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Items: 1 to 50 of 74

1.

Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases.

Alves A, Bassot A, Bulteau AL, Pirola L, Morio B.

Nutrients. 2019 Jun 16;11(6). pii: E1356. doi: 10.3390/nu11061356. Review.

2.

Maternal physical activity-induced adaptive transcriptional response in brain and placenta of mothers and rat offspring.

Fragoso J, Carvalho Jurema Santos G, Thomaz da Silva H, Oliveira Nogueira V, Loizon E, Vidal H, Costa-Silva JH, da Silva Aragão R, Pirola L, Leandro CG.

J Dev Orig Health Dis. 2019 Jun 17:1-10. doi: 10.1017/S2040174419000333. [Epub ahead of print]

PMID:
31203831
3.

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule.

Chriett S, Dąbek A, Wojtala M, Vidal H, Balcerczyk A, Pirola L.

Sci Rep. 2019 Jan 24;9(1):742. doi: 10.1038/s41598-018-36941-9.

4.

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension.

Luna RCP, de Oliveira Y, Lisboa JVC, Chaves TR, de Araújo TAM, de Sousa EE, Miranda Neto M, Pirola L, Braga VA, de Brito Alves JL.

Braz J Med Biol Res. 2018 Oct 18;51(12):e7437. doi: 10.1590/1414-431X20187437. Review.

5.

The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting.

Pirola L, Ciesielski O, Balcerczyk A.

Cancers (Basel). 2018 Aug 10;10(8). pii: E268. doi: 10.3390/cancers10080268. Review.

6.

Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells.

Wojtala M, Macierzyńska-Piotrowska E, Rybaczek D, Pirola L, Balcerczyk A.

Pharmacol Res. 2018 Feb;128:252-263. doi: 10.1016/j.phrs.2017.10.014. Epub 2017 Nov 4.

PMID:
29113759
7.

Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women.

Lima RPA, do Nascimento RAF, Luna RCP, Persuhn DC, da Silva AS, da Conceição Rodrigues Gonçalves M, de Almeida ATC, de Moraes RM, Junior EV, Fouilloux-Meugnier E, Vidal H, Pirola L, Magnani M, de Oliveira NFP, Prada PO, de Carvalho Costa MJ.

Clin Epigenetics. 2017 Oct 13;9:110. doi: 10.1186/s13148-017-0407-6. eCollection 2017.

8.

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats.

Fragoso J, Lira AO, Chagas GS, Lucena Cavalcanti CC, Beserra R, de Santana-Muniz G, Bento-Santos A, Martins G, Pirola L, da Silva Aragão R, Leandro CG.

Exp Physiol. 2017 Nov 1;102(11):1486-1499. doi: 10.1113/EP086400. Epub 2017 Sep 24.

PMID:
28833822
9.

Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity.

Pirola L, Ferraz JC.

World J Biol Chem. 2017 May 26;8(2):120-128. doi: 10.4331/wjbc.v8.i2.120. Review.

10.

Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.

Doñate Puertas R, Meugnier E, Romestaing C, Rey C, Morel E, Lachuer J, Gadot N, Scridon A, Julien C, Tronc F, Chapuis B, Valla C, Janin A, Pirola L, Méjat A, Rome S, Chevalier P.

Transl Res. 2017 Jun;184:57-67.e5. doi: 10.1016/j.trsl.2017.03.004. Epub 2017 Mar 30.

PMID:
28427903
11.

Transcriptional response of skeletal muscle to a low protein perinatal diet in rat offspring at different ages: The role of key enzymes of glucose-fatty acid oxidation.

de Brito Alves JL, Toscano AE, da Costa-Silva JH, Vidal H, Leandro CG, Pirola L.

J Nutr Biochem. 2017 Mar;41:117-123. doi: 10.1016/j.jnutbio.2016.12.002. Epub 2016 Dec 15.

PMID:
28088654
12.

