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Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy To Identify Metabolic Biomarkers in Pancreatic Cancer.

Dutta P, Perez MR, Lee J, Kang Y, Pratt M, Salzillo TC, Weygand J, Zacharias NM, Gammon ST, Koay EJ, Kim M, McAllister F, Sen S, Maitra A, Piwnica-Worms D, Fleming JB, Bhattacharya PK.

J Proteome Res. 2019 Jul 5;18(7):2826-2834. doi: 10.1021/acs.jproteome.9b00132. Epub 2019 Jun 4.


Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study.

Biagiotti G, Pisaneschi F, Gammon ST, Machetti F, Ligi MC, Giambastiani G, Tuci G, Powell E, Piwnica-Worms H, Pranzini E, Paoli P, Cicchi S, Piwnica-Worms D.

J Mater Chem B. 2019 Apr 28;7(16):2678-2687. doi: 10.1039/C8TB03299H. Epub 2019 Mar 12.


Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies.

Orteca G, Pisaneschi F, Rubagotti S, Liu TW, Biagiotti G, Piwnica-Worms D, Iori M, Capponi PC, Ferrari E, Asti M.

Molecules. 2019 Feb 12;24(3). pii: E644. doi: 10.3390/molecules24030644.


Caspase-3 Substrates for Noninvasive Pharmacodynamic Imaging of Apoptosis by PET/CT.

Engel BJ, Gammon ST, Chaudhari R, Lu Z, Pisaneschi F, Yang H, Ornelas A, Yan V, Kelderhouse L, Najjar AM, Tong WP, Zhang S, Piwnica-Worms D, Bast RC Jr, Millward SW.

Bioconjug Chem. 2018 Sep 19;29(9):3180-3195. doi: 10.1021/acs.bioconjchem.8b00514. Epub 2018 Aug 31.


A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models.

Zinn PO, Singh SK, Kotrotsou A, Hassan I, Thomas G, Luedi MM, Elakkad A, Elshafeey N, Idris T, Mosley J, Gumin J, Fuller GN, de Groot JF, Baladandayuthapani V, Sulman EP, Kumar AJ, Sawaya R, Lang FF, Piwnica-Worms D, Colen RR.

Clin Cancer Res. 2018 Dec 15;24(24):6288-6299. doi: 10.1158/1078-0432.CCR-17-3420. Epub 2018 Jul 27.


Spatial and Temporal Confined Photothermolysis of Cancer Cells Mediated by Hollow Gold Nanospheres Targeted to Epidermal Growth Factor Receptors.

Ku G, Huang Q, Wen X, Ye J, Piwnica-Worms D, Li C.

ACS Omega. 2018 May 31;3(5):5888-5895. doi: 10.1021/acsomega.8b00712.


Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo.

Zacharias N, Lee J, Ramachandran S, Shanmugavelandy S, McHenry J, Dutta P, Millward S, Gammon S, Efstathiou E, Troncoso P, Frigo DE, Piwnica-Worms D, Logothetis CJ, Maity SN, Titus MA, Bhattacharya P.

Mol Imaging Biol. 2019 Feb;21(1):86-94. doi: 10.1007/s11307-018-1199-6.


Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFκB Activation.

Flentie K, Gonzalez C, Kocher B, Wang Y, Zhu H, Marasa J, Piwnica-Worms D.

Mol Cancer Res. 2018 Jun;16(6):986-999. doi: 10.1158/1541-7786.MCR-17-0603. Epub 2018 Mar 9.


Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy.

Zhao J, Wang H, Hsiao CH, Chow DS, Koay EJ, Kang Y, Wen X, Huang Q, Ma Y, Bankson JA, Ullrich SE, Overwijk W, Maitra A, Piwnica-Worms D, Fleming JB, Li C.

Biomaterials. 2018 Mar;159:215-228. doi: 10.1016/j.biomaterials.2018.01.014. Epub 2018 Jan 9.


p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells.

Nickless A, Cheruiyot A, Flanagan KC, Piwnica-Worms D, Stewart SA, You Z.

