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UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM.

Escalante SG, Brightmore JA, Piper PW, Millson SH.

Cell Stress Chaperones. 2018 Jul;23(4):609-615. doi: 10.1007/s12192-017-0870-1. Epub 2017 Dec 29.


Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival.

Gomez-Escalante S, Piper PW, Millson SH.

Cell Stress Chaperones. 2017 Jan;22(1):135-141. doi: 10.1007/s12192-016-0750-0. Epub 2016 Nov 25.


Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).

Millson S, van Oosten-Hawle P, Alkuriji MA, Truman A, Siderius M, Piper PW.

Cell Stress Chaperones. 2014 Sep;19(5):695-703. doi: 10.1007/s12192-014-0497-4. Epub 2014 Jan 23.


Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics.

Piper PW, Millson SH.

Open Biol. 2012 Dec 12;2(12):120138. doi: 10.1098/rsob.120138. Review.


Maximising the yeast chronological lifespan.

Piper PW.

Subcell Biochem. 2012;57:145-59. doi: 10.1007/978-94-007-2561-4_7. Review.


Resistance of yeasts to weak organic acid food preservatives.

Piper PW.

Adv Appl Microbiol. 2011;77:97-113. doi: 10.1016/B978-0-12-387044-5.00004-2.


Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.

Piper PW, Millson SH.

Pharmaceuticals (Basel). 2011 Oct 25;4(11):1400-1422. Review.


Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90.

Millson SH, Chua CS, Roe SM, Polier S, Solovieva S, Pearl LH, Sim TS, Prodromou C, Piper PW.

FASEB J. 2011 Nov;25(11):3828-37. doi: 10.1096/fj.11-188821. Epub 2011 Jul 21.


Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity.

Mollapour M, Tsutsumi S, Truman AW, Xu W, Vaughan CK, Beebe K, Konstantinova A, Vourganti S, Panaretou B, Piper PW, Trepel JB, Prodromou C, Pearl LH, Neckers L.

Mol Cell. 2011 Mar 18;41(6):672-81. doi: 10.1016/j.molcel.2011.02.011.


Understanding of the Hsp90 molecular chaperone reaches new heights.

Vaughan CK, Neckers L, Piper PW.

Nat Struct Mol Biol. 2010 Dec;17(12):1400-4. doi: 10.1038/nsmb1210-1400. No abstract available.


The Fps1p aquaglyceroporin facilitates the use of small aliphatic amides as a nitrogen source by amidase-expressing yeasts.

Shepherd A, Piper PW.

FEMS Yeast Res. 2010 Aug 1;10(5):527-34. doi: 10.1111/j.1567-1364.2010.00636.x. Epub 2010 Apr 19.


Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.

Mollapour M, Tsutsumi S, Donnelly AC, Beebe K, Tokita MJ, Lee MJ, Lee S, Morra G, Bourboulia D, Scroggins BT, Colombo G, Blagg BS, Panaretou B, Stetler-Stevenson WG, Trepel JB, Piper PW, Prodromou C, Pearl LH, Neckers L.

Mol Cell. 2010 Feb 12;37(3):333-43. doi: 10.1016/j.molcel.2010.01.005.


A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta.

Millson SH, Prodromou C, Piper PW.

Biochem Pharmacol. 2010 Jun 1;79(11):1581-8. doi: 10.1016/j.bcp.2010.01.031. Epub 2010 Feb 4.


Presence of the Fps1p aquaglyceroporin channel is essential for Hog1p activation, but suppresses Slt2(Mpk1)p activation, with acetic acid stress of yeast.

Mollapour M, Shepherd A, Piper PW.

Microbiology. 2009 Oct;155(Pt 10):3304-11. doi: 10.1099/mic.0.030502-0. Epub 2009 Jul 16.


The Hsp90/Cdc37p chaperone system is a determinant of molybdate resistance in Saccharomyces cerevisiae.

Millson SH, Nuttall JM, Mollapour M, Piper PW.

Yeast. 2009 Jun;26(6):339-47. doi: 10.1002/yea.1670.


Structural basis of the radicicol resistance displayed by a fungal hsp90.

Prodromou C, Nuttall JM, Millson SH, Roe SM, Sim TS, Tan D, Workman P, Pearl LH, Piper PW.

ACS Chem Biol. 2009 Apr 17;4(4):289-97. doi: 10.1021/cb9000316.


A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s.

Vaughan CK, Piper PW, Pearl LH, Prodromou C.

FEBS J. 2009 Jan;276(1):199-209. doi: 10.1111/j.1742-4658.2008.06773.x. Epub 2008 Nov 20.


Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

Vaughan CK, Mollapour M, Smith JR, Truman A, Hu B, Good VM, Panaretou B, Neckers L, Clarke PA, Workman P, Piper PW, Prodromou C, Pearl LH.

Mol Cell. 2008 Sep 26;31(6):886-95. doi: 10.1016/j.molcel.2008.07.021.


