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Items: 1 to 50 of 80

1.

Unbiased MRI Analyses Identify Micropathologic Differences Between Upper Motor Neuron-Predominant ALS Phenotypes.

Rajagopalan V, Pioro EP.

Front Neurosci. 2019 Jul 12;13:704. doi: 10.3389/fnins.2019.00704. eCollection 2019. Review.

2.

Variation in noninvasive ventilation use in amyotrophic lateral sclerosis.

Thakore NJ, Lapin BR, Pioro EP, Aboussouan LS.

Neurology. 2019 Jul 16;93(3):e306-e316. doi: 10.1212/WNL.0000000000007776. Epub 2019 Jun 10.

PMID:
31182506
3.

Longitudinal 18F-FDG PET and MRI Reveal Evolving Imaging Pathology That Corresponds to Disease Progression in a Patient With ALS-FTD.

Rajagopalan V, Pioro EP.

Front Neurol. 2019 Mar 19;10:234. doi: 10.3389/fneur.2019.00234. eCollection 2019.

4.

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.

van den Berg LH, Sorenson E, Gronseth G, Macklin EA, Andrews J, Baloh RH, Benatar M, Berry JD, Chio A, Corcia P, Genge A, Gubitz AK, Lomen-Hoerth C, McDermott CJ, Pioro EP, Rosenfeld J, Silani V, Turner MR, Weber M, Brooks BR, Miller RG, Mitsumoto H; Airlie House ALS Clinical Trials Guidelines Group.

Neurology. 2019 Apr 2;92(14):e1610-e1623. doi: 10.1212/WNL.0000000000007242. Epub 2019 Mar 8.

5.

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyotrophic lateral sclerosis.

Pattee GL, Plowman EK, Focht Garand KL, Costello J, Brooks BR, Berry JD, Smith RA, Atassi N, Chapin JL, Yunusova Y, McIlduff CE, Young E, Macklin EA, Locatelli ER, Silani V, Heitzman D, Wymer J, Goutman SA, Gelinas DF, Perry B, Nalipinski P, Stipancic K, O'Brien M, Sullivan SL, Pioro EP, Gargiulo G, Green JR; Contributing Members of the NEALS Bulbar Subcommittee.

Muscle Nerve. 2019 May;59(5):531-536. doi: 10.1002/mus.26408. Epub 2019 Jan 22.

PMID:
30620104
6.

Additional evidence for a therapeutic effect of dextromethorphan/quinidine on bulbar motor function in patients with amyotrophic lateral sclerosis: A quantitative speech analysis.

Green JR, Allison KM, Cordella C, Richburg BD, Pattee GL, Berry JD, Macklin EA, Pioro EP, Smith RA.

Br J Clin Pharmacol. 2018 Dec;84(12):2849-2856. doi: 10.1111/bcp.13745. Epub 2018 Oct 1.

7.

Deconstructing progression of amyotrophic lateral sclerosis in stages: a Markov modeling approach.

Thakore NJ, Lapin BR, Kinzy TG, Pioro EP.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 Nov;19(7-8):483-494. doi: 10.1080/21678421.2018.1484925. Epub 2018 Jul 12.

PMID:
30001159
8.

Distal Predominance of Electrodiagnostic Abnormalities in Early-Stage Amyotrophic Lateral Sclerosis.

Shayya L, Babu S, Pioro EP, Li J, Li Y.

Muscle Nerve. 2018 Sep;58(3):389-395. doi: 10.1002/mus.26158. Epub 2018 Aug 23.

PMID:
29742797
9.

Assessment of bulbar function in amyotrophic lateral sclerosis: validation of a self-report scale (Center for Neurologic Study Bulbar Function Scale).

Smith RA, Macklin EA, Myers KJ, Pattee GL, Goslin KL, Meekins GD, Green JR, Shefner JM, Pioro EP.

Eur J Neurol. 2018 Jul;25(7):907-e66. doi: 10.1111/ene.13638. Epub 2018 Apr 16. Erratum in: Eur J Neurol. 2018 Oct;25(10):1303.

10.

