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Items: 1 to 50 of 202

1.

Expression of IL-7Rα and KLRG1 defines functionally distinct CD8+ T-cell populations in humans.

Remmerswaal EBM, Hombrink P, Nota B, Pircher H, Ten Berge IJM, van Lier RAW, van Aalderen MC.

Eur J Immunol. 2019 May;49(5):694-708. doi: 10.1002/eji.201847897. Epub 2019 Mar 25.

2.

Enhancing immunity prevents virus-induced T-cell-mediated immunopathology in B cell-deficient mice.

Straub T, Pircher H.

Eur J Immunol. 2019 May;49(5):782-789. doi: 10.1002/eji.201847962. Epub 2019 Mar 1.

3.

Residual LCMV antigen in transiently CD4+ T cell-depleted mice induces high levels of virus-specific antibodies but only limited B-cell memory.

Schweier O, Aichele U, Marx AF, Straub T, Verbeek JS, Pinschewer DD, Pircher H.

Eur J Immunol. 2019 Apr;49(4):626-637. doi: 10.1002/eji.201847772. Epub 2019 Feb 4.

PMID:
30636035
4.

NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infection.

Schuch A, Zecher BF, Müller PA, Correia MP, Daul F, Rennert C, Tauber C, Schlitt K, Boettler T, Neumann-Haefelin C, Hengel H, Pircher H, Cerwenka A, Thimme R, Hofmann M.

J Hepatol. 2019 Mar;70(3):351-360. doi: 10.1016/j.jhep.2018.10.006. Epub 2018 Oct 18.

5.

Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells.

Straub T, Freudenberg MA, Schleicher U, Bogdan C, Gasteiger G, Pircher H.

Nat Commun. 2018 Oct 8;9(1):4117. doi: 10.1038/s41467-018-06609-z.

6.

Memory vs memory-like: The different facets of CD8+ T-cell memory in HCV infection.

Hofmann M, Wieland D, Pircher H, Thimme R.

Immunol Rev. 2018 May;283(1):232-237. doi: 10.1111/imr.12642. Review.

PMID:
29664576
7.

Immunological tolerance to LCMV antigens differently affects control of acute and chronic virus infection in mice.

Woopen C, Straub T, Schweier O, Aichele U, Düker K, Boehm T, Pircher H.

Eur J Immunol. 2018 Jan;48(1):120-127. doi: 10.1002/eji.201747156. Epub 2017 Sep 15.

8.

CMV drives the expansion of highly functional memory T cells expressing NK-cell receptors in renal transplant recipients.

Makwana N, Foley B, Fernandez S, Lee S, Irish A, Pircher H, Price P.

Eur J Immunol. 2017 Aug;47(8):1324-1334. doi: 10.1002/eji.201747018. Epub 2017 Jul 3.

9.

Decoding NADPH oxidase 4 expression in human tumors.

Meitzler JL, Makhlouf HR, Antony S, Wu Y, Butcher D, Jiang G, Juhasz A, Lu J, Dahan I, Jansen-Dürr P, Pircher H, Shah AM, Roy K, Doroshow JH.

Redox Biol. 2017 Oct;13:182-195. doi: 10.1016/j.redox.2017.05.016. Epub 2017 May 26.

10.

KLRG1 impairs regulatory T-cell competitive fitness in the gut.

Meinicke H, Bremser A, Brack M, Schrenk K, Pircher H, Izcue A.

Immunology. 2017 Sep;152(1):65-73. doi: 10.1111/imm.12749. Epub 2017 Jun 20.

11.

Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells.

Petit M, Koziel R, Etemad S, Pircher H, Jansen-Dürr P.

Exp Gerontol. 2017 Jun;92:7-12. doi: 10.1016/j.exger.2017.03.004. Epub 2017 Mar 8.

PMID:
28286170
12.

NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.

Nlandu-Khodo S, Dissard R, Hasler U, Schäfer M, Pircher H, Jansen-Durr P, Krause KH, Martin PY, de Seigneux S.

Sci Rep. 2016 Dec 7;6:38598. doi: 10.1038/srep38598.

13.

Interferon-driven deletion of antiviral B cells at the onset of chronic infection.

Fallet B, Narr K, Ertuna YI, Remy M, Sommerstein R, Cornille K, Kreutzfeldt M, Page N, Zimmer G, Geier F, Straub T, Pircher H, Larimore K, Greenberg PD, Merkler D, Pinschewer DD.

