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Items: 1 to 50 of 56


Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control.

Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ.

Nat Metab. 2019 May;1(5):532-545. doi: 10.1038/s42255-019-0059-2. Epub 2019 Apr 29.


Sex-specific transcriptomic responses to changes in the nutritional environment.

Camus MF, Piper MD, Reuter M.

Elife. 2019 Aug 22;8. pii: e47262. doi: 10.7554/eLife.47262.


Transgenerational Obesity and Healthy Aging in Drosophila.

Camilleri-Carter TL, Dowling DK, L Robker R, Piper MDW.

J Gerontol A Biol Sci Med Sci. 2019 Sep 15;74(10):1582-1589. doi: 10.1093/gerona/glz154.


Turning food into eggs: insights from nutritional biology and developmental physiology of Drosophila.

Mirth CK, Nogueira Alves A, Piper MD.

Curr Opin Insect Sci. 2019 Feb;31:49-57. doi: 10.1016/j.cois.2018.08.006. Epub 2018 Aug 30. Review.


Using Mouse and Drosophila Models to Investigate the Mechanistic Links between Diet, Obesity, Type II Diabetes, and Cancer.

Warr CG, Shaw KH, Azim A, Piper MDW, Parsons LM.

Int J Mol Sci. 2018 Dec 18;19(12). pii: E4110. doi: 10.3390/ijms19124110. Review.


Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction.

Dobson AJ, He X, Blanc E, Bolukbasi E, Feseha Y, Yang M, Piper MDW.

NPJ Aging Mech Dis. 2018 Apr 17;4:5. doi: 10.1038/s41514-018-0024-4. eCollection 2018.


Using artificial diets to understand the nutritional physiology of Drosophila melanogaster.

Piper MD.

Curr Opin Insect Sci. 2017 Oct;23:104-111. doi: 10.1016/j.cois.2017.07.014. Epub 2017 Sep 23. Review.


Drosophila as a model for ageing.

Piper MDW, Partridge L.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2707-2717. doi: 10.1016/j.bbadis.2017.09.016. Epub 2017 Sep 28. Review.


Matching complex dietary landscapes with the signalling pathways that regulate life history traits.

Mirth CK, Piper MD.

Curr Opin Genet Dev. 2017 Dec;47:9-16. doi: 10.1016/j.gde.2017.08.001. Epub 2017 Aug 17. Review.


Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster.

Zandveld J, van den Heuvel J, Zwaan BJ, Piper MDW.

NPJ Aging Mech Dis. 2017 Feb 20;3:4. doi: 10.1038/s41514-017-0004-0. eCollection 2017.


Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan.

Piper MDW, Soultoukis GA, Blanc E, Mesaros A, Herbert SL, Juricic P, He X, Atanassov I, Salmonowicz H, Yang M, Simpson SJ, Ribeiro C, Partridge L.

Cell Metab. 2017 May 2;25(5):1206. doi: 10.1016/j.cmet.2017.04.020. No abstract available.


Commensal bacteria and essential amino acids control food choice behavior and reproduction.

Leitão-Gonçalves R, Carvalho-Santos Z, Francisco AP, Fioreze GT, Anjos M, Baltazar C, Elias AP, Itskov PM, Piper MDW, Ribeiro C.

PLoS Biol. 2017 Apr 25;15(4):e2000862. doi: 10.1371/journal.pbio.2000862. eCollection 2017 Apr.


Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan.

Piper MDW, Soultoukis GA, Blanc E, Mesaros A, Herbert SL, Juricic P, He X, Atanassov I, Salmonowicz H, Yang M, Simpson SJ, Ribeiro C, Partridge L.

Cell Metab. 2017 Mar 7;25(3):610-621. doi: 10.1016/j.cmet.2017.02.005. Erratum in: Cell Metab. 2017 May 2;25(5):1206.


Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets.

Dobson AJ, Ezcurra M, Flanagan CE, Summerfield AC, Piper MDW, Gems D, Alic N.

Cell Rep. 2017 Jan 10;18(2):299-306. doi: 10.1016/j.celrep.2016.12.029.


2,5-Dimethyl-Celecoxib Extends Drosophila Life Span via a Mechanism That Requires Insulin and Target of Rapamycin Signaling.

Wu Q, Lian T, Fan X, Song C, Gaur U, Mao X, Yang D, Piper MDW, Yang M.

J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1334-1341. doi: 10.1093/gerona/glw244.