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Shankaracharya, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A; ITALSGEN Consortium, Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, La Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D'Alfonso S, Corrado L, Capasso M, Ferrucci L; Genomic Translation for ALS Care (GTAC) Consortium, Moreno CAM, Kamalakaran S, Goldstein DB; ALS Sequencing Consortium, Gitler AD, Harris T, Myers RM; NYGC ALS Consortium, Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC; Answer ALS Foundation, Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, Van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E; Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J; SLAGEN Consortium, Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorarù G, Cereda C; French ALS Consortium, Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, Ten Asbroek ALMA, Muñoz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, Le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, Van Den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, Van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, Van Es MA, Weber M, Boylan KB, Van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-Pérez J, García-Redondo A, Al-Chalabi A; Project MinE ALS Sequencing Consortium, Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, Van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, Van Deerlin VM, Brown RH Jr, van den Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chiò A, Shaw CE, Traynor BJ, Landers JE.

Neuron. 2018 Mar 21;97(6):1268-1283.e6. doi: 10.1016/j.neuron.2018.02.027.

11.

MR Imaging-based Estimation of Upper Motor Neuron Density in Patients with Amyotrophic Lateral Sclerosis: A Feasibility Study.

Chen J, Kostenko V, Pioro EP, Trapp BD.

Radiology. 2018 Jun;287(3):955-964. doi: 10.1148/radiol.2018162967. Epub 2018 Jan 23.

12.

Trajectories of impairment in amyotrophic lateral sclerosis: Insights from the Pooled Resource Open-Access ALS Clinical Trials cohort.

Thakore NJ, Lapin BR, Pioro EP; Pooled Resource Open-Access ALS Clinical Trials Consortium.

Muscle Nerve. 2018 Jun;57(6):937-945. doi: 10.1002/mus.26042. Epub 2018 Jan 11.

PMID:
29244213
13.

Laughter, crying and sadness in ALS.

Thakore NJ, Pioro EP.

J Neurol Neurosurg Psychiatry. 2017 Oct;88(10):825-831. doi: 10.1136/jnnp-2017-315622. Epub 2017 Jun 1.

14.

Positron emission tomography imaging in a case of E200K mutation-related spongiform encephalopathy with non-diagnostic magnetic resonance imaging and cerebrospinal fluid testing.

George P, Newey CR, Mente KP, Pioro EP.

SAGE Open Med Case Rep. 2017 Mar 29;5:2050313X17700347. doi: 10.1177/2050313X17700347. eCollection 2017.

15.

Finger extension weakness and downbeat nystagmus motor neuron disease syndrome: A novel motor neuron disorder?

Delva A, Thakore N, Pioro EP, Poesen K, Saunders-Pullman R, Meijer IA, Rucker JC, Kissel JT, Van Damme P.

Muscle Nerve. 2017 Dec;56(6):1164-1168. doi: 10.1002/mus.25669. Epub 2017 May 15.

16.
17.

Depression in ALS in a large self-reporting cohort.

Kawada T, Thakore NJ, Pioro EP.

Neurology. 2016 Oct 11;87(15):1631-1632. No abstract available.

PMID:
27765825
18.

Optimizing muscle selection for electromyography in amyotrophic lateral sclerosis.

Babu S, Pioro EP, Li J, Li Y.

Muscle Nerve. 2017 Jul;56(1):36-44. doi: 10.1002/mus.25444. Epub 2017 Feb 15.

PMID:
27759887
19.

Depression in ALS in a large self-reporting cohort.

Thakore NJ, Pioro EP.

Neurology. 2016 Mar 15;86(11):1031-8. doi: 10.1212/WNL.0000000000002465. Epub 2016 Feb 17.

PMID:
26888995
20.

Brain Parenchymal Fraction: A Relatively Simple MRI Measure to Clinically Distinguish ALS Phenotypes.

Rajagopalan V, Pioro EP.

Biomed Res Int. 2015;2015:693206. doi: 10.1155/2015/693206. Epub 2015 Dec 13.

21.

Review of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA(®)) for Pseudobulbar Affect.

Pioro EP.

Neurol Ther. 2014 Jun 17;3(1):15-28. doi: 10.1007/s40120-014-0018-5. eCollection 2014 Jun. Review.

22.
23.

Comparing brain structural MRI and metabolic FDG-PET changes in patients with ALS-FTD: 'the chicken or the egg?' question.

Rajagopalan V, Pioro EP.

J Neurol Neurosurg Psychiatry. 2015 Sep;86(9):952-8. doi: 10.1136/jnnp-2014-308239. Epub 2014 Dec 17.

PMID:
25520437
24.

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.

Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD; ITALSGEN, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chiò A, Traynor BJ.

