326. doi: 10.1016/j.tim.2019.12.005. Epub 2020 Jan 10. Review.


Does vaccination with 4CMenB convey protection against meningococcal serogroup B strains not predicted to be covered by MATS? A study of the UK clonal complex cc269.

Stella M, Giuliani M, Biolchi A, Tomei S, De Paola R, Bai X, Borrow R, Lucidarme J, La Gaetana R, Toneatto D, Pizza M, Serino L, Mori E, Giuliani MM.

Hum Vaccin Immunother. 2019 Dec 6:1-4. doi: 10.1080/21645515.2019.1688039. [Epub ahead of print]


Identification of lipid A deacylase as a novel, highly conserved and protective antigen against enterohemorrhagic Escherichia coli.

Rojas-Lopez M, Martinelli M, Brandi V, Jubelin G, Polticelli F, Soriani M, Pizza M, Desvaux M, Rosini R.

Sci Rep. 2019 Nov 19;9(1):17014. doi: 10.1038/s41598-019-53197-z.


The meningococcal vaccine antigen GNA2091 is an analogue of YraP and plays key roles in outer membrane stability and virulence.

Seib KL, Haag AF, Oriente F, Fantappiè L, Borghi S, Semchenko EA, Schulz BL, Ferlicca F, Taddei AR, Giuliani MM, Pizza M, Delany I.

FASEB J. 2019 Nov;33(11):12324-12335. doi: 10.1096/fj.201900669R. Epub 2019 Aug 23.


NHBA is processed by kallikrein from human saliva.

Pantano E, Marchi S, Biagini M, Di Fede M, Nardi Dei V, Rossi Paccani S, Pizza M, Cartocci E.

PLoS One. 2019 Aug 1;14(8):e0203234. doi: 10.1371/journal.pone.0203234. eCollection 2019.


The Development of a Vaccine Against Meningococcus B Using Reverse Vaccinology.

Masignani V, Pizza M, Moxon ER.

Front Immunol. 2019 Apr 16;10:751. doi: 10.3389/fimmu.2019.00751. eCollection 2019. Review.


Mixed mucosal-parenteral immunizations with the broadly conserved pathogenic Escherichia coli antigen SslE induce a robust mucosal and systemic immunity without affecting the murine intestinal microbiota.

Naili I, Vinot J, Baudner BC, Bernalier-Donadille A, Pizza M, Desvaux M, Jubelin G, D'Oro U, Buonsanti C.

Vaccine. 2019 Jan 7;37(2):314-324. doi: 10.1016/j.vaccine.2018.10.008. Epub 2018 Nov 30.


Meningococcal B vaccine (4CMenB): the journey from research to real world experience.

Rappuoli R, Pizza M, Masignani V, Vadivelu K.

Expert Rev Vaccines. 2018 Dec;17(12):1111-1121. doi: 10.1080/14760584.2018.1547637. Epub 2018 Dec 5. Review.


Evaluation of strain coverage of the multicomponent meningococcal serogroup B vaccine (4CMenB) administered in infants according to different immunisation schedules.

Biolchi A, Tomei S, Santini L, Welsch JA, Toneatto D, Gaitatzis N, Bai X, Borrow R, Giuliani MM, Mori E, Pizza M.

Hum Vaccin Immunother. 2019;15(3):725-731. doi: 10.1080/21645515.2018.1537756. Epub 2019 Jan 2.


NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies.

Liguori A, Dello Iacono L, Maruggi G, Benucci B, Merola M, Lo Surdo P, López-Sagaseta J, Pizza M, Malito E, Bottomley MJ.

mBio. 2018 Oct 16;9(5). pii: e01914-18. doi: 10.1128/mBio.01914-18.


Vaccines Against Escherichia coli.

Nesta B, Pizza M.

Curr Top Microbiol Immunol. 2018;416:213-242. doi: 10.1007/82_2018_111. Review.


Intestinal Pathogenic Escherichia coli: Insights for Vaccine Development.

Rojas-Lopez M, Monterio R, Pizza M, Desvaux M, Rosini R.

Front Microbiol. 2018 Mar 20;9:440. doi: 10.3389/fmicb.2018.00440. eCollection 2018. Review.


