Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 101


Tribo-Charging Behaviour of Inhalable Mannitol Blends with Salbutamol Sulphate.

Zellnitz S, Pinto JT, Brunsteiner M, Schroettner H, Khinast J, Paudel A.

Pharm Res. 2019 Apr 9;36(6):80. doi: 10.1007/s11095-019-2612-9.


N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR.

Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29.


Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo.

Jeitner TM, Pinto JT, Cooper AJL.

Biosci Rep. 2018 Sep 5;38(5). pii: BSR20180691. doi: 10.1042/BSR20180691. Print 2018 Oct 31. Review.


Assessment of Dry Powder Inhaler Carrier Targeted Design: A Comparative Case Study of Diverse Anomeric Compositions and Physical Properties of Lactose.

Pinto JT, Zellnitz S, Guidi T, Roblegg E, Paudel A.

Mol Pharm. 2018 Jul 2;15(7):2827-2839. doi: 10.1021/acs.molpharmaceut.8b00333. Epub 2018 Jun 19.


Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates.

Nichenametla SN, Mattocks DAL, Malloy VL, Pinto JT.

Ann N Y Acad Sci. 2018 Apr;1418(1):80-94. doi: 10.1111/nyas.13556. Epub 2018 Jan 29.


Application of open-access databases to determine functional connectivity between resveratrol-binding protein QR2 and colorectal carcinoma.

Doonan BB, Schaafsma E, Pinto JT, Wu JM, Hsieh TC.

In Vitro Cell Dev Biol Anim. 2017 Aug;53(7):575-578. doi: 10.1007/s11626-017-0174-x. Epub 2017 Jun 23.


How does secondary processing affect the physicochemical properties of inhalable salbutamol sulphate particles? A temporal investigation.

Pinto JT, Radivojev S, Zellnitz S, Roblegg E, Paudel A.

Int J Pharm. 2017 Aug 7;528(1-2):416-428. doi: 10.1016/j.ijpharm.2017.06.027. Epub 2017 Jun 12.


Fluorination at the 4 position alters the substrate behavior of L-glutamine and L-glutamate: Implications for positron emission tomography of neoplasias.

Jeitner TM, Kristoferson E, Azcona JA, Pinto JT, Stalnecker C, Erickson JW, Kung HF, Li J, Ploessl K, Cooper AJL.

J Fluor Chem. 2016 Dec;192(A):58-67. doi: 10.1016/j.jfluchem.2016.10.008. Epub 2016 Oct 20.


Chymase-dependent production of angiotensin II: an old enzyme in old hearts.

Froogh G, Pinto JT, Le Y, Kandhi S, Aleligne Y, Huang A, Sun D.

Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H223-H231. doi: 10.1152/ajpheart.00534.2016. Epub 2016 Nov 4.



Pinto JT, Zempleni J.

Adv Nutr. 2016 Sep 15;7(5):973-5. doi: 10.3945/an.116.012716. Print 2016 Sep. No abstract available.


Erratum to: ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.

Cooper AJ, Shurubor YI, Dorai T, Pinto JT, Isakova EP, Deryabina YI, Denton TT, Krasnikov BF.

Amino Acids. 2015 Dec;47(12):2671-2. doi: 10.1007/s00726-015-2115-x. No abstract available.


ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.

Cooper AJ, Shurubor YI, Dorai T, Pinto JT, Isakova EP, Deryabina YI, Denton TT, Krasnikov BF.

Amino Acids. 2016 Jan;48(1):1-20. doi: 10.1007/s00726-015-2061-7. Epub 2015 Aug 11. Review. Erratum in: Amino Acids. 2015 Dec;47(12):2671-2.


Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane.

Wu JM, Oraee A, Doonan BB, Pinto JT, Hsieh TC.

Exp Hematol Oncol. 2016 Sep 13;5(1):27. doi: 10.1186/s40164-016-0056-z. eCollection 2015.


Role of homocysteinylation of ACE in endothelial dysfunction of arteries.

