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Items: 1 to 20 of 157


An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.

Gade AR, Marx SO, Pitt GS.

J Gen Physiol. 2020 Feb 3;152(2). pii: e201912434. doi: 10.1085/jgp.201912434.


Ca2+/CaM interaction with voltage-gated Na+ channels.

Pitt GS, Lee SY.

Proc Natl Acad Sci U S A. 2019 Dec 3. pii: 201909835. doi: 10.1073/pnas.1909835116. [Epub ahead of print] No abstract available.


Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.

Sinden DS, Holman CD, Bare CJ, Sun X, Gade AR, Cohen DE, Pitt GS.

FASEB J. 2019 Oct;33(10):11579-11594. doi: 10.1096/fj.201901178R. Epub 2019 Jul 24.


The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.

Cao C, Oswald AB, Fabella BA, Ren Y, Rodriguiz R, Trainor G, Greenblatt MB, Hilton MJ, Pitt GS.

Bone. 2019 Aug;125:160-168. doi: 10.1016/j.bone.2019.05.024. Epub 2019 May 20.


Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.

Yang L, Katchman A, Kushner J, Kushnir A, Zakharov SI, Chen BX, Shuja Z, Subramanyam P, Liu G, Papa A, Roybal D, Pitt GS, Colecraft HM, Marx SO.

J Clin Invest. 2019 Feb 1;129(2):647-658. doi: 10.1172/JCI123878. Epub 2019 Jan 7.


An update on the journey towards precision medicine in cardiology.

Pitt GS.

Eur Heart J. 2018 Oct 21;39(40):3627-3628. doi: 10.1093/eurheartj/ehy637. No abstract available.


The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.

Abraham DM, Lee TE, Watson LJ, Mao L, Chandok G, Wang HG, Frangakis S, Pitt GS, Shah SH, Wolf MJ, Rockman HA.

J Clin Invest. 2018 Nov 1;128(11):4843-4855. doi: 10.1172/JCI95945. Epub 2018 Oct 2.


Progress in Understanding and Treating SCN2A-Mediated Disorders.

Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ.

Trends Neurosci. 2018 Jul;41(7):442-456. doi: 10.1016/j.tins.2018.03.011. Epub 2018 Apr 23. Review.


Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.

Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SH, Park-Min KH, McNulty AL, Guilak F, Karner CM, Hilton MJ, Pitt GS.

JCI Insight. 2017 Nov 16;2(22). pii: 95512. doi: 10.1172/jci.insight.95512. eCollection 2017 Nov 16.


Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.

Katchman A, Yang L, Zakharov SI, Kushner J, Abrams J, Chen BX, Liu G, Pitt GS, Colecraft HM, Marx SO.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9194-9199. doi: 10.1073/pnas.1706054114. Epub 2017 Aug 7.


Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.

Wei EQ, Sinden DS, Mao L, Zhang H, Wang C, Pitt GS.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4010-E4019. doi: 10.1073/pnas.1616393114. Epub 2017 May 1.


Divide, multitask, and conquer: Coordination in channel regulation.

Pablo JL, Pitt GS.

Channels (Austin). 2017 Jul 4;11(4):268-270. doi: 10.1080/19336950.2017.1292814. Epub 2017 Mar 2. No abstract available.


Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.

Wang X, Tang H, Wei EQ, Wang Z, Yang J, Yang R, Wang S, Zhang Y, Pitt GS, Zhang H, Wang C.

J Mol Cell Cardiol. 2017 Mar;104:63-74. doi: 10.1016/j.yjmcc.2017.01.009. Epub 2017 Jan 21.


Calmodulin limits pathogenic Na+ channel persistent current.

Yan H, Wang C, Marx SO, Pitt GS.

J Gen Physiol. 2017 Feb;149(2):277-293. doi: 10.1085/jgp.201611721. Epub 2017 Jan 13.


A view from the side-line.

Pitt GS.

Eur Heart J. 2016 Dec 14;37(47):3488-3489. doi: 10.1093/eurheartj/ehw532. No abstract available.


FGF14 is a regulator of KCNQ2/3 channels.

Pablo JL, Pitt GS.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):154-159. doi: 10.1073/pnas.1610158114. Epub 2016 Dec 19.


Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.

Black JB, Adler AF, Wang HG, D'Ippolito AM, Hutchinson HA, Reddy TE, Pitt GS, Leong KW, Gersbach CA.

Cell Stem Cell. 2016 Sep 1;19(3):406-14. doi: 10.1016/j.stem.2016.07.001. Epub 2016 Aug 11.


Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.

Pitt GS, Lee SY.

Protein Sci. 2016 Sep;25(9):1573-84. doi: 10.1002/pro.2960. Epub 2016 Jun 13. Review.


FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.

Yang J, Wang Z, Sinden DS, Wang X, Shan B, Yu X, Zhang H, Pitt GS, Wang C.

Channels (Austin). 2016 Sep 2;10(5):410-420. Epub 2016 May 31.


Long QT Syndrome and Seizures.

Sun AY, Pitt GS.

JACC Clin Electrophysiol. 2016 Jun;2(3):277-278. doi: 10.1016/j.jacep.2015.12.015. Epub 2016 Mar 23. No abstract available.

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