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Items: 11


Crystal structures and protein engineering of three different penicillin G acylases from Gram-positive bacteria with different thermostability.

Mayer J, Pippel J, Günther G, Müller C, Lauermann A, Knuuti T, Blankenfeldt W, Jahn D, Biedendieck R.

Appl Microbiol Biotechnol. 2019 Jun 21. doi: 10.1007/s00253-019-09977-8. [Epub ahead of print]


Crystal Structures of R-Type Bacteriocin Sheath and Tube Proteins CD1363 and CD1364 From Clostridium difficile in the Pre-assembled State.

Schwemmlein N, Pippel J, Gazdag EM, Blankenfeldt W.

Front Microbiol. 2018 Aug 3;9:1750. doi: 10.3389/fmicb.2018.01750. eCollection 2018.


Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice.

Lambertz RLO, Pippel J, Gerhauser I, Kollmus H, Anhlan D, Hrincius ER, Krausze J, Kühn N, Schughart K.

J Gen Virol. 2018 Sep;99(9):1187-1198. doi: 10.1099/jgv.0.001128. Epub 2018 Aug 6.


Molecular Mechanisms of Vaspin Action - From Adipose Tissue to Skin and Bone, from Blood Vessels to the Brain.

Weiner J, Zieger K, Pippel J, Heiker JT.

Adv Exp Med Biol. 2018 Jul 27. doi: 10.1007/5584_2018_241. [Epub ahead of print]


Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System.

von Tesmar A, Hoffmann M, Pippel J, Fayad AA, Dausend-Werner S, Bauer A, Blankenfeldt W, Müller R.

Cell Chem Biol. 2017 Oct 19;24(10):1216-1227.e8. doi: 10.1016/j.chembiol.2017.08.001. Epub 2017 Sep 7.


Glycosylation of human vaspin (SERPINA12) and its impact on serpin activity, heparin binding and thermal stability.

Oertwig K, Ulbricht D, Hanke S, Pippel J, Bellmann-Sickert K, Sträter N, Heiker JT.

Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1188-1194. doi: 10.1016/j.bbapap.2017.06.020. Epub 2017 Jun 29.


Basic Residues of β-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12).

Ulbricht D, Oertwig K, Arnsburg K, Saalbach A, Pippel J, Sträter N, Heiker JT.

J Biol Chem. 2017 Jan 20;292(3):994-1004. doi: 10.1074/jbc.M116.748020. Epub 2016 Dec 9.


Crystal structure of cleaved vaspin (serpinA12).

Pippel J, Kuettner EB, Ulbricht D, Daberger J, Schultz S, Heiker JT, Sträter N.

Biol Chem. 2016 Jan 1;397(2):111-23. doi: 10.1515/hsz-2015-0229.


A unique serpin P1' glutamate and a conserved β-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin).

Ulbricht D, Pippel J, Schultz S, Meier R, Sträter N, Heiker JT.

Biochem J. 2015 Sep 15;470(3):357-67. doi: 10.1042/BJ20150643. Epub 2015 Jul 21.


α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors.

Bhattarai S, Freundlieb M, Pippel J, Meyer A, Abdelrahman A, Fiene A, Lee SY, Zimmermann H, Yegutkin GG, Sträter N, El-Tayeb A, Müller CE.

J Med Chem. 2015 Aug 13;58(15):6248-63. doi: 10.1021/acs.jmedchem.5b00802. Epub 2015 Jul 30.


Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling.

Knapp K, Zebisch M, Pippel J, El-Tayeb A, Müller CE, Sträter N.

Structure. 2012 Dec 5;20(12):2161-73. doi: 10.1016/j.str.2012.10.001. Epub 2012 Nov 8.

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