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Items: 1 to 50 of 369

1.

Cannabis and the Opioid Crisis.

Piomelli D, Weiss S, Boyd G, Pacula RL, Cooper Z.

Cannabis Cannabinoid Res. 2018 Apr 1;3(1):108-116. doi: 10.1089/can.2018.29011.rtl. eCollection 2018. No abstract available.

2.

Author Correction: Patch clamp-assisted single neuron lipidomics.

Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D.

Sci Rep. 2018 Apr 25;8(1):6772. doi: 10.1038/s41598-018-24605-7.

3.

Endocannabinoid System and Migraine Pain: An Update.

Greco R, Demartini C, Zanaboni AM, Piomelli D, Tassorelli C.

Front Neurosci. 2018 Mar 19;12:172. doi: 10.3389/fnins.2018.00172. eCollection 2018. Review.

4.

Familial abnormalities of endocannabinoid signaling in schizophrenia.

Koethe D, Pahlisch F, Hellmich M, Rohleder C, Mueller JK, Meyer-Lindenberg A, Torrey EF, Piomelli D, Leweke FM.

World J Biol Psychiatry. 2018 Mar 22:1-9. doi: 10.1080/15622975.2018.1449966. [Epub ahead of print]

PMID:
29521179
5.

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.

Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ.

J Biol Chem. 2018 Mar 2;293(9):3028-3038. doi: 10.1074/jbc.M117.802058. Epub 2018 Jan 11.

PMID:
29326169
6.

Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage.

Heinitz S, Basolo A, Piaggi P, Piomelli D, Jumpertz von Schwartzenberg R, Krakoff J.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):1077-1087. doi: 10.1210/jc.2017-02257.

PMID:
29300902
7.

Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD).

Castellani B, Diamanti E, Pizzirani D, Tardia P, Maccesi M, Realini N, Magotti P, Garau G, Bakkum T, Rivara S, Mor M, Piomelli D.

Chem Commun (Camb). 2017 Nov 28;53(95):12814-12817. doi: 10.1039/c7cc07582k.

PMID:
29143042
8.

Treating a novel plasticity defect rescues episodic memory in Fragile X model mice.

Wang W, Cox BM, Jia Y, Le AA, Cox CD, Jung KM, Hou B, Piomelli D, Gall CM, Lynch G.

Mol Psychiatry. 2017 Nov 14. doi: 10.1038/mp.2017.221. [Epub ahead of print]

9.

Expert Panel on Understanding Cannabis: Medicine, Society, Government.

Kazan K, Piomelli D, Rohrabacher D, Ajax L.

Cannabis Cannabinoid Res. 2017 Sep 1;2(1):247-251. doi: 10.1089/can.2017.29010.kka. eCollection 2017.

10.

The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of Allergic Dermatitis.

Sasso O, Summa M, Armirotti A, Pontis S, De Mei C, Piomelli D.

J Invest Dermatol. 2018 Mar;138(3):562-569. doi: 10.1016/j.jid.2017.07.853. Epub 2017 Oct 18.

PMID:
29054595
11.

Novel activity-based probes for N-acylethanolamine acid amidase.

Petracca R, Romeo E, Baggelaar MP, Artola M, Pontis S, Ponzano S, Overkleeft HS, van der Stelt M, Piomelli D.

Chem Commun (Camb). 2017 Aug 22;53(86):11810-11813. doi: 10.1039/c7cc06838g.

PMID:
29035406
12.

Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats.

Schoch H, Huerta MY, Ruiz CM, Farrell MR, Jung KM, Huang JJ, Campbell RR, Piomelli D, Mahler SV.

Psychopharmacology (Berl). 2018 Jan;235(1):121-134. doi: 10.1007/s00213-017-4749-8. Epub 2017 Oct 11.

PMID:
29022083
13.

A Guide to the National Academy of Science Report on Cannabis: An Exclusive Discussion with Panel Members.

Piomelli D, Cooper Z, Abrams D, Grant I, Patel S.

