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Items: 40


Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure.

Ferreira JP, Verdonschot J, Collier T, Wang P, Pizard A, Bär C, Björkman J, Boccanelli A, Butler J, Clark A, Cleland JG, Delles C, Diez J, Girerd N, González A, Hazebroek M, Huby AC, Jukema W, Latini R, Leenders J, Levy D, Mebazaa A, Mischak H, Pinet F, Rossignol P, Sattar N, Sever P, Staessen JA, Thum T, Vodovar N, Zhang ZY, Heymans S, Zannad F.

Circ Heart Fail. 2019 May;12(5):e005897. doi: 10.1161/CIRCHEARTFAILURE.118.005897.


Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case-control analyses.

Ferreira JP, Pizard A, Machu JL, Bresso E, Rocca HB, Girerd N, Leroy C, González A, Diez J, Heymans S, Devignes MD, Rossignol P, Zannad F; FIBRO-TARGETS investigators.

Clin Res Cardiol. 2020 Jan;109(1):22-33. doi: 10.1007/s00392-019-01480-4. Epub 2019 May 6.


Potential spironolactone effects on collagen metabolism biomarkers in patients with uncontrolled blood pressure.

Ferreira JP, Rossignol P, Pizard A, Machu JL, Collier T, Girerd N, Huby AC, Gonzalez A, Diez J, López B, Sattar N, Cleland JG, Sever PS, Zannad F.

Heart. 2019 Feb;105(4):307-314. doi: 10.1136/heartjnl-2018-313182. Epub 2018 Aug 18.


In need of signalling pathway data.

Pizard A.

Eur J Heart Fail. 2018 Aug;20(8):1202-1204. doi: 10.1002/ejhf.1219. Epub 2018 Jun 12. No abstract available.


The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease.

Cocchiaro P, De Pasquale V, Della Morte R, Tafuri S, Avallone L, Pizard A, Moles A, Pavone LM.

Front Cell Dev Biol. 2017 Dec 19;5:114. doi: 10.3389/fcell.2017.00114. eCollection 2017. Review.


Cohort Profile: Rationale and design of the fourth visit of the STANISLAS cohort: a familial longitudinal population-based cohort from the Nancy region of France.

Ferreira JP, Girerd N, Bozec E, Mercklé L, Pizard A, Bouali S, Eby E, Leroy C, Machu JL, Boivin JM, Lamiral Z, Rossignol P, Zannad F.

Int J Epidemiol. 2018 Apr 1;47(2):395-395j. doi: 10.1093/ije/dyx240. No abstract available.


Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis.

Ferreira JP, Machu JL, Girerd N, Jaisser F, Thum T, Butler J, González A, Diez J, Heymans S, McDonald K, Gyöngyösi M, Firat H, Rossignol P, Pizard A, Zannad F.

ESC Heart Fail. 2018 Feb;5(1):139-148. doi: 10.1002/ehf2.12218. Epub 2017 Oct 7. Review.


Response to: 'Spontaneous hypertensive rat exhibits bone and meniscus phenotypes of osteoarthritis: is it an appropriate control for MetS-associated OA?' by Chan and Wen.

Deng C, Bianchi A, Presle N, Moulin D, Koufany M, Guillaume C, Kempf H, Pizard A.

Ann Rheum Dis. 2018 May;77(5):e26. doi: 10.1136/annrheumdis-2017-212003. Epub 2017 Oct 7. No abstract available.


Eplerenone treatment alleviates the development of joint lesions in a new rat model of spontaneous metabolic-associated osteoarthritis.

Deng C, Bianchi A, Presle N, Moulin D, Koufany M, Guillaume C, Kempf H, Pizard A.

Ann Rheum Dis. 2018 Feb;77(2):315-316. doi: 10.1136/annrheumdis-2016-210700. Epub 2017 May 5. No abstract available.


Tailoring mineralocorticoid receptor antagonist therapy in heart failure patients: are we moving towards a personalized approach?

Ferreira JP, Mentz RJ, Pizard A, Pitt B, Zannad F.

Eur J Heart Fail. 2017 Aug;19(8):974-986. doi: 10.1002/ejhf.814. Epub 2017 Apr 12. Review.


Effect of eplerenone in patients with heart failure and reduced ejection fraction: potential effect modification by abdominal obesity. Insight from the EMPHASIS-HF trial.

Olivier A, Pitt B, Girerd N, Lamiral Z, Machu JL, McMurray JJV, Swedberg K, van Veldhuisen DJ, Collier TJ, Pocock SJ, Rossignol P, Zannad F, Pizard A.

Eur J Heart Fail. 2017 Sep;19(9):1186-1197. doi: 10.1002/ejhf.792. Epub 2017 Mar 16.


Myocardial fibrosis: biomedical research from bench to bedside.

Gyöngyösi M, Winkler J, Ramos I, Do QT, Firat H, McDonald K, González A, Thum T, Díez J, Jaisser F, Pizard A, Zannad F.

