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Items: 1 to 50 of 379

1.

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence.

Granzotto A, Bomba M, Castelli V, Navarra R, Massetti N, d'Aurora M, Onofrj M, Cicalini I, Del Boccio P, Gatta V, Cimini A, Piomelli D, Sensi SL.

Aging (Albany NY). 2019 Aug 29;11(16):6336-6357. doi: 10.18632/aging.102191. Epub 2019 Aug 29.

2.

Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus.

Vozella V, Realini N, Misto A, Piomelli D.

Int J Mol Sci. 2019 Aug 17;20(16). pii: E4008. doi: 10.3390/ijms20164008.

3.

Fast and Sensitive Quantification of Δ9-Tetrahydrocannabinol and Its Main Oxidative Metabolites by Liquid Chromatography/Tandem Mass Spectrometry.

Vozella V, Zibardi C, Ahmed F, Piomelli D.

Cannabis Cannabinoid Res. 2019 Jun 14;4(2):110-123. doi: 10.1089/can.2018.0075. eCollection 2019.

4.

Diurnal Profiles of N-Acylethanolamines in Goldfish Brain and Gastrointestinal Tract: Possible Role of Feeding.

Gómez-Boronat M, Isorna E, Armirotti A, Delgado MJ, Piomelli D, de Pedro N.

Front Neurosci. 2019 May 7;13:450. doi: 10.3389/fnins.2019.00450. eCollection 2019.

5.

Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study.

Vozella V, Basit A, Piras F, Realini N, Armirotti A, Bossù P, Assogna F, Sensi SL, Spalletta G, Piomelli D.

Aging (Albany NY). 2019 Jan 8;11(1):73-88. doi: 10.18632/aging.101719.

6.

Mast Cell-Derived Histamine Regulates Liver Ketogenesis via Oleoylethanolamide Signaling.

Misto A, Provensi G, Vozella V, Passani MB, Piomelli D.

Cell Metab. 2019 Jan 8;29(1):91-102.e5. doi: 10.1016/j.cmet.2018.09.014. Epub 2018 Oct 11.

PMID:
30318340
7.

Molecular mechanism of activation of the immunoregulatory amidase NAAA.

Gorelik A, Gebai A, Illes K, Piomelli D, Nagar B.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10032-E10040. doi: 10.1073/pnas.1811759115. Epub 2018 Oct 9.

8.

Effects of fatty acid amide hydrolase inhibitor URB597 in a rat model of trauma-induced long-term anxiety.

Danandeh A, Vozella V, Lim J, Oveisi F, Ramirez GL, Mears D, Wynn G, Piomelli D.

Psychopharmacology (Berl). 2018 Nov;235(11):3211-3221. doi: 10.1007/s00213-018-5020-7. Epub 2018 Sep 24.

PMID:
30251159
9.

Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit.

Spadoni G, Bedini A, Furiassi L, Mari M, Mor M, Scalvini L, Lodola A, Ghidini A, Lucini V, Dugnani S, Scaglione F, Piomelli D, Jung KM, Supuran CT, Lucarini L, Durante M, Sgambellone S, Masini E, Rivara S.

J Med Chem. 2018 Sep 13;61(17):7902-7916. doi: 10.1021/acs.jmedchem.8b00893. Epub 2018 Sep 4.

PMID:
30126274
10.

Endocannabinoid Anandamide Mediates the Effect of Skeletal Muscle Sphingomyelins on Human Energy Expenditure.

Heinitz S, Basolo A, Piomelli D, Krakoff J, Piaggi P.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3757-3766. doi: 10.1210/jc.2018-00780.

PMID:
30113648
11.

Cannabis and the Opioid Crisis.

Piomelli D, Weiss S, Boyd G, Pacula RL, Cooper Z.

Cannabis Cannabinoid Res. 2018 Apr 1;3(1):108-116. doi: 10.1089/can.2018.29011.rtl. eCollection 2018. No abstract available.

12.