Differential biotin labelling of the cell envelope proteins in lipopolysaccharidic diderm bacteria: Exploring the proteosurfaceome of Escherichia coli using sulfo-NHS-SS-biotin and sulfo-NHS-PEG4-bismannose-SS-biotin.

Monteiro R, Chafsey I, Leroy S, Chambon C, Hébraud M, Livrelli V, Pizza M, Pezzicoli A, Desvaux M.

J Proteomics. 2018 Jun 15;181:16-23. doi: 10.1016/j.jprot.2018.03.026. Epub 2018 Mar 30.


Human protective response induced by meningococcus B vaccine is mediated by the synergy of multiple bactericidal epitopes.

Giuliani M, Bartolini E, Galli B, Santini L, Lo Surdo P, Buricchi F, Bruttini M, Benucci B, Pacchiani N, Alleri L, Donnarumma D, Pansegrau W, Peschiera I, Ferlenghi I, Cozzi R, Norais N, Giuliani MM, Maione D, Pizza M, Rappuoli R, Finco O, Masignani V.

Sci Rep. 2018 Feb 27;8(1):3700. doi: 10.1038/s41598-018-22057-7.


Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.

López-Sagaseta J, Beernink PT, Bianchi F, Santini L, Frigimelica E, Lucas AH, Pizza M, Bottomley MJ.

Nat Commun. 2018 Feb 6;9(1):528. doi: 10.1038/s41467-018-02827-7.


Identification of the Autochaperone Domain in the Type Va Secretion System (T5aSS): Prevalent Feature of Autotransporters with a β-Helical Passenger.

Rojas-Lopez M, Zorgani MA, Kelley LA, Bailly X, Kajava AV, Henderson IR, Polticelli F, Pizza M, Rosini R, Desvaux M.

Front Microbiol. 2018 Jan 5;8:2607. doi: 10.3389/fmicb.2017.02607. eCollection 2017.


Outer Membrane Vesicles (OMV)-based and Proteomics-driven Antigen Selection Identifies Novel Factors Contributing to Bordetella pertussis Adhesion to Epithelial Cells.

Gasperini G, Biagini M, Arato V, Gianfaldoni C, Vadi A, Norais N, Bensi G, Delany I, Pizza M, Aricò B, Leuzzi R.

Mol Cell Proteomics. 2018 Feb;17(2):205-215. doi: 10.1074/mcp.RA117.000045. Epub 2017 Dec 4.


A phase I, randomized, controlled, dose-ranging study of investigational acellular pertussis (aP) and reduced tetanus-diphtheria-acellular pertussis (TdaP) booster vaccines in adults.

Leroux-Roels G, Lattanzi M, Solis CD, Contorni M, Costantini M, Moraschini L, Bardelli M, Bertholet S, Borgogni E, Buricchi F, Cantisani R, Faenzi E, Finco O, Leuzzi R, Pizza M, Rosa D, Schiavetti F, Seubert A, Spensieri F, Volpini G, Zedda L, Giudice GD, Galgani I.

Hum Vaccin Immunother. 2018 Jan 2;14(1):45-58. doi: 10.1080/21645515.2017.1385686. Epub 2017 Nov 27.


Potential impact of the 4CMenB vaccine on oropharyngeal carriage of Neisseria meningitidis.

Abad R, Medina V, Fariñas MDC, Martínez-Martínez L, Bambini S, Dari A, Medini D, Pizza M, Vázquez JA.

J Infect. 2017 Dec;75(6):511-520. doi: 10.1016/j.jinf.2017.09.021. Epub 2017 Oct 5.


Physiopathological roles of spontaneously released outer membrane vesicles of Bordetella pertussis.

Gasperini G, Arato V, Pizza M, Aricò B, Leuzzi R.

Future Microbiol. 2017 Nov;12:1247-1259. doi: 10.2217/fmb-2017-0064. Epub 2017 Oct 5.


Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model.

Misiak A, Leuzzi R, Allen AC, Galletti B, Baudner BC, D'Oro U, O'Hagan DT, Pizza M, Seubert A, Mills KHG.

