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Items: 44

1.

Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.

Martínez González S, Hernández AI, Varela C, Lorenzo M, Ramos-Lima F, Cendón E, Cebrián D, Aguirre E, Gomez-Casero E, Albarrán MI, Alfonso P, García-Serelde B, Mateos G, Oyarzabal J, Rabal O, Mulero F, Gonzalez-Granda T, Link W, Fominaya J, Barbacid M, Bischoff JR, Pizcueta P, Blanco-Aparicio C, Pastor J.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5208-14. doi: 10.1016/j.bmcl.2012.06.093. Epub 2012 Jul 4.

PMID:
22819764
2.

Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.

Martínez González S, Hernández AI, Varela C, Rodríguez-Arístegui S, Lorenzo M, Rodríguez A, Rivero V, Martín JI, Saluste CG, Ramos-Lima F, Cendón E, Cebrián D, Aguirre E, Gomez-Casero E, Albarrán M, Alfonso P, García-Serelde B, Oyarzabal J, Rabal O, Mulero F, Gonzalez-Granda T, Link W, Fominaya J, Barbacid M, Bischoff JR, Pizcueta P, Pastor J.

Bioorg Med Chem Lett. 2012 May 15;22(10):3460-6. doi: 10.1016/j.bmcl.2012.03.090. Epub 2012 Mar 29.

PMID:
22520259
3.

Biaryl analogues of teriflunomide as potent DHODH inhibitors.

Erra M, Moreno I, Sanahuja J, Andrés M, Reinoso RF, Lozoya E, Pizcueta P, Godessart N, Castro-Palomino JC.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7268-72. doi: 10.1016/j.bmcl.2011.10.052. Epub 2011 Oct 20.

PMID:
22078215
4.

A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

Puyol M, Martín A, Dubus P, Mulero F, Pizcueta P, Khan G, Guerra C, Santamaría D, Barbacid M.

Cancer Cell. 2010 Jul 13;18(1):63-73. doi: 10.1016/j.ccr.2010.05.025.

5.

Distinct synovial immunopathology in Behçet disease and psoriatic arthritis.

Cañete JD, Celis R, Noordenbos T, Moll C, Gómez-Puerta JA, Pizcueta P, Palacin A, Tak PP, Sanmartí R, Baeten D.

Arthritis Res Ther. 2009;11(1):R17. doi: 10.1186/ar2608. Epub 2009 Feb 6.

6.

Platelet deposition in remote cardiac regions after coronary occlusion.

Barrabés JA, Mirabet M, Agulló L, Figueras J, Pizcueta P, Garcia-Dorado D.

Eur J Clin Invest. 2007 Dec;37(12):939-46. Epub 2007 Oct 30.

PMID:
17971174
7.

Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule.

March S, Graupera M, Rosa Sarrias M, Lozano F, Pizcueta P, Bosch J, Engel P.

Am J Pathol. 2007 Jan;170(1):176-87.

8.

P-selectin mediates leukocyte rolling in concanavalin-A-induced hepatitis.

March S, Garcia-Pagán JC, Massaguer A, Pizcueta P, Panés J, Engel P, Bosch J.

Liver Int. 2005 Oct;25(5):1053-60.

PMID:
16162166
9.

CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse.

Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P.

J Immunol. 2005 Jun 1;174(11):7033-42.

10.

Characterization of platelet and soluble-porcine P-selectin (CD62P).

Massaguer A, Engel P, Tovar V, March S, Rigol M, Solanes N, Bosch J, Pizcueta P.

Vet Immunol Immunopathol. 2003 Dec 15;96(3-4):169-81.

PMID:
14592730
11.

Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors.

Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P.

Immunogenetics. 2002 Sep;54(6):394-402. Epub 2002 Jul 18.

PMID:
12242590
12.

Platelets activated by transient coronary occlusion exacerbate ischemia-reperfusion injury in rat hearts.

Mirabet M, Garcia-Dorado D, Inserte J, Barrabés JA, Lidón RM, Soriano B, Azevedo M, Padilla F, Agulló L, Ruiz-Meana M, Massaguer A, Pizcueta P, Soler-Soler J.

Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H1134-41.

13.

Concanavalin-A-induced liver injury is severely impaired in mice deficient in P-selectin.

Massaguer A, Perez-Del-Pulgar S, Engel P, Serratosa J, Bosch J, Pizcueta P.

J Leukoc Biol. 2002 Aug;72(2):262-70.

