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Items: 1 to 50 of 123

1.

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R.

Nat Biomed Eng. 2018 Aug;2(8):578-588. doi: 10.1038/s41551-018-0236-8. Epub 2018 May 21.

PMID:
31015631
2.

Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

Nat Commun. 2019 Apr 17;10(1):1883. doi: 10.1038/s41467-019-09838-y.

3.

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species.

Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ, Klein AM.

Immunity. 2019 May 21;50(5):1317-1334.e10. doi: 10.1016/j.immuni.2019.03.009. Epub 2019 Apr 9.

PMID:
30979687
4.

Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

Nat Commun. 2019 Apr 2;10(1):1486. doi: 10.1038/s41467-019-09415-3. Erratum in: Nat Commun. 2019 Apr 17;10(1):1883.

5.

Natural killer cells limit the clearance of senescent lung adenocarcinoma cells.

Stokes KL, Cortez-Retamozo V, Acosta J, Lauderback B, Robles-Oteiza C, Cicchini M, Pittet MJ, Feldser DM.

Oncogenesis. 2019 Apr 1;8(4):24. doi: 10.1038/s41389-019-0133-3.

6.

Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.

Courties G, Frodermann V, Honold L, Zheng Y, Herisson F, Schloss MJ, Sun Y, Presumey J, Severe N, Engblom C, Hulsmans M, Cremer S, Rohde D, Pittet MJ, Scadden DT, Swirski FK, Kim DE, Moskowitz MA, Nahrendorf M.

Circ Res. 2019 Apr 26;124(9):1372-1385. doi: 10.1161/CIRCRESAHA.118.314518.

PMID:
30782088
7.

Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages.

Arlauckas SP, Garren SB, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R.

Theranostics. 2018 Nov 12;8(21):5842-5854. doi: 10.7150/thno.26888. eCollection 2018.

8.

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ.

Immunity. 2018 Dec 18;49(6):1148-1161.e7. doi: 10.1016/j.immuni.2018.09.024. Epub 2018 Dec 11.

PMID:
30552023
9.

Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.

Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet MJ, Nahrendorf M, Weissleder R, Miller MA.

ACS Nano. 2018 Dec 26;12(12):12015-12029. doi: 10.1021/acsnano.8b04338. Epub 2018 Dec 11.

10.

Correction: Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.

Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-Kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ.

Mucosal Immunol. 2019 Mar;12(2):580. doi: 10.1038/s41385-018-0074-8.

PMID:
30514887
11.

Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells.

Oh J, Magnuson A, Benoist C, Pittet MJ, Weissleder R.

JCI Insight. 2018 Nov 2;3(21). pii: 122961. doi: 10.1172/jci.insight.122961.

12.

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R.

Nat Biomed Eng. 2018;2:578-588. Epub 2018 May 21.

13.

Recording the wild lives of immune cells.

Pittet MJ, Garris CS, Arlauckas SP, Weissleder R.

Sci Immunol. 2018 Sep 7;3(27). pii: eaaq0491. doi: 10.1126/sciimmunol.aaq0491. Review.

PMID:
30194240
14.

Understanding the tumor immune microenvironment (TIME) for effective therapy.

Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF.

Nat Med. 2018 May;24(5):541-550. doi: 10.1038/s41591-018-0014-x. Epub 2018 Apr 23. Review.

15.

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ.

Science. 2017 Dec 1;358(6367). pii: eaal5081. doi: 10.1126/science.aal5081.

16.

Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease.

Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R.

Chem Commun (Camb). 2017 Dec 19;54(1):42-45. doi: 10.1039/c7cc07581b.

17.

Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.

Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ.

Mucosal Immunol. 2018 May;11(3):703-715. doi: 10.1038/mi.2017.91. Epub 2017 Nov 15. Erratum in: Mucosal Immunol. 2019 Mar;12(2):580. Parada-kusz, M [added].

18.

Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts.

Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R.

Sci Transl Med. 2017 May 31;9(392). pii: eaal0225. doi: 10.1126/scitranslmed.aal0225.

PMID:
28566423
19.

In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy.

Arlauckas SP, Garris CS, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ.

Sci Transl Med. 2017 May 10;9(389). pii: eaal3604. doi: 10.1126/scitranslmed.aal3604.