Sci Immunol. 2016 Oct 21;1(4). pii: eaah6817. doi: 10.1126/sciimmunol.aah6817.

14.

α4 β1 integrin promotes accumulation of tissue-resident memory CD8+ T cells in salivary glands.

Woyciechowski S, Hofmann M, Pircher H.

Eur J Immunol. 2017 Feb;47(2):244-250. doi: 10.1002/eji.201646722. Epub 2016 Dec 7.

15.

A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells.

Weiher H, Pircher H, Jansen-Dürr P, Hegenbarth S, Knolle P, Grunau S, Vapola M, Hiltunen JK, Zwacka RM, Schmelzer E, Reumann K, Will H.

BMC Res Notes. 2016 Feb 27;9:128. doi: 10.1186/s13104-016-1939-0.

16.

The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.

Rapaport AS, Schriewer J, Gilfillan S, Hembrador E, Crump R, Plougastel BF, Wang Y, Le Friec G, Gao J, Cella M, Pircher H, Yokoyama WM, Buller RM, Colonna M.

Immunity. 2015 Dec 15;43(6):1112-24. doi: 10.1016/j.immuni.2015.11.005. Epub 2015 Dec 8.

17.

FAH domain containing protein 1 (FAHD-1) is required for mitochondrial function and locomotion activity in C. elegans.

Taferner A, Pircher H, Koziel R, von Grafenstein S, Baraldo G, Palikaras K, Liedl KR, Tavernarakis N, Jansen-Dürr P.

PLoS One. 2015 Aug 12;10(8):e0134161. doi: 10.1371/journal.pone.0134161. eCollection 2015.

18.

Id3 Controls Cell Death of 2B4+ Virus-Specific CD8+ T Cells in Chronic Viral Infection.

Menner AJ, Rauch KS, Aichele P, Pircher H, Schachtrup C, Schachtrup K.

J Immunol. 2015 Sep 1;195(5):2103-14. doi: 10.4049/jimmunol.1402607. Epub 2015 Jul 31.

19.

Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction.

Navarro E, Buendia I, Parada E, León R, Jansen-Duerr P, Pircher H, Egea J, Lopez MG.

Biochem Pharmacol. 2015 Oct 15;97(4):473-481. doi: 10.1016/j.bcp.2015.07.022. Epub 2015 Jul 23.

PMID:
26212551
20.

TGF-β downregulates KLRG1 expression in mouse and human CD8(+) T cells.

Schwartzkopff S, Woyciechowski S, Aichele U, Flecken T, Zhang N, Thimme R, Pircher H.

Eur J Immunol. 2015 Aug;45(8):2212-7. doi: 10.1002/eji.201545634. Epub 2015 Jun 15.

21.

Infection history determines the differentiation state of human CD8+ T cells.

van Aalderen MC, Remmerswaal EB, Verstegen NJ, Hombrink P, ten Brinke A, Pircher H, Kootstra NA, ten Berge IJ, van Lier RA.

J Virol. 2015 May;89(9):5110-23. doi: 10.1128/JVI.03478-14. Epub 2015 Feb 25.

22.

Ultrastructural Morphometry Points to a New Role for LAMTOR2 in Regulating the Endo/Lysosomal System.

Vogel GF, Ebner HL, de Araujo ME, Schmiedinger T, Eiter O, Pircher H, Gutleben K, Witting B, Teis D, Huber LA, Hess MW.

Traffic. 2015 Jun;16(6):617-34. doi: 10.1111/tra.12271. Epub 2015 Apr 14.

23.

T cell expansion is the limiting factor of virus control in mice with attenuated TCR signaling: implications for human immunodeficiency.

Hillen KM, Gather R, Enders A, Pircher H, Aichele P, Fisch P, Blumenthal B, Schamel WW, Straub T, Goodnow CC, Ehl S.

J Immunol. 2015 Mar 15;194(6):2725-34. doi: 10.4049/jimmunol.1400328. Epub 2015 Feb 11.

24.

Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase.

Pircher H, von Grafenstein S, Diener T, Metzger C, Albertini E, Taferner A, Unterluggauer H, Kramer C, Liedl KR, Jansen-Dürr P.

J Biol Chem. 2015 Mar 13;290(11):6755-62. doi: 10.1074/jbc.M114.609305. Epub 2015 Jan 9.

25.

ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells.

Höll M, Koziel R, Schäfer G, Pircher H, Pauck A, Hermann M, Klocker H, Jansen-Dürr P, Sampson N.