Author Correction: Patch clamp-assisted single neuron lipidomics.

Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D.

Sci Rep. 2018 Apr 25;8(1):6772. doi: 10.1038/s41598-018-24605-7.

13.

Endocannabinoid System and Migraine Pain: An Update.

Greco R, Demartini C, Zanaboni AM, Piomelli D, Tassorelli C.

Front Neurosci. 2018 Mar 19;12:172. doi: 10.3389/fnins.2018.00172. eCollection 2018. Review.

14.

Familial abnormalities of endocannabinoid signaling in schizophrenia.

Koethe D, Pahlisch F, Hellmich M, Rohleder C, Mueller JK, Meyer-Lindenberg A, Torrey EF, Piomelli D, Leweke FM.

World J Biol Psychiatry. 2019 Feb;20(2):117-125. doi: 10.1080/15622975.2018.1449966. Epub 2018 Mar 22.

PMID:
29521179
15.

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.

Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ.

J Biol Chem. 2018 Mar 2;293(9):3028-3038. doi: 10.1074/jbc.M117.802058. Epub 2018 Jan 11.

16.

Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage.

Heinitz S, Basolo A, Piaggi P, Piomelli D, Jumpertz von Schwartzenberg R, Krakoff J.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):1077-1087. doi: 10.1210/jc.2017-02257.

17.

Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD).

Castellani B, Diamanti E, Pizzirani D, Tardia P, Maccesi M, Realini N, Magotti P, Garau G, Bakkum T, Rivara S, Mor M, Piomelli D.

Chem Commun (Camb). 2017 Nov 28;53(95):12814-12817. doi: 10.1039/c7cc07582k.

18.

Treating a novel plasticity defect rescues episodic memory in Fragile X model mice.

Wang W, Cox BM, Jia Y, Le AA, Cox CD, Jung KM, Hou B, Piomelli D, Gall CM, Lynch G.

Mol Psychiatry. 2018 Aug;23(8):1798-1806. doi: 10.1038/mp.2017.221. Epub 2017 Nov 14.

19.

Expert Panel on Understanding Cannabis: Medicine, Society, Government.

Kazan K, Piomelli D, Rohrabacher D, Ajax L.

Cannabis Cannabinoid Res. 2017 Sep 1;2(1):247-251. doi: 10.1089/can.2017.29010.kka. eCollection 2017.

20.

The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of Allergic Dermatitis.

Sasso O, Summa M, Armirotti A, Pontis S, De Mei C, Piomelli D.

J Invest Dermatol. 2018 Mar;138(3):562-569. doi: 10.1016/j.jid.2017.07.853. Epub 2017 Oct 18.

21.

Novel activity-based probes for N-acylethanolamine acid amidase.

Petracca R, Romeo E, Baggelaar MP, Artola M, Pontis S, Ponzano S, Overkleeft HS, van der Stelt M, Piomelli D.

Chem Commun (Camb). 2017 Aug 22;53(86):11810-11813. doi: 10.1039/c7cc06838g.

PMID:
29035406
22.

Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats.

Schoch H, Huerta MY, Ruiz CM, Farrell MR, Jung KM, Huang JJ, Campbell RR, Piomelli D, Mahler SV.

Psychopharmacology (Berl). 2018 Jan;235(1):121-134. doi: 10.1007/s00213-017-4749-8. Epub 2017 Oct 11.

23.

A Guide to the National Academy of Science Report on Cannabis: An Exclusive Discussion with Panel Members.

Piomelli D, Cooper Z, Abrams D, Grant I, Patel S.

Cannabis Cannabinoid Res. 2017 Jun 1;2(1):155-159. doi: 10.1089/can.2017.29009.dpi. eCollection 2017. No abstract available.

24.

Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware.

Angelini R, Argueta DA, Piomelli D, DiPatrizio NV.

Cannabis Cannabinoid Res. 2017 Jun 1;2(1):123-132. doi: 10.1089/can.2017.0019. eCollection 2017.

25.

