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Items: 34


Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling.

Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED.

JCI Insight. 2020 Mar 26;5(6). pii: 134920. doi: 10.1172/jci.insight.134920.


Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling.

Buffolo M, Pires KM, Ferhat M, Ilkun O, Makaju A, Achenbach A, Bowman F, Atkinson DL, Holland WL, Amri EZ, Chaurasia B, Franklin S, Boudina S.

Cell Rep. 2019 Oct 8;29(2):270-282.e5. doi: 10.1016/j.celrep.2019.08.092.


Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling.

Pires KM, Torres NS, Buffolo M, Gunville R, Schaaf C, Davis K, Selzman CH, Gottlieb RA, Boudina S.

Antioxid Redox Signal. 2019 Aug 20;31(6):444-457. doi: 10.1089/ars.2018.7640. Epub 2019 Jun 20.


Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.

Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE, Boudina S.

Cell Rep. 2018 Nov 13;25(7):1708-1717.e5. doi: 10.1016/j.celrep.2018.10.040.


Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice.

Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S.

J Mol Cell Cardiol. 2017 Dec;113:39-50. doi: 10.1016/j.yjmcc.2017.10.001. Epub 2017 Oct 5.


OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.

Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KMP, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED.

EMBO J. 2017 Jul 14;36(14):2126-2145. doi: 10.15252/embj.201696179. Epub 2017 Jun 12.


Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis.

Han YH, Buffolo M, Pires KM, Pei S, Scherer PE, Boudina S.

Diabetes. 2016 Sep;65(9):2639-51. doi: 10.2337/db16-0283. Epub 2016 Jun 9.


Pulmonary and hepatic injury after sub-chronic exposure to sublethal doses of microcystin-LR.

Carvalho GM, Oliveira VR, Casquilho NV, Araujo AC, Soares RM, Azevedo SM, Pires KM, Valença SS, Zin WA.

Toxicon. 2016 Mar 15;112:51-8. doi: 10.1016/j.toxicon.2016.01.066. Epub 2016 Feb 1.


Grape skin extract-derived polyphenols modify programming-induced renal endowment in prenatal protein-restricted male mouse offspring.

Costa MR, Pires KM, Nalbones-Barbosa MN, Dos Santos Valença S, Resende ÂC, de Moura RS.

Eur J Nutr. 2016 Jun;55(4):1455-64. doi: 10.1007/s00394-015-0963-5. Epub 2015 Jun 22.


Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome.

Ilkun O, Wilde N, Tuinei J, Pires KM, Zhu Y, Bugger H, Soto J, Wayment B, Olsen C, Litwin SE, Abel ED.

J Mol Cell Cardiol. 2015 Aug;85:104-16. doi: 10.1016/j.yjmcc.2015.05.012. Epub 2015 May 22.


Antioxidant action of propolis on mouse lungs exposed to short-term cigarette smoke.

Lopes AA, Ferreira TS, Nesi RT, Lanzetti M, Pires KM, Silva AM, Borges RM, Silva AJ, Valença SS, Porto LC.

Bioorg Med Chem. 2013 Dec 15;21(24):7570-7. doi: 10.1016/j.bmc.2013.10.044. Epub 2013 Nov 7.


Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.

Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED.

J Clin Invest. 2013 Dec;123(12):5319-33. doi: 10.1172/JCI71171. Epub 2013 Nov 1.


The influence of 5-lipoxygenase on cigarette smoke-induced emphysema in mice.

Kennedy-Feitosa E, Pinto RF, Pires KM, Monteiro AP, Machado MN, Santos JC, Ribeiro ML, Zin WA, Canetti CA, Romana-Souza B, Porto LC, Valenca SS.

Biochim Biophys Acta. 2014 Jan;1840(1):199-208. doi: 10.1016/j.bbagen.2013.09.028. Epub 2013 Sep 26.


Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms.

Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S.

J Mol Cell Cardiol. 2013 Nov;64:20-9. doi: 10.1016/j.yjmcc.2013.08.005. Epub 2013 Aug 30.


Critical role for CCR2 and HMGB1 in induction of experimental endotoxic shock.

Alves JN, Pires KM, Lanzetti M, Barroso MV, Benjamim CF, Costa CA, Resende AC, Santos JC, Ribeiro ML, Porto LC, Valença SS.

Arch Biochem Biophys. 2013 Sep 1;537(1):72-81. doi: 10.1016/ Epub 2013 Jul 3.


Treatment with a SOD mimetic reduces visceral adiposity, adipocyte death, and adipose tissue inflammation in high fat-fed mice.

Pires KM, Ilkun O, Valente M, Boudina S.

Obesity (Silver Spring). 2014 Jan;22(1):178-87. doi: 10.1002/oby.20465. Epub 2013 Jun 13.


Effects of exercise on monocrotaline-induced changes in right heart function and pulmonary artery remodeling in rats.

Colombo R, Siqueira R, Becker CU, Fernandes TG, Pires KM, Valença SS, Souza-Rabbo MP, Araujo AS, Belló-Klein A.

Can J Physiol Pharmacol. 2013 Jan;91(1):38-44. doi: 10.1139/cjpp-2012-0261. Epub 2013 Jan 1.


Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.

Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED.

PLoS One. 2013;8(1):e54221. doi: 10.1371/journal.pone.0054221. Epub 2013 Jan 14.


