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PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice.

Chen YC, Mains RE, Eipper BA, Hoffman BG, Czyzyk TA, Pintar JE, Verchere CB.

Diabetologia. 2020 Jan 27. doi: 10.1007/s00125-019-05060-z. [Epub ahead of print]


NOP Receptor Antagonists Decrease Alcohol Drinking in the Dark in C57BL/6J Mice.

Brunori G, Weger M, Schoch J, Targowska-Duda K, Barnes M, Borruto AM, Rorick-Kehn LM, Zaveri NT, Pintar JE, Ciccocioppo R, Toll L, Cippitelli A.

Alcohol Clin Exp Res. 2019 Oct;43(10):2167-2178. doi: 10.1111/acer.14165. Epub 2019 Aug 21.


7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects.

Kruegel AC, Uprety R, Grinnell SG, Langreck C, Pekarskaya EA, Le Rouzic V, Ansonoff M, Gassaway MM, Pintar JE, Pasternak GW, Javitch JA, Majumdar S, Sames D.

ACS Cent Sci. 2019 Jun 26;5(6):992-1001. doi: 10.1021/acscentsci.9b00141. Epub 2019 May 29.


Contrasting effects of IGF binding protein-3 expression in mammary tumor cells and the tumor microenvironment.

Scully T, Scott CD, Firth SM, Pintar JE, Twigg SM, Baxter RC.

Exp Cell Res. 2019 Jan 1;374(1):38-45. doi: 10.1016/j.yexcr.2018.11.006. Epub 2018 Nov 9.


Enhancement of mammary tumour growth by IGFBP-3 involves impaired T cell accumulation.

Scully T, Scott CD, Firth SM, Sedger LM, Pintar JE, Twigg SM, Baxter RC.

Endocr Relat Cancer. 2018 Feb;25(2):111-122. doi: 10.1530/ERC-17-0384. Epub 2017 Dec 7.


Opioids and opioid receptors orchestrate wound repair.

Wang Y, Gupta M, Poonawala T, Farooqui M, Li Y, Peng F, Rao S, Ansonoff M, Pintar JE, Gupta K.

Transl Res. 2017 Jul;185:13-23. doi: 10.1016/j.trsl.2017.05.003. Epub 2017 May 18.


Mexneurin is a novel precursor of peptides in the central nervous system of rodents.

Matus-Ortega ME, Leff Gelman P, Calva-Nieves JC, Flores-Zamora A, Salazar-Juárez A, Torner-Aguilar CA, Gamba G, De Los Heros P, Peng B, Pintar JE, Gompf HS, Allen CN, Antón-Palma B.

FEBS Lett. 2017 Jun;591(12):1627-1636. doi: 10.1002/1873-3468.12679. Epub 2017 Jun 1.


The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor.

Samuels BA, Nautiyal KM, Kruegel AC, Levinstein MR, Magalong VM, Gassaway MM, Grinnell SG, Han J, Ansonoff MA, Pintar JE, Javitch JA, Sames D, Hen R.

Neuropsychopharmacology. 2017 Sep;42(10):2052-2063. doi: 10.1038/npp.2017.60. Epub 2017 Mar 17.


Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors.

Witkin JM, Rorick-Kehn LM, Benvenga MJ, Adams BL, Gleason SD, Knitowski KM, Li X, Chaney S, Falcone JF, Smith JW, Foss J, Lloyd K, Catlow JT, McKinzie DL, Svensson KA, Barth VN, Toledo MA, Diaz N, Lafuente C, Jiménez A, Benito A, Pedregal C, Martínez-Grau MA, Post A, Ansonoff MA, Pintar JE, Statnick MA.

Pharmacol Res Perspect. 2016 Nov 7;4(6):e00275. doi: 10.1002/prp2.275. eCollection 2016 Dec.


Insulin-like growth factor binding protein-3 links obesity and breast cancer progression.

