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Items: 39

1.

The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs.

Rossetto O, Pirazzini M, Lista F, Montecucco C.

Cell Microbiol. 2019 May 3:e13037. doi: 10.1111/cmi.13037. [Epub ahead of print] Review.

PMID:
31050145
2.

Primary resistance of human patients to botulinum neurotoxins A and B.

Pirazzini M, Carle S, Barth H, Rossetto O, Montecucco C.

Ann Clin Transl Neurol. 2018 Jul 17;5(8):971-975. doi: 10.1002/acn3.586. eCollection 2018 Aug.

3.

Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle.

Straka T, Vita V, Prokshi K, Hörner SJ, Khan MM, Pirazzini M, Williams MPI, Hafner M, Zaglia T, Rudolf R.

Int J Mol Sci. 2018 Jul 1;19(7). pii: E1935. doi: 10.3390/ijms19071935.

4.

Variability in venom composition of European viper subspecies limits the cross-effectiveness of antivenoms.

Zanetti G, Duregotti E, Locatelli CA, Giampreti A, Lonati D, Rossetto O, Pirazzini M.

Sci Rep. 2018 Jun 29;8(1):9818. doi: 10.1038/s41598-018-28135-0.

5.

Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls.

Bano L, Tonon E, Drigo I, Pirazzini M, Guolo A, Farina G, Agnoletti F, Montecucco C.

Toxins (Basel). 2018 Jun 19;10(6). pii: E248. doi: 10.3390/toxins10060248.

6.

Novel Botulinum Neurotoxins: Exploring Underneath the Iceberg Tip.

Tehran DA, Pirazzini M.

Toxins (Basel). 2018 May 10;10(5). pii: E190. doi: 10.3390/toxins10050190. Review.

7.

High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans.

Carle S, Pirazzini M, Rossetto O, Barth H, Montecucco C.

Toxins (Basel). 2017 Dec 19;9(12). pii: E404. doi: 10.3390/toxins9120404.

8.

Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals.

Pirazzini M, Azarnia Tehran D, Zanetti G, Rossetto O, Montecucco C.

Toxicon. 2018 Jun 1;147:32-37. doi: 10.1016/j.toxicon.2017.10.028. Epub 2017 Oct 28. Review.

PMID:
29111118
9.

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M.

PLoS Pathog. 2017 Aug 11;13(8):e1006567. doi: 10.1371/journal.ppat.1006567. eCollection 2017 Aug.

10.

CXCL12α/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals.

Negro S, Lessi F, Duregotti E, Aretini P, La Ferla M, Franceschi S, Menicagli M, Bergamin E, Radice E, Thelen M, Megighian A, Pirazzini M, Mazzanti CM, Rigoni M, Montecucco C.

EMBO Mol Med. 2017 Aug;9(8):1000-1010. doi: 10.15252/emmm.201607257.

11.

Ablation of S1P3 receptor protects mouse soleus from age-related drop in muscle mass, force, and regenerative capacity.

Bondì M, Germinario E, Pirazzini M, Zanetti G, Cencetti F, Donati C, Gorza L, Betto R, Bruni P, Danieli-Betto D.

Am J Physiol Cell Physiol. 2017 Jul 1;313(1):C54-C67. doi: 10.1152/ajpcell.00027.2017. Epub 2017 Apr 26.

12.

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.

Pirazzini M, Rossetto O, Eleopra R, Montecucco C.

Pharmacol Rev. 2017 Apr;69(2):200-235. doi: 10.1124/pr.116.012658. Review.

13.

Challenges in searching for therapeutics against Botulinum Neurotoxins.

Pirazzini M, Rossetto O.

Expert Opin Drug Discov. 2017 May;12(5):497-510. doi: 10.1080/17460441.2017.1303476. Epub 2017 Mar 17. Review.

PMID:
28271909
14.