Increased Renal 2-Arachidonoylglycerol Level Is Associated with Improved Renal Function in a Mouse Model of Acute Kidney Injury.

Moradi H, Oveisi F, Khanifar E, Moreno-Sanz G, Vaziri ND, Piomelli D.

Cannabis Cannabinoid Res. 2016 Sep 1;1(1):218-228. doi: 10.1089/can.2016.0013. eCollection 2016.

26.

Age-dependent changes in nervonic acid-containing sphingolipids in mouse hippocampus.

Vozella V, Basit A, Misto A, Piomelli D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Dec;1862(12):1502-1511. doi: 10.1016/j.bbalip.2017.08.008. Epub 2017 Aug 30.

PMID:
28855145
27.

Inhibition of monoacylglycerol lipase: Another signalling pathway for potential therapeutic targets in migraine?

Greco R, Demartini C, Zanaboni AM, Berliocchi L, Piomelli D, Tassorelli C.

Cephalalgia. 2018 May;38(6):1138-1147. doi: 10.1177/0333102417727537. Epub 2017 Aug 17.

PMID:
28816506
28.

Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARα and CB1 receptors.

Rock EM, Moreno-Sanz G, Limebeer CL, Petrie GN, Angelini R, Piomelli D, Parker LA.

Br J Pharmacol. 2017 Nov;174(21):3837-3847. doi: 10.1111/bph.13980. Epub 2017 Sep 20.

29.

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells.

Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, Pistello M, Mazzanti CM, Piomelli D.

Sci Rep. 2017 Aug 7;7(1):7411. doi: 10.1038/s41598-017-07606-w.

30.

Patch clamp-assisted single neuron lipidomics.

Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D.

Sci Rep. 2017 Jul 13;7(1):5318. doi: 10.1038/s41598-017-05607-3. Erratum in: Sci Rep. 2018 Apr 25;8(1):6772.

31.

Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex.

Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca MA, Piomelli D, Parolaro D, Papaleo F.

Mol Psychiatry. 2018 Apr;23(4):1040-1050. doi: 10.1038/mp.2017.126. Epub 2017 Jun 20.

PMID:
28630452
32.

Specific skeletal muscle sphingolipid compounds in energy expenditure regulation and weight gain in Native Americans of Southwestern heritage.

Heinitz S, Piaggi P, Vinales KL, Basolo A, Spranger J, Piomelli D, Krakoff J, Jumpertz von Schwartzenberg R.

Int J Obes (Lond). 2017 Oct;41(10):1585-1593. doi: 10.1038/ijo.2017.143. Epub 2017 Jun 13.

33.

Endocannabinoid Signaling in the Control of Social Behavior.

Wei D, Allsop S, Tye K, Piomelli D.

Trends Neurosci. 2017 Jul;40(7):385-396. doi: 10.1016/j.tins.2017.04.005. Epub 2017 May 26. Review.

34.

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.

Khurana L, Mackie K, Piomelli D, Kendall DA.

Neuropharmacology. 2017 Sep 15;124:3-12. doi: 10.1016/j.neuropharm.2017.05.018. Epub 2017 May 17. Review.

35.

Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus.

Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G.

Cereb Cortex. 2018 Jul 1;28(7):2253-2266. doi: 10.1093/cercor/bhx126.

36.

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.

Marrone MC, Morabito A, Giustizieri M, Chiurchiù V, Leuti A, Mattioli M, Marinelli S, Riganti L, Lombardi M, Murana E, Totaro A, Piomelli D, Ragozzino D, Oddi S, Maccarrone M, Verderio C, Marinelli S.

Nat Commun. 2017 May 10;8:15292. doi: 10.1038/ncomms15292.

37.

P007. Inhibition of monoacylglycerol lipase activity modulates the activation of brain structures relevant for migraine pathogenesis.

Greco R, Bandiera T, Mangione AS, Demartini C, Nappi G, Sandrini G, Piomelli D, Tassorelli C.