J Biol Chem. 2017 Sep 15;292(37):15266-15276. doi: 10.1074/jbc.M117.787846. Epub 2017 Aug 1.


Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers.

Pisaneschi F, Kelderhouse LE, Hardy A, Engel BJ, Mukhopadhyay U, Gonzalez-Lepera C, Gray JP, Ornelas A, Takahashi TT, Roberts RW, Fiacco SV, Piwnica-Worms D, Millward SW.

Bioconjug Chem. 2017 Feb 15;28(2):583-589. doi: 10.1021/acs.bioconjchem.6b00678. Epub 2017 Feb 2.


Synthesis of a [(18)F]-labeled ceritinib analogue for positron emission tomography of anaplastic lymphoma kinase, a receptor tyrosine kinase, in lung cancer.

Perera S, Piwnica-Worms D, Alauddin MM.

J Labelled Comp Radiopharm. 2016 Mar;59(3):103-8. doi: 10.1002/jlcr.3373. Epub 2016 Feb 8.


p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer.

Powell E, Shao J, Yuan Y, Chen HC, Cai S, Echeverria GV, Mistry N, Decker KF, Schlosberg C, Do KA, Edwards JR, Liang H, Piwnica-Worms D, Piwnica-Worms H.

Breast Cancer Res. 2016 Jan 27;18(1):13. doi: 10.1186/s13058-016-0673-9.


Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival.

Tinkum KL, Stemler KM, White LS, Loza AJ, Jeter-Jones S, Michalski BM, Kuzmicki C, Pless R, Stappenbeck TS, Piwnica-Worms D, Piwnica-Worms H.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7148-54. doi: 10.1073/pnas.1509249112. Epub 2015 Dec 7.


The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas.

Rosario M, Liu B, Kong L, Collins LI, Schneider SE, Chen X, Han K, Jeng EK, Rhode PR, Leong JW, Schappe T, Jewell BA, Keppel CR, Shah K, Hess B, Romee R, Piwnica-Worms DR, Cashen AF, Bartlett NL, Wong HC, Fehniger TA.

Clin Cancer Res. 2016 Feb 1;22(3):596-608. doi: 10.1158/1078-0432.CCR-15-1419. Epub 2015 Sep 30.


Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions.

Sengupta R, Barone A, Marasa J, Taylor S, Jackson E, Warrington NM, Rao S, Kim AH, Leonard JR, Piwnica-Worms D, Rubin JB.

Oncotarget. 2015 Jul 30;6(21):18282-92.


Glypican-1 identifies cancer exosomes and detects early pancreatic cancer.

Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Weitz J, Rahbari N, Reissfelder C, Pilarsky C, Fraga MF, Piwnica-Worms D, Kalluri R.

Nature. 2015 Jul 9;523(7559):177-82. doi: 10.1038/nature14581. Epub 2015 Jun 24.


From the Guest Editor: Illuminating Cancer In Vivo With Molecular Imaging.

Piwnica-Worms D.

Cancer J. 2015 May-Jun;21(3):150-1. doi: 10.1097/PPO.0000000000000121. No abstract available.


[(18)F]FHBG PET/CT Imaging of CD34-TK75 Transduced Donor T Cells in Relapsed Allogeneic Stem Cell Transplant Patients: Safety and Feasibility.

Eissenberg LG, Rettig MP, Ritchey JK, Prior JL, Schwarz SW, Frye J, White BS, Fulton RS, Ghobadi A, Cooper ML, Couriel DR, Seegulam ME, Piwnica-Worms D, Dehdashti F, Cornetta K, DiPersio JF.

Mol Ther. 2015 Jun;23(6):1110-1122. doi: 10.1038/mt.2015.48. Epub 2015 Mar 25.


A rapid bioluminescence assay for measuring myeloperoxidase activity in human plasma.

Goiffon RJ, Martinez SC, Piwnica-Worms D.

Nat Commun. 2015 Feb 10;6:6271. doi: 10.1038/ncomms7271.


Type I interferons link viral infection to enhanced epithelial turnover and repair.

Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS.

Cell Host Microbe. 2015 Jan 14;17(1):85-97. doi: 10.1016/j.chom.2014.11.004. Epub 2014 Dec 4.


