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Items: 22

1.

Nectar foragers contribute to the pollination of buzz-pollinated plant species.

Moquet L, Bruyère L, Pirard B, Jacquemart AL.

Am J Bot. 2017 Oct;104(10):1451-1463. doi: 10.3732/ajb.1700090.

2.

Building Compound Archives for the Future.

Lewis R, Deheuvels J, Ertl P, Pirard B, Sirockin F.

Mol Inform. 2016 Dec;35(11-12):580-582. doi: 10.1002/minf.201600042. Epub 2016 Jun 1.

PMID:
27870238
3.

Evaluation of a semi-automated workflow for fragment growing.

Pirard B, Ertl P.

J Chem Inf Model. 2015 Jan 26;55(1):180-93. doi: 10.1021/ci5006355. Epub 2015 Jan 6.

PMID:
25514394
4.

The quest for novel chemical matter and the contribution of computer-aided de novo design.

Pirard B.

Expert Opin Drug Discov. 2011 Mar;6(3):225-31. doi: 10.1517/17460441.2011.554394.

PMID:
22647201
5.

New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck.

Gommermann N, Buehlmayer P, von Matt A, Breitenstein W, Masuya K, Pirard B, Furet P, Cowan-Jacob SW, Weckbecker G.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3628-31. doi: 10.1016/j.bmcl.2010.04.112. Epub 2010 Apr 29.

PMID:
20483608
6.

Structure-based chemogenomics: analysis of protein family landscapes.

Pirard B.

Methods Mol Biol. 2009;575:281-96. doi: 10.1007/978-1-60761-274-2_12. Review.

PMID:
19727620
7.

Insight into the structural determinants for selective inhibition of matrix metalloproteinases.

Pirard B.

Drug Discov Today. 2007 Aug;12(15-16):640-6. Epub 2007 Jul 27. Review.

PMID:
17706545
8.

Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation.

Decher N, Kumar P, Gonzalez T, Pirard B, Sanguinetti MC.

Mol Pharmacol. 2006 Oct;70(4):1204-11. Epub 2006 Jul 11.

PMID:
16835355
10.

Knowledge-driven lead discovery.

Pirard B.

Mini Rev Med Chem. 2005 Nov;5(11):1045-52. Review.

PMID:
16307533
11.

The discovery of Kv1.5 blockers as a case study for the application of virtual screening approaches.

Pirard B, Brendel J, Peukert S.

J Chem Inf Model. 2005 Mar-Apr;45(2):477-85.

PMID:
15807513
12.

Structural basis for the highly selective inhibition of MMP-13.

Engel CK, Pirard B, Schimanski S, Kirsch R, Habermann J, Klingler O, Schlotte V, Weithmann KU, Wendt KU.

Chem Biol. 2005 Feb;12(2):181-9.

13.

Computational methods for the identification and optimisation of high quality leads.

Pirard B.

Comb Chem High Throughput Screen. 2004 Jun;7(4):271-80. Review.

PMID:
15200376
14.

Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1.5 channel.

Peukert S, Brendel J, Pirard B, Strübing C, Kleemann HW, Böhme T, Hemmerle H.

Bioorg Med Chem Lett. 2004 Jun 7;14(11):2823-7.

PMID:
15125940
16.

Molecular basis for Kv1.5 channel block: conservation of drug binding sites among voltage-gated K+ channels.

Decher N, Pirard B, Bundis F, Peukert S, Baringhaus KH, Busch AE, Steinmeyer K, Sanguinetti MC.

J Biol Chem. 2004 Jan 2;279(1):394-400. Epub 2003 Oct 25.

17.

Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5.

Peukert S, Brendel J, Pirard B, Brüggemann A, Below P, Kleemann HW, Hemmerle H, Schmidt W.

J Med Chem. 2003 Feb 13;46(4):486-98.

PMID:
12570371
18.

A structure-based design approach to the development of novel, reversible AChE inhibitors.

Doucet-Personeni C, Bentley PD, Fletcher RJ, Kinkaid A, Kryger G, Pirard B, Taylor A, Taylor R, Taylor J, Viner R, Silman I, Sussman JL, Greenblatt HM, Lewis T.

J Med Chem. 2001 Sep 27;44(20):3203-15.

PMID:
11563919
19.

Computational approaches towards the rational design of drug-like compound libraries.

Matter H, Baringhaus KH, Naumann T, Klabunde T, Pirard B.

Comb Chem High Throughput Screen. 2001 Sep;4(6):453-75. Review.

PMID:
11562252
20.

Classification of kinase inhibitors using BCUT descriptors.

Pirard B, Pickett SD.

J Chem Inf Comput Sci. 2000 Nov-Dec;40(6):1431-40.

PMID:
11128102
21.

Molecular modelling and conformational analysis of a GABAB antagonist.

Pirard B, Durant F.

J Comput Aided Mol Des. 1996 Feb;10(1):31-40.

PMID:
8786413
22.

Structure-affinity relationships of baclofen and 3-heteroaromatic analogues.

Pirard B, Carrupt PA, Testa B, Tsai RS, Berthelot P, Vaccher C, Debaert M, Durant F.

Bioorg Med Chem. 1995 Nov;3(11):1537-45.

PMID:
8634834

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