Scully T, Firth SM, Scott CD, de Silva HC, Pintar JE, Chan-Ling T, Twigg SM, Baxter RC.

Oncotarget. 2016 Aug 23;7(34):55491-55505. doi: 10.18632/oncotarget.10675.


A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder.

Statnick MA, Chen Y, Ansonoff M, Witkin JM, Rorick-Kehn L, Suter TM, Song M, Hu C, Lafuente C, Jiménez A, Benito A, Diaz N, Martínez-Grau MA, Toledo MA, Pintar JE.

J Pharmacol Exp Ther. 2016 Feb;356(2):493-502. doi: 10.1124/jpet.115.228221. Epub 2015 Dec 9.


IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine.

Austin K, Imam NA, Pintar JE, Brubaker PL.

Endocrinology. 2015 Feb;156(2):429-36. doi: 10.1210/en.2014-1829. Epub 2014 Dec 16.


Loss of the mu opioid receptor induces strain-specific alterations in hippocampal neurogenesis and spatial learning.

Cominski TP, Ansonoff MA, Turchin CE, Pintar JE.

Neuroscience. 2014 Oct 10;278:11-9. doi: 10.1016/j.neuroscience.2014.07.039. Epub 2014 Jul 31.


Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA.

Grinnell SG, Majumdar S, Narayan A, Le Rouzic V, Ansonoff M, Pintar JE, Pasternak GW.

J Pharmacol Exp Ther. 2014 Sep;350(3):710-8. doi: 10.1124/jpet.114.213199. Epub 2014 Jun 26.


The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.

Witkin JM, Statnick MA, Rorick-Kehn LM, Pintar JE, Ansonoff M, Chen Y, Tucker RC, Ciccocioppo R.

Pharmacol Ther. 2014 Mar;141(3):283-99. doi: 10.1016/j.pharmthera.2013.10.011. Epub 2013 Nov 1. Review. Erratum in: Pharmacol Ther. 2014 Sep;143(3):351.


GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.

Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, Rodriguiz RM, Kumar S, Wetsel WC, Pintar JE, Fricker LD, Devi LA.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-6. doi: 10.1073/pnas.1312938110. Epub 2013 Sep 16.


IGF-II promotes stemness of neural restricted precursors.

Ziegler AN, Schneider JS, Qin M, Tyler WA, Pintar JE, Fraidenraich D, Wood TL, Levison SW.

Stem Cells. 2012 Jun;30(6):1265-76. doi: 10.1002/stem.1095.


Exogenous GLP-2 and IGF-I induce a differential intestinal response in IGF binding protein-3 and -5 double knockout mice.

Murali SG, Brinkman AS, Solverson P, Pun W, Pintar JE, Ney DM.

Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G794-804. doi: 10.1152/ajpgi.00372.2011. Epub 2012 Jan 26.


Loss of the mu opioid receptor on different genetic backgrounds leads to increased bromodeoxyuridine labeling in the dentate gyrus only after repeated injection.

Cominski TP, Turchin CE, Hsu MS, Ansonoff MA, Pintar JE.

Neuroscience. 2012 Mar 29;206:49-59. doi: 10.1016/j.neuroscience.2011.12.046. Epub 2012 Jan 16.


Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.

Atkins N Jr, Mitchell JW, Romanova EV, Morgan DJ, Cominski TP, Ecker JL, Pintar JE, Sweedler JV, Gillette MU.

PLoS One. 2010 Sep 7;5(9):e12612. doi: 10.1371/journal.pone.0012612.


Potentiating effect of morphine on oral Salmonella enterica serovar Typhimurium infection is μ-opioid receptor-dependent.

Breslow JM, Feng P, Meissler JJ, Pintar JE, Gaughan J, Adler MW, Eisenstein TK.

Microb Pathog. 2010 Dec;49(6):330-5. doi: 10.1016/j.micpath.2010.07.006. Epub 2010 Aug 3.


The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation.