J Headache Pain. 2015 Dec;16(Suppl 1):A165. doi: 10.1186/1129-2377-16-S1-A165. No abstract available.

38.

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels.

den Hoedt S, Janssen CIF, Astarita G, Piomelli D, Leijten FPJ, Crivelli SM, Verhoeven AJM, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJG, Kiliaan AJ, Mulder MT.

J Alzheimers Dis. 2017;60(3):769-781. doi: 10.3233/JAD-160739.

PMID:
28035926
39.

Dysfunctional oleoylethanolamide signaling in a mouse model of Prader-Willi syndrome.

Igarashi M, Narayanaswami V, Kimonis V, Galassetti PM, Oveisi F, Jung KM, Piomelli D.

Pharmacol Res. 2017 Mar;117:75-81. doi: 10.1016/j.phrs.2016.12.024. Epub 2016 Dec 19.

40.

Progress in the development of β-lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives.

Petracca R, Ponzano S, Bertozzi SM, Sasso O, Piomelli D, Bandiera T, Bertozzi F.

Eur J Med Chem. 2017 Jan 27;126:561-575. doi: 10.1016/j.ejmech.2016.11.039. Epub 2016 Nov 23.

PMID:
27915171
41.

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase.

Romeo E, Pontis S, Ponzano S, Bonezzi F, Migliore M, Di Martino S, Summa M, Piomelli D.

J Vis Exp. 2016 Nov 23;(117). doi: 10.3791/54652.

42.

Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission.

Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I.

Brain Struct Funct. 2017 Jul;222(5):2345-2357. doi: 10.1007/s00429-016-1345-3. Epub 2016 Nov 30.

43.

Bile Acid Recognition by NAPE-PLD.

Margheritis E, Castellani B, Magotti P, Peruzzi S, Romeo E, Natali F, Mostarda S, Gioiello A, Piomelli D, Garau G.

ACS Chem Biol. 2016 Oct 21;11(10):2908-2914. Epub 2016 Sep 12.

44.

A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation.

Wang W, Trieu BH, Palmer LC, Jia Y, Pham DT, Jung KM, Karsten CA, Merrill CB, Mackie K, Gall CM, Piomelli D, Lynch G.

eNeuro. 2016 Aug 8;3(4). pii: ENEURO.0160-16.2016. doi: 10.1523/ENEURO.0160-16.2016. eCollection 2016 Jul-Aug.

45.

Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL.

Scalvini L, Vacondio F, Bassi M, Pala D, Lodola A, Rivara S, Jung KM, Piomelli D, Mor M.

Sci Rep. 2016 Aug 8;6:31046. doi: 10.1038/srep31046.

46.

Endogenous N-acyl taurines regulate skin wound healing.

Sasso O, Pontis S, Armirotti A, Cardinali G, Kovacs D, Migliore M, Summa M, Moreno-Sanz G, Picardo M, Piomelli D.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4397-406. doi: 10.1073/pnas.1605578113. Epub 2016 Jul 13.

47.

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.

Migliore M Dr, Pontis S Dr, Fuentes de Arriba AL, Realini N, Torrente E, Armirotti A, Romeo E, Di Martino S, Russo D, Pizzirani D, Summa M, Lanfranco M, Ottonello G, Busquet P, Jung KM, Garcia-Guzman M, Heim R, Scarpelli R, Piomelli D.

Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197. doi: 10.1002/anie.201603746. Epub 2016 Jul 12.

48.
49.

Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition.

Wang H, Taussig MD, DiPatrizio NV, Bruce K, Piomelli D, Eckel RH.

Metabolism. 2016 Jul;65(7):987-97. doi: 10.1016/j.metabol.2016.01.015. Epub 2016 Feb 4.

PMID:
27282869
50.

Assay of Monoacylglycerol Lipase Activity.

Jung KM, Piomelli D.

Methods Mol Biol. 2016;1412:157-68. doi: 10.1007/978-1-4939-3539-0_17.

PMID:
27245902

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