Vaccine. 2017 Sep 18;35(39):5256-5263. doi: 10.1016/j.vaccine.2017.08.009. Epub 2017 Aug 18.


Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis.

Nascimento IP, Rodriguez D, Santos CC, Amaral EP, Rofatto HK, Junqueira-Kipnis AP, Gonçalves EDC, D'Império-Lima MR, Hirata MH, Silva CL, Winter N, Gicquel B, Mills KHG, Pizza M, Rappuoli R, Leite LCC.

Sci Rep. 2017 May 18;7(1):2109. doi: 10.1038/s41598-017-02003-9.


Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Portugal.

Simões MJ, Bettencourt C, De Paola R, Giuliani M, Pizza M, Moschioni M, Machado J.

PLoS One. 2017 May 1;12(5):e0176177. doi: 10.1371/journal.pone.0176177. eCollection 2017.


Emerging experience with meningococcal serogroup B protein vaccines.

Toneatto D, Pizza M, Masignani V, Rappuoli R.

Expert Rev Vaccines. 2017 May;16(5):433-451. doi: 10.1080/14760584.2017.1308828. Epub 2017 Apr 10. Review.


Meningococcal serogroup B strain coverage of the multicomponent 4CMenB vaccine with corresponding regional distribution and clinical characteristics in England, Wales, and Northern Ireland, 2007-08 and 2014-15: a qualitative and quantitative assessment.

Parikh SR, Newbold L, Slater S, Stella M, Moschioni M, Lucidarme J, De Paola R, Giuliani M, Serino L, Gray SJ, Clark SA, Findlow J, Pizza M, Ramsay ME, Ladhani SN, Borrow R.

Lancet Infect Dis. 2017 Jul;17(7):754-762. doi: 10.1016/S1473-3099(17)30170-6. Epub 2017 Mar 30.


Spotlight on... Mariagrazia Pizza.

Pizza M.

FEMS Microbiol Lett. 2017 Mar 1;364(5). doi: 10.1093/femsle/fnw299. No abstract available.


Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells.

Vacca I, Del Tordello E, Gasperini G, Pezzicoli A, Di Fede M, Rossi Paccani S, Marchi S, Mubaiwa TD, Hartley-Tassell LE, Jennings MP, Seib KL, Masignani V, Pizza M, Serruto D, Aricò B, Delany I.

PLoS One. 2016 Oct 25;11(10):e0162878. doi: 10.1371/journal.pone.0162878. eCollection 2016.


A novel high-throughput assay to quantify the vaccine-induced inhibition of Bordetella pertussis adhesion to airway epithelia.

Zanaboni E, Arato V, Pizza M, Seubert A, Leuzzi R.

BMC Microbiol. 2016 Sep 15;16:215. doi: 10.1186/s12866-016-0829-x.


Exploring host-pathogen interactions through genome wide protein microarray analysis.

Scietti L, Sampieri K, Pinzuti I, Bartolini E, Benucci B, Liguori A, Haag AF, Lo Surdo P, Pansegrau W, Nardi-Dei V, Santini L, Arora S, Leber X, Rindi S, Savino S, Costantino P, Maione D, Merola M, Speziale P, Bottomley MJ, Bagnoli F, Masignani V, Pizza M, Scharenberg M, Schlaeppi JM, Nissum M, Liberatori S.

Sci Rep. 2016 Jun 15;6:27996. doi: 10.1038/srep27996.


Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA.

Liguori A, Malito E, Lo Surdo P, Fagnocchi L, Cantini F, Haag AF, Brier S, Pizza M, Delany I, Bottomley MJ.

PLoS Pathog. 2016 Apr 22;12(4):e1005557. doi: 10.1371/journal.ppat.1005557. eCollection 2016 Apr.


Erratum for Baddal et al., Dual RNA-seq of Nontypeable Haemophilus influenzae and Host Cell Transcriptomes Reveals Novel Insights into Host-Pathogen Cross Talk.

Baddal B, Muzzi A, Censini S, Calogero RA, Torricelli G, Guidotti S, Taddei AR, Covacci A, Pizza M, Rappuoli R, Soriani M, Pezzicoli A.

mBio. 2016 Apr 12;7(2):e00373-16. doi: 10.1128/mBio.00373-16. No abstract available.


Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.

Biagini M, Spinsanti M, De Angelis G, Tomei S, Ferlenghi I, Scarselli M, Rigat F, Messuti N, Biolchi A, Muzzi A, Anderloni G, Brunelli B, Cartocci E, Buricchi F, Tani C, Stella M, Moschioni M, Del Tordello E, Colaprico A, Savino S, Giuliani MM, Delany I, Pizza M, Costantino P, Norais N, Rappuoli R, Masignani V.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2714-9. doi: 10.1073/pnas.1521142113. Epub 2016 Feb 17.


Effectiveness of Meningococcal B Vaccine against Endemic Hypervirulent Neisseria meningitidis W Strain, England.

Ladhani SN, Giuliani MM, Biolchi A, Pizza M, Beebeejaun K, Lucidarme J, Findlow J, Ramsay ME, Borrow R.

Emerg Infect Dis. 2016 Feb;22(2):309-11. doi: 10.3201/eid2202.150369.


Dual RNA-seq of Nontypeable Haemophilus influenzae and Host Cell Transcriptomes Reveals Novel Insights into Host-Pathogen Cross Talk.

Baddal B, Muzzi A, Censini S, Calogero RA, Torricelli G, Guidotti S, Taddei AR, Covacci A, Pizza M, Rappuoli R, Soriani M, Pezzicoli A.

mBio. 2015 Nov 17;6(6):e01765-15. doi: 10.1128/mBio.01765-15. Erratum in: MBio. 2016;7(2). pii: e00373-16. doi: 10.1128/mBio.00373-16.


Exploiting chimeric human antibodies to characterize a protective epitope of Neisseria adhesin A, one of the Bexsero vaccine components.

Bertoldi I, Faleri A, Galli B, Lo Surdo P, Liguori A, Norais N, Santini L, Masignani V, Pizza M, Giuliani MM.

FASEB J. 2016 Jan;30(1):93-101. doi: 10.1096/fj.15-273813. Epub 2015 Aug 24.


The potential of adjuvants to improve immune responses against TdaP vaccines: A preclinical evaluation of MF59 and monophosphoryl lipid A.

Agnolon V, Bruno C, Leuzzi R, Galletti B, D'Oro U, Pizza M, Seubert A, O'Hagan DT, Baudner BC.

Int J Pharm. 2015 Aug 15;492(1-2):169-76. doi: 10.1016/j.ijpharm.2015.06.030. Epub 2015 Jul 3.


The Neisseria meningitidis ADP-Ribosyltransferase NarE Enters Human Epithelial Cells and Disrupts Epithelial Monolayer Integrity.

Valeri M, Zurli V, Ayala I, Colanzi A, Lapazio L, Corda D, Soriani M, Pizza M, Rossi Paccani S.

PLoS One. 2015 May 21;10(5):e0127614. doi: 10.1371/journal.pone.0127614. eCollection 2015.


Molecular Engineering of Ghfp, the Gonococcal Orthologue of Neisseria meningitidis Factor H Binding Protein.

Rippa V, Santini L, Lo Surdo P, Cantini F, Veggi D, Gentile MA, Grassi E, Iannello G, Brunelli B, Ferlicca F, Palmieri E, Pallaoro M, Aricò B, Banci L, Pizza M, Scarselli M.

Clin Vaccine Immunol. 2015 Jul;22(7):769-77. doi: 10.1128/CVI.00794-14. Epub 2015 May 6.


Development of a serological assay to predict antibody bactericidal activity against non-typeable Haemophilus influenzae.

Ercoli G, Baddal B, Alessandra G, Marchi S, Petracca R, Aricò B, Pizza M, Soriani M, Rossi-Paccani S.

BMC Microbiol. 2015 Apr 18;15:87. doi: 10.1186/s12866-015-0420-x.


Carboplatin in the treatment of Ewing sarcoma: Results of the first Brazilian collaborative study group for Ewing sarcoma family tumors-EWING1.