Morgan DJ, Wei S, Gomes I, Czyzyk T, Mzhavia N, Pan H, Devi LA, Fricker LD, Pintar JE.

J Neurochem. 2010 Jun;113(5):1275-84. doi: 10.1111/j.1471-4159.2010.06706.x. Epub 2010 Mar 26.


Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands.

Ansonoff MA, Portoghese PS, Pintar JE.

Psychopharmacology (Berl). 2010 Jun;210(2):161-8. doi: 10.1007/s00213-010-1826-7. Epub 2010 Mar 24.


Lack of genotype effect on D1, D2 receptors and dopamine transporter binding in triple MOP-, DOP-, and KOP-opioid receptor knockout mice of three different genetic backgrounds.

Yoo JH, Bailey A, Ansonoff M, Pintar JE, Matifas A, Kieffer BL, Kitchen I.

Synapse. 2010 Jul;64(7):520-7. doi: 10.1002/syn.20757.


Kappa opioid receptor contributes to EGF-stimulated neurite extension in development.

Tsai NP, Tsui YC, Pintar JE, Loh HH, Wei LN.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3216-21. doi: 10.1073/pnas.0912367107. Epub 2010 Jan 26.


Kappa2 opioid receptor subtype binding requires the presence of the DOR-1 gene.

Ansonoff MA, Wen T, Pintar JE.

Front Biosci (Schol Ed). 2010 Jan 1;2:772-80.


Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis.

Zhang X, Pan H, Peng B, Steiner DF, Pintar JE, Fricker LD.

J Neurochem. 2010 Mar;112(5):1168-79. doi: 10.1111/j.1471-4159.2009.06530.x. Epub 2009 Dec 7.


Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic β-Cell Growth.

Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ.

Endocr Rev. 2009 Dec 1;30(7):930. doi: 10.1210/edrv.30.7.9990. No abstract available.


kappa-Opioid receptors control the metabolic response to a high-energy diet in mice.

Czyzyk TA, Nogueiras R, Lockwood JF, McKinzie JH, Coskun T, Pintar JE, Hammond C, Tschöp MH, Statnick MA.

FASEB J. 2010 Apr;24(4):1151-9. doi: 10.1096/fj.09-143610. Epub 2009 Nov 16.


Role of opioid receptor like-1 receptor in modulation of endocrine, immunological, and behavioral responses to the T-cell superantigen staphylococcal enterotoxin A.

Mallimo EM, Ansonoff MA, Pintar JE, Kusnecov AW.

J Neuroimmunol. 2010 Jan 25;218(1-2):48-56. doi: 10.1016/j.jneuroim.2009.10.014. Epub 2009 Nov 13.


Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth.

Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ.

Mol Endocrinol. 2010 Jan;24(1):178-92. doi: 10.1210/me.2009-0167. Epub 2009 Nov 6.


Electroacupuncture analgesia is enhanced in transgenic nociceptin/orphanin FQ knock-out mice.

Wan Y, Han JS, Pintar JE.

Beijing Da Xue Xue Bao Yi Xue Ban. 2009 Jun 18;41(3):376-9.


The MOR-1 opioid receptor regulates glucose homeostasis by modulating insulin secretion.

Wen T, Peng B, Pintar JE.

Mol Endocrinol. 2009 May;23(5):671-8. doi: 10.1210/me.2008-0345. Epub 2009 Feb 12.


PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions.

Miyako K, Cobb LJ, Francis M, Huang A, Peng B, Pintar JE, Ariga H, Cohen P.

Mol Endocrinol. 2009 Feb;23(2):169-75. doi: 10.1210/me.2008-0168. Epub 2008 Dec 18.


Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper.

Bousquet-Moore D, Ma XM, Nillni EA, Czyzyk TA, Pintar JE, Eipper BA, Mains RE.

Endocrinology. 2009 Apr;150(4):1739-47. doi: 10.1210/en.2008-1202. Epub 2008 Nov 20.