PMID:
12149416
14.

Lack of effect of glycoprotein IIb/IIIa blockade on myocardial platelet or polymorphonuclear leukocyte accumulation and on infarct size after transient coronary occlusion in pigs.

Barrabés JA, Garcia-Dorado D, Mirabet M, Lidón RM, Soriano B, Ruiz-Meana M, Pizcueta P, Blanco J, Puigfel Y, Soler-Soler J.

J Am Coll Cardiol. 2002 Jan 2;39(1):157-65.

15.

CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1.

Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P.

J Immunol. 2001 Oct 1;167(7):3668-76.

16.

Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9.

de la Fuente MA, Tovar V, Villamor N, Zapater N, Pizcueta P, Campo E, Bosch J, Engel P.

Blood. 2001 Jun 1;97(11):3513-20.

PMID:
11369645
17.

Neutrophil adhesion is impaired in the mesentery but not in the liver sinusoids of portal hypertensive rats.

Pérez-Del-Pulgar S, Pizcueta P, Engel P, Bosch J, Rodés J.

Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1351-9.

18.

Effects of blood volume restitution following a portal hypertensive-related bleeding in anesthetized cirrhotic rats.

Castañeda B, Morales J, Lionetti R, Moitinho E, Andreu V, Pérez-Del-Pulgar S, Pizcueta P, Rodés J, Bosch J.

Hepatology. 2001 Apr;33(4):821-5.

PMID:
11283845
19.

Differential role of selectins in experimental colitis.

Sans M, Salas A, Soriano A, Prats N, Gironella M, Pizcueta P, Elena M, Anderson DC, Piqué JM, Panés J.

Gastroenterology. 2001 Apr;120(5):1162-72.

PMID:
11266380
20.

Production and characterization of monoclonal antibodies against conserved epitopes of P-selectin (CD62P).

Massaguer A, Engel P, Pérez-del-Pulgar S, Bosch J, Pizcueta P.

Tissue Antigens. 2000 Aug;56(2):117-28.

PMID:
11019911
21.

Gene structure of the mouse leukocyte cell surface molecule Ly9.

Tovar V, de la Fuente MA, Pizcueta P, Bosch J, Engel P.

Immunogenetics. 2000 Aug;51(10):788-93.

PMID:
10970093
22.

Circulating concentrations of soluble L-selectin (CD62L) in patients with primary Sjögren's syndrome.

García-Carrasco M, Pizcueta P, Cervera R, Ramos-Casals M, Sisó A, de La Red G, Ingelmo M, Font J, Engel P.

Ann Rheum Dis. 2000 Apr;59(4):297-9.

23.

The role of portal pressure in the severity of bleeding in portal hypertensive rats.

Castañeda B, Debernardi-Venon W, Bandi JC, Andreu V, Pérez-del-Pulgar S, Moitinho E, Pizcueta P, Bosch J.

Hepatology. 2000 Mar;31(3):581-6.

PMID:
10706546
24.

Enhanced monocyte activation and hepatotoxicity in response to endotoxin in portal hypertension.

Pérez del Pulgar S, Pizcueta P, Engel P, Bosch J.

J Hepatol. 2000 Jan;32(1):25-31.

PMID:
10673063
25.

Increased serum levels of soluble L-selectin (CD62L) in patients with active systemic lupus erythematosus (SLE).

Font J, Pizcueta P, Ramos-Casals M, Cervera R, García-Carrasco M, Navarro M, Ingelmo M, Engel P.

Clin Exp Immunol. 2000 Jan;119(1):169-74.

26.

Impaired mesenteric leukocyte recruitment in experimental portal hypertension in the rat.

Panés J, Pérez-del-Pulgar S, Casadevall M, Salas A, Pizcueta P, Bosch J, Anderson DC, Granger DN, Piqué JM.

Hepatology. 1999 Aug;30(2):445-53.

PMID:
10421653
27.

Molecular cloning, characterization, and chromosomal localization of the mouse homologue of CD84, a member of the CD2 family of cell surface molecules.

de la Fuente MA, Tovar V, Pizcueta P, Nadal M, Bosch J, Engel P.

Immunogenetics. 1999 Apr;49(4):249-55.

PMID:
10079287
28.

CD84 leukocyte antigen is a new member of the Ig superfamily.

de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P.

Blood. 1997 Sep 15;90(6):2398-405.

PMID:
9310491
29.

