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Items: 1 to 50 of 80

1.

Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice.

Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum JL, Tsimikas S.

Circulation. 2008 Aug 12;118(7):743-53. doi: 10.1161/CIRCULATIONAHA.108.786822. Epub 2008 Jul 28.

PMID:
18663084
2.

The effects of second-hand smoke on biological processes important in atherogenesis.

Yuan H, Wong LS, Bhattacharya M, Ma C, Zafarani M, Yao M, Schneider M, Pitas RE, Martins-Green M.

BMC Cardiovasc Disord. 2007 Jan 8;7:1.

3.

Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1.

Rizki G, Arnaboldi L, Gabrielli B, Yan J, Lee GS, Ng RK, Turner SM, Badger TM, Pitas RE, Maher JJ.

J Lipid Res. 2006 Oct;47(10):2280-90. Epub 2006 Jul 8.

4.

High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins.

Schneider M, Witztum JL, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE.

J Lipid Res. 2005 Apr;46(4):769-78. Epub 2005 Jan 16.

5.
6.

Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low-density lipoprotein-containing human apolipoprotein B100.

Flood C, Gustafsson M, Pitas RE, Arnaboldi L, Walzem RL, Borén J.

Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):564-70. Epub 2004 Jan 15.

7.

The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix.

Santiago-García J, Kodama T, Pitas RE.

J Biol Chem. 2003 Feb 28;278(9):6942-6. Epub 2002 Dec 17.

8.

Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.

Hopkins PC, Huang Y, McGuire JG, Pitas RE.

J Lipid Res. 2002 Nov;43(11):1881-9.

9.

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.

Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV Jr.

J Clin Invest. 2002 Apr;109(8):1049-55.

10.

Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor.

Santiago-García J, Mas-Oliva J, Innerarity TL, Pitas RE.

J Biol Chem. 2001 Aug 17;276(33):30655-61. Epub 2001 Jun 1.

12.

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.

Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L.

Neuroscience. 2000;97(2):207-10.

PMID:
10799751
13.

Apolipoprotein E and cognitive performance.

Raber J, Wong D, Yu GQ, Buttini M, Mahley RW, Pitas RE, Mucke L.

Nature. 2000 Mar 23;404(6776):352-4. No abstract available.

PMID:
10746713
14.
15.

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW.

J Neurosci. 1999 Jun 15;19(12):4867-80.

17.

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.

Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L.

Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10914-9.

18.

Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E.

Pitas RE, Ji ZS, Weisgraber KH, Mahley RW.

Biochem Soc Trans. 1998 May;26(2):257-62. Review. No abstract available.

PMID:
9649758
19.

Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma.

Zhu Y, Bellosta S, Langer C, Bernini F, Pitas RE, Mahley RW, Assmann G, von Eckardstein A.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7585-90.

21.

Fresh mouse peritoneal macrophages have low scavenger receptor activity.

Kim JG, Keshava C, Murphy AA, Pitas RE, Parthasarathy S.

J Lipid Res. 1997 Nov;38(11):2207-15.

22.

Regulation of scavenger receptor expression in smooth muscle cells by protein kinase C: a role for oxidative stress.

Mietus-Snyder M, Friera A, Glass CK, Pitas RE.

Arterioscler Thromb Vasc Biol. 1997 May;17(5):969-78.

PMID:
9157963
23.

Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates beta-amyloid protein activation of complement in vitro.

McGeer PL, Walker DG, Pitas RE, Mahley RW, McGeer EG.

Brain Res. 1997 Feb 21;749(1):135-8.

PMID:
9070638
24.

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.

Meiner VL, Cases S, Myers HM, Sande ER, Bellosta S, Schambelan M, Pitas RE, McGuire J, Herz J, Farese RV Jr.

Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14041-6.

25.

Apolipoprotein E. Structure, function, and possible roles in Alzheimer's disease.

Mahley RW, Nathan BP, Pitas RE.

Ann N Y Acad Sci. 1996 Jan 17;777:139-45. Review.

PMID:
8624076
26.