New Insights on the Use of Dietary Polyphenols or Probiotics for the Management of Arterial Hypertension.

de Brito Alves JL, de Sousa VP, Cavalcanti Neto MP, Magnani M, Braga VA, da Costa-Silva JH, Leandro CG, Vidal H, Pirola L.

Front Physiol. 2016 Oct 6;7:448. eCollection 2016. Review.

13.

Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells.

Balcerczyk A, Rybaczek D, Wojtala M, Pirola L, Okabe J, El-Osta A.

Biochem Pharmacol. 2016 Dec 1;121:18-32. doi: 10.1016/j.bcp.2016.09.013. Epub 2016 Sep 19.

PMID:
27659811
14.

The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice.

Casteras S, Abdul-Wahed A, Soty M, Vulin F, Guillou H, Campana M, Le Stunff H, Pirola L, Rajas F, Mithieux G, Gautier-Stein A.

Diabetologia. 2016 Dec;59(12):2645-2653. Epub 2016 Sep 9.

PMID:
27631137
15.

The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1.

Chriett S, Zerzaihi O, Vidal H, Pirola L.

Mol Cell Endocrinol. 2017 Jan 5;439:224-232. doi: 10.1016/j.mce.2016.09.006. Epub 2016 Sep 13.

PMID:
27619406
16.

Adipocytes, like their progenitors, contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes, in obese subjects.

Chehimi M, Robert M, Bechwaty ME, Vial G, Rieusset J, Vidal H, Pirola L, Eljaafari A.

Adipocyte. 2016 Jan 25;5(3):275-82. doi: 10.1080/21623945.2015.1134402. eCollection 2016 Jul-Sep.

17.

Maternal protein restriction induced-hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata.

de Brito Alves JL, de Oliveira JM, Ferreira DJ, Barros MA, Nogueira VO, Alves DS, Vidal H, Leandro CG, Lagranha CJ, Pirola L, da Costa-Silva JH.

Clin Exp Pharmacol Physiol. 2016 Dec;43(12):1177-1184. doi: 10.1111/1440-1681.12667.

PMID:
27612187
18.

Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics.

Wojtala M, Pirola L, Balcerczyk A.

Biofactors. 2017 Jan 2;43(1):5-16. doi: 10.1002/biof.1306. Epub 2016 Jun 29. Review.

PMID:
27355807
19.

[Epigenetics in transgenerational responses to environmental impacts: from facts and gaps].

Junien C, Panchenko P, Fneich S, Pirola L, Chriett S, Amarger V, Kaeffer B, Parnet P, Torrisani J, Bolaños Jimenez F, Jammes H, Gabory A.

Med Sci (Paris). 2016 Jan;32(1):35-44. doi: 10.1051/medsci/20163201007. Epub 2016 Feb 5. Review. French.

20.

[The new paradigm of the developmental origin of health and diseases (DOHaD)--Epigenetics and environment: evidence and missing links].

Junien C, Panchenko P, Pirola L, Amarger V, Kaeffer B, Parnet P, Torrisani J, Bolaños Jimenez F, Jammes H, Gabory A.

Med Sci (Paris). 2016 Jan;32(1):27-34. doi: 10.1051/medsci/20163201006. Epub 2016 Feb 5. Review. French.

21.

Dysregulation of sirtuins and key metabolic genes in skeletal muscle of pigs with spontaneous intrauterine growth restriction is associated with alterations of circulating IGF-1.

Chriett S, Le Huërou-Luron I, Vidal H, Pirola L.

Gen Comp Endocrinol. 2016 Jun 1;232:76-85. doi: 10.1016/j.ygcen.2015.12.028. Epub 2016 Jan 6.

PMID:
26769588
22.

Essential roles of four-carbon backbone chemicals in the control of metabolism.

Chriett S, Pirola L.

World J Biol Chem. 2015 Aug 26;6(3):223-30. doi: 10.4331/wjbc.v6.i3.223. Review.

23.

Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation.

Eljaafari A, Robert M, Chehimi M, Chanon S, Durand C, Vial G, Bendridi N, Madec AM, Disse E, Laville M, Rieusset J, Lefai E, Vidal H, Pirola L.