Protocols to Study Aging in Drosophila.

Piper MD, Partridge L.

Methods Mol Biol. 2016;1478:291-302. Review.


Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila.

Afschar S, Toivonen JM, Hoffmann JM, Tain LS, Wieser D, Finlayson AJ, Driege Y, Alic N, Emran S, Stinn J, Froehlich J, Piper MD, Partridge L.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1321-6. doi: 10.1073/pnas.1515137113. Epub 2016 Jan 19.


Erratum to "Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease." [Neurobiol. Aging 32 (2011) 1977-1989].

Kerr F, Augustin H, Piper MDW, Gandy C, Allen MJ, Lovestone S, Partridge L.

Neurobiol Aging. 2015 Jul;36(7):2331. doi: 10.1016/j.neurobiolaging.2015.05.007. Epub 2015 May 29. No abstract available.


QuantiFly: Robust Trainable Software for Automated Drosophila Egg Counting.

Waithe D, Rennert P, Brostow G, Piper MD.

PLoS One. 2015 May 18;10(5):e0127659. doi: 10.1371/journal.pone.0127659. eCollection 2015.


Using doubly-labeled water to measure energy expenditure in an important small ectotherm Drosophila melanogaster.

Piper MD, Selman C, Speakman JR, Partridge L.

J Genet Genomics. 2014 Sep 20;41(9):505-12. doi: 10.1016/j.jgg.2014.07.004. Epub 2014 Aug 10.


A holidic medium for Drosophila melanogaster.

Piper MD, Blanc E, Leitão-Gonçalves R, Yang M, He X, Linford NJ, Hoddinott MP, Hopfen C, Soultoukis GA, Niemeyer C, Kerr F, Pletcher SD, Ribeiro C, Partridge L.

Nat Methods. 2014 Jan;11(1):100-5. doi: 10.1038/nmeth.2731. Epub 2013 Nov 17. Erratum in: Nat Methods. 2014 Sep;11(9):971. Nat Methods. 2015 Nov;12(11):1098.


Analysing variation in Drosophila aging across independent experimental studies: a meta-analysis of survival data.

Ziehm M, Piper MD, Thornton JM.

Aging Cell. 2013 Oct;12(5):917-22. doi: 10.1111/acel.12123. Epub 2013 Jul 22.


Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies.

Alic N, Hoddinott MP, Foley A, Slack C, Piper MD, Partridge L.

PLoS One. 2012;7(9):e45367. doi: 10.1371/journal.pone.0045367. Epub 2012 Sep 17.


Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D.

Nature. 2011 Sep 21;477(7365):482-5. doi: 10.1038/nature10296.


Dietary restriction and aging: a unifying perspective.

Piper MD, Partridge L, Raubenheimer D, Simpson SJ.

Cell Metab. 2011 Aug 3;14(2):154-60. doi: 10.1016/j.cmet.2011.06.013.


Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network.

Partridge L, Alic N, Bjedov I, Piper MD.

Exp Gerontol. 2011 May;46(5):376-81. doi: 10.1016/j.exger.2010.09.003. Epub 2010 Sep 16. Review.


Water-independent effects of dietary restriction in Drosophila.

Piper MD, Wong R, Grandison RC, Bass TM, Martinez PM, Partridge L.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):E54-6; author reply E57. doi: 10.1073/pnas.0914686107. Epub 2010 Apr 2. No abstract available.


Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease.

Kerr F, Augustin H, Piper MD, Gandy C, Allen MJ, Lovestone S, Partridge L.

Neurobiol Aging. 2011 Nov;32(11):1977-89. doi: 10.1016/j.neurobiolaging.2009.10.015. Epub 2009 Dec 7. Erratum in: Neurobiol Aging. 2015 Jul;36(7):2331. Neurobiol Aging. 2015 Jul;36(7):2331.


Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila.

Grandison RC, Piper MD, Partridge L.

Nature. 2009 Dec 24;462(7276):1061-4. doi: 10.1038/nature08619. Epub 2009 Dec 2.


Quantification of food intake in Drosophila.

Wong R, Piper MD, Wertheim B, Partridge L.

PLoS One. 2009 Jun 26;4(6):e6063. doi: 10.1371/journal.pone.0006063.


Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster.

Grandison RC, Wong R, Bass TM, Partridge L, Piper MD.

PLoS One. 2009;4(1):e4067. doi: 10.1371/journal.pone.0004067. Epub 2009 Jan 1.