A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.

Young SG, Cham CM, Pitas RE, Burri BJ, Connolly A, Flynn L, Pappu AS, Wong JS, Hamilton RL, Farese RV Jr.

J Clin Invest. 1995 Dec;96(6):2932-46.

27.

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth.

Bellosta S, Nathan BP, Orth M, Dong LM, Mahley RW, Pitas RE.

J Biol Chem. 1995 Nov 10;270(45):27063-71.

28.

Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.

Bellosta S, Mahley RW, Sanan DA, Murata J, Newland DL, Taylor JM, Pitas RE.

J Clin Invest. 1995 Nov;96(5):2170-9.

29.

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL.

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9480-4.

30.
31.

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization.

Nathan BP, Chang KC, Bellosta S, Brisch E, Ge N, Mahley RW, Pitas RE.

J Biol Chem. 1995 Aug 25;270(34):19791-9.

32.

Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.

Mahley RW, Nathan BP, Bellosta S, Pitas RE.

Curr Opin Lipidol. 1995 Apr;6(2):86-91. Review.

PMID:
7773573
33.

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro.

Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE.

Science. 1994 May 6;264(5160):850-2.

PMID:
8171342
34.

Isolation and characterization of a platelet-derived macrophage-binding proteoglycan.

Mas-Oliva J, Arnold KS, Wagner WD, Phillips DR, Pitas RE, Innerarity TL.

J Biol Chem. 1994 Apr 1;269(13):10177-83.

35.
36.

Oxidized low density lipoproteins bind to the scavenger receptor expressed by rabbit smooth muscle cells and macrophages.

Dejager S, Mietus-Synder M, Pitas RE.

Arterioscler Thromb. 1993 Mar;13(3):371-8.

PMID:
7680228
37.
38.

Further characterization of the acetyl LDL (scavenger) receptor expressed by rabbit smooth muscle cells and fibroblasts.

Pitas RE, Friera A, McGuire J, Dejager S.

Arterioscler Thromb. 1992 Nov;12(11):1235-44.

PMID:
1420082
39.

Evidence that the scavenger receptor is not involved in the uptake of negatively charged liposomes by cells.

Lee KD, Pitas RE, Papahadjopoulos D.

Biochim Biophys Acta. 1992 Oct 19;1111(1):1-6.

PMID:
1390854
40.

Regulation of endothelial cell protein C activation by native and oxidized low density lipoprotein.

Wilson BD, Pitas RE, Rodgers GM.

Semin Thromb Hemost. 1992 Jan;18(1):11-7.

PMID:
1574712
41.
42.

Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic mice.

Simonet WS, Bucay N, Pitas RE, Lauer SJ, Taylor JM.

J Biol Chem. 1991 May 15;266(14):8651-4.

44.

In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice.

Simonet WS, Bucay N, Lauer SJ, Wirak DO, Stevens ME, Weisgraber KH, Pitas RE, Taylor JM.

J Biol Chem. 1990 Jul 5;265(19):10809-12.

45.

Downstream regulatory elements stimulate expression of the human apolipoprotein E gene in the liver and suppress expression in the kidney of transgenic mice.

Simonet WS, Bucay N, Lauer SJ, Pitas RE, Weisgraber KH, Taylor JM.

Trans Assoc Am Physicians. 1990;103:119-28. Review. No abstract available.

PMID:
2132523
46.

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.

Boyles JK, Zoellner CD, Anderson LJ, Kosik LM, Pitas RE, Weisgraber KH, Hui DY, Mahley RW, Gebicke-Haerter PJ, Ignatius MJ, et al.

J Clin Invest. 1989 Mar;83(3):1015-31.

47.
49.

Lipoprotein uptake by neuronal growth cones in vitro.

Ignatius MJ, Shooter EM, Pitas RE, Mahley RW.

Science. 1987 May 22;236(4804):959-62.

PMID:
3576212
50.

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins.

Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW.

Biochim Biophys Acta. 1987 Jan 13;917(1):148-61.

PMID:
3539206

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