Cannabis Cannabinoid Res. 2017 Jun 1;2(1):155-159. doi: 10.1089/can.2017.29009.dpi. eCollection 2017. No abstract available.

14.

Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware.

Angelini R, Argueta DA, Piomelli D, DiPatrizio NV.

Cannabis Cannabinoid Res. 2017 Jun 1;2(1):123-132. doi: 10.1089/can.2017.0019. eCollection 2017.

15.

Increased Renal 2-Arachidonoylglycerol Level Is Associated with Improved Renal Function in a Mouse Model of Acute Kidney Injury.

Moradi H, Oveisi F, Khanifar E, Moreno-Sanz G, Vaziri ND, Piomelli D.

Cannabis Cannabinoid Res. 2016 Sep 1;1(1):218-228. doi: 10.1089/can.2016.0013. eCollection 2016.

16.

Age-dependent changes in nervonic acid-containing sphingolipids in mouse hippocampus.

Vozella V, Basit A, Misto A, Piomelli D.

Biochim Biophys Acta. 2017 Dec;1862(12):1502-1511. doi: 10.1016/j.bbalip.2017.08.008. Epub 2017 Aug 30.

PMID:
28855145
17.

Inhibition of monoacylglycerol lipase: Another signalling pathway for potential therapeutic targets in migraine?

Greco R, Demartini C, Zanaboni AM, Berliocchi L, Piomelli D, Tassorelli C.

Cephalalgia. 2018 May;38(6):1138-1147. doi: 10.1177/0333102417727537. Epub 2017 Aug 17.

PMID:
28816506
18.

Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARα and CB1 receptors.

Rock EM, Moreno-Sanz G, Limebeer CL, Petrie GN, Angelini R, Piomelli D, Parker LA.

Br J Pharmacol. 2017 Nov;174(21):3837-3847. doi: 10.1111/bph.13980. Epub 2017 Sep 20.

PMID:
28805944
19.

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells.

Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, Pistello M, Mazzanti CM, Piomelli D.

Sci Rep. 2017 Aug 7;7(1):7411. doi: 10.1038/s41598-017-07606-w.

20.

Patch clamp-assisted single neuron lipidomics.

Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D.

Sci Rep. 2017 Jul 13;7(1):5318. doi: 10.1038/s41598-017-05607-3. Erratum in: Sci Rep. 2018 Apr 25;8(1):6772.

21.

Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex.

Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca MA, Piomelli D, Parolaro D, Papaleo F.

Mol Psychiatry. 2018 Apr;23(4):1040-1050. doi: 10.1038/mp.2017.126. Epub 2017 Jun 20.

PMID:
28630452
22.

Specific skeletal muscle sphingolipid compounds in energy expenditure regulation and weight gain in Native Americans of Southwestern heritage.

Heinitz S, Piaggi P, Vinales KL, Basolo A, Spranger J, Piomelli D, Krakoff J, Jumpertz von Schwartzenberg R.

Int J Obes (Lond). 2017 Oct;41(10):1585-1593. doi: 10.1038/ijo.2017.143. Epub 2017 Jun 13.

23.

Endocannabinoid Signaling in the Control of Social Behavior.

Wei D, Allsop S, Tye K, Piomelli D.

Trends Neurosci. 2017 Jul;40(7):385-396. doi: 10.1016/j.tins.2017.04.005. Epub 2017 May 26. Review.

24.

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.

Khurana L, Mackie K, Piomelli D, Kendall DA.

Neuropharmacology. 2017 Sep 15;124:3-12. doi: 10.1016/j.neuropharm.2017.05.018. Epub 2017 May 17. Review.

PMID:
28527758
25.

Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus.

Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G.

Cereb Cortex. 2018 Jul 1;28(7):2253-2266. doi: 10.1093/cercor/bhx126.

PMID:
28520937
26.

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.