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

Peck MW, Smith TJ, Anniballi F, Austin JW, Bano L, Bradshaw M, Cuervo P, Cheng LW, Derman Y, Dorner BG, Fisher A, Hill KK, Kalb SR, Korkeala H, Lindström M, Lista F, Lúquez C, Mazuet C, Pirazzini M, Popoff MR, Rossetto O, Rummel A, Sesardic D, Singh BR, Stringer SC.

Toxins (Basel). 2017 Jan 18;9(1). pii: E38. doi: 10.3390/toxins9010038. Review.

15.

Erratum to "Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism" [Biochem. Pharmacol. 98 (2015) 522-530].

Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C.

Biochem Pharmacol. 2016 Sep 1;115:152. doi: 10.1016/j.bcp.2016.07.006. Epub 2016 Jul 12. No abstract available.

PMID:
27498956
16.

Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals.

Azarnia Tehran D, Pirazzini M, Leka O, Mattarei A, Lista F, Binz T, Rossetto O, Montecucco C.

Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12647. Epub 2016 Aug 4.

PMID:
27404998
17.

A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins.

Azarnia Tehran D, Zanetti G, Leka O, Lista F, Fillo S, Binz T, Shone CC, Rossetto O, Montecucco C, Paradisi C, Mattarei A, Pirazzini M.

Sci Rep. 2015 Dec 16;5:17513. doi: 10.1038/srep17513.

18.

Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction.

Duregotti E, Zanetti G, Scorzeto M, Megighian A, Montecucco C, Pirazzini M, Rigoni M.

Toxins (Basel). 2015 Dec 8;7(12):5322-36. doi: 10.3390/toxins7124887.

19.

Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism.

Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C.

Biochem Pharmacol. 2015 Dec 1;98(3):522-30. doi: 10.1016/j.bcp.2015.09.023. Epub 2015 Oct 9.

PMID:
26449594
20.

On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments.

Pirazzini M, Azarnia Tehran D, Leka O, Zanetti G, Rossetto O, Montecucco C.

Biochim Biophys Acta. 2016 Mar;1858(3):467-74. doi: 10.1016/j.bbamem.2015.08.014. Epub 2015 Aug 22. Review.

21.

Current gaps in basic science knowledge of botulinum neurotoxin biological actions.

Rossetto O, Pirazzini M, Montecucco C.

Toxicon. 2015 Dec 1;107(Pt A):59-63. doi: 10.1016/j.toxicon.2015.07.002. Epub 2015 Jul 7.

PMID:
26163315
22.

The thioredoxin reductase--Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles.

Pirazzini M, Azarnia Tehran D, Zanetti G, Lista F, Binz T, Shone CC, Rossetto O, Montecucco C.

Toxicon. 2015 Dec 1;107(Pt A):32-6. doi: 10.1016/j.toxicon.2015.06.019. Epub 2015 Jun 27.

PMID:
26130523
23.

Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.

Pirazzini M, Azarnia Tehran D, Zanetti G, Megighian A, Scorzeto M, Fillo S, Shone CC, Binz T, Rossetto O, Lista F, Montecucco C.

Cell Rep. 2014 Sep 25;8(6):1870-1878. doi: 10.1016/j.celrep.2014.08.017. Epub 2014 Sep 15.

24.

Botulinum neurotoxins: genetic, structural and mechanistic insights.

Rossetto O, Pirazzini M, Montecucco C.

Nat Rev Microbiol. 2014 Aug;12(8):535-49. doi: 10.1038/nrmicro3295. Epub 2014 Jun 30. Review.

PMID:
24975322
25.

Diphtheria toxin conformational switching at acidic pH.

Leka O, Vallese F, Pirazzini M, Berto P, Montecucco C, Zanotti G.

FEBS J. 2014 May;281(9):2115-22. doi: 10.1111/febs.12783. Epub 2014 Apr 1.

26.

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T.

FEBS Lett. 2013 Nov 29;587(23):3831-6. doi: 10.1016/j.febslet.2013.10.010. Epub 2013 Oct 21.

27.

Botulinum neurotoxin type A is internalized and translocated from small synaptic vesicles at the neuromuscular junction.

