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Items: 17


Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile.

Li L, Piontek KB, Kumbhari V, Ishida M, Selaru FM.

J Vis Exp. 2016 Jun 13;(112). doi: 10.3791/54036.


MicroRNA-224 Induces G1/S Checkpoint Release in Liver Cancer.

An F, Olaru AV, Mezey E, Xie Q, Li L, Piontek KB, Selaru FM.

J Clin Med. 2015 Aug 26;4(9):1713-28. doi: 10.3390/jcm4091713.


Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.

Wissing MD, Dadon T, Kim E, Piontek KB, Shim JS, Kaelber NS, Liu JO, Kachhap SK, Nelkin BD.

Oncol Rep. 2014 Jul;32(1):419-24. doi: 10.3892/or.2014.3174. Epub 2014 May 13.


Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.

Rowe I, Chiaravalli M, Piontek KB, Germino GG, Boletta A.

Biochem Biophys Res Commun. 2014 Feb 21;444(4):473-9. doi: 10.1016/j.bbrc.2014.01.068. Epub 2014 Jan 25.


Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.

Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG.

PLoS Genet. 2012;8(11):e1003053. doi: 10.1371/journal.pgen.1003053. Epub 2012 Nov 29.


Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.

Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek KB, Germino GG, Zhou MI, Cohen HT.

Hum Mol Genet. 2012 Dec 15;21(26):5456-71. doi: 10.1093/hmg/dds391. Epub 2012 Sep 21.


Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts.

Paul BM, Vassmer D, Taylor A, Magenheimer L, Carlton CG, Piontek KB, Germino GG, Vanden Heuvel GB.

Dev Dyn. 2011 Jun;240(6):1493-501. doi: 10.1002/dvdy.22625. Epub 2011 Apr 4.


Pkd1 and Pkd2 are required for normal placental development.

Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T.

PLoS One. 2010 Sep 16;5(9). pii: e12821. doi: 10.1371/journal.pone.0012821.


Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.

Shillingford JM, Piontek KB, Germino GG, Weimbs T.

J Am Soc Nephrol. 2010 Mar;21(3):489-97. doi: 10.1681/ASN.2009040421. Epub 2010 Jan 14.


Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

Distefano G, Boca M, Rowe I, Wodarczyk C, Ma L, Piontek KB, Germino GG, Pandolfi PP, Boletta A.

Mol Cell Biol. 2009 May;29(9):2359-71. doi: 10.1128/MCB.01259-08. Epub 2009 Mar 2.


Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells.

Raphael KL, Strait KA, Stricklett PK, Miller RL, Nelson RD, Piontek KB, Germino GG, Kohan DE.

Kidney Int. 2009 Mar;75(6):626-33. doi: 10.1038/ki.2008.659. Epub 2009 Jan 14.


Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.

Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG.

Hum Mol Genet. 2007 Aug 15;16(16):1940-50. Epub 2007 Jun 16.


The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T.

Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5466-71. Epub 2006 Mar 27.


Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.

Allen E, Piontek KB, Garrett-Mayer E, Garcia-Gonzalez M, Gorelick KL, Germino GG.

Hum Mol Genet. 2006 Jan 1;15(1):11-21. Epub 2005 Nov 21.


A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.

Piontek KB, Huso DL, Grinberg A, Liu L, Bedja D, Zhao H, Gabrielson K, Qian F, Mei C, Westphal H, Germino GG.

J Am Soc Nephrol. 2004 Dec;15(12):3035-43.


Murine Pkd1 introns 21 and 22 lack the extreme polypyrimidine bias present in human PKD1.

Piontek KB, Germino GG.

Mamm Genome. 1999 Feb;10(2):194-6. No abstract available.


An unusual pattern of mutation in the duplicated portion of PKD1 is revealed by use of a novel strategy for mutation detection.

Watnick TJ, Piontek KB, Cordal TM, Weber H, Gandolph MA, Qian F, Lens XM, Neumann HP, Germino GG.

Hum Mol Genet. 1997 Sep;6(9):1473-81.


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