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Items: 32


Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model.

Pischke SE, Hestenes S, Johansen HT, Fure H, Bugge JF, Espinoza A, Skulstad H, Edvardsen T, Fosse E, Mollnes TE, Halvorsen PS, Nielsen EW.

PLoS One. 2019 Jun 27;14(6):e0218624. doi: 10.1371/journal.pone.0218624. eCollection 2019.


Biphasic Release of the Alarmin High Mobility Group Box 1 Protein Early After Trauma Predicts Poor Clinical Outcome.

Ottestad W, Rognes IN, Pischke SE, Mollnes TE, Andersson U, Eken T.

Crit Care Med. 2019 Aug;47(8):e614-e622. doi: 10.1097/CCM.0000000000003800.


The Role of Complement in Liver Injury, Regeneration, and Transplantation.

Thorgersen EB, Barratt-Due A, Haugaa H, Harboe M, Pischke SE, Nilsson PH, Mollnes TE.

Hepatology. 2019 Aug;70(2):725-736. doi: 10.1002/hep.30508. Epub 2019 Jul 15. Review.


IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.

Orrem HL, Nilsson PH, Pischke SE, Kleveland O, Yndestad A, Ekholt K, Damås JK, Espevik T, Bendz B, Halvorsen B, Gregersen I, Wiseth R, Andersen GØ, Ueland T, Gullestad L, Aukrust P, Barratt-Due A, Mollnes TE.

Front Immunol. 2018 Sep 12;9:2035. doi: 10.3389/fimmu.2018.02035. eCollection 2018.


Bile and circulating HMGB1 contributes to systemic inflammation in obstructive jaundice.

Yang R, Zhu S, Pischke SE, Haugaa H, Zou X, Tonnessen TI.

J Surg Res. 2018 Aug;228:14-19. doi: 10.1016/j.jss.2018.02.049. Epub 2018 Mar 21. Review.


Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock.

Orrem HL, Nilsson PH, Pischke SE, Grindheim G, Garred P, Seljeflot I, Husebye T, Aukrust P, Yndestad A, Andersen GØ, Barratt-Due A, Mollnes TE.

ESC Heart Fail. 2018 Jun;5(3):292-301. doi: 10.1002/ehf2.12266. Epub 2018 Feb 9.


Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis.

Hellerud BC, Orrem HL, Dybwik K, Pischke SE, Baratt-Due A, Castellheim A, Fure H, Bergseth G, Christiansen D, Nunn MA, Espevik T, Lau C, Brandtzæg P, Nielsen EW, Mollnes TE.

J Intensive Care. 2017 Feb 27;5:21. doi: 10.1186/s40560-017-0217-0. eCollection 2017.


Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function.

Pischke SE, Gustavsen A, Orrem HL, Egge KH, Courivaud F, Fontenelle H, Despont A, Bongoni AK, Rieben R, Tønnessen TI, Nunn MA, Scott H, Skulstad H, Barratt-Due A, Mollnes TE.

Basic Res Cardiol. 2017 May;112(3):20. doi: 10.1007/s00395-017-0610-9. Epub 2017 Mar 3.


A neglected organ in multiple organ failure - 'skin in the game'?

Pischke SE, Haugaa H, Haney M.

Acta Anaesthesiol Scand. 2017 Jan;61(1):5-7. doi: 10.1111/aas.12823. No abstract available.


Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets.

Barratt-Due A, Pischke SE, Nilsson PH, Espevik T, Mollnes TE.

J Leukoc Biol. 2017 Jan;101(1):193-204. doi: 10.1189/jlb.3VMR0316-132R. Epub 2016 Aug 31. Review.


Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex.

Gustavsen A, Nymo S, Landsem A, Christiansen D, Ryan L, Husebye H, Lau C, Pischke SE, Lambris JD, Espevik T, Mollnes TE.

J Infect Dis. 2016 Jul 1;214(1):140-50. doi: 10.1093/infdis/jiw100. Epub 2016 Mar 14.


Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial.

Fretland AA, Sokolov A, Postriganova N, Kazaryan AM, Pischke SE, Nilsson PH, Rognes IN, Bjornbeth BA, Fagerland MW, Mollnes TE, Edwin B.

Medicine (Baltimore). 2015 Oct;94(42):e1786. doi: 10.1097/MD.0000000000001786. Erratum in: Medicine (Baltimore). 2016 Mar;95(10):e367e.


[Local ischemia can be detected by internal organ CO2 measurement].

Pischke SE.

Tidsskr Nor Laegeforen. 2015 Oct 20;135(19):1774. doi: 10.4045/tidsskr.15.0916. eCollection 2015 Oct 20. Norwegian. No abstract available.


Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis.

Khan F, Pharo A, Lindstad JK, Mollnes TE, Tønnessen TI, Pischke SE.

Scand J Immunol. 2015 Nov;82(5):467-75. doi: 10.1111/sji.12332.


Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14.

Egge KH, Thorgersen EB, Pischke SE, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn MA, Barratt-Due A, Mollnes TE.

Immunobiology. 2015 Aug;220(8):999-1005. doi: 10.1016/j.imbio.2015.04.002. Epub 2015 Apr 27.


Continuous monitoring of regional function by a miniaturized ultrasound transducer allows early quantification of low-grade myocardial ischemia.