Suicide genes: monitoring cells in patients with a safety switch.

Eissenberg LG, Rettig M, Dehdashti F, Piwnica-Worms D, DiPersio JF.

Front Pharmacol. 2014 Nov 6;5:241. doi: 10.3389/fphar.2014.00241. eCollection 2014.


A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion.

Sharma V, Sivapackiam J, Harpstrite SE, Prior JL, Gu H, Rath NP, Piwnica-Worms D.

PLoS One. 2014 Oct 29;9(10):e109361. doi: 10.1371/journal.pone.0109361. eCollection 2014.


DAPK3 suppresses acini morphogenesis and is required for mouse development.

Kocher BA, White LS, Piwnica-Worms D.

Mol Cancer Res. 2015 Feb;13(2):358-67. doi: 10.1158/1541-7786.MCR-14-0333. Epub 2014 Oct 10.


Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma.

Barone A, Sengupta R, Warrington NM, Smith E, Wen PY, Brekken RA, Romagnoli B, Douglas G, Chevalier E, Bauer MP, Dembowsky K, Piwnica-Worms D, Rubin JB.

Oncotarget. 2014 Oct 30;5(20):9811-22.


Chemical reaction-induced multi-molecular polarization (CRIMP).

Lee Y, Zacharias NM, Piwnica-Worms D, Bhattacharya PK.

Chem Commun (Camb). 2014 Nov 7;50(86):13030-3. doi: 10.1039/c4cc06199c.


PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.

Brooks MD, Jackson E, Warrington NM, Luo J, Forys JT, Taylor S, Mao DD, Leonard JR, Kim AH, Piwnica-Worms D, Mitra RD, Rubin JB.

PLoS One. 2014 Sep 9;9(9):e107397. doi: 10.1371/journal.pone.0107397. eCollection 2014.


Intracellular calcium regulates nonsense-mediated mRNA decay.

Nickless A, Jackson E, Marasa J, Nugent P, Mercer RW, Piwnica-Worms D, You Z.

Nat Med. 2014 Aug;20(8):961-6. doi: 10.1038/nm.3620. Epub 2014 Jul 27.


Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imaging.

Hensley H, Devarajan K, Johnson JR, Piwnica-Worms D, Godwin AK, von Mehren M, Rink L.

Cancer Biol Ther. 2014 Jul;15(7):911-8. doi: 10.4161/cbt.28880. Epub 2014 Apr 22.


A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.

Elhammali A, Ippolito JE, Collins L, Crowley J, Marasa J, Piwnica-Worms D.

Cancer Discov. 2014 Jul;4(7):828-39. doi: 10.1158/2159-8290.CD-13-0572. Epub 2014 Apr 16.


Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4.

Liu H, Westergard TD, Cashen A, Piwnica-Worms DR, Kunkle L, Vij R, Pham CG, DiPersio J, Cheng EH, Hsieh JJ.

Cancer Cell. 2014 Apr 14;25(4):530-42. doi: 10.1016/j.ccr.2014.03.008.


p38MAPK plays a crucial role in stromal-mediated tumorigenesis.

Alspach E, Flanagan KC, Luo X, Ruhland MK, Huang H, Pazolli E, Donlin MJ, Marsh T, Piwnica-Worms D, Monahan J, Novack DV, McAllister SS, Stewart SA.

Cancer Discov. 2014 Jun;4(6):716-29. doi: 10.1158/2159-8290.CD-13-0743. Epub 2014 Mar 26.


Contribution of p53 to metastasis.

Powell E, Piwnica-Worms D, Piwnica-Worms H.

Cancer Discov. 2014 Apr;4(4):405-14. doi: 10.1158/2159-8290.CD-13-0136. Epub 2014 Mar 21. Review.


Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer.

Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG, Spitzer D.

Mol Cancer. 2014 Mar 7;13:50. doi: 10.1186/1476-4598-13-50.


Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe.

Qiu X, Johnson JR, Wilson BS, Gammon ST, Piwnica-Worms D, Barnett EM.