Nat Neurosci. 2014 May;17(5):664-666. doi: 10.1038/nn.3688. Epub 2014 Mar 30.

25.

Distinct patterns of cortical atrophy in ALS patients with or without dementia: an MRI VBM study.

Rajagopalan V, Pioro EP.

Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):216-25. doi: 10.3109/21678421.2014.880179. Epub 2014 Feb 20.

PMID:
24555884
26.
27.

Brain white matter shape changes in amyotrophic lateral sclerosis (ALS): a fractal dimension study.

Rajagopalan V, Liu Z, Allexandre D, Zhang L, Wang XF, Pioro EP, Yue GH.

PLoS One. 2013 Sep 9;8(9):e73614. doi: 10.1371/journal.pone.0073614. eCollection 2013.

28.

Use of intrathecal baclofen for treatment of severe spasticity in selected patients with motor neuron disease.

Bethoux F, Boulis N, McClelland S 3rd, Willis MA, Hussain M, Machado A, Mychkovsky L, Stough D, Sutliff M, Pioro EP.

Neurorehabil Neural Repair. 2013 Nov-Dec;27(9):828-33. doi: 10.1177/1545968313496325. Epub 2013 Jul 24.

PMID:
23884016
29.

Brain white matter diffusion tensor metrics from clinical 1.5T MRI distinguish between ALS phenotypes.

Rajagopalan V, Yue GH, Pioro EP.

J Neurol. 2013 Oct;260(10):2532-40. doi: 10.1007/s00415-013-7012-1. Epub 2013 Jul 18.

PMID:
23864396
30.

T2 relaxometry measurements in low spatial frequency brain regions differ between fast spin-echo and multiple-echo spin-echo sequences.

Rajagopalan V, Lowe MJ, Beall EB, Yue GH, Pioro EP.

MAGMA. 2013 Oct;26(5):443-50. doi: 10.1007/s10334-012-0364-1. Epub 2013 Jan 26.

PMID:
23354513
31.

Amyotrophic lateral sclerosis and novel therapeutic strategies.

Morrison B, Hensley K, Pioro EP, Petri S, Kiaei M.

Neurol Res Int. 2012;2012:798028. doi: 10.1155/2012/798028. Epub 2012 Dec 19. No abstract available.

32.

Diffusion Tensor Imaging Evaluation of Corticospinal Tract Hyperintensity in Upper Motor Neuron-Predominant ALS Patients.

Rajagopalan V, Allexandre D, Yue GH, Pioro EP.

J Aging Res. 2011;2011:481745. doi: 10.4061/2011/481745. Epub 2011 Oct 26.

33.

Current concepts in the pharmacotherapy of pseudobulbar affect.

Pioro EP.

Drugs. 2011 Jun 18;71(9):1193-207. doi: 10.2165/11591450-000000000-00000. Review.

PMID:
21711063
34.

Eye movements in amyotrophic lateral sclerosis and its mimics: a review with illustrative cases.

Donaghy C, Thurtell MJ, Pioro EP, Gibson JM, Leigh RJ.

J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):110-6. doi: 10.1136/jnnp.2010.212407. Epub 2010 Nov 19. Review.

PMID:
21097546
35.

Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect.

Pioro EP, Brooks BR, Cummings J, Schiffer R, Thisted RA, Wynn D, Hepner A, Kaye R; Safety, Tolerability, and Efficacy Results Trial of AVP-923 in PBA Investigators.

Ann Neurol. 2010 Nov;68(5):693-702. doi: 10.1002/ana.22093.

PMID:
20839238
36.

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex.

Pérez-Victoria FJ, Abascal-Palacios G, Tascón I, Kajava A, Magadán JG, Pioro EP, Bonifacino JS, Hierro A.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12860-5. doi: 10.1073/pnas.1004756107. Epub 2010 Jul 6.

37.

Cervical epidural injection complicated by syrinx formation: a case report.

Khan S, Pioro EP.

Spine (Phila Pa 1976). 2010 Jun 1;35(13):E614-6. doi: 10.1097/BRS.0b013e3181cf7621.

PMID:
20461029
38.

Familial ALS with SOD1 mutation misdiagnosed with polyradiculopathy and myopathy.

Zhou L, Pioro EP.

Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):476-8. doi: 10.3109/17482960802449278.

PMID:
19922143
39.

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III.