Eur J Heart Fail. 2017 Feb;19(2):177-191. doi: 10.1002/ejhf.696. Review.


Preventive and chronic mineralocorticoid receptor antagonism is highly beneficial in obese SHHF rats.

Youcef G, Olivier A, Nicot N, Muller A, Deng C, Labat C, Fay R, Rodriguez-Guéant RM, Leroy C, Jaisser F, Zannad F, Lacolley P, Vallar L, Pizard A.

Br J Pharmacol. 2016 Jun;173(11):1805-19. doi: 10.1111/bph.13479. Epub 2016 Apr 26.


Searching for new mechanisms of myocardial fibrosis with diagnostic and/or therapeutic potential.

Heymans S, González A, Pizard A, Papageorgiou AP, López-Andrés N, Jaisser F, Thum T, Zannad F, Díez J.

Eur J Heart Fail. 2015 Aug;17(8):764-71. doi: 10.1002/ejhf.312. Epub 2015 Jun 30. Review. Erratum in: Eur J Heart Fail. 2015 Sep;17(9):985.


Tissue kallikrein is required for the cardioprotective effect of cyclosporin A in myocardial ischemia in the mouse.

Youcef G, Belaidi E, Waeckel L, Fazal L, Clemessy M, Vincent MP, Zadigue G, Richer C, Alhenc-Gelas F, Ovize M, Pizard A.

Biochem Pharmacol. 2015 Mar 1;94(1):22-9. doi: 10.1016/j.bcp.2015.01.007. Epub 2015 Jan 23.


Simultaneous characterization of metabolic, cardiac, vascular and renal phenotypes of lean and obese SHHF rats.

Youcef G, Olivier A, L'Huillier CP, Labat C, Fay R, Tabcheh L, Toupance S, Rodriguez-Guéant RM, Bergerot D, Jaisser F, Lacolley P, Zannad F, Laurent Vallar, Pizard A.

PLoS One. 2014 May 15;9(5):e96452. doi: 10.1371/journal.pone.0096452. eCollection 2014.


Disseminated arterial calcification and enhanced myogenic response are associated with abcc6 deficiency in a mouse model of pseudoxanthoma elasticum.

Kauffenstein G, Pizard A, Le Corre Y, Vessières E, Grimaud L, Toutain B, Labat C, Mauras Y, Gorgels TG, Bergen AA, Le Saux O, Lacolley P, Lefthériotis G, Henrion D, Martin L.

Arterioscler Thromb Vasc Biol. 2014 May;34(5):1045-56. doi: 10.1161/ATVBAHA.113.302943. Epub 2014 Mar 27. Erratum in: Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):e16.


Smooth muscle cell mineralocorticoid receptors are mandatory for aldosterone-salt to induce vascular stiffness.

Galmiche G, Pizard A, Gueret A, El Moghrabi S, Ouvrard-Pascaud A, Berger S, Challande P, Jaffe IZ, Labat C, Lacolley P, Jaisser F.

Hypertension. 2014 Mar;63(3):520-526. doi: 10.1161/HYPERTENSIONAHA.113.01967. Epub 2013 Dec 2.


Opposite predictive value of pulse pressure and aortic pulse wave velocity on heart failure with reduced left ventricular ejection fraction: insights from an Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) substudy.

Regnault V, Lagrange J, Pizard A, Safar ME, Fay R, Pitt B, Challande P, Rossignol P, Zannad F, Lacolley P.

Hypertension. 2014 Jan;63(1):105-11. doi: 10.1161/HYPERTENSIONAHA.113.02046. Epub 2013 Oct 14.


A new pyrroline compound selective for I1-imidazoline receptors improves metabolic syndrome in rats.

Fellmann L, Regnault V, Greney H, Gasparik V, Muscat A, Max JP, Gigou L, Oréa V, Chetrite G, Pizard A, Niederhoffer N, Julien C, Lacolley P, Fève B, Bousquet P.

J Pharmacol Exp Ther. 2013 Sep;346(3):370-80. doi: 10.1124/jpet.113.205328. Epub 2013 Jul 1. Erratum in: J Pharmacol Exp Ther. 2013 Oct;347(1):249.


Selective involvement of serum response factor in pressure-induced myogenic tone in resistance arteries.

Retailleau K, Toutain B, Galmiche G, Fassot C, Sharif-Naeini R, Kauffenstein G, Mericskay M, Duprat F, Grimaud L, Merot J, Lardeux A, Pizard A, Baudrie V, Jeunemaitre X, Feil R, Göthert JR, Lacolley P, Henrion D, Li Z, Loufrani L.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):339-46. doi: 10.1161/ATVBAHA.112.300708. Epub 2012 Dec 20.


Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney.

Pizard A, Richer C, Bouby N, Picard N, Meneton P, Azizi M, Alhenc-Gelas F.

Biol Chem. 2008 Jun;389(6):701-6. doi: 10.1515/BC.2008.081. Review.