PLoS One. 2014 Feb 21;9(2):e88855. doi: 10.1371/journal.pone.0088855. eCollection 2014.


A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer.

Ippolito JE, Piwnica-Worms D.

PLoS One. 2014 Feb 13;9(2):e88667. doi: 10.1371/journal.pone.0088667. eCollection 2014.


Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3.

Garg G, Gibbs J, Belt B, Powell MA, Mutch DG, Goedegebuure P, Collins L, Piwnica-Worms D, Hawkins WG, Spitzer D.

BMC Cancer. 2014 Jan 21;14:35. doi: 10.1186/1471-2407-14-35.


F11R is a novel monocyte prognostic biomarker for malignant glioma.

Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH.

PLoS One. 2013 Oct 11;8(10):e77571. doi: 10.1371/journal.pone.0077571. eCollection 2013.


Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging.

Macdonald-Obermann JL, Adak S, Landgraf R, Piwnica-Worms D, Pike LJ.

J Biol Chem. 2013 Oct 18;288(42):30773-84. doi: 10.1074/jbc.M113.489534. Epub 2013 Sep 6.


Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice.

Tinkum KL, White LS, Marpegan L, Herzog E, Piwnica-Worms D, Piwnica-Worms H.

J Biol Chem. 2013 Sep 27;288(39):27999-8008. doi: 10.1074/jbc.M113.494328. Epub 2013 Aug 5.


The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.

Liu Z, Chen S, Boyle S, Zhu Y, Zhang A, Piwnica-Worms DR, Ilagan MX, Kopan R.

Dev Cell. 2013 Jun 24;25(6):585-98. doi: 10.1016/j.devcel.2013.05.022.


18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas.

Sai KK, Huang C, Yuan L, Zhou D, Piwnica-Worms D, Garbow JR, Engelbach JA, Mach RH, Rich KM, McConathy J.

J Nucl Med. 2013 Jul;54(7):1120-6. doi: 10.2967/jnumed.112.113217. Epub 2013 May 6.


The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.

Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD.

Nat Cell Biol. 2013 Jun;15(6):677-87. doi: 10.1038/ncb2743. Epub 2013 May 5.


Illuminating cancer systems with genetically engineered mouse models and coupled luciferase reporters in vivo.

Kocher B, Piwnica-Worms D.

Cancer Discov. 2013 Jun;3(6):616-29. doi: 10.1158/2159-8290.CD-12-0503. Epub 2013 Apr 12. Review.


Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation.

Yang C, Davis JL, Zeng R, Vora P, Su X, Collins LI, Vangveravong S, Mach RH, Piwnica-Worms D, Weilbaecher KN, Faccio R, Novack DV.

Cancer Discov. 2013 Feb;3(2):212-23. doi: 10.1158/2159-8290.CD-12-0271. Epub 2012 Dec 26.


Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.

Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG.

Cancer Res. 2013 Feb 1;73(3):1128-41. doi: 10.1158/0008-5472.CAN-12-2731. Epub 2012 Dec 5.


The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.

Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN.

J Clin Invest. 2012 Oct;122(10):3579-92. doi: 10.1172/JCI38576. Epub 2012 Sep 17.


IFNγR signaling mediates alloreactive T-cell trafficking and GVHD.

Choi J, Ziga ED, Ritchey J, Collins L, Prior JL, Cooper ML, Piwnica-Worms D, DiPersio JF.

Blood. 2012 Nov 8;120(19):4093-103. doi: 10.1182/blood-2012-01-403196. Epub 2012 Sep 12.


Caspase-activated cell-penetrating peptides reveal temporal coupling between endosomal release and apoptosis in an RGC-5 cell model.

Johnson JR, Kocher B, Barnett EM, Marasa J, Piwnica-Worms D.

Bioconjug Chem. 2012 Sep 19;23(9):1783-93. Epub 2012 Aug 30.


Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.

Li Y, Macdonald-Obermann J, Westfall C, Piwnica-Worms D, Pike LJ.

J Biol Chem. 2012 Sep 7;287(37):31116-25. doi: 10.1074/jbc.M112.373647. Epub 2012 Jul 20.

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