Marrone MC, Morabito A, Giustizieri M, Chiurchiù V, Leuti A, Mattioli M, Marinelli S, Riganti L, Lombardi M, Murana E, Totaro A, Piomelli D, Ragozzino D, Oddi S, Maccarrone M, Verderio C, Marinelli S.

Nat Commun. 2017 May 10;8:15292. doi: 10.1038/ncomms15292.

27.

P007. Inhibition of monoacylglycerol lipase activity modulates the activation of brain structures relevant for migraine pathogenesis.

Greco R, Bandiera T, Mangione AS, Demartini C, Nappi G, Sandrini G, Piomelli D, Tassorelli C.

J Headache Pain. 2015 Dec;16(Suppl 1):A165. doi: 10.1186/1129-2377-16-S1-A165. No abstract available.

28.

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels.

den Hoedt S, Janssen CIF, Astarita G, Piomelli D, Leijten FPJ, Crivelli SM, Verhoeven AJM, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJG, Kiliaan AJ, Mulder MT.

J Alzheimers Dis. 2017;60(3):769-781. doi: 10.3233/JAD-160739.

PMID:
28035926
29.

Dysfunctional oleoylethanolamide signaling in a mouse model of Prader-Willi syndrome.

Igarashi M, Narayanaswami V, Kimonis V, Galassetti PM, Oveisi F, Jung KM, Piomelli D.

Pharmacol Res. 2017 Mar;117:75-81. doi: 10.1016/j.phrs.2016.12.024. Epub 2016 Dec 19.

30.

Progress in the development of β-lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives.

Petracca R, Ponzano S, Bertozzi SM, Sasso O, Piomelli D, Bandiera T, Bertozzi F.

Eur J Med Chem. 2017 Jan 27;126:561-575. doi: 10.1016/j.ejmech.2016.11.039. Epub 2016 Nov 23.

PMID:
27915171
31.

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase.

Romeo E, Pontis S, Ponzano S, Bonezzi F, Migliore M, Di Martino S, Summa M, Piomelli D.

J Vis Exp. 2016 Nov 23;(117). doi: 10.3791/54652.

PMID:
27911411
32.

Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission.

Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I.

Brain Struct Funct. 2017 Jul;222(5):2345-2357. doi: 10.1007/s00429-016-1345-3. Epub 2016 Nov 30.

33.

Bile Acid Recognition by NAPE-PLD.

Margheritis E, Castellani B, Magotti P, Peruzzi S, Romeo E, Natali F, Mostarda S, Gioiello A, Piomelli D, Garau G.

ACS Chem Biol. 2016 Oct 21;11(10):2908-2914. Epub 2016 Sep 12.

34.

A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation.

Wang W, Trieu BH, Palmer LC, Jia Y, Pham DT, Jung KM, Karsten CA, Merrill CB, Mackie K, Gall CM, Piomelli D, Lynch G.

eNeuro. 2016 Aug 8;3(4). pii: ENEURO.0160-16.2016. doi: 10.1523/ENEURO.0160-16.2016. eCollection 2016 Jul-Aug.

35.

Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL.

Scalvini L, Vacondio F, Bassi M, Pala D, Lodola A, Rivara S, Jung KM, Piomelli D, Mor M.

Sci Rep. 2016 Aug 8;6:31046. doi: 10.1038/srep31046.

36.

Endogenous N-acyl taurines regulate skin wound healing.

Sasso O, Pontis S, Armirotti A, Cardinali G, Kovacs D, Migliore M, Summa M, Moreno-Sanz G, Picardo M, Piomelli D.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4397-406. doi: 10.1073/pnas.1605578113. Epub 2016 Jul 13.

37.

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.

Migliore M Dr, Pontis S Dr, Fuentes de Arriba AL, Realini N, Torrente E, Armirotti A, Romeo E, Di Martino S, Russo D, Pizzirani D, Summa M, Lanfranco M, Ottonello G, Busquet P, Jung KM, Garcia-Guzman M, Heim R, Scarpelli R, Piomelli D.

Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197. doi: 10.1002/anie.201603746. Epub 2016 Jul 12.