The tail pigmentation pattern of C57BL/6J mice affects nociception/pain quantification in the tail flick test.

Wen T, Ansonoff MA, Pintar JE.

Eur J Pain. 2009 Jul;13(6):564-7. doi: 10.1016/j.ejpain.2008.07.012. Epub 2008 Sep 19.


Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension, and diuresis are absent in N/OFQ peptide (NOP) receptor knockout mice.

Burmeister MA, Ansonoff MA, Pintar JE, Kapusta DR.

J Pharmacol Exp Ther. 2008 Sep;326(3):897-904. doi: 10.1124/jpet.107.135905. Epub 2008 Jun 6.


Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors.

Weber ML, Farooqui M, Nguyen J, Ansonoff M, Pintar JE, Hebbel RP, Gupta K.

Am J Physiol Renal Physiol. 2008 Jun;294(6):F1388-97. doi: 10.1152/ajprenal.00389.2007. Epub 2008 Apr 2.


Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo.

Ning Y, Schuller AG, Conover CA, Pintar JE.

Mol Endocrinol. 2008 May;22(5):1213-25. doi: 10.1210/me.2007-0536. Epub 2008 Feb 7.


Epidermal stem cells are retained in vivo throughout skin aging.

Giangreco A, Qin M, Pintar JE, Watt FM.

Aging Cell. 2008 Mar;7(2):250-9. doi: 10.1111/j.1474-9726.2008.00372.x. Epub 2008 Jan 21.


Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.

Gendron L, Pintar JE, Chavkin C.

Neuroscience. 2007 Dec 19;150(4):807-17. Epub 2007 Oct 5.


Brain region-specific N-glycosylation and lipid rafts association of the rat mu opioid receptor.

Huang P, Chen C, Xu W, Yoon SI, Unterwald EM, Pintar JE, Wang Y, Chong PL, Liu-Chen LY.

Biochem Biophys Res Commun. 2008 Jan 4;365(1):82-8. Epub 2007 Oct 31.


IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.

Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10589-94. Epub 2007 Jun 13.


Nociception increases during opioid infusion in opioid receptor triple knock-out mice.

Juni A, Klein G, Pintar JE, Kest B.

Neuroscience. 2007 Jun 29;147(2):439-44. Epub 2007 Jun 1.


The absence of endogenous beta-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation.

Petraschka M, Li S, Gilbert TL, Westenbroek RE, Bruchas MR, Schreiber S, Lowe J, Low MJ, Pintar JE, Chavkin C.

Neuroscience. 2007 Jun 8;146(4):1795-807. Epub 2007 Apr 30.


Strain-specific steroidal control of pituitary function.

Lee SN, Peng B, Desjardins R, Pintar JE, Day R, Lindberg I.

J Endocrinol. 2007 Mar;192(3):515-25.


Intestinotrophic effects of exogenous IGF-I are not diminished in IGF binding protein-5 knockout mice.

Murali SG, Liu X, Nelson DW, Hull AK, Grahn M, Clayton MK, Pintar JE, Ney DM.

Am J Physiol Regul Integr Comp Physiol. 2007 Jun;292(6):R2144-50. Epub 2007 Mar 1.


Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene.

Ning Y, Hoang B, Schuller AG, Cominski TP, Hsu MS, Wood TL, Pintar JE.

Endocrinology. 2007 May;148(5):2138-47. Epub 2007 Jan 25.


Differential involvement of endogenous opioids in sucrose consumption and food reinforcement.

Hayward MD, Schaich-Borg A, Pintar JE, Low MJ.

Pharmacol Biochem Behav. 2006 Nov;85(3):601-11. Epub 2006 Dec 12.


Demonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift method.

Della Valle MC, Sleat DE, Sohar I, Wen T, Pintar JE, Jadot M, Lobel P.

J Biol Chem. 2006 Nov 17;281(46):35436-45. Epub 2006 Sep 5.

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