Kaufmann P, Thompson JL, Levy G, Buchsbaum R, Shefner J, Krivickas LS, Katz J, Rollins Y, Barohn RJ, Jackson CE, Tiryaki E, Lomen-Hoerth C, Armon C, Tandan R, Rudnicki SA, Rezania K, Sufit R, Pestronk A, Novella SP, Heiman-Patterson T, Kasarskis EJ, Pioro EP, Montes J, Arbing R, Vecchio D, Barsdorf A, Mitsumoto H, Levin B; QALS Study Group.

Ann Neurol. 2009 Aug;66(2):235-44. doi: 10.1002/ana.21743.

40.

Lack of evidence of monomer/misfolded superoxide dismutase-1 in sporadic amyotrophic lateral sclerosis.

Liu HN, Sanelli T, Horne P, Pioro EP, Strong MJ, Rogaeva E, Bilbao J, Zinman L, Robertson J.

Ann Neurol. 2009 Jul;66(1):75-80. doi: 10.1002/ana.21704.

PMID:
19670443
41.

Abnormal eye movements in Kennedy disease.

Thurtell MJ, Pioro EP, Leigh RJ.

Neurology. 2009 Apr 28;72(17):1528-30. doi: 10.1212/WNL.0b013e3181a2e936. No abstract available.

42.

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.

Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, Ding J, Crews C, Rafferty I, Washecka N, Hernandez D, Ferrucci L, Bandinelli S, Guralnik J, Macciardi F, Torri F, Lupoli S, Chanock SJ, Thomas G, Hunter DJ, Gieger C, Wichmann HE, Calvo A, Mutani R, Battistini S, Giannini F, Caponnetto C, Mancardi GL, La Bella V, Valentino F, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Siciliano G, Carlesi C, Orrell RW, Talbot K, Simmons Z, Connor J, Pioro EP, Dunkley T, Stephan DA, Kasperaviciute D, Fisher EM, Jabonka S, Sendtner M, Beck M, Bruijn L, Rothstein J, Schmidt S, Singleton A, Hardy J, Traynor BJ.

Hum Mol Genet. 2009 Apr 15;18(8):1524-32. doi: 10.1093/hmg/ddp059. Epub 2009 Feb 4.

43.

Racing against the clock: recognizing, differentiating, diagnosing, and referring the amyotrophic lateral sclerosis patient.

Shook SJ, Pioro EP.

Ann Neurol. 2009 Jan;65 Suppl 1:S10-6. doi: 10.1002/ana.21545.

PMID:
19191305
44.

Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain relief.

McClelland S 3rd, Bethoux FA, Boulis NM, Sutliff MH, Stough DK, Schwetz KM, Gogol DM, Harrison M, Pioro EP.

Muscle Nerve. 2008 Mar;37(3):396-8.

PMID:
17894358
45.

A randomized controlled trial of resistance exercise in individuals with ALS.

Bello-Haas VD, Florence JM, Kloos AD, Scheirbecker J, Lopate G, Hayes SM, Pioro EP, Mitsumoto H.

Neurology. 2007 Jun 5;68(23):2003-7.

PMID:
17548549
46.

Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS.

Robertson J, Sanelli T, Xiao S, Yang W, Horne P, Hammond R, Pioro EP, Strong MJ.

Neurosci Lett. 2007 Jun 13;420(2):128-32. Epub 2007 Apr 8.

PMID:
17543992
47.

Defining and diagnosing involuntary emotional expression disorder.

Cummings JL, Arciniegas DB, Brooks BR, Herndon RM, Lauterbach EC, Pioro EP, Robinson RG, Scharre DW, Schiffer RB, Weintraub D.

CNS Spectr. 2006 Jun;11(S6):1-7.

PMID:
16816786
48.

Control of microglial neurotoxicity by the fractalkine receptor.

Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM, Dijkstra IM, Huang D, Kidd G, Dombrowski S, Dutta R, Lee JC, Cook DN, Jung S, Lira SA, Littman DR, Ransohoff RM.

Nat Neurosci. 2006 Jul;9(7):917-24. Epub 2006 Jun 18.

PMID:
16732273
49.
50.

Dysmyelinated lower motor neurons retract and regenerate dysfunctional synaptic terminals.

Yin X, Kidd GJ, Pioro EP, McDonough J, Dutta R, Feltri ML, Wrabetz L, Messing A, Wyatt RM, Balice-Gordon RJ, Trapp BD.

J Neurosci. 2004 Apr 14;24(15):3890-8.

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