Chaperone ligand-discrimination by the TPR-domain protein Tah1.

Millson SH, Vaughan CK, Zhai C, Ali MM, Panaretou B, Piper PW, Pearl LH, Prodromou C.

Biochem J. 2008 Jul 15;413(2):261-8. doi: 10.1042/BJ20080105.


Novel stress responses facilitate Saccharomyces cerevisiae growth in the presence of the monocarboxylate preservatives.

Mollapour M, Shepherd A, Piper PW.

Yeast. 2008 Mar;25(3):169-77. doi: 10.1002/yea.1576. Review.


In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity.

Truman AW, Millson SH, Nuttall JM, Mollapour M, Prodromou C, Piper PW.

Eukaryot Cell. 2007 Apr;6(4):744-52. Epub 2007 Feb 9.


Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae.

Phelan JP, Millson SH, Parker PJ, Piper PW, Cooke FT.

J Cell Sci. 2006 Oct 15;119(Pt 20):4225-34. Epub 2006 Sep 26.


Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase.

Truman AW, Millson SH, Nuttall JM, King V, Mollapour M, Prodromou C, Pearl LH, Piper PW.

Eukaryot Cell. 2006 Nov;5(11):1914-24. Epub 2006 Sep 1.


Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex.

Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper PW, Prodromou C, Pearl LH.

Nature. 2006 Apr 20;440(7087):1013-7.


Long-lived yeast as a model for ageing research.

Piper PW.

Yeast. 2006 Feb;23(3):215-26. Review.


Weak acid and alkali stress regulate phosphatidylinositol bisphosphate synthesis in Saccharomyces cerevisiae.

Mollapour M, Phelan JP, Millson SH, Piper PW, Cooke FT.

Biochem J. 2006 Apr 1;395(1):73-80.


Hypoxia abolishes transience of the heat-shock response in the methylotrophic yeast Hansenula polymorpha.

Guerra E, Chye PP, Berardi E, Piper PW.

Microbiology. 2005 Mar;151(Pt 3):805-11.


Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex.

Hu B, Liao C, Millson SH, Mollapour M, Prodromou C, Pearl LH, Piper PW, Panaretou B.

Mol Microbiol. 2005 Mar;55(6):1735-50.


Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach.

Millson SH, Truman AW, Wolfram F, King V, Panaretou B, Prodromou C, Pearl LH, Piper PW.

Cell Stress Chaperones. 2004 Winter;9(4):359-68.


Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle.

Siligardi G, Hu B, Panaretou B, Piper PW, Pearl LH, Prodromou C.

J Biol Chem. 2004 Dec 10;279(50):51989-98. Epub 2004 Oct 2.


Screening the yeast deletant mutant collection for hypersensitivity and hyper-resistance to sorbate, a weak organic acid food preservative.

Mollapour M, Fong D, Balakrishnan K, Harris N, Thompson S, Schüller C, Kuchler K, Piper PW.

Yeast. 2004 Aug;21(11):927-46.


Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

Meyer P, Prodromou C, Liao C, Hu B, Roe SM, Vaughan CK, Vlasic I, Panaretou B, Piper PW, Pearl LH.

EMBO J. 2004 Mar 24;23(6):1402-10.


Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

Meyer P, Prodromou C, Liao C, Hu B, Mark Roe S, Vaughan CK, Vlasic I, Panaretou B, Piper PW, Pearl LH.

EMBO J. 2004 Feb 11;23(3):511-9. Epub 2004 Jan 22. Erratum in: EMBO J. 2004 Mar 24;23(6):1402. Corrected and republished in: EMBO J. 2004 Mar 24;23(6):1402-10.


The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37).

Roe SM, Ali MM, Meyer P, Vaughan CK, Panaretou B, Piper PW, Prodromou C, Pearl LH.

Cell. 2004 Jan 9;116(1):87-98.


Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast.

Piper PW, Millson SH, Mollapour M, Panaretou B, Siligardi G, Pearl LH, Prodromou C.

Eur J Biochem. 2003 Dec;270(23):4689-95.


Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae.

Schüller C, Mamnun YM, Mollapour M, Krapf G, Schuster M, Bauer BE, Piper PW, Kuchler K.

Mol Biol Cell. 2004 Feb;15(2):706-20. Epub 2003 Nov 14.


Base excision repair activities required for yeast to attain a full chronological life span.

Maclean MJ, Aamodt R, Harris N, Alseth I, Seeberg E, Bjørås M, Piper PW.

Aging Cell. 2003 Apr;2(2):93-104.


Vectors for N- or C-terminal positioning of the yeast Gal4p DNA binding or activator domains.

Millson SH, Truman AW, Piper PW.

Biotechniques. 2003 Jul;35(1):60-4. No abstract available.


Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.

Harris N, Costa V, MacLean M, Mollapour M, Moradas-Ferreira P, Piper PW.

Free Radic Biol Med. 2003 Jun 15;34(12):1599-606.


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