Huang A, Pinto JT, Froogh G, Kandhi S, Qin J, Wolin MS, Hintze TH, Sun D.

Am J Physiol Heart Circ Physiol. 2015 Jan 15;308(2):H92-100. doi: 10.1152/ajpheart.00577.2014. Epub 2014 Nov 21.


Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.

Sleiman SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J, Wagner FF, Basso M, Coppola G, Pinto JT, Holson EB, Ratan RR.

J Neurosci. 2014 Oct 22;34(43):14328-37. doi: 10.1523/JNEUROSCI.1010-14.2014. Erratum in: J Neurosci. 2015 Jan 7;35(1):438.


HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.

Kang Y, Nian H, Rajendran P, Kim E, Dashwood WM, Pinto JT, Boardman LA, Thibodeau SN, Limburg PJ, Löhr CV, Bisson WH, Williams DE, Ho E, Dashwood RH.

Cell Death Dis. 2014 Oct 16;5:e1476. doi: 10.1038/cddis.2014.422.


Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate β-lyase activity and can transaminate L-selenomethionine.

Pinto JT, Krasnikov BF, Alcutt S, Jones ME, Dorai T, Villar MT, Artigues A, Li J, Cooper AJ.

J Biol Chem. 2014 Nov 7;289(45):30950-61. doi: 10.1074/jbc.M114.591461. Epub 2014 Sep 17.


Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.

Csiszár A, Csiszar A, Pinto JT, Gautam T, Kleusch C, Hoffmann B, Tucsek Z, Toth P, Sonntag WE, Ungvari Z.

J Gerontol A Biol Sci Med Sci. 2015 Mar;70(3):303-13. doi: 10.1093/gerona/glu029. Epub 2014 Mar 18.


From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D.

Pinto JT, Cooper AJ.

Adv Nutr. 2014 Mar 1;5(2):144-63. doi: 10.3945/an.113.005181. Review.


Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia.

Sinha I, Allen JE, Pinto JT, Sinha R.

Cancer Med. 2014 Apr;3(2):252-64. doi: 10.1002/cam4.198. Epub 2014 Feb 7.


Stable isotope gas chromatography-tandem mass spectrometry determination of aminoethylcysteine ketimine decarboxylated dimer in biological samples.

Tsikas D, Evans CE, Denton TT, Mitschke A, Gutzki FM, Pinto JT, Khomenko T, Szabo S, Cooper AJ.

Anal Biochem. 2012 Nov 1;430(1):4-15. doi: 10.1016/j.ab.2012.07.022. Epub 2012 Jul 31.


New mechanistic explanation for the localization of ulcers in the rat duodenum: role of iron and selective uptake of cysteamine.

Khomenko T, Kolodney J, Pinto JT, McLaren GD, Deng X, Chen L, Tolstanova G, Paunovic B, Krasnikov BF, Hoa N, Cooper AJ, Szabo S.

Arch Biochem Biophys. 2012 Sep 1;525(1):60-70. doi: 10.1016/ Epub 2012 Jun 7.


Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate.

Cooper AJ, Krasnikov BF, Pinto JT, Kung HF, Li J, Ploessl K.

Comp Biochem Physiol B Biochem Mol Biol. 2012 Sep;163(1):108-20. doi: 10.1016/j.cbpb.2012.05.010. Epub 2012 May 19.


Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells.

Facompre ND, Sinha I, El-Bayoumy K, Pinto JT, Sinha R.

Int J Cancer. 2012 Nov 1;131(9):2134-42. doi: 10.1002/ijc.27468. Epub 2012 Mar 20.


Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?

Csiszar A, Podlutsky A, Podlutskaya N, Sonntag WE, Merlin SZ, Philipp EE, Doyle K, Davila A, Recchia FA, Ballabh P, Pinto JT, Ungvari Z.

J Gerontol A Biol Sci Med Sci. 2012 Aug;67(8):841-52. doi: 10.1093/gerona/glr216. Epub 2012 Jan 4.


New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine γ-lyase.