20.

Tumor Microenvironment: No Effector T Cells without Dendritic Cells.

Pfirschke C, Siwicki M, Liao HW, Pittet MJ.

Cancer Cell. 2017 May 8;31(5):614-615. doi: 10.1016/j.ccell.2017.04.007.

21.

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.

Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R.

Nat Commun. 2017 Feb 8;8:14293. doi: 10.1038/ncomms14293.

22.

PF4 Promotes Platelet Production and Lung Cancer Growth.

Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ.

Cell Rep. 2016 Nov 8;17(7):1764-1772. doi: 10.1016/j.celrep.2016.10.031.

23.

Gal3 Links Inflammation and Insulin Resistance.

Siwicki M, Engblom C, Pittet MJ.

Cell Metab. 2016 Nov 8;24(5):655-656. doi: 10.1016/j.cmet.2016.10.014.

24.

The role of myeloid cells in cancer therapies.

Engblom C, Pfirschke C, Pittet MJ.

Nat Rev Cancer. 2016 Jul;16(7):447-62. doi: 10.1038/nrc.2016.54. Review.

PMID:
27339708
25.

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.

Spiegel A, Brooks MW, Houshyar S, Reinhardt F, Ardolino M, Fessler E, Chen MB, Krall JA, DeCock J, Zervantonakis IK, Iannello A, Iwamoto Y, Cortez-Retamozo V, Kamm RD, Pittet MJ, Raulet DH, Weinberg RA.

Cancer Discov. 2016 Jun;6(6):630-49. doi: 10.1158/2159-8290.CD-15-1157. Epub 2016 Apr 12.

26.

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.

Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ.

Science. 2016 Apr 8;352(6282):242-6. doi: 10.1126/science.aaf1328. Epub 2016 Mar 17.

27.

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy.

Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ, Kroemer G, Zitvogel L, Weissleder R, Pittet MJ.

Immunity. 2016 Feb 16;44(2):343-54. doi: 10.1016/j.immuni.2015.11.024. Epub 2016 Feb 9.

28.

Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.

Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ, Kelleher CM, Scadden DT, Sweetser DA.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1871-6. doi: 10.1073/pnas.1511380113. Epub 2016 Feb 1.

29.

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle.

Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R.

Sci Transl Med. 2015 Nov 18;7(314):314ra183. doi: 10.1126/scitranslmed.aac6522.

30.

ER Stress in Dendritic Cells Promotes Cancer.

Garris CS, Pittet MJ.

Cell. 2015 Jun 18;161(7):1492-3. doi: 10.1016/j.cell.2015.06.006.

31.

Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor.

Azroyan A, Cortez-Retamozo V, Bouley R, Liberman R, Ruan YC, Kiselev E, Jacobson KA, Pittet MJ, Brown D, Breton S.

PLoS One. 2015 Mar 23;10(3):e0121419. doi: 10.1371/journal.pone.0121419. eCollection 2015.

32.

Common TLR5 mutations control cancer progression.

Pfirschke C, Garris C, Pittet MJ.

Cancer Cell. 2015 Jan 12;27(1):1-3. doi: 10.1016/j.ccell.2014.12.008.

33.

Mononuclear phagocytes rapidly clear apoptotic epithelial cells in the proximal epididymis.

Smith TB, Cortez-Retamozo V, Grigoryeva LS, Hill E, Pittet MJ, Da Silva N.

Andrology. 2014 Sep;2(5):755-62. doi: 10.1111/j.2047-2927.2014.00251.x. Epub 2014 Aug 1.

34.

Harnessing the intestinal microbiome for optimal therapeutic immunomodulation.

Viaud S, Daillère R, Boneca IG, Lepage P, Pittet MJ, Ghiringhelli F, Trinchieri G, Goldszmid R, Zitvogel L.

Cancer Res. 2014 Aug 15;74(16):4217-21. doi: 10.1158/0008-5472.CAN-14-0987. Epub 2014 Jul 29. Review.

35.

Gut microbiome and anticancer immune response: really hot Sh*t!

Viaud S, Daillère R, Boneca IG, Lepage P, Langella P, Chamaillard M, Pittet MJ, Ghiringhelli F, Trinchieri G, Goldszmid R, Zitvogel L.