38.
39.

Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition.

Wang H, Taussig MD, DiPatrizio NV, Bruce K, Piomelli D, Eckel RH.

Metabolism. 2016 Jul;65(7):987-97. doi: 10.1016/j.metabol.2016.01.015. Epub 2016 Feb 4.

PMID:
27282869
40.

Assay of Monoacylglycerol Lipase Activity.

Jung KM, Piomelli D.

Methods Mol Biol. 2016;1412:157-68. doi: 10.1007/978-1-4939-3539-0_17.

PMID:
27245902
41.

Ion mobility mass spectrometry enhances low-abundance species detection in untargeted lipidomics.

Basit A, Pontis S, Piomelli D, Armirotti A.

Metabolomics. 2016;12:50. Epub 2016 Feb 8.

42.

A simple and accurate protocol for absolute polar metabolite quantification in cell cultures using quantitative nuclear magnetic resonance.

Goldoni L, Beringhelli T, Rocchia W, Realini N, Piomelli D.

Anal Biochem. 2016 May 15;501:26-34. doi: 10.1016/j.ab.2016.02.009. Epub 2016 Feb 18.

PMID:
26898303
43.

Vaccenic acid suppresses intestinal inflammation by increasing anandamide and related N-acylethanolamines in the JCR:LA-cp rat.

Jacome-Sosa M, Vacca C, Mangat R, Diane A, Nelson RC, Reaney MJ, Shen J, Curtis JM, Vine DF, Field CJ, Igarashi M, Piomelli D, Banni S, Proctor SD.

J Lipid Res. 2016 Apr;57(4):638-49. doi: 10.1194/jlr.M066308. Epub 2016 Feb 17.

44.

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.

Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S.

J Med Chem. 2016 Mar 24;59(6):2612-32. doi: 10.1021/acs.jmedchem.5b01812. Epub 2016 Mar 7.

45.

A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice.

Wei D, Lee D, Li D, Daglian J, Jung KM, Piomelli D.

Psychopharmacology (Berl). 2016 May;233(10):1911-9. doi: 10.1007/s00213-016-4222-0. Epub 2016 Feb 13.

46.

Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies.

Nuzzi A, Fiasella A, Ortega JA, Pagliuca C, Ponzano S, Pizzirani D, Bertozzi SM, Ottonello G, Tarozzo G, Reggiani A, Bandiera T, Bertozzi F, Piomelli D.

Eur J Med Chem. 2016 Mar 23;111:138-59. doi: 10.1016/j.ejmech.2016.01.046. Epub 2016 Jan 27.

PMID:
26866968
47.

Enhancement of Anandamide-Mediated Endocannabinoid Signaling Corrects Autism-Related Social Impairment.

Wei D, Dinh D, Lee D, Li D, Anguren A, Moreno-Sanz G, Gall CM, Piomelli D.

Cannabis Cannabinoid Res. 2016 Feb 1;1(1):81-89. doi: 10.1089/can.2015.0008. eCollection 2016.

48.

Medicinal Cannabis in California: An Interview with Igor Grant, MD.

Piomelli D, Grant I.

Cannabis Cannabinoid Res. 2016 Feb 1;1(1):78-80. doi: 10.1089/can.2016.29005.igr. eCollection 2016.

49.

Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.

Migliore M, Habrant D, Sasso O, Albani C, Bertozzi SM, Armirotti A, Piomelli D, Scarpelli R.

Eur J Med Chem. 2016 Feb 15;109:216-37. doi: 10.1016/j.ejmech.2015.12.036. Epub 2015 Dec 23.

50.

An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund's Adjuvant Rat Model of Arthritis.

Bonezzi FT, Sasso O, Pontis S, Realini N, Romeo E, Ponzano S, Nuzzi A, Fiasella A, Bertozzi F, Piomelli D.

J Pharmacol Exp Ther. 2016 Mar;356(3):656-63. doi: 10.1124/jpet.115.230516. Epub 2016 Jan 14.

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