Mol Carcinog. 2016 Jan;55(1):27-39. doi: 10.1002/mc.22255. Epub 2015 Jan 5.

26.

Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients.

Hoffmann J, Shmeleva EV, Boag SE, Fiser K, Bagnall A, Murali S, Dimmick I, Pircher H, Martin-Ruiz C, Egred M, Keavney B, von Zglinicki T, Das R, Todryk S, Spyridopoulos I.

Circ Res. 2015 Jan 2;116(1):87-98. doi: 10.1161/CIRCRESAHA.116.304393. Epub 2014 Nov 10.

27.

Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function.

Remmerswaal EB, Klarenbeek PL, Alves NL, Doorenspleet ME, van Schaik BD, Esveldt RE, Idu MM, van Leeuwen EM, van der Bom-Baylon N, van Kampen AH, Koch SD, Pircher H, Bemelman FJ, Ten Brinke A, Baas F, Ten Berge IJ, van Lier RA, de Vries N.

J Virol. 2015 Jan;89(1):568-80. doi: 10.1128/JVI.02003-14. Epub 2014 Oct 22.

28.

Analysis of human papillomavirus E7 protein status in C-33A cervical cancer cells.

Kaiser A, Jenewein B, Pircher H, Rostek U, Jansen-Dürr P, Zwerschke W.

Virus Genes. 2015 Feb;50(1):12-21. doi: 10.1007/s11262-014-1129-x. Epub 2014 Oct 19.

PMID:
25326774
29.

Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules.

Raziorrouh B, Heeg M, Kurktschiev P, Schraut W, Zachoval R, Wendtner C, Wächtler M, Spannagl M, Denk G, Ulsenheimer A, Bengsch B, Pircher H, Diepolder HM, Grüner NH, Jung MC.

PLoS One. 2014 Aug 21;9(8):e105703. doi: 10.1371/journal.pone.0105703. eCollection 2014.

30.

Efficiency of dendritic cell vaccination against B16 melanoma depends on the immunization route.

Edele F, Dudda JC, Bachtanian E, Jakob T, Pircher H, Martin SF.

PLoS One. 2014 Aug 14;9(8):e105266. doi: 10.1371/journal.pone.0105266. eCollection 2014.

31.

Expanded Human Blood-Derived γδT Cells Display Potent Antigen-Presentation Functions.

Khan MW, Curbishley SM, Chen HC, Thomas AD, Pircher H, Mavilio D, Steven NM, Eberl M, Moser B.

Front Immunol. 2014 Jul 23;5:344. doi: 10.3389/fimmu.2014.00344. eCollection 2014.

32.

Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency.

Rensing-Ehl A, Völkl S, Speckmann C, Lorenz MR, Ritter J, Janda A, Abinun M, Pircher H, Bengsch B, Thimme R, Fuchs I, Ammann S, Allgäuer A, Kentouche K, Cant A, Hambleton S, Bettoni da Cunha C, Huetker S, Kühnle I, Pekrun A, Seidel MG, Hummel M, Mackensen A, Schwarz K, Ehl S.

Blood. 2014 Aug 7;124(6):851-60. doi: 10.1182/blood-2014-03-564286. Epub 2014 Jun 3.

PMID:
24894771
33.

KLRG1 activity is regulated by association with the transferrin receptor.

Schweier O, Hofmann M, Pircher H.

Eur J Immunol. 2014 Jun;44(6):1851-6. doi: 10.1002/eji.201344234. Epub 2014 Mar 7.

34.

Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells.

Legat A, Speiser DE, Pircher H, Zehn D, Fuertes Marraco SA.

Front Immunol. 2013 Dec 19;4:455. doi: 10.3389/fimmu.2013.00455. eCollection 2013.

35.

Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.

Stärck L, Popp K, Pircher H, Uckert W.

J Immunol. 2014 Jan 1;192(1):206-13. doi: 10.4049/jimmunol.1202591. Epub 2013 Nov 29.

36.

Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype.

Göthert JR, Eisele L, Klein-Hitpass L, Weber S, Zesewitz ML, Sellmann L, Röth A, Pircher H, Dührsen U, Dürig J.

Cancer Immunol Immunother. 2013 Nov;62(11):1697-1709.

PMID:
24022692
37.

In situ evolution of virus-specific cytotoxic T cell responses in the lung.

Frey S, Pircher H, Follo M, Collins P, Krempl C, Ehl S.

J Virol. 2013 Oct;87(20):11267-75. doi: 10.1128/JVI.00255-13. Epub 2013 Aug 14.