Brunetto AL, Castillo LA, Petrilli AS, Macedo CD, Boldrini E, Costa C, Almeida MT, Kirst D, Rodriguez-Galindo C, Pereira WV, Watanabe FM, Pizza M, Benites E, Morais V, Gadelha A, Nakasato A, Abujamra AL, Gregianin LJ; Brazilian Collaborative On behalf of the Brazilian Collaborative Study Group of Ewing Family of Tumors EWING1 and the Brazilian Society of Pediatric Oncology SOBOPE.

Pediatr Blood Cancer. 2015 Oct;62(10):1747-53. doi: 10.1002/pbc.25562. Epub 2015 Apr 27.


Whole-Genome Sequences of Nonencapsulated Haemophilus influenzae Strains Isolated in Italy.

Giufrè M, De Chiara M, Censini S, Guidotti S, Torricelli G, De Angelis G, Cardines R, Pizza M, Muzzi A, Cerquetti M, Soriani M.

Genome Announc. 2015 Mar 26;3(2). pii: e00110-15. doi: 10.1128/genomeA.00110-15.


Neisseria meningitidis subverts the polarized organization and intracellular trafficking of host cells to cross the epithelial barrier.

Barrile R, Kasendra M, Rossi-Paccani S, Merola M, Pizza M, Baldari C, Soriani M, Aricò B.

Cell Microbiol. 2015 Sep;17(9):1365-75. doi: 10.1111/cmi.12439. Epub 2015 Apr 23.


Pathogenic E. coli exploits SslE mucinase activity to translocate through the mucosal barrier and get access to host cells.

Valeri M, Rossi Paccani S, Kasendra M, Nesta B, Serino L, Pizza M, Soriani M.

PLoS One. 2015 Mar 19;10(3):e0117486. doi: 10.1371/journal.pone.0117486. eCollection 2015.


Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.

Bottazzi B, Santini L, Savino S, Giuliani MM, Dueñas Díez AI, Mancuso G, Beninati C, Sironi M, Valentino S, Deban L, Garlanda C, Teti G, Pizza M, Rappuoli R, Mantovani A.

PLoS One. 2015 Mar 18;10(3):e0120807. doi: 10.1371/journal.pone.0120807. eCollection 2015.


LytM proteins play a crucial role in cell separation, outer membrane composition, and pathogenesis in nontypeable Haemophilus influenzae.

Ercoli G, Tani C, Pezzicoli A, Vacca I, Martinelli M, Pecetta S, Petracca R, Rappuoli R, Pizza M, Norais N, Soriani M, Aricò B.

mBio. 2015 Feb 24;6(2):e02575. doi: 10.1128/mBio.02575-14.


A large portion of meningococcal antigen typing system-negative meningococcal strains from spain is killed by sera from adolescents and infants immunized with 4CMenB.

Abad R, Biolchi A, Moschioni M, Giuliani MM, Pizza M, Vázquez JA.

Clin Vaccine Immunol. 2015 Apr;22(4):357-60. doi: 10.1128/CVI.00669-14. Epub 2015 Jan 28.


Neisseria meningitidis: pathogenesis and immunity.

Pizza M, Rappuoli R.

Curr Opin Microbiol. 2015 Feb;23:68-72. doi: 10.1016/j.mib.2014.11.006. Epub 2014 Nov 22. Review.


Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody.

Malito E, Biancucci M, Faleri A, Ferlenghi I, Scarselli M, Maruggi G, Lo Surdo P, Veggi D, Liguori A, Santini L, Bertoldi I, Petracca R, Marchi S, Romagnoli G, Cartocci E, Vercellino I, Savino S, Spraggon G, Norais N, Pizza M, Rappuoli R, Masignani V, Bottomley MJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17128-33. doi: 10.1073/pnas.1419686111. Epub 2014 Nov 17.


Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo.

Nair N, Buti L, Faenzi E, Buricchi F, Nuti S, Sammicheli C, Tavarini S, Popp MW, Ploegh H, Berti F, Pizza M, Castellino F, Finco O, Rappuoli R, Del Giudice G, Galli G, Bardelli M.

Immun Inflamm Dis. 2013 Oct;1(1):3-13. doi: 10.1002/iid3.3. Epub 2013 Oct 30.

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