Diabetes. 2015 Jul;64(7):2477-88. doi: 10.2337/db15-0162. Epub 2015 Mar 12.

24.

The DCCT/EDIC study: epigenetic clues after three decades.

Pirola L.

Diabetes. 2014 May;63(5):1460-2. doi: 10.2337/db14-0238. No abstract available.

25.
26.

Dietary polyphenols and their effects on cell biochemistry and pathophysiology.

Angeloni C, Pirola L, Vauzour D, Maraldi T.

Oxid Med Cell Longev. 2012;2012:583901. doi: 10.1155/2012/583901. Epub 2012 Nov 6. No abstract available.

27.

Protein acetylation mechanisms in the regulation of insulin and insulin-like growth factor 1 signalling.

Pirola L, Zerzaihi O, Vidal H, Solari F.

Mol Cell Endocrinol. 2012 Oct 15;362(1-2):1-10. doi: 10.1016/j.mce.2012.05.011. Epub 2012 Jun 6. Review.

PMID:
22683437
28.

The use of methotrexate for treatment of inflammatory bowel disease in clinical practice.

Saibeni S, Bollani S, Losco A, Michielan A, Sostegni R, Devani M, Lupinacci G, Pirola L, Cucino C, Meucci G, Basilisco G, D'Incà R, Bruno S.

Dig Liver Dis. 2012 Feb;44(2):123-7. doi: 10.1016/j.dld.2011.09.015. Epub 2011 Nov 2.

PMID:
22051323
29.

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells.

Pirola L, Balcerczyk A, Tothill RW, Haviv I, Kaspi A, Lunke S, Ziemann M, Karagiannis T, Tonna S, Kowalczyk A, Beresford-Smith B, Macintyre G, Kelong M, Hongyu Z, Zhu J, El-Osta A.

Genome Res. 2011 Oct;21(10):1601-15. doi: 10.1101/gr.116095.110. Epub 2011 Sep 2.

30.

Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.

Jaafar R, Zeiller C, Pirola L, Di Grazia A, Naro F, Vidal H, Lefai E, Némoz G.

J Biol Chem. 2011 Jun 24;286(25):22609-21. doi: 10.1074/jbc.M110.203885. Epub 2011 Apr 27.

31.

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1.

Fröjdö S, Durand C, Molin L, Carey AL, El-Osta A, Kingwell BA, Febbraio MA, Solari F, Vidal H, Pirola L.

Mol Cell Endocrinol. 2011 Mar 30;335(2):166-76. doi: 10.1016/j.mce.2011.01.008. Epub 2011 Jan 15.

32.

Epigenetic phenomena linked to diabetic complications.

Pirola L, Balcerczyk A, Okabe J, El-Osta A.

Nat Rev Endocrinol. 2010 Dec;6(12):665-75. doi: 10.1038/nrendo.2010.188. Epub 2010 Nov 2. Review.

PMID:
21045787
33.

A special BioFactors issue dedicated to resveratrol.

Pirola L.

Biofactors. 2010 Sep-Oct;36(5):329-30. doi: 10.1002/biof.128. No abstract available.

PMID:
20872759
34.

Therapeutic potential of activators and inhibitors of sirtuins.

Balcerczyk A, Pirola L.

Biofactors. 2010 Sep-Oct;36(5):383-93. doi: 10.1002/biof.112. Review.

PMID:
20848588
35.

Contrast-enhanced ultrasonography in evaluating hepatic metastases from neuroendocrine tumours.

Massironi S, Conte D, Sciola V, Pirola L, Paggi S, Fraquelli M, Ciafardini C, Spampatti MP, Peracchi M.

Dig Liver Dis. 2010 Sep;42(9):635-41. doi: 10.1016/j.dld.2010.01.009. Epub 2010 Feb 20.

PMID:
20172770
36.

Metabolic effects of resveratrol in mammals--a link between improved insulin action and aging.

Fröjdö S, Durand C, Pirola L.

Curr Aging Sci. 2008 Dec;1(3):145-51. Review.