38.

Phenotypic and functional characterization of circulating polyomavirus BK VP1-specific CD8+ T cells in healthy adults.

van Aalderen MC, Remmerswaal EB, Heutinck KM, ten Brinke A, Pircher H, van Lier RA, ten Berge IJ.

J Virol. 2013 Sep;87(18):10263-72. doi: 10.1128/JVI.01540-13. Epub 2013 Jul 17.

39.

Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcγR.

Straub T, Schweier O, Bruns M, Nimmerjahn F, Waisman A, Pircher H.

Eur J Immunol. 2013 Sep;43(9):2338-48. doi: 10.1002/eji.201343565. Epub 2013 Jul 15.

40.

Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-α production by interaction with its soluble E-cadherin ligand in chronically inflamed joints.

Melis L, Van Praet L, Pircher H, Venken K, Elewaut D.

Ann Rheum Dis. 2014 Jun;73(6):1223-31. doi: 10.1136/annrheumdis-2013-203881. Epub 2013 Jun 5.

PMID:
23740233
41.

Thymus-resident memory CD8+ T cells mediate local immunity.

Hofmann M, Oschowitzer A, Kurzhals SR, Krüger CC, Pircher H.

Eur J Immunol. 2013 Sep;43(9):2295-304. doi: 10.1002/eji.201343519. Epub 2013 Jun 26.

42.

The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans.

Spielmann G, Bollard CM, Bigley AB, Hanley PJ, Blaney JW, LaVoy EC, Pircher H, Simpson RJ.

Brain Behav Immun. 2014 Jul;39:142-51. doi: 10.1016/j.bbi.2013.05.003. Epub 2013 May 15.

PMID:
23684819
43.

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4.

Kozieł R, Pircher H, Kratochwil M, Lener B, Hermann M, Dencher NA, Jansen-Dürr P.

Biochem J. 2013 Jun 1;452(2):231-9. doi: 10.1042/BJ20121778.

PMID:
23514110
44.

Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans.

Dolfi DV, Mansfield KD, Polley AM, Doyle SA, Freeman GJ, Pircher H, Schmader KE, Wherry EJ.

J Leukoc Biol. 2013 Jun;93(6):825-36. doi: 10.1189/jlb.0912438. Epub 2013 Feb 25.

45.

Characterisation of Nox4 inhibitors from edible plants.

Kofler PA, Pircher H, von Grafenstein S, Diener T, Höll M, Liedl KR, Siems K, Jansen-Dürr P.

Planta Med. 2013 Mar;79(3-4):244-52. doi: 10.1055/s-0032-1328129. Epub 2013 Jan 23.

PMID:
23345167
46.

Killer cell lectin-like receptor G1 deficiency significantly enhances survival after Mycobacterium tuberculosis infection.

Cyktor JC, Carruthers B, Stromberg P, Flaño E, Pircher H, Turner J.

Infect Immun. 2013 Apr;81(4):1090-9. doi: 10.1128/IAI.01199-12. Epub 2013 Jan 22.

47.

High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction.

Hoffmann J, Fiser K, Weaver J, Dimmick I, Loeher M, Pircher H, Martin-Ruiz C, Veerasamy M, Keavney B, von Zglinicki T, Spyridopoulos I.

PLoS One. 2012;7(10):e47155. doi: 10.1371/journal.pone.0047155. Epub 2012 Oct 16.

48.

CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.

Hervas-Stubbs S, Mancheño U, Riezu-Boj JI, Larraga A, Ochoa MC, Alignani D, Alfaro C, Morales-Kastresana A, Gonzalez I, Larrea E, Pircher H, Le Bon A, Lopez-Picazo JM, Martín-Algarra S, Prieto J, Melero I.

J Immunol. 2012 Oct 1;189(7):3299-310. Epub 2012 Aug 27.

49.

Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells.

Hechinger AK, Maas K, Dürr C, Leonhardt F, Prinz G, Marks R, Gerlach U, Hofmann M, Fisch P, Finke J, Pircher H, Zeiser R.

Haematologica. 2013 Jan;98(1):31-40. doi: 10.3324/haematol.2012.065789. Epub 2012 Jul 16.

50.

Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo.

Mueller K, von Mässenhausen A, Aichele U, Stärck L, Leisegang M, Uckert W, Pircher H.

J Virol. 2012 Oct;86(19):10866-9. doi: 10.1128/JVI.01472-12. Epub 2012 Jul 11.

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