Colasante C, Rossetto O, Morbiato L, Pirazzini M, Molgó J, Montecucco C.

Mol Neurobiol. 2013 Aug;48(1):120-7. doi: 10.1007/s12035-013-8423-9. Epub 2013 Mar 8.

PMID:
23471747
28.

Botulinum neurotoxin serotype D is poorly effective in humans: an in vivo electrophysiological study.

Eleopra R, Montecucco C, Devigili G, Lettieri C, Rinaldo S, Verriello L, Pirazzini M, Caccin P, Rossetto O.

Clin Neurophysiol. 2013 May;124(5):999-1004. doi: 10.1016/j.clinph.2012.11.004. Epub 2012 Dec 13.

PMID:
23245668
29.

Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons.

Pirazzini M, Rossetto O, Bertasio C, Bordin F, Shone CC, Binz T, Montecucco C.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):38-42. doi: 10.1016/j.bbrc.2012.11.048. Epub 2012 Nov 27.

PMID:
23200837
30.

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.

Pirazzini M, Bordin F, Rossetto O, Shone CC, Binz T, Montecucco C.

FEBS Lett. 2013 Jan 16;587(2):150-5. doi: 10.1016/j.febslet.2012.11.007. Epub 2012 Nov 21.

31.

An update on the mechanism of action of tetanus and botulinum neurotoxins.

Rossetto O, Pirazzini M, Bolognese P, Rigoni M, Montecucco C.

Acta Chim Slov. 2011 Dec;58(4):702-7. Review.

PMID:
24061118
32.

Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity.

Ferrari E, Maywood ES, Restani L, Caleo M, Pirazzini M, Rossetto O, Hastings MH, Niranjan D, Schiavo G, Davletov B.

Toxins (Basel). 2011 Apr;3(4):345-55. doi: 10.3390/toxins3040345. Epub 2011 Mar 24.

33.

Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.

Pirazzini M, Rossetto O, Bolognese P, Shone CC, Montecucco C.

Cell Microbiol. 2011 Nov;13(11):1731-43. doi: 10.1111/j.1462-5822.2011.01654.x. Epub 2011 Aug 25.

PMID:
21790947
34.

pH-sensitive PEG-based micelles for tumor targeting.

Salmaso S, Bersani S, Pirazzini M, Caliceti P.

J Drug Target. 2011 May;19(4):303-13. doi: 10.3109/1061186X.2010.499466. Epub 2010 Nov 24.

PMID:
21091382
35.

Rates of surgical-site infection: an international comparison.

Moro ML, Morsillo F, Tangenti M, Mongardi M, Pirazzini MC, Ragni P; ICN Regional Group.

Infect Control Hosp Epidemiol. 2005 May;26(5):442-8.

PMID:
15954481
36.

[Methicillin-resistant staphylococci in pediatric resuscitation].

Pigna A, Pirazzini M, Grillione G, Gatti M, Corticelli AS.

Minerva Anestesiol. 1995 Jun;61(6):249-57. Italian.

PMID:
8584190
37.

[Comparison between bacterial contamination of the circular circuit and of the non-rebreathing circle used with an antibacterial filter].

Gregorini P, Ronca A, Festa C, De Patre P, Di Pede B, Giamperoli A, Tangenti M, Pirazzini MC.

Minerva Anestesiol. 1993 Apr;59(4):205-9. Italian.

PMID:
8327174
38.

[Nosocomial infections in pediatric resuscitation: incidence study].

Pigna A, Grillone G, Pirazzini M, Mondardini MC, De Rose R, Rossi F.

Minerva Anestesiol. 1991 Oct;57(10):818-9. Italian. No abstract available.

PMID:
1961498
39.

Intensive care units as a source of methicillin-resistant Staphylococcus aureus.

Corticelli AS, Di Nino GF, Gatti M, Melotti RM, Petrini F, Pigna A, Pirazzini M, Rossi R, Varoli O.

Microbiologica. 1987 Oct;10(4):345-51.

PMID:
3695983

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