Bridges CC, Krasnikov BF, Joshee L, Pinto JT, Hallen A, Li J, Zalups RK, Cooper AJ.

Arch Biochem Biophys. 2012 Jan 1;517(1):20-9. doi: 10.1016/ Epub 2011 Nov 10.


Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.

Bailey-Downs LC, Mitschelen M, Sosnowska D, Toth P, Pinto JT, Ballabh P, Valcarcel-Ares MN, Farley J, Koller A, Henthorn JC, Bass C, Sonntag WE, Ungvari Z, Csiszar A.

J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):313-29. doi: 10.1093/gerona/glr164. Epub 2011 Oct 21.


Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.

Smirnova NA, Haskew-Layton RE, Basso M, Hushpulian DM, Payappilly JB, Speer RE, Ahn YH, Rakhman I, Cole PA, Pinto JT, Ratan RR, Gazaryan IG.

Chem Biol. 2011 Jun 24;18(6):752-65. doi: 10.1016/j.chembiol.2011.03.013.


A survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates: implications for ROS production, cancer etiology, and neurodegenerative diseases.

Bunik VI, Schloss JV, Pinto JT, Dudareva N, Cooper AJ.

Adv Enzymol Relat Areas Mol Biol. 2011;77:307-60. Review. No abstract available.


Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.

Ungvari Z, Bailey-Downs L, Gautam T, Sosnowska D, Wang M, Monticone RE, Telljohann R, Pinto JT, de Cabo R, Sonntag WE, Lakatta EG, Csiszar A.

J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):866-75. doi: 10.1093/gerona/glr092. Epub 2011 May 28.


Reversible and irreversible protein glutathionylation: biological and clinical aspects.

Cooper AJ, Pinto JT, Callery PS.

Expert Opin Drug Metab Toxicol. 2011 Jul;7(7):891-910. doi: 10.1517/17425255.2011.577738. Epub 2011 May 11. Review. Erratum in: Expert Opin Drug Metab Toxicol. 2011 Sep;7(9):1183.


Methylseleninic acid downregulates hypoxia-inducible factor-1α in invasive prostate cancer.

Sinha I, Null K, Wolter W, Suckow MA, King T, Pinto JT, Sinha R.

Int J Cancer. 2012 Mar 15;130(6):1430-9. doi: 10.1002/ijc.26141. Epub 2011 Jul 21.


Measurement of cysteine S-conjugate β-lyase activity.

Cooper AJ, Krasnikov BF, Pinto JT, Bruschi SA.

Curr Protoc Toxicol. 2010 May;Chapter 4:Unit 4.36. doi: 10.1002/0471140856.tx0436s44.


Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats.

Ungvari Z, Gautam T, Koncz P, Henthorn JC, Pinto JT, Ballabh P, Yan H, Mitschelen M, Farley J, Sonntag WE, Csiszar A.

J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1145-56. doi: 10.1093/gerona/glq147. Epub 2010 Aug 16.


1,4-phenylenebis(methylene)selenocyanate, but not selenomethionine, inhibits androgen receptor and Akt signaling in human prostate cancer cells.

Facompre ND, El-Bayoumy K, Sun YW, Pinto JT, Sinha R.

Cancer Prev Res (Phila). 2010 Aug;3(8):975-84. doi: 10.1158/1940-6207.CAPR-10-0054. Epub 2010 Jul 6.


Chemopreventive mechanisms of α-keto acid metabolites of naturally occurring organoselenium compounds.

Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ.

Amino Acids. 2011 Jun;41(1):29-41. doi: 10.1007/s00726-010-0578-3. Epub 2010 Apr 10. Review.


Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents.

Cooper AJ, Krasnikov BF, Niatsetskaya ZV, Pinto JT, Callery PS, Villar MT, Artigues A, Bruschi SA.

Amino Acids. 2011 Jun;41(1):7-27. doi: 10.1007/s00726-010-0552-0. Epub 2010 Mar 22. Review.