Euterpe oleracea Mart.-derived polyphenols prevent endothelial dysfunction and vascular structural changes in renovascular hypertensive rats: role of oxidative stress.

da Costa CA, de Oliveira PR, de Bem GF, de Cavalho LC, Ognibene DT, da Silva AF, Dos Santos Valença S, Pires KM, da Cunha Sousa PJ, de Moura RS, Resende AC.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Dec;385(12):1199-209. doi: 10.1007/s00210-012-0798-z. Epub 2012 Oct 9.


Oxidative stress and nitrosative stress are involved in different stages of proteolytic pulmonary emphysema.

Lanzetti M, da Costa CA, Nesi RT, Barroso MV, Martins V, Victoni T, Lagente V, Pires KM, e Silva PM, Resende AC, Porto LC, Benjamim CF, Valença SS.

Free Radic Biol Med. 2012 Dec 1;53(11):1993-2001. doi: 10.1016/j.freeradbiomed.2012.09.015. Epub 2012 Sep 19.


Oxidative damage in alveolar macrophages exposed to cigarette smoke extract and participation of nitric oxide in redox balance.

Pires KM, Lanzetti M, Rueff-Barroso CR, Castro P, Abrahão A, Koatz VL, Valença SS, Porto LC.

Toxicol In Vitro. 2012 Sep;26(6):791-8. doi: 10.1016/j.tiv.2012.05.011. Epub 2012 Jun 1.


Redox imbalance and pulmonary function in bleomycin-induced fibrosis in C57BL/6, DBA/2, and BALB/c mice.

Santos-Silva MA, Pires KM, Trajano ET, Martins V, Nesi RT, Benjamin CF, Caetano MS, Sternberg C, Machado MN, Zin WA, Valença SS, Porto LC.

Toxicol Pathol. 2012 Jul;40(5):731-41. doi: 10.1177/0192623312441404. Epub 2012 May 1.


Low tidal volume mechanical ventilation and oxidative stress in healthy mouse lungs.

Pires KM, Melo AC, Lanzetti M, Casquilho NV, Zin WA, Porto LC, Valença SS.

J Bras Pneumol. 2012 Jan-Feb;38(1):98-104. English, Portuguese.


Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.

Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED.

J Mol Cell Cardiol. 2012 May;52(5):1019-26. doi: 10.1016/j.yjmcc.2012.02.001. Epub 2012 Feb 9.


Effects of Euterpe oleracea Mart. (AÇAÍ) extract in acute lung inflammation induced by cigarette smoke in the mouse.

Moura RS, Ferreira TS, Lopes AA, Pires KM, Nesi RT, Resende AC, Souza PJ, Silva AJ, Borges RM, Porto LC, Valenca SS.

Phytomedicine. 2012 Feb 15;19(3-4):262-9. doi: 10.1016/j.phymed.2011.11.004. Epub 2011 Dec 3.


Grape skin extract reduced pulmonary oxidative response in mice exposed to cigarette smoke.

Pires KM, Valença SS, Resende ÂC, Porto LC, Queiroz EF, Moreira DD, de Moura RS.

Med Sci Monit. 2011 Aug;17(8):BR187-195.


PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.

Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED.

Circ Res. 2011 Sep 16;109(7):783-93. doi: 10.1161/CIRCRESAHA.111.243964. Epub 2011 Jul 28.


Long-term exposure to cigarette smoke impairs lung function and increases HMGB-1 expression in mice.

Bezerra FS, Valença SS, Pires KM, Lanzetti M, Pimenta WA, Schmidt AC, Porto LC, Zin WA.

Respir Physiol Neurobiol. 2011 Jul 31;177(2):120-6. doi: 10.1016/j.resp.2011.03.023. Epub 2011 Mar 30.


N-(2-mercaptopropionyl)-glycine but not allopurinol prevented cigarette smoke-induced alveolar enlargement in mouse.

Pires KM, Bezerra FS, Machado MN, Zin WA, Porto LC, Valença SS.

Respir Physiol Neurobiol. 2011 Mar 15;175(3):322-30. doi: 10.1016/j.resp.2010.12.010. Epub 2010 Dec 25.


Addition of açaí (Euterpe oleracea) to cigarettes has a protective effect against emphysema in mice.

de Moura RS, Pires KM, Santos Ferreira T, Lopes AA, Nesi RT, Resende AC, Sousa PJ, da Silva AJ, Porto LC, Valenca SS.

Food Chem Toxicol. 2011 Apr;49(4):855-63. doi: 10.1016/j.fct.2010.12.007. Epub 2010 Dec 13.


Organ-related cigarette smoke-induced oxidative stress is strain-dependent.

Rueff-Barroso CR, Trajano ET, Alves JN, Paiva RO, Lanzetti M, Pires KM, Bezerra FS, Pinho RA, Valenca SS, Porto LC.

Med Sci Monit. 2010 Jul;16(7):BR218-26.


Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.

Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED.

Endocrinology. 2010 Aug;151(8):3536-42. doi: 10.1210/en.2010-0256. Epub 2010 May 25.


Early renal structure alteration in rat offspring from dams fed low protein diet.

Pires KM, Aguila MB, Mandarim-de-Lacerda CA.

Life Sci. 2006 Oct 26;79(22):2128-34. Epub 2006 Jul 12.


Amlodipine preserves the glomerular number in spontaneously hypertensive rats.

Bezerra DG, Pires KM, Mandarim-de-Lacerda CA.

J Cell Mol Med. 2005 Oct-Dec;9(4):966-71.

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