Hyler S, Pischke SE, Halvorsen PS, Espinoza A, Bergsland J, Tønnessen TI, Fosse E, Skulstad H.

J Am Soc Echocardiogr. 2015 Apr;28(4):486-94. doi: 10.1016/j.echo.2014.12.014. Epub 2015 Jan 27.


Myocardial tissue CO2 tension detects coronary blood flow reduction after coronary artery bypass in real-time†.

Pischke SE, Hyler S, Tronstad C, Bergsland J, Fosse E, Halvorsen PS, Skulstad H, Tønnessen TI.

Br J Anaesth. 2015 Mar;114(3):414-22. doi: 10.1093/bja/aeu381. Epub 2014 Nov 12.


Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice.

Huber-Lang M, Barratt-Due A, Pischke SE, Sandanger Ø, Nilsson PH, Nunn MA, Denk S, Gaus W, Espevik T, Mollnes TE.

J Immunol. 2014 Jun 1;192(11):5324-31. doi: 10.4049/jimmunol.1400341. Epub 2014 Apr 30.


Systemic CD14 inhibition attenuates organ inflammation in porcine Escherichia coli sepsis.

Thorgersen EB, Pischke SE, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Hellerud BC, Mollnes TE.

Infect Immun. 2013 Sep;81(9):3173-81. doi: 10.1128/IAI.00390-13. Epub 2013 Jun 17.


Lipid peroxidation in multidrug-resistant Gram-negative sepsis: translating science to the septic patient?

Scheiermann P, Pischke SE.

Crit Care. 2013 Mar 1;17(2):120. doi: 10.1186/cc12505.


Clinical experience with microdialysis catheters in pediatric liver transplants.

Haugaa H, Almaas R, Thorgersen EB, Foss A, Line PD, Sanengen T, Bergmann GB, Ohlin P, Waelgaard L, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI.

Liver Transpl. 2013 Mar;19(3):305-14. doi: 10.1002/lt.23578.


Bride and groom in systemic inflammation--the bells ring for complement and Toll in cooperation.

Barratt-Due A, Pischke SE, Brekke OL, Thorgersen EB, Nielsen EW, Espevik T, Huber-Lang M, Mollnes TE.

Immunobiology. 2012 Nov;217(11):1047-56. doi: 10.1016/j.imbio.2012.07.019. Review.


Hepatic and abdominal carbon dioxide measurements detect and distinguish hepatic artery occlusion and portal vein occlusion in pigs.

Pischke SE, Tronstad C, Holhjem L, Line PD, Haugaa H, Tønnessen TI.

Liver Transpl. 2012 Dec;18(12):1485-94. doi: 10.1002/lt.23544.


Polyvalent immunoglobulin significantly attenuated the formation of IL-1β in Escherichia coli-induced sepsis in pigs.

Barratt-Due A, Sokolov A, Gustavsen A, Hellerud BC, Egge K, Pischke SE, Lindstad JK, Pharo A, Castellheim A, Thorgersen EB, Mollnes TE.

Immunobiology. 2013 May;218(5):683-9. doi: 10.1016/j.imbio.2012.08.268. Epub 2012 Aug 9.


Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts.

Haugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Waelgaard L, Pischke SE, Mollnes TE, Inge Tønnessen T.

Liver Transpl. 2012 Dec;18(12):1421-9. doi: 10.1002/lt.23503. Epub 2012 Sep 26.


Early bedside detection of ischemia and rejection in liver transplants by microdialysis.

Håugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI.

Liver Transpl. 2012 Jul;18(7):839-49. doi: 10.1002/lt.23425.


Perioperative detection of myocardial ischaemia/reperfusion with a novel tissue CO2 monitoring technology.

Pischke SE, Tronstad C, Holhjem L, Halvorsen PS, Tønnessen TI.

Eur J Cardiothorac Surg. 2012 Jul;42(1):157-63. doi: 10.1093/ejcts/ezr278. Epub 2012 Jan 20.


Early detection of cardiac ischemia using a conductometric pCO(2) sensor: real-time drift correction and parameterization.

Tronstad C, Pischke SE, Holhjem L, Tønnessen TI, Martinsen OG, Grimnes S.

Physiol Meas. 2010 Sep;31(9):1241-55. doi: 10.1088/0967-3334/31/9/013. Epub 2010 Aug 11.


Phosphatidylinositol 3-kinase/Akt pathway mediates heme oxygenase-1 regulation by lipopolysaccharide.

Pischke SE, Zhou Z, Song R, Ning W, Alam J, Ryter SW, Choi AM.

Cell Mol Biol (Noisy-le-grand). 2005 Oct 3;51(5):461-70.


Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1.

Humar M, Andriopoulos N, Pischke SE, Loop T, Schmidt R, Hoetzel A, Roesslein M, Pahl HL, Geiger KK, Pannen BH.

J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. Epub 2004 Jul 19.


Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells.

Humar M, Pischke SE, Loop T, Hoetzel A, Schmidt R, Klaas C, Pahl HL, Geiger KK, Pannen BH.

Mol Pharmacol. 2004 Feb;65(2):350-61.


Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.

Morse D, Pischke SE, Zhou Z, Davis RJ, Flavell RA, Loop T, Otterbein SL, Otterbein LE, Choi AM.

J Biol Chem. 2003 Sep 26;278(39):36993-8. Epub 2003 Jul 11.

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