Diet and aging.

Piper MD, Bartke A.

Cell Metab. 2008 Aug;8(2):99-104. doi: 10.1016/j.cmet.2008.06.012. Review.


Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster.

Wong R, Piper MDW, Blanc E, Partridge L.

Nat Methods. 2008 Mar;5(3):214-215. doi: 10.1038/nmeth0308-214. No abstract available.


Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?

Piper MD, Selman C, McElwee JJ, Partridge L.

J Intern Med. 2008 Feb;263(2):179-91. doi: 10.1111/j.1365-2796.2007.01906.x. Review.


Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.

Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ.

FASEB J. 2008 Mar;22(3):807-18. Epub 2007 Oct 10.


Optimization of dietary restriction protocols in Drosophila.

Bass TM, Grandison RC, Wong R, Martinez P, Partridge L, Piper MD.

J Gerontol A Biol Sci Med Sci. 2007 Oct;62(10):1071-81.


Evolutionary conservation of regulated longevity assurance mechanisms.

McElwee JJ, Schuster E, Blanc E, Piper MD, Thomas JH, Patel DS, Selman C, Withers DJ, Thornton JM, Partridge L, Gems D.

Genome Biol. 2007;8(7):R132.


Dietary restriction in Drosophila: delayed aging or experimental artefact?

Piper MD, Partridge L.

PLoS Genet. 2007 Apr 27;3(4):e57. Review.


Transcriptional responses of Saccharomyces cerevisiae to preferred and nonpreferred nitrogen sources in glucose-limited chemostat cultures.

Boer VM, Tai SL, Vuralhan Z, Arifin Y, Walsh MC, Piper MD, de Winde JH, Pronk JT, Daran JM.

FEMS Yeast Res. 2007 Jun;7(4):604-20. Epub 2007 Apr 10.


Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.

Selman C, Kerrison ND, Cooray A, Piper MD, Lingard SJ, Barton RH, Schuster EF, Blanc E, Gems D, Nicholson JK, Thornton JM, Partridge L, Withers DJ.

Physiol Genomics. 2006 Nov 27;27(3):187-200. Epub 2006 Aug 1.


Diet, metabolism and lifespan in Drosophila.

Piper MD, Skorupa D, Partridge L.

Exp Gerontol. 2005 Nov;40(11):857-62. Epub 2005 Aug 30. Review.


Calories do not explain extension of life span by dietary restriction in Drosophila.

Mair W, Piper MD, Partridge L.

PLoS Biol. 2005 Jul;3(7):e223. Epub 2005 May 31.


Counting the calories: the role of specific nutrients in extension of life span by food restriction.

Piper MD, Mair W, Partridge L.

J Gerontol A Biol Sci Med Sci. 2005 May;60(5):549-55. Review.


Dietary restriction in Drosophila.

Partridge L, Piper MD, Mair W.

Mech Ageing Dev. 2005 Sep;126(9):938-50. Review.


Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.

Broughton SJ, Piper MD, Ikeya T, Bass TM, Jacobson J, Driege Y, Martinez P, Hafen E, Withers DJ, Leevers SJ, Partridge L.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3105-10. Epub 2005 Feb 11.


Prolonged maltose-limited cultivation of Saccharomyces cerevisiae selects for cells with improved maltose affinity and hypersensitivity.

Jansen ML, Daran-Lapujade P, de Winde JH, Piper MD, Pronk JT.

Appl Environ Microbiol. 2004 Apr;70(4):1956-63.


Directed evolution of pyruvate decarboxylase-negative Saccharomyces cerevisiae, yielding a C2-independent, glucose-tolerant, and pyruvate-hyperproducing yeast.

van Maris AJ, Geertman JM, Vermeulen A, Groothuizen MK, Winkler AA, Piper MD, van Dijken JP, Pronk JT.

Appl Environ Microbiol. 2004 Jan;70(1):159-66.


Comparative genotyping of the Saccharomyces cerevisiae laboratory strains S288C and CEN.PK113-7D using oligonucleotide microarrays.

Daran-Lapujade P, Daran JM, Kötter P, Petit T, Piper MD, Pronk JT.

FEMS Yeast Res. 2003 Dec;4(3):259-69.


Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae.

Gelling CL, Piper MD, Hong SP, Kornfeld GD, Dawes IW.

J Biol Chem. 2004 Feb 20;279(8):7072-81. Epub 2003 Nov 26.

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