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Items: 7


High-level semi-synthetic production of the potent antimalarial artemisinin.

Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD.

Nature. 2013 Apr 25;496(7446):528-32. doi: 10.1038/nature12051. Epub 2013 Apr 10.


Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.

Westfall PJ, Pitera DJ, Lenihan JR, Eng D, Woolard FX, Regentin R, Horning T, Tsuruta H, Melis DJ, Owens A, Fickes S, Diola D, Benjamin KR, Keasling JD, Leavell MD, McPhee DJ, Renninger NS, Newman JD, Paddon CJ.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E111-8. doi: 10.1073/pnas.1110740109. Epub 2012 Jan 12.


Application of functional genomics to pathway optimization for increased isoprenoid production.

Kizer L, Pitera DJ, Pfleger BF, Keasling JD.

Appl Environ Microbiol. 2008 May;74(10):3229-41. doi: 10.1128/AEM.02750-07. Epub 2008 Mar 14.


Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli.

Pitera DJ, Paddon CJ, Newman JD, Keasling JD.

Metab Eng. 2007 Mar;9(2):193-207. Epub 2006 Nov 23.


Microbial sensors for small molecules: development of a mevalonate biosensor.

Pfleger BF, Pitera DJ, Newman JD, Martin VJ, Keasling JD.

Metab Eng. 2007 Jan;9(1):30-8. Epub 2006 Aug 15.


Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes.

Pfleger BF, Pitera DJ, Smolke CD, Keasling JD.

Nat Biotechnol. 2006 Aug;24(8):1027-32. Epub 2006 Jul 16.


Engineering a mevalonate pathway in Escherichia coli for production of terpenoids.

Martin VJ, Pitera DJ, Withers ST, Newman JD, Keasling JD.

Nat Biotechnol. 2003 Jul;21(7):796-802. Epub 2003 Jun 1.


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