Aspirin inhibits human bradykinin B2 receptor ligand binding function.

Gardes J, Michineau S, Pizard A, Alhenc-Gelas F, Rajerison RM.

Biochem Pharmacol. 2008 May 1;75(9):1807-16. doi: 10.1016/j.bcp.2008.02.001. Epub 2008 Feb 12.


Whole-mount in situ hybridization and detection of RNAs in vertebrate embryos and isolated organs.

Pizard A, Haramis A, Carrasco AE, Franco P, López S, Paganelli A.

Curr Protoc Mol Biol. 2004 May;Chapter 14:Unit 14.9. doi: 10.1002/0471142727.mb1409s66.


Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease.

Wolf CM, Wang L, Alcalai R, Pizard A, Burgon PG, Ahmad F, Sherwood M, Branco DM, Wakimoto H, Fishman GI, See V, Stewart CL, Conner DA, Berul CI, Seidman CE, Seidman JG.

J Mol Cell Cardiol. 2008 Feb;44(2):293-303. doi: 10.1016/j.yjmcc.2007.11.008. Epub 2007 Dec 3.


Tissue kallikrein is involved in the cardioprotective effect of AT1-receptor blockade in acute myocardial ischemia.

Messadi-Laribi E, Griol-Charhbili V, Pizard A, Vincent MP, Heudes D, Meneton P, Alhenc-Gelas F, Richer C.

J Pharmacol Exp Ther. 2007 Oct;323(1):210-6. Epub 2007 Jul 16.


Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.

Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG.

Dev Biol. 2006 Sep 15;297(2):566-86. Epub 2006 May 24. Erratum in: Dev Biol. 2007 Sep 15;309(2):386.


Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.

Pizard A, Burgon PG, Paul DL, Bruneau BG, Seidman CE, Seidman JG.

Mol Cell Biol. 2005 Jun;25(12):5073-83.


Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.

Schönberger J, Wang L, Shin JT, Kim SD, Depreux FF, Zhu H, Zon L, Pizard A, Kim JB, Macrae CA, Mungall AJ, Seidman JG, Seidman CE.

Nat Genet. 2005 Apr;37(4):418-22. Epub 2005 Feb 27.


The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.

Moskowitz IP, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JG.

Development. 2004 Aug;131(16):4107-16.


N-linked glycosylation of the human bradykinin B2 receptor is required for optimal cell-surface expression and coupling.

Michineau S, Muller L, Pizard A, Alhenc-Gélas F, Rajerison RM.

Biol Chem. 2004 Jan;385(1):49-57.


Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.

Arad M, Moskowitz IP, Patel VV, Ahmad F, Perez-Atayde AR, Sawyer DB, Walter M, Li GH, Burgon PG, Maguire CT, Stapleton D, Schmitt JP, Guo XX, Pizard A, Kupershmidt S, Roden DM, Berul CI, Seidman CE, Seidman JG.

Circulation. 2003 Jun 10;107(22):2850-6. Epub 2003 Jun 2.


A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation.

Duchene J, Schanstra JP, Pecher C, Pizard A, Susini C, Esteve JP, Bascands JL, Girolami JP.

J Biol Chem. 2002 Oct 25;277(43):40375-83. Epub 2002 Aug 12.


Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity.

Slim R, Torremocha F, Moreau T, Pizard A, Hunt SC, Vuagnat A, Williams GH, Gauthier F, Jeunemaitre X, Alhenc-Gelas F.

J Am Soc Nephrol. 2002 Apr;13(4):968-76.


Palmitoylation of the human bradykinin B2 receptor influences ligand efficacy.

Pizard A, Blaukat A, Michineau S, Dikic I, Müller-Esterl W, Alhenc-Gelas F, Rajerison RM.

Biochemistry. 2001 Dec 25;40(51):15743-51.


Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I.

J Biol Chem. 2001 Nov 2;276(44):40431-40. Epub 2001 Aug 21.


Activation of mitogen-activated protein kinase by the bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation-triggered internalization.

Blaukat A, Pizard A, Rajerison RM, Alhenc-Gelas F, Müller-Esterl W, Dikic I.

FEBS Lett. 1999 May 28;451(3):337-41.


Bradykinin-induced internalization of the human B2 receptor requires phosphorylation of three serine and two threonine residues at its carboxyl tail.

Pizard A, Blaukat A, Müller-Esterl W, Alhenc-Gelas F, Rajerison RM.

J Biol Chem. 1999 Apr 30;274(18):12738-47.


Negative cooperativity in the human bradykinin B2 receptor.

Pizard A, Marchetti J, Allegrini J, Alhenc-Gelas F, Rajerison RM.

J Biol Chem. 1998 Jan 16;273(3):1309-15.


Receptors for kinins in the human isolated umbilical vein.

Gobeil F, Pheng LH, Badini I, Nguyen-Le XK, Pizard A, Rizzi A, Blouin D, Regoli D.

Br J Pharmacol. 1996 May;118(2):289-94.

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