Cell Death Differ. 2015 Feb;22(2):199-214. doi: 10.1038/cdd.2014.56. Epub 2014 May 16. Review.

36.

The journey from stem cell to macrophage.

Pittet MJ, Nahrendorf M, Swirski FK.

Ann N Y Acad Sci. 2014 Jun;1319:1-18. doi: 10.1111/nyas.12393. Epub 2014 Mar 27. Review.

37.

Epithelial basal cells are distinct from dendritic cells and macrophages in the mouse epididymis.

Shum WW, Smith TB, Cortez-Retamozo V, Grigoryeva LS, Roy JW, Hill E, Pittet MJ, Breton S, Da Silva N.

Biol Reprod. 2014 May 1;90(5):90. doi: 10.1095/biolreprod.113.116681. Print 2014 May.

38.

Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer.

Schietinger A, Arina A, Liu RB, Wells S, Huang J, Engels B, Bindokas V, Bartkowiak T, Lee D, Herrmann A, Piston DW, Pittet MJ, Lin PC, Zal T, Schreiber H.

Oncoimmunology. 2013 Nov 1;2(11):e26677. Epub 2013 Nov 4.

39.

Imaging macrophages with nanoparticles.

Weissleder R, Nahrendorf M, Pittet MJ.

Nat Mater. 2014 Feb;13(2):125-38. doi: 10.1038/nmat3780. Review.

PMID:
24452356
40.

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.

Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, Schlitzer A, Ginhoux F, Apetoh L, Chachaty E, Woerther PL, Eberl G, Bérard M, Ecobichon C, Clermont D, Bizet C, Gaboriau-Routhiau V, Cerf-Bensussan N, Opolon P, Yessaad N, Vivier E, Ryffel B, Elson CO, Doré J, Kroemer G, Lepage P, Boneca IG, Ghiringhelli F, Zitvogel L.

Science. 2013 Nov 22;342(6161):971-6. doi: 10.1126/science.1240537.

41.

The spleen in local and systemic regulation of immunity.

Bronte V, Pittet MJ.

Immunity. 2013 Nov 14;39(5):806-18. doi: 10.1016/j.immuni.2013.10.010. Review.

42.

Therapeutically reeducating macrophages to treat GBM.

Garris C, Pittet MJ.

Nat Med. 2013 Oct;19(10):1207-8. doi: 10.1038/nm.3355.

PMID:
24100977
43.

Remote control of macrophage production by cancer.

Cortez-Retamozo V, Engblom C, Pittet MJ.

Oncoimmunology. 2013 May 1;2(5):e24183.

44.

MicroRNA-mediated control of macrophages and its implications for cancer.

Squadrito ML, Etzrodt M, De Palma M, Pittet MJ.

Trends Immunol. 2013 Jul;34(7):350-9. doi: 10.1016/j.it.2013.02.003. Epub 2013 Mar 13. Review.

45.

Molecular pathways: tumor-derived microvesicles and their interactions with immune cells in vivo.

Pucci F, Pittet MJ.

Clin Cancer Res. 2013 May 15;19(10):2598-604. doi: 10.1158/1078-0432.CCR-12-0962. Epub 2013 Feb 20.

46.

Angiotensin II drives the production of tumor-promoting macrophages.

Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ.

Immunity. 2013 Feb 21;38(2):296-308. doi: 10.1016/j.immuni.2012.10.015. Epub 2013 Jan 17.

47.

Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium.

Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM.

PLoS Biol. 2012;10(9):e1001393. doi: 10.1371/journal.pbio.1001393. Epub 2012 Sep 25.

48.

Myocardial infarction accelerates atherosclerosis.

Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M.

Nature. 2012 Jul 19;487(7407):325-9. doi: 10.1038/nature11260.

49.

Regulation of monocyte functional heterogeneity by miR-146a and Relb.

Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ.

Cell Rep. 2012 Apr 19;1(4):317-24.

50.

Regulation of macrophage and dendritic cell responses by their lineage precursors.

Cortez-Retamozo V, Etzrodt M, Pittet MJ.

J Innate Immun. 2012;4(5-6):411-23. doi: 10.1159/000335733. Epub 2012 Mar 16. Review.

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