Western-style diets induce oxidative stress and dysregulate immune responses in the colon in a mouse model of sporadic colon cancer.

Erdelyi I, Levenkova N, Lin EY, Pinto JT, Lipkin M, Quimby FW, Holt PR.

J Nutr. 2009 Nov;139(11):2072-8. doi: 10.3945/jn.108.104125. Epub 2009 Sep 16.


Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells.

Ungvari Z, Labinskyy N, Mukhopadhyay P, Pinto JT, Bagi Z, Ballabh P, Zhang C, Pacher P, Csiszar A.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1876-81. doi: 10.1152/ajpheart.00375.2009. Epub 2009 Sep 11.


Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.

Csiszar A, Labinskyy N, Olson S, Pinto JT, Gupte S, Wu JM, Hu F, Ballabh P, Podlutsky A, Losonczy G, de Cabo R, Mathew R, Wolin MS, Ungvari Z.

Hypertension. 2009 Sep;54(3):668-75. doi: 10.1161/HYPERTENSIONAHA.109.133397. Epub 2009 Jul 13.


Identification of the putative tumor suppressor Nit2 as omega-amidase, an enzyme metabolically linked to glutamine and asparagine transamination.

Krasnikov BF, Chien CH, Nostramo R, Pinto JT, Nieves E, Callaway M, Sun J, Huebner K, Cooper AJ.

Biochimie. 2009 Sep;91(9):1072-80. doi: 10.1016/j.biochi.2009.07.003. Epub 2009 Jul 10.


Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells.

Lee JI, Nian H, Cooper AJ, Sinha R, Dai J, Bisson WH, Dashwood RH, Pinto JT.

Cancer Prev Res (Phila). 2009 Jul;2(7):683-93. doi: 10.1158/1940-6207.CAPR-09-0047.


Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.

Csiszar A, Labinskyy N, Jimenez R, Pinto JT, Ballabh P, Losonczy G, Pearson KJ, de Cabo R, Ungvari Z.

Mech Ageing Dev. 2009 Aug;130(8):518-27. doi: 10.1016/j.mad.2009.06.004. Epub 2009 Jun 21.


Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells.

Nian H, Bisson WH, Dashwood WM, Pinto JT, Dashwood RH.

Carcinogenesis. 2009 Aug;30(8):1416-23. doi: 10.1093/carcin/bgp147. Epub 2009 Jun 15.


Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism.

Pinto JT, Khomenko T, Szabo S, McLaren GD, Denton TT, Krasnikov BF, Jeitner TM, Cooper AJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 15;877(28):3434-41. doi: 10.1016/j.jchromb.2009.05.041. Epub 2009 May 28.


Assay and purification of omega-amidase/Nit2, a ubiquitously expressed putative tumor suppressor, that catalyzes the deamidation of the alpha-keto acid analogues of glutamine and asparagine.

Krasnikov BF, Nostramo R, Pinto JT, Cooper AJ.

Anal Biochem. 2009 Aug 15;391(2):144-50. doi: 10.1016/j.ab.2009.05.025. Epub 2009 May 21.


Resveratrol induces mitochondrial biogenesis in endothelial cells.

Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, Pearson K, de Cabo R, Pacher P, Zhang C, Ungvari Z.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H13-20. doi: 10.1152/ajpheart.00368.2009. Epub 2009 May 8.


Transglutaminases and neurodegeneration.

Jeitner TM, Pinto JT, Krasnikov BF, Horswill M, Cooper AJ.

J Neurochem. 2009 May;109 Suppl 1:160-6. doi: 10.1111/j.1471-4159.2009.05843.x. Review.


Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus.

Labinskyy N, Mukhopadhyay P, Toth J, Szalai G, Veres M, Losonczy G, Pinto JT, Pacher P, Ballabh P, Podlutsky A, Austad SN, Csiszar A, Ungvari Z.

Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H946-56. doi: 10.1152/ajpheart.00693.2008. Epub 2009 Jan 30.

Supplemental Content

Loading ...
Support Center