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p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3.

Baresova P, Musilova J, Pitha PM, Lubyova B.

Mol Cell Biol. 2014 Feb;34(3):386-99. doi: 10.1128/MCB.01011-13. Epub 2013 Nov 18.


Distinct roles of Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factors in inflammatory response and cancer.

Baresova P, Pitha PM, Lubyova B.

J Virol. 2013 Sep;87(17):9398-410. doi: 10.1128/JVI.03315-12. Epub 2013 Jun 19. Review.


Role of hsp90 in systemic lupus erythematosus and its clinical relevance.

Shukla HD, Pitha PM.

Autoimmune Dis. 2012;2012:728605. doi: 10.1155/2012/728605. Epub 2012 Oct 4.


Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists.

Polumuri SK, Jayakar GG, Shirey KA, Roberts ZJ, Perkins DJ, Pitha PM, Vogel SN.

J Immunol. 2012 Jul 1;189(1):50-60. doi: 10.4049/jimmunol.1003554. Epub 2012 May 25.


Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain.

Cao H, Dai P, Wang W, Li H, Yuan J, Wang F, Fang CM, Pitha PM, Liu J, Condit RC, McFadden G, Merghoub T, Houghton AN, Young JW, Shuman S, Deng L.

PLoS One. 2012;7(5):e36823. doi: 10.1371/journal.pone.0036823. Epub 2012 May 14.


Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.

Fang CM, Roy S, Nielsen E, Paul M, Maul R, Paun A, Koentgen F, Raval FM, Szomolanyi-Tsuda E, Pitha PM.

Genes Immun. 2012 Jul;13(5):421-30. doi: 10.1038/gene.2012.10. Epub 2012 Apr 26.


Kaposi sarcoma-associated herpesvirus vIRF-3 protein binds to F-box of Skp2 protein and acts as a regulator of c-Myc protein function and stability.

Baresova P, Pitha PM, Lubyova B.

J Biol Chem. 2012 May 11;287(20):16199-208. doi: 10.1074/jbc.M111.335216. Epub 2012 Mar 27.


Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis.

Panchanathan R, Liu H, Liu H, Fang CM, Erickson LD, Pitha PM, Choubey D.

J Immunol. 2012 Jan 1;188(1):270-8. doi: 10.4049/jimmunol.1102311. Epub 2011 Nov 23.


Innate antiviral response: role in HIV-1 infection.

Pitha PM.

Viruses. 2011 Jul;3(7):1179-203. doi: 10.3390/v3071179. Epub 2011 Jul 14. Review.


Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway.

Dai P, Cao H, Merghoub T, Avogadri F, Wang W, Parikh T, Fang CM, Pitha PM, Fitzgerald KA, Rahman MM, McFadden G, Hu X, Houghton AN, Shuman S, Deng L.

J Virol. 2011 Oct;85(20):10814-25. doi: 10.1128/JVI.00104-11. Epub 2011 Aug 10. Erratum in: J Virol. 2011 Dec;85(23):12835.


Critical role of IRF-5 in the development of T helper 1 responses to Leishmania donovani infection.

Paun A, Bankoti R, Joshi T, Pitha PM, Stäger S.

PLoS Pathog. 2011 Jan 6;7(1):e1001246. doi: 10.1371/journal.ppat.1001246.


Critical role of IRF-5 in regulation of B-cell differentiation.

Lien C, Fang CM, Huso D, Livak F, Lu R, Pitha PM.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4664-8. doi: 10.1073/pnas.0911193107. Epub 2010 Feb 22.


Interaction between Ebola virus glycoprotein and host toll-like receptor 4 leads to induction of proinflammatory cytokines and SOCS1.

Okumura A, Pitha PM, Yoshimura A, Harty RN.

J Virol. 2010 Jan;84(1):27-33. doi: 10.1128/JVI.01462-09.


IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.

Balkhi MY, Fitzgerald KA, Pitha PM.

Cell Signal. 2010 Jan;22(1):117-27. doi: 10.1016/j.cellsig.2009.09.021. Epub 2009 Sep 25.


Antiviral activity of innate immune protein ISG15.

Harty RN, Pitha PM, Okumura A.

J Innate Immun. 2009;1(5):397-404. doi: 10.1159/000226245. Review.


My interferon years.

Pitha PM.

J Interferon Cytokine Res. 2008 Dec;28(12):699-702. doi: 10.1089/jir.2008.2812.hp. No abstract available.


Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.

Balkhi MY, Fitzgerald KA, Pitha PM.

Mol Cell Biol. 2008 Dec;28(24):7296-308. doi: 10.1128/MCB.00662-08. Epub 2008 Sep 29.


Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response.

Paun A, Reinert JT, Jiang Z, Medin C, Balkhi MY, Fitzgerald KA, Pitha PM.

J Biol Chem. 2008 May 23;283(21):14295-308. doi: 10.1074/jbc.M800501200. Epub 2008 Mar 10.


ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.

Okumura A, Pitha PM, Harty RN.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3974-9. doi: 10.1073/pnas.0710629105. Epub 2008 Feb 27.


HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation.

Okumura A, Alce T, Lubyova B, Ezelle H, Strebel K, Pitha PM.

Virology. 2008 Mar 30;373(1):85-97. Epub 2007 Dec 20.


Type I interferon: the ever unfolding story.

Pitha PM, Kunzi MS.

Curr Top Microbiol Immunol. 2007;316:41-70. Review.


Stimulation of c-Myc transcriptional activity by vIRF-3 of Kaposi sarcoma-associated herpesvirus.

Lubyova B, Kellum MJ, Frisancho JA, Pitha PM.

J Biol Chem. 2007 Nov 2;282(44):31944-53. Epub 2007 Aug 29.


Viral defense, carcinogenesis and ISG15: novel roles for an old ISG.

Pitha-Rowe IF, Pitha PM.

Cytokine Growth Factor Rev. 2007 Oct-Dec;18(5-6):409-17. Epub 2007 Aug 3. Review.


The IRF family, revisited.

Paun A, Pitha PM.

Biochimie. 2007 Jun-Jul;89(6-7):744-53. Epub 2007 Feb 20. Review.


The innate antiviral response: new insights into a continuing story.

Paun A, Pitha PM.

Adv Virus Res. 2007;69:1-66. Review. No abstract available.


ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation.

Lu G, Reinert JT, Pitha-Rowe I, Okumura A, Kellum M, Knobeloch KP, Hassel B, Pitha PM.

Cell Mol Biol (Noisy-le-grand). 2006 May 15;52(1):29-41.


Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15.

Okumura A, Lu G, Pitha-Rowe I, Pitha PM.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1440-5. Epub 2006 Jan 24.


Interferon research: a brief history.

Kunzi MS, Pitha PM.

Methods Mol Med. 2005;116:25-35. Review.


Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function.

Mancl ME, Hu G, Sangster-Guity N, Olshalsky SL, Hoops K, Fitzgerald-Bocarsly P, Pitha PM, Pinder K, Barnes BJ.

J Biol Chem. 2005 Jun 3;280(22):21078-90. Epub 2005 Mar 31.


The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.

Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA, Golenbock DT.

J Biol Chem. 2005 Apr 29;280(17):17005-12. Epub 2005 Jan 28.


Cell defence against viral/bacterial infections: closer mechanism than anticipated?

Pitha PM.

Folia Biol (Praha). 2004;50(3-4):93-9. Review. No abstract available.


Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection.

Barnes BJ, Richards J, Mancl M, Hanash S, Beretta L, Pitha PM.

J Biol Chem. 2004 Oct 22;279(43):45194-207. Epub 2004 Aug 11.


Interferon targeted genes in host defense.

Kunzi MS, Pitha PM.

Autoimmunity. 2003 Dec;36(8):457-61. Review.


Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma.

Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E.

J Immunol. 2004 Mar 1;172(5):2739-43.


Unexpected similarities in cellular responses to bacterial and viral invasion.

Pitha PM.

Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):695-6. Epub 2004 Jan 12. No abstract available.


Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 stimulates the transcriptional activity of cellular IRF-3 and IRF-7.

Lubyova B, Kellum MJ, Frisancho AJ, Pitha PM.

J Biol Chem. 2004 Feb 27;279(9):7643-54. Epub 2003 Dec 10.


Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death.

Barnes BJ, Kellum MJ, Pinder KE, Frisancho JA, Pitha PM.

Cancer Res. 2003 Oct 1;63(19):6424-31.


LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT.

J Exp Med. 2003 Oct 6;198(7):1043-55. Epub 2003 Sep 29. Erratum in: J Exp Med. 2003 Nov 3;198(9):following 1450.


Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells.

Izaguirre A, Barnes BJ, Amrute S, Yeow WS, Megjugorac N, Dai J, Feng D, Chung E, Pitha PM, Fitzgerald-Bocarsly P.

J Leukoc Biol. 2003 Dec;74(6):1125-38. Epub 2003 Sep 2.


Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7.

Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. Epub 2003 May 8.


Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors.

Sasaki S, Amara RR, Yeow WS, Pitha PM, Robinson HL.

J Virol. 2002 Jul;76(13):6652-9.


On the role of IRF in host defense.

Barnes B, Lubyova B, Pitha PM.

J Interferon Cytokine Res. 2002 Jan;22(1):59-71. Review.


Monocyte differentiation to macrophage requires interferon regulatory factor 7.

Lu R, Pitha PM.

J Biol Chem. 2001 Nov 30;276(48):45491-6. Epub 2001 Oct 3.


Interferon-kappa, a novel type I interferon expressed in human keratinocytes.

LaFleur DW, Nardelli B, Tsareva T, Mather D, Feng P, Semenuk M, Taylor K, Buergin M, Chinchilla D, Roshke V, Chen G, Ruben SM, Pitha PM, Coleman TA, Moore PA.

J Biol Chem. 2001 Oct 26;276(43):39765-71. Epub 2001 Aug 20.


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