PMID:
20021385
37.

Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation.

Zeiller C, Mebarek S, Jaafar R, Pirola L, Lagarde M, Prigent AF, Némoz G.

Biochim Biophys Acta. 2009 Jul;1793(7):1236-49. doi: 10.1016/j.bbamcr.2009.04.001. Epub 2009 Apr 14.

38.

Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans.

Fröjdö S, Vidal H, Pirola L.

Biochim Biophys Acta. 2009 Feb;1792(2):83-92. doi: 10.1016/j.bbadis.2008.10.019. Epub 2008 Nov 5. Review.

39.

Resveratrol: one molecule, many targets.

Pirola L, Fröjdö S.

IUBMB Life. 2008 May;60(5):323-32. doi: 10.1002/iub.47. Review.

40.

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients.

Cozzone D, Fröjdö S, Disse E, Debard C, Laville M, Pirola L, Vidal H.

Diabetologia. 2008 Mar;51(3):512-21. doi: 10.1007/s00125-007-0913-8. Epub 2008 Jan 18.

PMID:
18204829
41.

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor.

Fröjdö S, Cozzone D, Vidal H, Pirola L.

Biochem J. 2007 Sep 15;406(3):511-8.

42.

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation.

Solinas G, Summermatter S, Mainieri D, Gubler M, Pirola L, Wymann MP, Rusconi S, Montani JP, Seydoux J, Dulloo AG.

FEBS Lett. 2004 Nov 19;577(3):539-44.

43.

In-phantom imaging of all dose components in boron neutron capture therapy by means of gel dosimeters.

Gambarini G, Colli V, Gay S, Petrovich C, Pirola L, Rosi G.

Appl Radiat Isot. 2004 Nov;61(5):759-63.

PMID:
15308140
44.

118th ENMC International Workshop on Advances in Myotubular Myopathy. 26-28 September 2003, Naarden, The Netherlands. (5th Workshop of the International Consortium on Myotubular Myopathy).

Bertini E, Biancalana V, Bolino A, Buj Bello A, Clague M, Guicheney P, Jungbluth H, Kress W, Musaro' A, Nandurkar H, Pirola L, Romero N, Senderek J, Suter U, Sewry C, Tronchere H, Wallgren-Pettersson C, Wishart MJ, Laporte J.

Neuromuscul Disord. 2004 Jun;14(6):387-96. No abstract available.

PMID:
15145343
45.

Modulation of insulin action.

Pirola L, Johnston AM, Van Obberghen E.

Diabetologia. 2004 Feb;47(2):170-84. Epub 2004 Jan 13. Review.

PMID:
14722654
46.

Modulators of insulin action and their role in insulin resistance.

Pirola L, Johnston AM, Van Obberghen E.

Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S61-4. Review.

PMID:
14704748
47.

Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells.

Tronchère H, Laporte J, Pendaries C, Chaussade C, Liaubet L, Pirola L, Mandel JL, Payrastre B.

J Biol Chem. 2004 Feb 20;279(8):7304-12. Epub 2003 Dec 1.

48.

Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin.

Demozay D, Rocchi S, Mas JC, Grillo S, Pirola L, Chavey C, Van Obberghen E.

J Biol Chem. 2004 Feb 20;279(8):6261-70. Epub 2003 Nov 24.

49.

Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport.

Chaussade C, Pirola L, Bonnafous S, Blondeau F, Brenz-Verca S, Tronchère H, Portis F, Rusconi S, Payrastre B, Laporte J, Van Obberghen E.

Mol Endocrinol. 2003 Dec;17(12):2448-60. Epub 2003 Sep 18.

PMID:
14500759
50.

Gene expression profile unravels significant differences between childhood and adult Ph+ acute lymphoblastic leukemia.

Scrideli CA, Cazzaniga G, Fazio G, Pirola L, Callegaro A, Bassan R, Rambaldi A, Lo Nigro L, Basso G, Masera G, Biondi A.

Leukemia. 2003 Nov;17(11):2234-7. No abstract available.

PMID:
12931222

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