Platelet activation In mice and human Helicobacter pylori infection.

Elizalde JI, Gómez J, Panés J, Lozano M, Casadevall M, Ramírez J, Pizcueta P, Marco F, Rojas FD, Granger DN, Piqué JM.

J Clin Invest. 1997 Sep 1;100(5):996-1005.

30.

L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites.

Tedder TF, Steeber DA, Pizcueta P.

J Exp Med. 1995 Jun 1;181(6):2259-64.

31.

Neonatal capsaicin treatment does not prevent splanchnic vasodilatation in portal-hypertensive rats.

Fernández M, Casadevall M, Schuligoi R, Pizcueta P, Panés J, Barrachina MD, Donnerer J, Piqué JM, Esplugues JV, Bosch J, et al.

Hepatology. 1994 Dec;20(6):1609-14.

PMID:
7982662
32.

Effects of continued NO inhibition on portal hypertensive syndrome after portal vein stenosis in rat.

García-Pagán JC, Fernández M, Bernadich C, Pizcueta P, Piqué JM, Bosch J, Rodés J.

Am J Physiol. 1994 Dec;267(6 Pt 1):G984-90.

PMID:
7810666
34.

Nicardipine increases hepatic blood flow and the hepatic clearance of indocyanine green in patients with cirrhosis.

García-Pagán JC, Feu F, Luca A, Fernández M, Pizcueta P, Bosch J, Rodés J.

J Hepatol. 1994 Jun;20(6):792-6.

PMID:
7930480
35.

Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.

Luscinskas FW, Kansas GS, Ding H, Pizcueta P, Schleiffenbaum BE, Tedder TF, Gimbrone MA Jr.

J Cell Biol. 1994 Jun;125(6):1417-27.

36.

Impaired function of pancreatic islets from rats with portal hypertension resulting from cirrhosis and partial portal vein ligation.

Gomis R, Fernández-Alvarez J, Pizcueta P, Fernández M, Casamitjana R, Bosch J, Rodés J.

Hepatology. 1994 May;19(5):1257-61.

PMID:
8175150
37.

Effects of low-sodium diet and spironolactone on portal pressure in patients with compensated cirrhosis.

García-Pagán JC, Salmerón JM, Feu F, Luca A, Ginés P, Pizcueta P, Claria J, Piera C, Arroyo V, Bosch J, et al.

Hepatology. 1994 May;19(5):1095-9.

PMID:
8175131
38.

Effects of ritanserin, a selective and specific S2-serotonergic antagonist, on portal pressure and splanchnic hemodynamics in rats with long-term bile duct ligation.

Fernández M, Pizcueta P, García-Pagán JC, Feu F, Cirera I, Bosch J, Rodés J.

Hepatology. 1993 Aug;18(2):389-93.

PMID:
8340068
39.

Hemodynamic effects of acute changes in intra-abdominal pressure in patients with cirrhosis.

Luca A, Cirera I, García-Pagán JC, Feu F, Pizcueta P, Bosch J, Rodés J.

Gastroenterology. 1993 Jan;104(1):222-7.

PMID:
8419245
40.

New approaches in the pharmacologic treatment of portal hypertension.

Bosch J, García-Pagán JC, Feu F, Luca A, Fernández M, Pizcueta P, Rodés J.

J Hepatol. 1993;17 Suppl 2:S41-5. Review.

PMID:
8098342
41.

Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition.

Pizcueta P, Piqué JM, Fernández M, Bosch J, Rodés J, Whittle BJ, Moncada S.

Gastroenterology. 1992 Dec;103(6):1909-15.

PMID:
1451984
42.

Pathophysiology of portal hypertension.

Bosch J, Pizcueta P, Feu F, Fernández M, García-Pagán JC.

Gastroenterol Clin North Am. 1992 Mar;21(1):1-14. Review.

PMID:
1568769
43.

Effects of propranolol on gastric microcirculation and acid secretion in portal hypertensive rats.

Piqué JM, Pizcueta P, Pérez Ayuso RM, Bosch J.

Hepatology. 1990 Sep;12(3 Pt 1):476-80.

PMID:
2401453
44.

Enhancement of portal pressure reduction by the association of isosorbide-5-mononitrate to propranolol administration in patients with cirrhosis.

Garcia-Pagán JC, Navasa M, Bosch J, Bru C, Pizcueta P, Rodés J.

Hepatology. 1990 Feb;11(2):230-8.

PMID:
2307401

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